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All Journal Bali Dermatology and Venereology Journal Physical Therapy Journal of Indonesia
Indrakusuma, Anak Agung Bagus Putra
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Focus on the dabrafenib, vemurafenib, and trametinib in clinical outcome of melanoma: a systematic review and meta-analysis Widya Anjani, Ida Ayu; Indrakusuma, Anak Agung Bagus Putra; Arim Sadeva, I Gede Krisna; Wulandari, Putri Ayu; Rusyati, Luh Made Mas; Sudarsa, Prima Sanjiwani Saraswati; Supadmanaba, I Gede Putu; Wihandani, Desak Made
Bali Dermatology and Venereology Journal Vol 3, No 2 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i2.38

Abstract

Background: Melanoma is the most serious lethal skin cancer, affects the melanin producer cells (melanocytes). Surgery is the most common treatment, whereas for the advance stage the development of a treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is used as the most frequently targeted therapy of melanoma due to more than 80% patient with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome.Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by 3 different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2  and Chi2 statisticResult: There are 20 studies used in this article (13 RCT and 7 cohorts). The overall survival (OS) and progression-free survival (PFS) of study that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other therapies (chemotherapy, immunotherapy,etc) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17;  I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13;I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other therapy for a better clinical outcome rather than monotherapy.Keyword: melanoma, dabrafenib, vemurafenib, and trametinib
Integrating simulation, role-play, and technology in physiotherapy education: A narrative review on teaching methods for patient education Manuaba, Ida Bagus Amertha Putra; Yani, Made Violin Weda; Indrakusuma, Anak Agung Bagus Putra; Dewi, Ketut Liana Arya; Wulandari, Putri Ayu; Mahadipaka K.A, Ngurah Arya T.; Sasmitha, Ni Luh Ayu; Supadmanaba, I Gede Putu
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.399

Abstract

Physiotherapists play a crucial role in patient education, as effective communication and educational strategies directly influence treatment adherence, functional outcomes, patient satisfaction, and trust in healthcare services. The increasing global burden of musculoskeletal and neurological disorders has intensified the demand for physiotherapy services, emphasizing the need for graduates who are not only clinically competent but also proficient in patient-centered education. This narrative review aims to synthesize evidence from 2015 to 2025 regarding the integration of simulation, role-play, and educational technology in physiotherapy education, with a particular focus on teaching methods that enhance patient education competencies. Relevant peer-reviewed literature was identified from major academic databases, including PubMed, Scopus, and Google Scholar, and analyzed thematically to examine educational outcomes related to communication skills, learner engagement, confidence, empathy, and clinical preparedness. The findings indicate that simulation-based learning and structured role-play provide safe and experiential environments for students to practice patient communication and education, while technology-enhanced approaches such as virtual simulations and digital learning platforms offer scalable and flexible learning opportunities. Collectively, these methods demonstrate consistent benefits in improving students’ ability to deliver clear, structured, and empathetic patient education, thereby supporting readiness for clinical practice. Integrating simulation, role-play, and technology within physiotherapy curricula represents a strategic approach to strengthening patient education competencies and preparing graduates to deliver high-quality, patient-centered, and trusted physiotherapy care in response to contemporary healthcare demands.
Co-Authors Arim Sadeva, I Gede Krisna Desak Made Wihandani Dewi, Ketut Liana Arya I G. P. Supadmanaba Ida Bagus Amertha Putra Manuaba Luh Made Mas Rusyati Mahadipaka K.A, Ngurah Arya T. Prima Saraswati Sanjiwani Sudarsa Putri Ayu Wulandari, Putri Ayu Sasmitha, Ni Luh Ayu Widya Anjani, Ida Ayu Yani, Made Violin Weda