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The Effect Of Compliance Calcium Supplementation modification Tablet On Calcium and Blood Pressure In Pregnant Women Dahniarti, Dhany; Idris, Irfan; Am, Nasrudin
PALAPA: Jurnal Studi Keislaman dan Ilmu Pendidikan Vol 6 No 1 (2018): Mei
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) STIT Palapa Nusantara Lombok NTB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (18.214 KB)

Abstract

A low intake of calcium leads to an increase in high blood pressure by stimulating the release of paratiroid and  renin hormones that lead to increase in intracellular calcium concentration in the vasculer smooth muscle cells and result in vasocontriction. This study aims to determine the influence of compliance to supply modified calcium tablet toward calcium level and blood pressure in pregnant mothers. This research was conducted at RSIA Sitti Khadijah I Maternity Hospital Makassar with research design of quasy experiment with pre-post test group control design. There were 30 pregnant mother sampels of prehypertension in gestational age> 20 weeks, 12 pregnant women were given normal calcium tablets and 18 pregnant women given modified calcium tablets for 8 weeks each. Data analysis use paired t test. The results indicate that there is a different changes of calcium level and blood pressure between pregnant mothers of intervention group and control group with the value of p = 0.000 (p<0.05). After intervention averagely the calcium level increase in intervention group 0.4 mg/dl while in control group 0.1 mg/dl, followed by the average decrease in blood pressure of systole and dyastole in the intervention group 15.4/9.6 mmHg while in the control group 3.5/4.5 mmHg.
Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults Mulyamin, Winda; Kurniawan, Liong Boy; Adnan, Endy; Widaningsih, Yuyun; Idris, Irfan; Santoso, Arif; Yustisia, Ika
Universa Medicina Vol. 40 No. 1 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.22-28

Abstract

BACKGROUNDHigh-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to determine the association between several obesity indices namely body mass index (BMI), waist circumference (WC), body fat percentage (fat), and visceral fat (VF) with hsCRP in non-diabetic adults. METHODSThis was a cross-sectional study performed on 80 non-diabetic adults with ages ranging from 20-40 years. The obesity indices BMI, WC, body fat percentage, and VF were measured. We then measured the hsCRP levels using an immunoturbidimetric method. Simple and multiple linear regression tests were used to analyze the association between obesity indices and hsCRP levels. RESULTSMean of log BMI, log WC, and log VF was 1.41 ± 0.08 kg/m2, 1.93 ± 0.06 cm, and 0.95 ± 0.27 units, respectively. Simple linear regression tests showed that log BMI (â=3.506; p<0.001), log WC (â=3.672; p<0.001), log VF (â=0.833; p<0.001), and log systolic blood pressure (â=3.739; p=0.024) had a significant positive correlation with log hsCRP levels. Further multiple linear regression test showed that log BMI (â=3.772; Beta=0.674; p<0.001) had the greater effect on log hsCRP levels compared to other indices. CONCLUSIONS    BMI had a greater influence on hsCRP levels compared to other obesity indices in non-diabetic adults. Body mass index can be used as a better index in predicting hsCRP levels compared to other indices.
Pengaruh Cahaya LED Putih di Malam Hari Terhadap Kadar Malondialdehyde (MDA) Otak dan Histopatologi Sel CA3 dan CA1 Hipokampus Pada Tikus Wistar Jantan Mallisa, Hilda Emma; Arsyad, Aryadi; Idris, Irfan
Poltekita : Jurnal Ilmu Kesehatan Vol. 15 No. 2 (2021): August
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v15i2.452

