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All Journal The Indonesian Biomedical Journal Universa Medicina Jurnal Ilmiah Ecosystem JI-KES (Jurnal Ilmu Kesehatan)
Yustisia, Ika
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Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults Mulyamin, Winda; Kurniawan, Liong Boy; Adnan, Endy; Widaningsih, Yuyun; Idris, Irfan; Santoso, Arif; Yustisia, Ika
Universa Medicina Vol. 40 No. 1 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.22-28

Abstract

BACKGROUNDHigh-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to determine the association between several obesity indices namely body mass index (BMI), waist circumference (WC), body fat percentage (fat), and visceral fat (VF) with hsCRP in non-diabetic adults. METHODSThis was a cross-sectional study performed on 80 non-diabetic adults with ages ranging from 20-40 years. The obesity indices BMI, WC, body fat percentage, and VF were measured. We then measured the hsCRP levels using an immunoturbidimetric method. Simple and multiple linear regression tests were used to analyze the association between obesity indices and hsCRP levels. RESULTSMean of log BMI, log WC, and log VF was 1.41 ± 0.08 kg/m2, 1.93 ± 0.06 cm, and 0.95 ± 0.27 units, respectively. Simple linear regression tests showed that log BMI (â=3.506; p<0.001), log WC (â=3.672; p<0.001), log VF (â=0.833; p<0.001), and log systolic blood pressure (â=3.739; p=0.024) had a significant positive correlation with log hsCRP levels. Further multiple linear regression test showed that log BMI (â=3.772; Beta=0.674; p<0.001) had the greater effect on log hsCRP levels compared to other indices. CONCLUSIONS    BMI had a greater influence on hsCRP levels compared to other obesity indices in non-diabetic adults. Body mass index can be used as a better index in predicting hsCRP levels compared to other indices.
Efek Penghambatan Aktivitas Enzim Polo-Like Kinase 1 (PLK1) Pada Pembelahan Mitosis Sel Kanker Serviks Hartono; Hasri; Yustisia, Ika; Bte Ladju, Rusdina; Rapi, Irma; Putri Amelia, Tiara; Putri Apriliani Basri, Nur; Risdayanti, Eka; Afdalia, St. Sulfia
Jurnal Ilmiah Ecosystem Vol. 22 No. 2 (2022): ECOSYSTEM Vol. 22 No 2, Mei - Agustus Tahun 2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35965/eco.v22i2.1975

Abstract

Andrographis paniculata Leaf Extract Increases Interleukin-2 in Malnutrition Rat Model Dwiningsih, Fortuna; Natzir, Rosdiana; Ilhamuddin, Ilhamuddin; Yustisia, Ika; Sulfahri, Sulfahri
The Indonesian Biomedical Journal Vol 16, No 3 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i3.2950

Abstract

BACKGROUND: Malnutrition is a global health concern that results in changes in nutritional status, as indicated by alterations in phenotypic markers, hematological and biochemical parameters, and increased susceptibility to infection, as shown by decreased interleukin (IL)-2 levels. Andrographolide, the active component of Andrographis paniculata, stimulates the immune system and exhibits antibacterial and antiviral activity. Therefore, A. paniculata may serve as a potential adjuvant therapy for malnutrition. This study was conducted to analyze the effect of A. paniculata as an immunomodulator against malnutrition with characteristics of environmental enteric dysfunction (EED) and a low-protein diet by examining phenotypic markers, hematological, biochemical, and IL-2 levels.METHODS: Forty-five male Wistar rats were divided into seven groups. They were fed either a standard or a low-protein diet before receiving oral administration of various concentrations of A. paniculata leaf extract (APLE). APLE was administered 21 days after the initial low-protein diet. Hematological, biochemical, and phenotypic markers were assessed to determine the nutritional status of the rats. The protective effects of APLE were evaluated by measuring IL-2 levels using enzyme-linked immunosorbent assay (ELISA).RESULTS: Malnourished rats exhibited slow body growth, physical and behavioral changes, reduced leukocyte count, total protein, albumin, cholesterol, and villi length. Malnourished rats treated with APLE showed a more effective and significant increase in IL-2 levels, with higher concentrations of APLE resulting in higher IL-2 levels.CONCLUSION: APLE, in a concentration-dependent manner, can increase IL-2 levels, suggesting that APLE may have potential protective effects in a rat model of malnutrition.KEYWORDS: Andrographis paniculata, environmental enteric dysfunction, interleukin (IL)-2, low protein, malnutrition
Efek Restriksi Kalori dan Restriksi Kalori Mimetic pada Tikus Tua Nurliana, Nurliana; Syahrijuita, Syahrijuita; Yustisia, Ika; Kwenang, Agnes; Hardjo, Marhaen; Soraya, Gita Vita
JI-KES (Jurnal Ilmu Kesehatan) Vol. 5 No. 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.343

