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All Journal METAMORFOSA Journal of Biological Sciences Jurnal Kesehatan Islam : Islamic Health Journal Medical and Health Science Journal Journal of Community Development Diversity
Adyan Donastin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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PENGARUH SUPLEMENTASI VITAMIN D TERHADAP NILAI PENGUKURAN FEV1/ FVC PADA PENDERITA ASMA TERKONTROL SEBAGIAN Adyan Donastin; Arief Bakhtiar; Daniel Maranatha
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.617

Abstract

Background:Airflow resistance in asthma caused by changes in the airways that is bronchoconstriction,airway edema, airway hyperresponsiveness and airway remodeling. Vitamin D supplementation is expectedto raise the value of the measurement of FEV1/ FVC in patients with asthma controlled in part through therole of vitamin D in terms of antiviral effects, atopic response, response improvement steroid and preventairway remodeling process.Objective:Comparing the measurement values of FEV1/ FVC in patients withasthma controlled most of which do not get supplemental vitamin D than getting supplemental vitaminD.Methods:This study is a randomized experimental simple study. This research was conducted in drSoetomo Hospital from June to July 2015. The sampling technique using consecutive sampling. Sampleswere divided into two groups each consisting of 14 samples which have earned a combined therapy ofinhaled corticosteroids and LABA. The control group that was not given additional vitamin Dsupplementation and the treatment group were given supplements of vitamin D for 1 month. Measurementand main result:Testing of data distribution using the ShapiroWilk method because the sample size is lessthan 50. The result of the difference in FEV1 / FVC with a paired sample t - test is known that in the controlgroup (not given additional vitamin D supplements) did not occur significant difference (p = 0.219> 0.05),while the treatment group (given additional vitamin supplements D) proved significant difference (p = 0.020<0.05) where the value of FEV1 / FVC after being given additional vitamin D supplements increased to96.071% of the initial conditions is 84.786%.Conclusions:The measurement values of FEV1/ FVC in patientswith asthma controlled most of which get vitamin D supplementation are the most significant increasecompared to the control group who did not receive supplementation ofvitamin D.
HUBUNGAN POLA MAKAN DAN KEBIASAAN OLAHRAGA YANG BAIK DENGAN KADAR GULA DARAH PENDERITA DIABETES MELLITUS TIPE II DI RSI JEMURSARI Marlia Alief Rachmawati; Handayani .; Adyan Donastin
Jurnal Ilmu Kesehatan dan Kesehatan Vol 2 No 1 (2018): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v2i1.966

Abstract

Abstrak: Diabetes Mellitus tipe II adalah penyakit kronis mengalami resistansi terhadap aksi insulindan ketidakmampuan pankreas untuk menghasilkan cukup insulin. DM tipe II sendiri mendudukiperingkat ke-2 di dunia dengan penderita terbanyak Pola makan yang buruk dan kurangnya olahragadapat memengaruhi terjadinya DM tipe II. Perkembangan pola makan yang salah arah saat inimempercepat peningkatan jumlah penderita DM di Indonesia. Pada saat tubuh melakukan gerakan,maka sejumlah gula akan dibakar untuk dijadikan tenaga gerak. Sehingga sejumlah gula dalamtubuh akan berkurang dan kebutuhan akan hormon insulin juga akan berkurang. Penelitian inibertujuan adalah untuk mengetahui hubungan pola makan dan kebiasaan olahraga dengan kadargula penderita Diabetes Mellitus II pada penderita Diabetes Mellitus II di RSI Jemursari Penelitianini dilakukan dengan metode survey atau observasional dengan pendekatan crosssectional. Sampelyang diambil sebanyak 24 pasien. Populasi dalam penelitian ini adalah semua pasien DiabetesMellitus Tipe 2 yang menjalani rawat jalan pada poli penyakit dalam, namun dibatasi dengankriteria inklusi dan eksklusi yang penulis buat. Dari 24 pasien, pada hubungan pola makan dengankadar gula darah sebanyak 13 pasien (54,2%) mempunyai kadar gula tidak tinggi. 11 pasien (45,8%)mempunyai kadar gula tinggi. Dengan hasil uji statistik didapatkan nilai p=1,000 (p>0,05). Makadapat disimpulkan bahwa terdapat hubungan yang tidak signifikan antara pola makan dan kadargula. Serta hubungan olahraga dengan kadar gula darah sebanyak 13 pasien (54,2%) mempunyaikadar gula tidak tinggi. 11 pasien (45,8%) mempunyai kadar gula tinggi. Dengan hasil uji statistikdidapatkan nilai p=0,432 (p>0,05). Maka dapat disimpulkan bahwa terdapat hubungan yang tidaksignifikan antara olahraga dan kadar gula.
Comparison of Three DNA Isolation Methods of Aspergillus Niger Adyan Donastin; Maharani Pertiwi Koentjoro; Muhamad Taufik Hidayat; Endry Nugroho Prasetyo
Metamorfosa: Journal of Biological Sciences Vol 9 No 1 (2022)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2022.v09.i01.p07

