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Hermawati, Resna
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Pengaruh Kepatuhan Diet, Tingkat Stres, dan Aktivitas Fisik Terhadap Kadar Glukosa Darah Puasa Penderita Diabetes Melitus di RSUD Dr.R.Soedjono Selong Septiana, Sintia; Hermawati, Resna; Pramana, Kadek Dwi; Hidayati, Sulatun
MAHESA : Malahayati Health Student Journal Vol 5, No 7 (2025): Volume 5 Nomor 7 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i7.18844

Abstract

ABSTRACT Diabetes Mellitus (DM) remains a public health problem. Blood glucose levels in diabetic patients can be influenced by various factors such as dietary compliance, stress level, physical activity, obesity, carbohydrate intake, and medication compliance. This cross-sectional study collected data at RSUD dr.R.Soedjono Selong using a stratified random sampling technique with as many as 47 samples from September to October 2024. Data were obtained from interviews and the completion of dietary compliance questionnaires using the PDAQ questionnaire, stress levels were assessed using the PSS questionnaire, physical activity was evaluated using the GPAQ questionnaire, and GDP levels were obtained from medical records. The Fisher’s Exact test was used to assess the relationship between the dependent variable and independent variable. Logistic regression was used to assess the effect of the dependent variable on the independent variable. The study sample was predominantly female (70.2%) with an average age ranging from 40 to 55 years (59.6%) and unemployed/housewives (36.2%). The majority of the study sample exhibited low dietary compliance (76.6%), moderate stress levels (51.1%), light physical activity (53.2%), and high GDP levels (78.7%). Dietary adherence was significantly related to the GDP levels of diabetes patients (p-value <0.001), as were stress levels (p-value <0.001) and physical activity (p-value 0.029). Dietary adherence, stress levels, and physical activity had a significant level of 66.7%. There is an influence of diet compliance, stress levels, and physical activity on the GDP levels of DM patients at RSUD dr. R. Soedjono Selong Keywords: Diabetes Mellitus, Fasting Blood Glucose, Dietary Compliance, Stress Levels, Physical Activity  ABSTRAK Diabetes Melitus (DM) masih menjadi masalah kesehatan masyarakat. Kadar glukosa darah pada pasien diabetes dapat dipengaruhi oleh berbagai macam faktor seperti kepatuhan diet, tingkat stres, aktivitas fisik, obesitas, asupan karbohidrat, serta kepatuhan minum obat. Studi cross-sectional ini mengumpulkan data di RSUD dr.R.Soedjono Selong dengan teknik stratified random sampling sebanyak 47 sampel dari September – Oktober 2024. Data diperoleh dari wawancara dan pengisian kuesioner kepatuhan diet dengan kuesioner PDAQ, tingkat stres dinilai dengan kuesioner PSS, aktivitas fisik dinilai dengan kuesioner GPAQ, dan data kadar GDP diperoleh dari rekam medis. Uji Fisher’s Exact digunakan untuk menilai hubungan antara variabel dependen dengan variabel independent. Uji regresi logistik digunakan untuk menilai pengaruh variabel dependen terhadap variabel independen. Sampel penelitian sebagian besar perempuan (70,2%) dengan usia rata-rata berkisar antara 40-55 tahun (59,6%) dan tidak bekerja/IRT (36,2%). Mayoritas kepatuhan diet sampel penelitian rendah (76,6%), tingkat stres sedang (51,1%), aktivitas fisik ringan (53,2%) dan kadar GDP tinggi (78,7%). Kepatuhan diet berhubungan secara signifikan terhadap kadar GDP penderita diababetes (p-value <0,001), demikian pula dengan tingkat stres (p-value <0,001) dan aktivitas fisik (p-value 0,029). Kepatuhan diet, tingkat stres, dan aktivitas fisik memiliki tingkat signifikan sebesar 66,7%. Terdapat pengaruh kepatuhan diet, tingkat stres, dan aktivitas fisik terhadap kadar GDP penderita DM di RSUD dr.R.Soedjono Selong Kata Kunci: Diabetes Melitus, Glukosa Darah Puasa, Kepatuhan Diet, Tingkat Stres, Aktivitas Fisik
Aktivitas Antibakteri Kombinasi Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) dan Daun Kelor (Moringa Oleifera L.) terhadap Pertumbuhan Staphylococcus Aureus Dermana, Kadek Diah Ari Wulan; Hidayati, Diani Sri; Herlinawati, Herlinawati; Hermawati, Resna
MAHESA : Malahayati Health Student Journal Vol 5, No 8 (2025): Volume 5 Nomor 8 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i8.18983

