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Dhama, Kuldeep
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Bibliometric analysis of the top 100 most cited studies in apolipoprotein E (ApoE) research Ahmad, Tauseef; Dhama, Kuldeep; Tiwari, Ruchi; Chaicumpa, Wanpen; Hui, Jin
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.2

Abstract

The apolipoprotein E (ApoE) is a glycoprotein which plays a vital role in different inflammatory conditions and in the catabolism of lipids and triglycerides. The aim of this study was to identify and evaluate the top 100 most cited studies on ApoE research. A bibliometric study was conducted. On January 18, 2021, studies published on ApoE were searched in the Web of Science Core Collection database without any limitations. The obtained data were analyzed for a number of attributes using HistCiteTM and VOSviewer software. The search yielded a total of 16,242 results. Of the total retrieved results, the top 100 most cited studies were selected. The top 100 most cited studies on ApoE were published from 1977 to 2017 and were cited 86,181 times. Single study citations ranged from 426 to 6,327. The studies were published in 41 journals authored by 589 authors. The study “Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families” was cited 6,327 times. Mahley RW, Roses AD, and Saunders AM were the most prolific authors who published ten studies each. Most of the studies were published in Proceedings of the National Academy of Sciences of the United States of America. A total of 151 institutions were involved, and the USA was the most productive country. Our finding provides valuable insight on ApoE research which may be useful for researchers, academia, and funding agencies to identify new future research domains.
Diagnostic performance of GeneXpert MTB/RIF assay compared to conventional Mycobacterium tuberculosis culture for diagnosis of pulmonary and extrapulmonary tuberculosis, Nepal Chaudhary, Raina; Bhatta, Sabita; Singh, Alina; Pradhan, Manoj; Shrivastava, Brijendra; Singh, Yengkokpam I.; Sah, Ranjit; Fathah, Zareena; Mehta, Rachana; Rabaan, Ali A.; Rodriguez-Morales, Alfonso J.; Dhama, Kuldeep
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.33

Abstract

Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis. It is a global health problem and major cause of death in resource-limited countries like Nepal. Timely diagnosis with sensitive testing methods could assist in early management of the disease. This study was conducted to compare the diagnostic performance of GeneXpert MTB/RIF and conventional acid-fast staining with M. tuberculosis culture. The study was carried out in the Department of Microbiology, Shree Birendra Army Hospital, Nepal. Samples (n=500) were tested with a GeneXpert MTB/RIF assay and acid-fast bacilli (AFB) smear microscopy. All samples were sent for M. tuberculosis conventional culture by the German-Nepal Tuberculosis Project, Kathmandu, Nepal (GENETUP). Out of a total 500 pulmonary and extrapulmonary samples tested, 97 samples were positive for M. tuberculosis by GeneXpert MTB/RIF assay. Out of the positive samples, only 95 samples were found positive by the culture method. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of AFB microscopy was 45.3%, 99.5%, 99.5% and 88.5%, respectively. The sensitivity, specificity, PPV and NPV of GeneXpert MTB/RIF was found to be 100%, 99.5%, 97.5% and 100%, respectively compared to the gold standard culture method. The GeneXpert MTB/RIF test was comparable with culture diagnosis of both pulmonary and extrapulmonary tuberculosis cases.
SARS-CoV-2 and Orientia tsutsugamushi co-infection in a young teen, Nepal: Significant burden in limited-resource countries in Asia? Bastola, Anup; Sah, Ranjit; Rajbhandari, Sagar K.; Jha, Runa; Fathah, Zareena; Chalise, Bimal S.; Shrestha, Bikesh; Shah, Rajesh K.; Balla, Pujan; Nepal, Richa; Adhikari, Bipin; Rabaan, Ali A.; Dhama, Kuldeep; Rodriguez-Morales, Alfonso J.
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.34

Abstract

Scrub typhus is caused by Orientia tsutsugamushi, transmitted through bites of infected chiggers (larval mites). During the coronavirus disease 2019 (COVID-19) pandemic, reports of co-infections with endemic pathogens are increasing around the world. Disease with similar clinical presentation may mask other disease diagnosis and increase the morbidity and mortality of the patients. We report co-infection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and O. tsutsugamushi in a patient in Nepal presenting with fever, headache, retro-orbital pain, generalized body ache, and knee joints pain with a history of dry cough and dyspnea at night. Since scrub typhus is prevalent and considerate as one of the public health consents in Asian countries and the possible overlapping clinical manifestation with other infections including COVID-19, a further investigation required to determine the burden of SARS-CoV-2 and O. tsutsugamushi co-infection in scrub typhus-endemic countries in Asia.
Hepatitis E virus in pigs and the environment: An updated review of public health concerns Ahmad, Tauseef; Jin, Hui; Dhama, Kuldeep; Yatoo, Mohd. Iqbal; Tiwari, Ruchi; Bilal, Muhammad; Dhawan, Manish; Emran, Talha B.; Alestad, Jeehan H.; Alhani, Hatem M.; BinKhalaf, Habib K.; Rabaan, Ali A.
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.78

