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Sharun, Khan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Willingness-to-pay for COVID-19 vaccine in ten low-middle-income countries in Asia, Africa and South America: A cross-sectional study Sallam, Malik; Anwar, Samsul; Yufika, Amanda; Fahriani, Marhami; Husnah, Milda; Kusuma, Hendrix I.; Raad, Rawan; Khiri, Namareg ME.; Abdalla, Rashed YA.; Adam, Rashed Y.; Ismaeil, Mohajer IH.; Ismail, Asma Y.; Kacem, Wajdi; Teyeb, Zeineb; Aloui , Khaoula; Hafsi , Montacer; Dahman, Nesrine Ben Hadj; Ferjani, Manel; Deeb, Dalia; Emad , Dina; Sami, Farah S.; Abbas, Kirellos Said; Monib, Fatma A.; R , Subramaniam; Panchawagh, Suhrud; Sharun, Khan; Anandu, Sunil; Gachabayov, Mahir; Haque , Md A.; Emran, Talha B.; Wendt, Guilherme W.; Ferreto, Lirane ED.; Castillo-Briones, María F.; Inostroza-Morales, Rocío B.; Lazcano-Díaz, Sebastián A.; Ordóñez-Aburto, José T.; Troncoso-Rojas, Jorge E.; Balogun, Emmanuel O.; Yomi, Akele R.; Durosinmi, Abiodun; Adejumo, Esther N.; Ezigbo, Eyiuche D.; Arab-Zozani, Morteza; Babadi, Elham; Kakemam, Edris; Ullah, Irfan; Malik, Najma I.; Dababseh, Deema; Rosiello, Francesco; Enitan , Seyi S.
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.74

Abstract

Vaccine hesitancy is considered as one of the greatest challenges to control the ongoing coronavirus disease 2019 (COVID-19) pandemic. A related challenge is the unwillingness of the general public to pay for vaccination. The objective of this study was to determine willingness-to-pay (WTP) for COVID-19 vaccine among individuals from ten low-middle-income countries (LMICs) in Asia, Africa, and South America. Data were collected using an online questionnaire distributed during February - May 2021 in ten LMICs (Bangladesh, Brazil, Chile, Egypt, India, Iran, Nigeria, Pakistan, Sudan, and Tunisia). The major response variable of in this study was WTP for a COVID-19 vaccine. The assessment of COVID-19 vaccine hesitancy was based on items adopted from the World Health Organization (WHO) Strategic Advisory Group of Experts (SAGE) vaccine hesitancy scale constructs. In this study, 1337 respondents included in the final analysis where the highest number of respondents was from India, while the lowest number was from Egypt. A total of 88.9% (1188/1337) respondents were willing to pay for the COVID-19 vaccination, and 11.1% (149/1337) were not. The average WTP for COVID-19 vaccination was 87.9 US dollars ($), (range: $5-$200). The multivariate model analysis showed that the country, monthly household income, having a history of respiratory disease, the agreement that routine vaccines recommended by health workers are beneficial and having received the flu vaccination within the previous 12 months were strongly associated with the WTP. Based on the country of origin, the highest mean WTP for COVID-19 vaccine was reported in Chile, while the lowest mean WTP for the vaccine was seen among the respondents from Sudan. The availability of free COVID-19 vaccination services appears as a top priority in the LMICs for successful control of the ongoing pandemic. This is particularly important for individuals of a lower socio-economic status. The effects of complacency regarding COVID-19 extends beyond vaccine hesitancy to involve less willingness to pay for COVID-19 vaccine and a lower value of WTP for the vaccine.
Acute severe hepatitis of unknown etiology in children: A mini-review Frediansyah, Andri; Sallam, Malik; Yufika, Amanda; Sharun, Khan; Iqhrammullah, Muhammad; Chandran, Deepak; Mamada, Sukamto S.; Sallam, Dina E.; Khader, Yousef; Lemu, Yohannes K.; Yusuf, Fauzi; Kretchy, James-Paul; Abdeen, Ziad; Torres-Roman, J. Smith; Acharya, Yogesh; Bondarenko, Anastasia; Ikram, Aamer; Jamil, Kurnia F.; Kotfis, Katarzyna; Koyanagi, Ai; Smith, Lee; Megawati, Dewi; Rademaker, Marius; Emran, Talha B.; Memish, Ziad A.; Vento, Sandro; Nainu, Firzan; Harapan, Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19 Sharun, Khan; Tiwari, Ruchi; Yatoo, Mohd I.; Natesan, Senthilkumar; Megawati, Dewi; Singh, Karam P.; Michalak, Izabela; Dhama, Kuldeep
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.92