Abstract

ABSTRACT Infectious diseases are still the cause of high morbidity and mortality rates in the world, including in Indonesia. Infectious diseases can be caused by Staphylococcus aureus bacteria. Synthetic antibiotics are used to treat these bacterial infections. Improper use of antibiotics can cause resistance, making it difficult to treat Staphylococcus aureus bacteria. There are several ways to overcome this, namely by using natural ingredients such as Averrhoa bilimbi L and Moringa oleifera L which are known as antimicrobials. This research used a true experimental completely randomized design (CRD) using the Cup-plate diffusion technique/welling diffusion method with 5 treatment groups and 2 controls (clindamycin 10ug for positive control and sterile distilled water on negative control). In a ratio of 1:0, bilimbi leaf (Averrhoa bilimbi L) extract and Moringa leaf (Moringa oleifera L) extract have an inhibitory zone diameter of 15 mm. Meanwhile, in the ratios of 0:1, 1:1, 1:2 and 2:1, no inhibition zone was formed against the growth of Staphylococcus aureus bacteria. The results of data analysis using the unpaired T test showed a significant difference in value (p 0.0007). This research showed that the combination of bilimbi leaf (Averrhoa bilimbi L) extract and Moringa leaf (Moringa oleifera L) extract had no antibacterial activity against Staphylococcus aureus bacteria. Keywords: Antibacterial, Averrhoa Bilimbi L, Moringa Oleifera L, Growth, Staphylococcus Aureus  ABSTRAK Penyakit infeksi masih menjadi penyebab tingginya angka kesakitan dan kematian di dunia termasuk di Indonesia. Penyakit infeksi dapat disebabkan oleh Staphylococcus aureus. Penggunaan antibiotik secara tidak tepat dapat menimbulkan resistensi sehingga menyulitkan dalam mengobati Staphylococcus aureus. Terdapat upaya untuk mengatasi hal tersebut yaitu dengan penggunaan bahan alami seperti Averrhoa bilimbi L dan Moringa oleifera L yang dikenal sebagai antimikroba. Penelitian ini menggunakan True experimental dengan Rancangan Acak Lengkap (RAL) menggunakan metode difusi Cup-plate technique/sumuran dengan 5 kelompok perlakuan dan 2 kontrol (kontrol positif Klindamisin 10 ug, kontrol negatif akuades steril). Hasil perbandingan 1:0 ekstrak Daun Belimbing Wuluh dan Daun Kelor memiliki diameter zona hambat sebesar 15 mm. Sedangkan pada perbandingan 0:1, 1:1, 1:2 dan 2:1 tidak terbentuk zona hambat terhadap pertumbuhan Staphylococcus aureus. Hasil analisis data menggunakan uji T tidak berpasangan menunjukkan perbedaan signifikan dengan nilai (p 0,0007).  Kombinasi ekstrak daun belimbing wuluh (Averrhoa bilimbi L) dan daun kelor (Moringa oleifera L) tidak memiliki aktivitas antibakteri terhadap Staphylococcus aureus.  Kata Kunci: Antibakteri, Averrhoa bilimbi L, Moringa oleifera L, Pertumbuhan, Staphylococcus aureus
Analisis Interaksi Senyawa Flavonoid Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Aktivitas Enzim Glukosidase Secara In Silico Sebagai Anti Hiperglikemia Keninten, Ida Surya Prabawa Satya; Arjita, I Putu Dedy; Saputra, I Putu Bayu Agus; Hermawati, Resna
MAHESA : Malahayati Health Student Journal Vol 5, No 8 (2025): Volume 5 Nomor 8 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i8.19263