Abstract

Hepatitis E virus (HEV) is an important public health problem and is responsible for both acute and chronic viral hepatitis. Public health implications of HEV are derived from its transmission route, either water-borne or food-borne, and its zoonotic potential. Not only in developing countries, but HEV cases are also found in a high number in developed countries. The spread of HEV to the environment might pollute surface waters, which could act as the source of infection for both humans and animals. Identification of the virus in animal products suggests the circulation of HEV within water and food chains. High seroprevalence and circulation of HEV in livestock, in particular pigs, as well as in environmental samples warrants further investigation into pig markets. HEV virulence in different environments and meat supply chains could shed light on the possible sources of infection in humans and the degree of occupational risk. The purpose of this review is to discuss HEV infections with an emphasis on livestock- and environment-related risk factors, and food-borne, water-borne, and zoonotic transmissions.
A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19 Sharun, Khan; Tiwari, Ruchi; Yatoo, Mohd I.; Natesan, Senthilkumar; Megawati, Dewi; Singh, Karam P.; Michalak, Izabela; Dhama, Kuldeep
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.92

Abstract

The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout the world. As urgency is a necessity, most efforts have focused on identifying small molecule drugs that can be repurposed for use as anti-SARS-CoV-2 agents. Although several drug candidates have been identified using in silico method and in vitro studies, most of these drugs require the support of in vivo data before they can be considered for clinical trials. Several drugs are considered promising therapeutic agents for COVID-19. In addition to the direct-acting antiviral drugs, supportive therapies including traditional Chinese medicine, immunotherapies, immunomodulators, and nutritional therapy could contribute a major role in treating COVID-19 patients. Some of these drugs have already been included in the treatment guidelines, recommendations, and standard operating procedures. In this article, we comprehensively review the approved and potential therapeutic drugs, immune cells-based therapies, immunomodulatory agents/drugs, herbs and plant metabolites, nutritional and dietary for COVID-19.
Monkeypox virus infection and myocarditis: A review of current evidence and possible pathogenesis Ahmed, Sirwan K.; Dabou, Eman A.; Abdelsamad, Shaimaa; Mohamed, Mona G.; Chandran, Deepak; Chakraborty, Sandip; Emran, Talha B.; Dhama, Kuldeep
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.104

Abstract

The recent spread of the monkeypox virus (MPXV), causing monkeypox (mpox), to non-endemic areas, and the atypical and unusual clinical manifestations observed during its 2022 outbreak has focused international interest on the clinical features of the disease. Mpox is usually a self-limiting disease with mild symptoms with common manifestations, including fever and skin lesions; however, severe manifestations could occur in some vulnerable groups (children and those with impaired immune systems) and may present multisystem complications and fatal outcomes. In most cases, a fever is the first sign of disease, followed by the development of various inflammatory lesions on the skin, such as vesiculopustular rashes and ulcers. Pneumonitis, encephalitis, keratitis, secondary bacterial infections, acute kidney injury, and myocarditis are all possible outcomes of the infection. Myocarditis has been reported to be caused by orthopoxviruses, and it is a serious condition of which its pathophysiology is little understood. Recent reports have indicated myocarditis with cardiac involvement as a possible atypical and unusual consequence of the MPXV infection during present outbreak. This review provides an overview of the clinical manifestations of mpox with a special focus on its effects on the heart, including myocarditis. The evidence of the myocarditis in mpox patients and its possible pathogenesis are discussed.
Sailing on the ark of Scopus: Narra J new journey Wendt, Guilherme W.; Wagner, Abram; Dhama, Kuldeep; Harapan, Harapan
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.120

Abstract

Not available.
Identification and evaluation of antimicrobial and anti-arthritis activities of hydroethanolic extract of Rubus ellipticus leaves Kumari, Anjana; Prakash, Vinit; Gupta, Dinesh; Kashyap, Lokender; Rajat Goyal; Chopra, Hitesh; Gautam, Rupesh K.; Chakraborty, Sandip; Chandran, Deepak; Dhama, Kuldeep
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.152