Abstract

The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout the world. As urgency is a necessity, most efforts have focused on identifying small molecule drugs that can be repurposed for use as anti-SARS-CoV-2 agents. Although several drug candidates have been identified using in silico method and in vitro studies, most of these drugs require the support of in vivo data before they can be considered for clinical trials. Several drugs are considered promising therapeutic agents for COVID-19. In addition to the direct-acting antiviral drugs, supportive therapies including traditional Chinese medicine, immunotherapies, immunomodulators, and nutritional therapy could contribute a major role in treating COVID-19 patients. Some of these drugs have already been included in the treatment guidelines, recommendations, and standard operating procedures. In this article, we comprehensively review the approved and potential therapeutic drugs, immune cells-based therapies, immunomodulatory agents/drugs, herbs and plant metabolites, nutritional and dietary for COVID-19.
Comparative assessment of smartphone‐based digital planimetry for wound area measurement Sharun, Khan; Banu, Shajahan A.; Mamachan, Merlin; Vinodhkumar, Obli R.; Manjusha, Kallemuchikal M.; Kumar, Rohit; Pawde, Abhijit M.; Dhama, Kuldeep; Pal, Amar
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1987

Abstract

Accurate wound area measurement is essential for effective wound care as it helps determine the progression of healing in patients. The aim of this study was to compare two wound area measurement techniques wound tracing (manual planimetry) and imitoMeasure (smartphone-based digital planimetry) with standard ImageJ-based digital image analysis in a rabbit wound healing study. The study involved 291 wounds categorized into small, intermediate, and large wounds. ImageJ was used as the reference method for comparisons. The intraclass correlation coefficient (ICC) was computed to assess the agreement and reliability between different wound measurement techniques. A mountain plot was used to assess the agreement between measurement methods, and a Bland-Altman plot was used to evaluate the agreement and concordance between measurement methods. The time required for analysis (processing time) was also compared. The study revealed that the imitoMeasure consistently demonstrated a greater level of agreement with ImageJ, especially in small and intermediate wounds. The ICC values indicated substantial agreement between ImageJ and imitoMeasure, with an exceptionally high ICC value for small wounds. Mountain plots revealed that the imitoMeasure had better agreement with ImageJ across all wound sizes. Bland-Altman plots further supported these findings, with wound tracing exhibiting wider limits of agreement and greater variability than imitoMeasure. ImitoMeasure consistently proved to be the quickest method across all wound sizes, whereas wound tracing required the longest processing time. These findings indicate that the imitoMeasure is a more reliable and consistent method for measuring the wound area, in particular for small and intermediate wounds.
Co-Authors Abbas, Kirellos Said Abdalla, Rashed YA. Abdeen, Ziad Acharya, Yogesh Adam, Rashed Y. Adejumo, Esther N. Aloui , Khaoula Anak Agung Dewi Megawati, Anak Agung Dewi Anandu, Sunil Andri Frediansyah, Andri Arab-Zozani, Morteza Babadi, Elham Balogun, Emmanuel O. Banu, Shajahan A. Bondarenko, Anastasia Castillo-Briones, María F. Chandran, Deepak Dababseh, Deema Dahman, Nesrine Ben Hadj Deeb, Dalia Dhama, Kuldeep Durosinmi, Abiodun Emad , Dina Emran, Talha B. Enitan , Seyi S. Ezigbo, Eyiuche D. Fahriani, Marhami Fauzi Yusuf, Fauzi Ferjani, Manel Ferreto, Lirane ED. Firzan Nainu Gachabayov, Mahir Hafsi , Montacer Haque , Md A. Harapan Harapan Husnah, Milda Ikram, Aamer Inostroza-Morales, Rocío B. Iqhrammullah, Muhammad Ismaeil, Mohajer IH. Ismail, Asma Y. Kacem, Wajdi Kakemam, Edris Khader, Yousef Khiri, Namareg ME. Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kumar, Rohit Kurnia F. Jamil Kusuma, Hendrix I. Lazcano-Díaz, Sebastián A. Lemu, Yohannes K. Malik, Najma I. Mamachan, Merlin Mamada, Sukamto S. Manjusha, Kallemuchikal M. Memish, Ziad A. Michalak, Izabela Monib, Fatma A. Natesan, Senthilkumar Ordóñez-Aburto, José T. Pal, Amar Panchawagh, Suhrud Pawde, Abhijit M. R , Subramaniam Raad, Rawan Rademaker, Marius Rosiello, Francesco Sallam, Dina E. Sallam, Malik Sami, Farah S. Samsul Anwar Singh, Karam P. Smith, Lee Teyeb, Zeineb Tiwari, Ruchi Torres-Roman, J. Smith Troncoso-Rojas, Jorge E. Ullah, Irfan Vento, Sandro Vinodhkumar, Obli R. Wendt, Guilherme W. Yatoo, Mohd I. Yomi, Akele R. Yufika, Amanda