Abstract

ABSTRACT Diabetes mellitus is a condition of chronic hyperglycemia due to impaired insulin secretion. a-glucosidase is an enzyme on the surface of small intestinal epithelial cells that breaks down disaccharides or oligosaccharides into free monosaccharides, which then enter the bloodstream. This research used descriptive exploratory research through several stages including: ligand preparation, a-glucosidase enzyme preparation, Human Intestinal Absorption (HIA) test, Lipinski Rule of Five (Ro5) test, Prediction of Activity Spectra for Substance (PASS) test, molecular docking, and visualization of docking results. Data was analyzed by grouping values based on categories from the HIA test, Ro5 test, and PASS test. The docking results are analyzed by grouping the ligand models according to the energy and types of bonds formed. The results of the research showed that of the ten flavonoid compounds of bilimbi leaves (Averrhoa bilimbi L.) tested, the compounds quercetin/3,5,7,3',4'-pentahydroxyflavonone; 5,7,3',4',5'-pentahydroxyflavone; apigenin; retusin 7-o-neohesperidoside; and catechin 3-o-gallate/ epigallocatechin gallate has a binding affinity value for the activity of the a-glucosidase enzyme as antihyperglycemia. The compounds quercetin, 5,7,3',4',5'-pentahydroxyflavone, apigenin 7-cellobioside, catechin 3-o-gallate/epigallocatechin gallate are effective in the activity of the a-glucosidase enzyme as antihyperglycemia. Keywords: Flavonoids, Averrhoa Bilimbi L., a-glucosidase, In Silico, Anti Hyperglycemia  ABSTRAK Diabetes melitus merupakan kondisi hiperglikemia kronis akibat gangguan sekresi insulin. a-glukosidase merupakan enzim di permukaan sel epitel usus halus yang memecah disakarida atau oligosakarida menjadi monosakarida bebas, yang kemudian masuk ke aliran darah. Penelitian ini menggunakan deskriptif eksploratif dengan melalui beberapa tahap meliputi: preparasi ligan, preparasi enzim a-glukosidase, uji Human Intestinal Absorption (HIA), uji LipinskiRule of Five (Ro5), uji Prediction of Activity Spectra for Substance (PASS), molecular docking, dan visualisasi hasil docking. Data dianalisis dengan mengelompokkan nilai berdasarkan kategori dari uji HIA, uji Ro5, dan uji PASS. Hasil docking dianalisis dengan cara mengelompokkan model ligan yang memiliki energi dan jenis ikatan yang terbentuk. Hasil penelitian menunjukkan bahwa dari sepuluh senyawa flavonoid daun belimbing wuluh (Averrhoa bilimbi L.) yang diujikan, senyawa quercetin/3, 5, 7, 3’, 4’-pentahydroxyflavonone; 5, 7, 3’, 4’ ,5’-pentahydroxyflavone; apigenin; retusin 7-o-neohesperidoside; dan catechin 3-o-gallate/ epigallocatechin gallate memiliki nilai binding affinityterhadap aktivitas enzim a-glukosidase sebagai antihiperglikemia. Senyawa quercetin, 5,7,3’,4’,5’-pentahydroxyflavone, apigenin 7-cellobioside, catechin 3-o-gallate/epigallocatechin gallate efektif terhadap aktivitas enzim a-glukosidase sebagai antihiperglikemia. Kata Kunci: Flavonoid, Averrhoa Bilimbi L, a-Glukosidase, In Silico, Anti Hiperglikemia
Co-Authors Arjita, I Putu Dedy Dermana, Kadek Diah Ari Wulan Herlinawati Herlinawati Hidayati, Diani Sri Hidayati, Sulatun I Putu Bayu Agus Saputra Keninten, Ida Surya Prabawa Satya Pramana, Kadek Dwi Septiana, Sintia