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All Journal Teknosains: Media Informasi Sains dan Teknologi Indonesian Journal of Pure and Applied Chemistry Jurnal Medika: Medika Hayyan Journal Mammiri: Jurnal Pengabdian Masyarakat
Amir, Nur Insani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Engineering Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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In Silico Studies and Admet Predictions Diterpenoid Compound Andrographis paniculata (Burm.f.) Nees as Inhibitor of Streptococcus mutans Nurfadillah, Arafah; Amir, Nur Insani; Ramadhani, Sindi
Hayyan Journal Vol. 2 No. 1 (2025): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i1.2679

Abstract

Andrographis paniculata (Burm.f.) Nees are reported to have many bioactivities, including antibacterial, hepatoprotective, antimalarial, antihypertensive, antipyretic, antithrombolytic, and other pharmacological effects. This study aims to determine the benefits of the active compound Andrographis paniculata in inhibiting the activity of the enzyme glucosyltransferase. This research method was carried out in silico on 3AIC receptors using Chimera, ChemDraw Ultra 12.0, MGLtools, Autodock4, Biovia Discovery Studio, and Toxtree software. The results showed that of the 12 test compounds, the AP11 compound has the lowest ∆G free bond energy of -8.5KKal/mol, lower than natural ligands, and more hydrogen bonds than natural ligands, MES. Therefore, it can be concluded that the AP11 compound has the most potential to inhibit glucosyltransferase receptors
Indonesia Penerapan Kecerdasan Buatan dalam Pembelajaran Sains Amir, Nur Insani; Arafah Nurfadillah; Marshanda D. Abd. Karim
MAMMIRI: JURNAL PENGABDIAN MASYARAKAT Vol. 2 No. 1 (2025): Februari 2025
Publisher : Education and Talent Development Center Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/mammiri.v2i1.2680

Abstract

Artificial intelligence (AI)-based tools and software are very easy to find and some of them can be accessed for free. There are various types of AI-based tools and software that can be used to increase student interest and learning experience. This activity aims to increase students' knowledge about the use of tools and software to support the science learning process. This activity is descriptive and experimental, starting from the process of delivering material, simulating the use of tools and software, and discussions. The number of participants was 29 students and 3 science teachers in the science classrooms and laboratories of SMAS Immim Putra Makassar.
Potensi ekstrak tulang ikan cakalang (Katsuwonus pelamis) sebagai stimulus regenerasi sel pada luka bakar Rattus norvegicus Wahdaniar, Wahdaniar; Amir, Nur Insani; Pashar, Imran
Teknosains Vol 19 No 1 (2025): Januari-April
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v19i1.55932

Abstract

Luka bakar adalah kerusakan jaringan yang terjadi pada permukaan kulit sehingga menyebabkan peradangan yang dikenal dengan eritema. Eritema adalah respons peradangan yang pertama kali muncul selama proses penyembuhan luka bakar. Semakin cepat derajat eritema menurun, semakin cepat proses penyembuhan luka bakar. Tulang ikan memiliki kandungan kolagen, kolagen dari ikan memiliki keunggulan tersendiri dibandingkan ekstrak kolagen dari unggas dan sapi, yaitu bebas dari penyakit yang berpotensi berbahaya pada unggas dan sapi, halal, dan memiliki imunoreaktivitas yang rendah pada tubuh manusia. Kandungan kolagen yang berasal dari tulang ikan dapat digunakan untuk mengobati luka bakar dan memperbaiki jaringan. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak ikan cakalang terhadap penurunan eritema pada penyembuhan luka bakar derajat II Rattus norvegicus. Penelitian ini bersifat eksperimental, menggunakan 25 tikus putih dibagi menjadi 5 kelompok perlakuan berbeda. Pada K0 sebagai kontrol diberikan aquadest, K1 normal saline, K2 ekstrak tulang ikan cakalang 40%, K3 ekstrak tulang ikan cakalang 60%. dan K4 ekstrak tulang ikan cakalang 80%. Perawatan dilakukan selama 7 hari. Data yang diperoleh dianalisis dengan Uji One Way Analysis of Variance (ANOVA). Berdasarkan uji homogenitas menggunakan uji Levene, diketahui bahwa nilai signifikansi 0,980> 0,05, sehingga disimpulkan bahwa data homogen. Normalitas data menggunakan uji Shapiro-Wilk dimana nilai P> 0,05 dapat disimpulkan bahwa data berdistribusi normal. Hasil penelitian menunjukkan bahwa pemberian ekstrak tulang ikan cakalang dengan konsentrasi 80% selama 7 hari dapat mempercepat pengurangan eritema, secara signifikan dengan P<0,05 dan paling efektif diantara semua ekstrak, sehingga dapat menjadi acuan sebagai terapi alternatif untuk luka bakar.
MOLECULAR DOCKING AND ADME STUDIES OF STIGMASTEROL COMPOUNDS AS ANTI-BREAST CANCER Amir, Nur Insani; Nurfadillah, Arafah; Miladiarsi, Miladiarsi; Irma, Ade; Wahdaniar, Wahdaniar
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 1 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i1.83224

Abstract

Molecular docking studies of stigmasterol (test ligand) and estradiol (control ligand) against the ER-α receptor were performed using PyRx software. This study aims to determine the interaction between stigmasterol ligands and ER-α receptors by the molecular docking method using PyRx. The study results show that stigmasterol and estradiol have the same binding energy value of -7.3 kcal/mol. The stigmasterol compound could therefore be used as a candidate for breast cancer drugs.
Pemberdayaan Kelompok Masyarakat Padatuo Kabupaten Bone Melalui Pelatihan Produksi Pakan Ternak Berbasis Limbah Kepiting Rajungan Wahdaniar, Wahdaniar; Amir, Nur Insani; Nurfiana, Rika
Jurnal Medika: Medika Vol. 4 No. 4 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/x5q08559

Abstract

This community service program focused on utilizing swimming crab shell waste as an innovative solution to reduce livestock feed costs and environmental issue in the Padatuo community group, Bone regency. The activity aimed to enhance participants knowledge and skills in processing the waste into high-nutrient feed flour through practical simulation method. The approach involved three stages: (1) observation and needs analysis; (2) simulation of flour production including washing, boiling, drying and grinding; and (3) evaluation through pre-test and post test. The results showed a significant improvement in participants understanding, with post-test score (86.2) far higher than pre-test score (42.6). Participants successfully produced quality flour with fine texture, non offensive odor, and high mineral content. Economic impacts included up to 30% reduction in feed costs, while environmental benefits were achieved through waste reduction. This activity demonstrates that participatory simulation-based approach are effective in empowering communities and creating sustainable solution.
Co-Authors Ade Irma Arafah Nurfadillah Imran Pashar Marshanda D. Abd. Karim Miladiarsi, Miladiarsi Nurfadillah, Arafah Nurfiana, Rika Ramadhani, Sindi W, Wahdaniar