Abstract

Rubus ellipticus is a native plant to India's tropical and subtropical regions and has been used as a traditional medicinal. The aim of the study was to identify and evaluate the antimicrobial and anti-arthritis activities of hydroethanolic extract of R. ellipticus leaves (HEERE). The leaves were collected from the Narkanda Valley, India and were shade-dried and finely ground to produce the powder. The hydroethanolic extract was utilized for phytochemical analysis to determine the existence of carbohydrate, phenolic, terpenoid, flavonoid, saponin, glycoside, tannin, protein, and alkaloid. The HEERE was further analyzed by gas chromatography-mass spectrometry (GC-MS) for the characterization of the phytoconstituents. The antimicrobial activity was tested against Escherichia coli, Staphylococcus aureus as well as Aspergillus niger. To assess its anti-arthritic activities, different doses of HEERE were given orally to complete Freund’s adjuvant (CFA)-induced albino Wistar rats for twenty-one days. The GC-MS analysis of hydroethanolic extracts from leaves detected and identified the presence of 33 phytochemical compounds. HEERE showed significant effects against E. coli, S. aureus, and A. niger strains at 600 ppm. Our data indicated that HEERE 200 mg/kg was more effective than 50 mg/kg as anti-arthritis. Paw volume, ankle-joint diameter, the number of leucocytes, and erythrocyte sedimentation rate (ESR) were all significantly reduced in experimental rats. Furthermore, when compared to respective standard drugs, the body weight, erythrocyte, hemoglobin, and synobium healing effect have all improved. These data demonstrated the potential of R. ellipticus for the long-term investigation of antimicrobial and anti-arthritic properties.
Comparative assessment of smartphone‐based digital planimetry for wound area measurement Sharun, Khan; Banu, Shajahan A.; Mamachan, Merlin; Vinodhkumar, Obli R.; Manjusha, Kallemuchikal M.; Kumar, Rohit; Pawde, Abhijit M.; Dhama, Kuldeep; Pal, Amar
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1987

Abstract

Accurate wound area measurement is essential for effective wound care as it helps determine the progression of healing in patients. The aim of this study was to compare two wound area measurement techniques wound tracing (manual planimetry) and imitoMeasure (smartphone-based digital planimetry) with standard ImageJ-based digital image analysis in a rabbit wound healing study. The study involved 291 wounds categorized into small, intermediate, and large wounds. ImageJ was used as the reference method for comparisons. The intraclass correlation coefficient (ICC) was computed to assess the agreement and reliability between different wound measurement techniques. A mountain plot was used to assess the agreement between measurement methods, and a Bland-Altman plot was used to evaluate the agreement and concordance between measurement methods. The time required for analysis (processing time) was also compared. The study revealed that the imitoMeasure consistently demonstrated a greater level of agreement with ImageJ, especially in small and intermediate wounds. The ICC values indicated substantial agreement between ImageJ and imitoMeasure, with an exceptionally high ICC value for small wounds. Mountain plots revealed that the imitoMeasure had better agreement with ImageJ across all wound sizes. Bland-Altman plots further supported these findings, with wound tracing exhibiting wider limits of agreement and greater variability than imitoMeasure. ImitoMeasure consistently proved to be the quickest method across all wound sizes, whereas wound tracing required the longest processing time. These findings indicate that the imitoMeasure is a more reliable and consistent method for measuring the wound area, in particular for small and intermediate wounds.
Co-Authors Abdelsamad, Shaimaa Adhikari, Bipin Ahmad, Tauseef Ahmed, Sirwan K. Alestad, Jeehan H. Alhani, Hatem M. Anak Agung Dewi Megawati, Anak Agung Dewi Balla, Pujan Banu, Shajahan A. Bastola, Anup Bhatta, Sabita Bilal, Muhammad BinKhalaf, Habib K. Chaicumpa, Wanpen Chakraborty, Sandip Chalise, Bimal S. Chandran, Deepak Chaudhary, Raina Chopra, Hitesh Dabou, Eman A. Dhawan, Manish Emran, Talha B. Fathah, Zareena Gautam, Rupesh K. Gupta, Dinesh Harapan Harapan Hui, Jin Jha, Runa Jin, Hui Kashyap, Lokender Kumar, Rohit Kumari, Anjana Mamachan, Merlin Manjusha, Kallemuchikal M. Mehta, Rachana Michalak, Izabela Mohamed, Mona G. Natesan, Senthilkumar Nepal, Richa Pal, Amar Pawde, Abhijit M. Pradhan, Manoj Prakash, Vinit Rabaan, Ali A. Rajat Goyal Rajbhandari, Sagar K. Rodriguez-Morales, Alfonso J. Sah, Ranjit Shah, Rajesh K. Sharun, Khan Shrestha, Bikesh Shrivastava, Brijendra Singh, Alina Singh, Karam P. Singh, Yengkokpam I. Tiwari, Ruchi Vinodhkumar, Obli R. Wagner, Abram Wendt, Guilherme W. Yatoo, Mohd I. Yatoo, Mohd. Iqbal