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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Pengabdian Kepada Masyarakat MEMBANGUN NEGERI Journal of Fundamental and Applied Pharmaceutical Science Prosiding Seminar Nasional Program Pengabdian Masyarakat
Krisridwany, Annisa
Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Evaluation of Sidr Leaf Ethanol (Ziziphus mauritiana Lam.) Extract-Based Tablets as Antihypercholesterolemia Orbayinah, Salmah; Dewi, Yunita P.; Kurniawan, Fariez; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57926

Abstract

Sidr leaf extract (Ziziphus mauritiana Lam.) is effective against hypercholesterolemia by blocking the HMG-CoA reductase. This study seeks to identify the characteristics of tablets formulated from the ethanol extract of Sidr leaf and their efficacy in lowering total blood cholesterol levels. The tablets were produced using the wet granulation method and processed into three formulations, F1, F2, and F3, with differing dosages of 100, 150, and 250 mg, along with placebo. The granules produced were evaluated for their physical characteristics. The tablets were evaluated for their physical characteristics and tested for effectiveness in lowering cholesterol levels. The efficacy of tablet-form sidr leaf ethanol extract was assessed by analyzing cholesterol levels in mouse serum samples compared to simvastatin. The data were statistically analyzed using one-way ANOVA and post-hoc Tukey HSD test. In the disintegration time test, F1 and F2 tablets satisfied the criteria. However, F3 exceeded the limit of 60 minutes. Among the three tablet doses, the F2 tablet (150 mg) demonstrated superior efficacy in lowering total cholesterol levels relative to the F1 and F3 tablets. Consequently, tablets containing Sidr leaf extract demonstrate potential for hypercholesterolemia management at an effective dosage of 150 mg, warranting further investigation through clinical trials.
Immunomodulatory Activity of Parijoto Fruit (Medinilla speciosa) on Macrophage Phagocytosis, Lymphocyte Proliferation, and IgG Production Jannah, Asni F.; Winanta, Aji; Anggreani, Ira; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57948

Abstract

Parijoto fruit (Medinilla speciosa) contains flavonoid compounds that are potentially immunomodulators because they increase macrophage phagocytosis activity and lymphocyte proliferation in vitro. This study aims to determine the phytochemical compound content of parijoto fruit and its potential as an immunomodulatory agent in vivo. Parijoto fruit was extracted using 70% ethanol solvent. The ethanol extract of parijoto fruit (EEPF) was qualitatively identified by phytochemical screening. The immunomodulatory activity test in vivo was conducted using BALB/c mice, which were separated into five groups: untreated, Phyllanthus niruri L. (PN) extract (positive control), and test groups (125mg/KgBW; 250mg/KgBW and 375mg/KgBW). The treatment duration was 18 days, with the induction of the hepatitis B vaccine on days 7 and 14. An immunomodulatory activity test was conducted on the 19th day, which included a macrophage phagocytosis activity test, lymphocyte proliferation, and measurement of IgG levels. The identification results showed that EEPF contains flavonoids, tannins, and saponins. Macrophage phagocytosis activity showed that EEPF increased macrophages' phagocytosis capacity (PC) and phagocytosis index (PI). EEPF increased lymphocyte proliferation activity and IgG levels, significantly different from control and not substantially different from positive control. Collectively, EEPF increases immunomodulatory activity in vivo.
Co-Authors Aji Winanta Aji Winanta Aji Winanta Anggreani, Ira Chaessy Yori Anggraini Dewi, Yunita P. Dhecella Winy Cintya Ningrum Dina Latifah Hanum Dyani Primasari Sukamdi Erlangga Jun Prasetya Hasna Nuansa Sasadara Jannah, Asni F. Khrisna Heryanti Kurniawan, Fariez Labibah, Lana Maura Shavira Alamsyah Melisa Juniananda Muhammad Ananda S Muhammad Arif Rizqi Neva Valencia Eka Apriliana Nita Fajar Maharani Pramitha Esha Nirmala Dewi Primasari, Dyani Radhwa Fauztina Rifki Febriansah Rizka Wahyu Septiasih Sabtanti Harimurti Sabtanti Harimurti, Sabtanti Salmah Orbayinah Sayidah Aulia Ul Haque Sri Tasminatun SYAHRANI SYAHRANI Tatsufumi Okino Triana Arum Kusumaningtyas Tsania Khusnul Khotimah Vella Lailli Damarwati Wahid, Rahmat A Hi Wardah Dwi Latifah Zaki Tiffani Lazuardian Zelmi Dwi Novita