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh cahaya LED putih di malam hari terhadap kadar malondialdehyde (MDA) otak dan histopatalogi sel CA3 dan CA1 hipokampus. Jenis penelitian true eksperimental dengan post-test only control group design yang dilakukan pada 24 ekor tikus. Kelompok terbagi berdasarkan waktu paparannya: 15 hari dan 30 hari, masing-masing memiliki kelompok kontrol dan perlakuan. Kelompok kontrol: terang-gelap normal (12L:12D) dan kelompok perlakuan: terang-terang (12L:12L) dengan pencahayaan berasal dari lampu LED putih 1500 lux saat malam hari. Hasil penelitian menunjukkan kadar MDA otak pada kelompok perlakuan lebih tinggi dibandingkan dengan kelompok kontrol dan signifikan (p=0,001). Hasil pemeriksaan histopatologi sel CA3 dan CA1 pada kelompok perlakuan 15 hari didapatkan mengalami kerusakan sedang (50%) hingga berat (50%) sedangkan pada kelompok kontrol 15 hari hanya dominan pada kerusakan ringan (83,3%) dengan hasil yang signifikan (p= 0,011). Pada kelompok perlakuan 30 hari dominan mengalami kerusakan berat (83,3%) sedangkan pada kelompok kontrol 30 hari berada diantara kerusakan ringan (33,3%) hingga sedang (66,7%) dan hasil yang diperoleh signifikan (p=0,012). Cahaya LED putih di malam hari bertindak sebagai stressor apabila intensitas, durasi paparan dan panjang gelombangnya sesuai. Stressor ini meningkatkan produksi ROS dan mengarahkan sel pada stress oksidatif yang ditandai dengan meningkatnya kadar MDA. Peningkatan kadar MDA bersifat neurotoksik pada otak khususnya hipokampus yang mengarahkan sel CA3 dan CA1 pada kerusakan maka perlu adanya pengurangan dalam penggunaan lampu LED pada malam hari
Pengaruh Cahaya Light Emiting Diode (LED) di Malam Hari terhadap Kortisol Serum dan Parameter Hematologi pada Tikus Wistar Jantan Arief, Nila Ardilla; Arsyad, Aryadi; Idris, Irfan
Jurnal Kesehatan Vol 12 No 3 (2021): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v12i3.2670

Abstract

This modern era has changed the pattern of how humans do their daily activities in 24 hours. The pattern change includes time-shifting, most human activities now are performed at night. The consequences of the changes in human activities pattern and the increase of artificial lighting use in the night were assumed unhealthy, but how the mechanism worked was not identified yet. This was an experimental study conducted on male Wistar rats aged 12-16 weeks which were divided into 4 categories: 1 intervention group exposed for 15 days, 1 intervention group exposed for 30 days, and 2 control groups for each time exposure, light intensity 1200lux. At the end of exposures, the blood samples were taken from rats that had been anesthetized before by using ether. Then blood samples were taken to analyze their cortisol levels using the Enzyme-linked immunosorbent assay (ELISA) method and the hematology was examined through autoanalyzer Abaxis. The data were analyzed using an independent T-test and Mann-Whitney test and considered significant if p-value<0,05. Overall, the cortisol and hematology levels indicated, especially Red Blood Cell (RBC), Mean Corpuscular Hemoglobin Concentration (MCHC), and neutrophil specifically for the group which had been exposed by LED lighting for 30 days. 
EFEK NEUROPROTEKTIF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) DENGAN TINGKAT DEPRESI PASCA STROKE ISKEMIK : STUDI CROSS SECTIONAL Minarti, Deri Lidya; Bintang, Andi Kurnia; Akbar, Muhammad; Aulina, Susi; Bahar, Ashari; Idris, Irfan
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 3 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i3.1246

Abstract

Latar belakang dan tujuan: Brain Derived Neurotrophic Factor (BDNF) berperan penting dalam melindungi saraf, plastisitas otak, terutama setelah kerusakan sistem saraf pusat. Efek neuroprotektif BDNF dengan tingkat depresi pasca stroke iskemik perlu dikaji lebih mendalam. Penelitian ini bertujuan untuk mengetahui hubungan kadar BDNF dengan tingkat depresi pasca stroke iskemik. Metode: Penelitian ini merupakan jenis penelitian analitik observasional dengan menggunakan desain cross-sectional. Total sampel 41 orang subyek yang memenuhi kriteria inklusi. Kadar BDNF seum dukur dengan menggunakan metode ELISA. Tingkat depresi diukur menggunakan skor HDRS. Data yang terkumpul kemudian dianalisis dengan menggunakan uji statistik. Hasil: Berdasarkan hasil analisis, diperoleh p = 0,000 (p<0,05) dengan nilai r = -0,573, bahwa terdapat efek neuroprotektif kadar BDNF serum dengan tingkat depresi pasca stroke iskemik.Terdapat korelasi negatif kadar BDNF serum dengan tingkat depresi pasien pasca stroke iskemik. Kesimpulan : Terdapat efek neuroprotektif kadar BDNF serum dengan tingkat depresi pasca stroke iskemik. Semakin rendah kadar BDNF serum maka semakin berat tingkat depresi pasca stroke iskemik.
Carbohydrate Over Nutrition Harmfull to both Obese Pregnant Mice and Fetus Idris, Irfan; Paharu, Kabah; Satriana, Satriana; Tadjuddin Chalid, Maisuri; Wardihan Sinrang, Andi
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.25339