Abstract

Polymerase Chain Reaction (PCR) is a technique that is applied to detect and test the presence of genetic material from pathogenic fungi. This method was further developed because it has a high sensitivity compared to the culture method in detecting the presence of pathogenic fungi. To perform sensitive, specific and reliable PCR-based assays, the availability of pure DNA as well as an easy-to-perform DNA extraction protocol is essential. Currently, existing protocols for DNA extraction generally require specialized kits and with the addition of enzymes. Therefore, this study was conducted to compare the quantity and quality of Aspergillus niger DNA isolation with three different methods. The stages of the research carried out included pure A. niger culture and total DNA isolation using three methods, namely the protocol according to the Wizard® Genomic DNA Purification Kit (P1) instructions, Modified Wizard® Genomic DNA Purification Kit (P2) and Monarch Genomic DNA Purification Kit NEB (P3). The results of the evaluation of DNA isolation using a spectrophotometer at a wavelength of A260/280 nm showed a ratio of 1.4, 1.8, and 1.7 at P1 and P2, and P3 respectively. The quantity obtained ranged from 210 to 305 ng/µL. The total DNA results obtained were then used for PCR testing of ITS ribosomal DNA fragments using ITS1 and ITS4 primers. Electrophorosis observation of PCR results showed that all samples produced bands with a length of 500 bp. The results of DNA isolation in the P1 method did not show bands on the agarose gel, but could be seen in the PCR product. Methods P2 and P3 showed DNA that had good quality and quality. The P2 and P3 methods use a cell destruction technique with liquid nitrogen and a combination of addition of proteinase K. The obtained protocol is expected to provide fast and good method information in the isolation of total DNA from A. niger. Keyword: Aspergillus niger, total DNA isolation, ITS1, ITS4
Comparison The Value Of Bta Sputum Between Pulmonary Tuberculosis Patients With Diabetes Mellitus And Pulmonary Tuberculosis Patients Non-Diabetes Mellitus. Bagas Setiawan Ihsan Zaini; Adyan Donastin; Lea Maera Shanty; Hotimah Masdan Salim
Jurnal Kesehatan Islam : Islamic Health Journal Vol 9, No 2 (2020): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v9i2.8869

Abstract

Background & Aims: Tuberculosis (TB) is a health problem. Based on the WHO report in 2016, Indonesia is a developing country with the second largest TB case. One risk factor for pulmonary tuberculosis is having a history of diabetes mellitus disease. The aim of this research is to examine the differences the value of BTA sputum between pulmonary TB patients with diabetes mellitus and pulmonary TB patients non-diabetes mellitus.Methods: This research is descriptive analytic with comparative study. This study uses secondary data in Islamic Jemursari Surabaya Hospital period January - December 2017. The results will be processed using descriptive analysis and Mann-Whitney test with SPSS 25.00 for windows.Results: This research obtained 68 samples consisting of 34 the pulmonary TB non-diabetes mellitus and 34 pulmonary TB with diabetes mellitus. In pulmonary TB patients non-diabetes mellitus most have negative BTA sputum values, while pulmonary TB with diabetes mellitus is positive (+1), so there are differences in the value of BTA sputum with a significance value 0.001 (<0.05).Conclusion: There is a difference in the value of BTA sputum between pulmonary TB patients with diabetes mellitus and pulmonary TB patients non-diabetes mellitus. It caused in patients with diabetes mellitus have immunological abnormalities, especially IFN-γ and pulmonary physiological disorder.
Edukasi Pencegahan Penyakit Paru sebagai Upaya Menjaga Kesehatan Individu dan Lingkungan Pondok Pesantren Titin Sholihah Agustina; Mulyadi; Adyan Donastin; Matin, Nur Sophia
Journal of Community Development Diversity Vol. 1 No. 3 (2025): November
Publisher : Pro Panoramic Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64595/jcdd.395

Abstract

Penyakit paru seperti ISPA dan TBC masih menjadi masalah kesehatan yang banyak dijumpai di lingkungan padat hunian seperti pondok pesantren. Kurangnya kesadaran tentang perilaku hidup bersih, ventilasi yang buruk, serta rendahnya kualitas udara memperbesar risiko penyebaran penyakit pernapasan di kalangan santri. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman dan kesadaran santri Pondok Pesantren Wachid Hasyim, Bangil, melalui edukasi preventif penyakit paru dan intervensi lingkungan berbasis partisipatif. Metode yang digunakan meliputi edukasi melalui ceramah dan diskusi interaktif, penanaman tanaman antipolutan, perbaikan sanitasi, serta pretest dan posttest untuk mengukur pemahaman peserta. Hasil kegiatan menunjukkan adanya perubahan perilaku positif, seperti penggunaan masker dan keterlibatan dalam menjaga kebersihan lingkungan, meskipun secara statistik nilai posttest menunjukkan penurunan yang perlu ditinjau dari segi metode edukasi yang digunakan. Secara keseluruhan, kegiatan ini menunjukkan bahwa edukasi pencegahan penyakit paru yang disertai dengan intervensi lingkungan dapat membangun kesadaran kolektif di kalangan santri untuk menjaga kesehatan pernapasan dan menciptakan lingkungan pondok pesantren yang lebih sehat. Pendekatan berbasis komunitas dan edukatif aplikatif direkomendasikan untuk pelaksanaan program sejenis di masa mendatang.
Co-Authors Bagas Setiawan Ihsan Zaini Bakhtiar, Arief Endry Nugroho Prasetyo Handayani . Lea Maera Shanty Maharani Pertiwi Koentjoro Maranatha, Daniel Marlia Alief Rachmawati Matin, Nur Sophia Muhammad Taufiq Hidayat MULYADI Salim, Hotimah Masdan Titin Sholihah Agustina