Abstract

AbstrakSecara global sekitar 2,3 miliar lansia mengalami overweight dan obesitas. Restriksi kalori adalah intervensi yang berpengaruh untuk memperpanjang hidup, namun sulit bagi setiap orang untuk menerapkan restriksi kalori seumur hidup. Oleh karena itu diperlukan intervensi lain yang memiliki manfaat sama dengan restriksi kalori. Penelitian ini bertujuan untuk mengetahui pengaruh restriksi kalori, dan  restriksi  kalori mimetik terhadap profil lipid tikus tua. Penelitian ini termasuk penelitian eksperimental menggunakan metode acak terkontrol dengan Pre and Post test with controlled group design. Menggunakan 18 ekor tikus dibagi menjadi 3 kelompok, A (kontrol), B (restriksi kalori), dan C (restriksi kalori mimetik) dan tiap kelompok terdiri dari 6 ekor tikus. Uji One Way Anova digunakan untuk melihat perbedaan sebelum dan sesudah intervensi. Dari hasil uji perbandingan secara keseluruhan terdapat perbedaan kolesterol, trygliserida, LDL-Cholesterol, HDL-Cholesterol serum tikus antara kelompok A,B, dan C setelah 30 hari perlakuan dengan nilai p<0.005. Dari hasil penelitian dapat disimpulkan bahwa restriksi kalori dan restriksi kalori mimetik mempengaruhi profil lipid. Kata kunci : restriksi kalori, restriksi kalori mimetik, profil lipid, penuaan AbstractGlobally around 2.3 billion elderly are overweight and obese. Calorie restriction is a powerful intervention for prolonging life, but it is difficult for everyone to implement calorie restriction for life. Therefore, other interventions are needed that have the same benefits as calorie restriction. This study aims to determine the effect of calorie restriction, and mimetic calorie restriction on the lipid profile of elderly rats and includes an experimental study using a randomized controlled method with Pre and Post test with controlled group design. Using 18 rats were divided into 3 groups, A (control), B (calorie restriction), and C (mimetic calorie restriction) and each group consisted of 6 rats. One Way Anova test was used to see the difference before and after the intervention. From the results of the overall comparison test, there were differences in cholesterol, triglycerides, LDL-Cholesterol, HDL-Cholesterol in rat serum between groups A, B, C, and D after 30 days of treatment with p < 0,005. From the results of the study it can be concluded that calorie restriction and mimetic calorie restriction affect the lipid profile. Keywords: calorie restriction, mimetic calorie restriction, intermittent fasting, lipid profile, aging
Co-Authors Adnan, Endy Afdalia, St. Sulfia Aminuyati Arif Santoso Bte Ladju, Rusdina Dwiningsih, Fortuna Hardjo, Marhaen Hasri Ilhamuddin Ilhamuddin, Ilhamuddin IRFAN IDRIS Kwenang, Agnes Liong Boy Kurniawan, Liong Boy Mulyamin, Winda NURLIANA NURLIANA Putri Amelia, Tiara Putri Apriliani Basri, Nur Rapi, Irma Risdayanti, Eka Rosdiana Natzir Soraya, Gita Vita Sulfahri, Sulfahri Syahrijuita, Syahrijuita Widaningsih, Yuyun