Abstract

Background : Obesity in pregnancy due to carbohydrate over nutrition is still rarely reported and the incidence of obesity in pregnancy in the developing countries begin to increase. The aims of this study is to observe the detrimental effect of obesity in both mother and developing fetus of mice which fed by high carbohydrate diet. Methods : Female mice were divided to four groups. Group 1 (obese group) were fed with high carbohydrate (HC) diet and group 2 (control group) with standard diet for 12 weeks. All mice will be mated until pregnant and terminated for collecting blood with cardiac puncture every trimester. Another mice (7 mice from obese group and 7 mice from control group) will follow until 3rd trimester than terminated to collecting lipid profile of blood and examined the fetal’s anthrophometric. Lipid and blood glucose were examined by chemichal photometric and glucometer kit, while anthrophometric’s variables measured by weight scale and meter scale. Results : Blood glucose, total cholesterol, HDL and LDL are similar between obesity group and normal weight group every trimester, while only blood TG increased in obesity group particularly in first and second trimester of pregnancy. The detrimental effect also found in the developing fetus of obesity group which have significance higher of bodyweight, body lengths, head circumference, and waist circumference. Conclusions: Obesity in pregnancy due to carbohydrate over nutrition could have detrimental effect to both mother and developing fetus.
ACE2 EXPRESSION OF HYPERTENSIVE RAT LUNGS GIVEN ACE-I, CCB, AND SWITCHING ACEI TO CCB Abustani, Muthiah; Arsyad, Aryadi; Idris, Irfan; Djabir, Yulia Yusrini; Djaharuddin, Irawaty; Kasim, Hasim; Ismail, Amirah Febrianti
Jurnal Kesehatan Vol 17 No 2 (2024): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v17i2.38444

Abstract

Latar belakang : Hipertensi merupakan komorbid terbanyak pada COVID-19 dan ACE2 sebagai reseptor yang akan berikatan dengan virus SARS-COV-2, juga berperan dalam regulasi tekanan darah. Penggunaan obat antihipertensi seperti ACE-I atau CCB dapat mempengaruhi ekspresi ACE2. Penggunaan ACE-I selama pandemi menuai pro dan kontra yang memunculkan saran penggantian golongan obat antihipertensi seperti CCB. Tujuan : Mengetahui ekspresi ACE2 jaringan paru tikus setelah induksi hipertensi dan dilanjutkan dengan pemberian ACE-I (kaptopril) atau CCB (amlodipine), dan switching ACE-I menjadi CCB. Metode : Post control group design menggunakan 30 sampel tikus Sprague dawley yang dibagi menjadi 5 kelompok yaitu non-hipertensi, hipertensi, hipertensi + ACE-I, hipertensi + CCB, dan hipertensi + ACE-I switching CCB. Induksi hipertensi menggunakan L-NAME selama 6 minggu dan pengukuran tekanan darah menggunakan metode non-invasif. Pemberian obat antihipertensi diberikan selama 1 minggu. Ekspresi ACE2 diukur menggunakan ELISA kit Elabscience®. Hasil : Ekspresi ACE2 pada kelompok non hipertensi vs hipertensi tidak ditemukan perbedaan bermakna. Ekspresi ACE2 pada kelompok hipertensi dengan pengobatan ACE-I vs CCB ditemukan lebih tinggi pada kelompok CCB (p = 0.042). Ekspresi ACE2 pada kelompok hipertensi dengan pengobatan lebih tinggi dibanding kelompok hipertensi tanpa pengobatan (p = 0.001). Diskusi : Ekspresi ACE2 lebih tinggi pada kelompok dengan pengobatan ACE-I dengan cara menghambat efek Angiotensin II, sehingga kadar ACE2 meningkat sebagai mekanisme kompensasi. Sedangkan CCB akan meningkatkan kadar Angiotensin I dan menurunkan rasio Angiotensin (1-7)/ Angiotensin I dan menurunkan rasio ACE2/ACE Kesimpulan : Ekspresi ACE2 meningkat pada jaringan paru hipertensi dengan pengobatan ACE-I, CCB, dan switching ACE-I menjadi CCB.
Evaluation of an E. coli-expressed spike protein-based in-house ELISA system for assessment of antibody responses after COVID-19 infection and vaccination Nurisyah, Sitti; Iyori, Mitsuhiro; Hasyim, Ammar A.; Amru, Khaeriah; Itani, Kei; Nakamura, Kurumi; Zainal, Kartika H.; Halik, Handayani; Djaharuddin, Irawaty; Bukhari, Agussalim; Asih, Puji BS.; Syafruddin, Din; Yoshida, Shigeto; Idris, Irfan; Yusuf, Yenni
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1250

Abstract

Evaluating long-term immunity after COVID-19 infection and vaccination is critical for managing potential outbreaks. The aim of this study was to develop a cost-effective in-house enzyme-linked immunosorbent assay (ELISA) based on Escherichia coli-expressed SARS-CoV-2 spike protein (E-S1) for antibody detection and to evaluate its performance. The system was validated by comparing the in-house ELISA results with those obtained using a commercial ELISA with HEK293-expressed spike protein (H-S1). Recombinant SARS-CoV-2 spike protein was produced in E. coli, purified, and validated for antigenicity via ELISA. Indirect ELISAs with both E-S1 and H-S1 antigens were performed on 386 serum samples from COVID-19 survivors, vaccinated individuals, and pre-pandemic controls collected at different time points. The E-S1 ELISA showed a statistically significant but weak correlation with H-S1 ELISA across all samples (r=0.205; p=0.0001). Stronger correlations were observed among vaccinated individuals with prior infection on day 90 (r=0.6017; p<0.001) and in naïve vaccine recipients on day 30 (r=0.5361; p=0.0003). Pre-pandemic sera from a rural population in Sumba Island exhibited high background reactivity in E-S1 ELISA, likely due to anti-E. coli antibodies, while urban pre-pandemic sera from Jakarta showed a stronger correlation with H-S1 ELISA. This suggests potential regional or immune background differences influencing assay performance. Although E-S1 retained antigenic properties, its diagnostic utility is limited by non-specific reactivity and reduced sensitivity compared to H-S1. In conclusion, E. coli expression systems may not be ideal for producing spike protein-based ELISA antigens specific to SARS-CoV-2. Alternative expression systems, such as human or baculovirus, could enhance diagnostic accuracy and specificity for COVID-19 antibody detection.
PENGARUH COLD PRESSOR TEST TERHADAP TEKANAN DARAH DAN KADAR KORTISOL DARAH Rahayu, Irma; Yusuf, Irawan; Idris, Irfan
Jurnal Ilmiah Kesehatan Promotif Vol. 9 No. 2 (2025): Juni 2025
Publisher : Institut Toraja Raya Indonesia (ITRI)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cold pressor test (CPT) adalah satu tes yang dapat digunakan untuk mengukur reaktivitas tekanan darah terhadap stimulus dingin eksternal yang telah umum digunakan untuk mengevaluasi reaktivitas kardiovaskular terhadap stres pada subjek normotensi dan hipertensi dimana reaktivitas kardiovaskular dipercaya dapat memprediksi resiko terjadinya hipertensi dikemudian hari dengan melibatkan kortisol. Penelitian ini bertujuan untuk mengetahui hubungan antara peningkatan tekanan darah dengan kadar kortisol terhadap pemberian CPT. Jenis penelitian merupakan penelitian eksperimental dengan desain One-Group Pretest - Posttest Design, dengan jumlah subjek sebanyak 42 orang yang berusia sekitar 18-73 tahun dengan cara pengambilan sampel teknik purposive sampling. Penelitian dilakuan di laboratorium Hasanuddin University Medical Research Centre dengan cara memberikan stressor dingin pada lengan dengan merendam kedalam air es dengan suhu 3-5 0C selama 1 menit dan di ambil darah serta mengukur tekanan darah sebelum dan setelah perendaman tangan kiri hingga melewati batas pergelangan. Selanjutnya darah yang diambil diukur kadar kortisolnya dan dibandingkan dengan hasil pengukuran tekanan darah. Hasil penelitian menunjukkan terdapat perubahan yang signifikan pada tekanan darah terhadap cold pressor test. Sedangkan pada perubahan tekanan darah dan kadar kortisol terdapat perubahan meskipun tidak signifikan.
Co-Authors Abustani, Muthiah Adnan, Endy Allo, Sarjani Linggi Am, Nasrudin Amru, Khaeriah Andi Kurnia Bintang, Andi Kurnia Arief, Nila Ardilla Arif Santoso Arsyad, Muhammad Aryadi Asih, Puji BS. Bahar, Ashari Bukhari, Agussalim Dahniarti, Dhany Din Syafruddin Djabir, Yulia Yusrini Djaharuddin, Irawaty Hadi, Anto J. Halik, Handayani Hasyim, Ammar A. Irawan Yusuf Irma Rahayu, Irma Ismail, Amirah Febrianti Itani, Kei Iyori, Mitsuhiro Kasim, Hasim Liong Boy Kurniawan, Liong Boy Mallisa, Hilda Emma Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Minarti, Deri Lidya Mulyamin, Winda Nakamura, Kurumi Nurisyah, Sitti Paharu, Kabah Rambulangi, Samrichard RR. Ella Evrita Hestiandari Satriana Satriana Tadjuddin Chalid, Maisuri Tombeg, Zadrak Wardihan Sinrang, Andi Widaningsih, Yuyun Yetti R, Erni Yoshida, Shigeto Yustisia, Ika Yusuf Yenni Zainal, Kartika H.