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All Journal Jurnal Ilmiah Kesehatan (JIKA) Molucca Medica JI-KES (Jurnal Ilmu Kesehatan)
Soraya, Gita Vita
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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EFEK MEDIATOR VASCULAR CELL ADHESION MOLECULE-1 (VCAM-1) TERHADAP SEVERITAS DAN OUTCOME PASIEN STROKE ISKEMIK AKUT Assa, Christantina Pradescha; Bahar, Ashari; Akbar, Muhammad; Bintang, Andi Kurnia; Tammasse, Jumraini; Soraya, Gita Vita; Halim, Wijoyo
Molucca Medica Vol 17 No 1 (2024): VOLUME 17, NOMOR 1, APRIL 2024
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/10.30598/molmed.2024.v17.i1.16

Abstract

Introduction: Atherosclerosis is currently recognized as part of the inflammatory disease. In the acute phase, inflammation causes brain edema and expansion of ischaemic area. Vascular cell adhesion molecule 1 (VCAM-1) plays a crucial role in the inflammation mechanism immediately after cerebral damage in stroke, facilitating the migration of leukocytes across the endhothelial cells. Objective: This study aimed to establish the correlation between VCAM-1 serum levels and severity and outcomes in stroke patients. Research Methodology: It was a cross-sectional study conducted from September to November 2023 on 51 patients with acute ischemic stroke at RSUP Wahidin Sudirohusodo Makassar and other affiliated hospitals. VCAM-1 serum levels were examined using the ELISA principle. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) upon admission, and clinical outcomes were evaluated using the modified Rankin Scale (mRS) on the 30th day of onset. Results: Mann- Whitney test results showed no difference in serum VCAM-1 levels between severity groups (mild and moderate) and clinical outcome groups (good and poor). Spearman correlation test results indicated a correlation between serum VCAM-1 levels and severity (p=0.635, r=-0.068) and clinical outcomes (p=0.459, r=-0.106). Conclusion: There is no association between serum VCAM-1 levels and the severity and clinical outcomes of acute ischemic stroke patients. Recommendation: Further research is needed to explore the relationship between serum VCAM-1 levels and severity and clinical outcomes in acute ischemic stroke patients at various centers in Indonesia.
Blood Urea Nitrogen-Serum Albumin Ratio As a Predictor of Clinical Outcome in Acute Ischemic Stroke Suseno, Endy; Akbar, Muhammad; Bintang, Andi Kurnia; Soraya, Gita Vita; Lotisna, Mimi; Sompa, Andi Weri
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 1 (2024): Volume 6 Nomor 1 April 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i1.573

Abstract

Stroke is a global health issue with high morbidity and fatality rates. Treatment decisions for ischemic stroke rely on clinical outcome prediction. The NIHSS score is commonly used to predict the AIS's clinical outcomes. However, its use is hindered by its complexity, which requires the assessment of many variables. Therefore, there is an urgent need to develop a simpler yet still effective evaluation tool in assessing the AIS’s clinical outcome. The study aimed to predict AIS outcomes using the blood urea nitrogen to albumin serum ratio (RBA). This study was a prospective cohort study design, with subjects being first-time AIS patients hospitalized at RSUP Dr. Wahidin Sudirohusodo and several hospitals in Makassar from December 2022–April 2023. Demographic and clinical data were collected, assessing RBA and comparing it according to the good (mRS 0-2) and poor (mRS 3-6) outcome groups. RBA performance was assessed by receiver operating characteristic curve (ROC) analysis to assess the AIS's clinical outcome. The study's findings on 62 participants meeting the criteria revealed a significant association between RBA and the AIS's clinical outcome (p-value=0,0004). The mean RBA differed significantly between the good and poor AIS outcome groups (p-value =0,006). In the ROC analysis, the area under the curve (AUC) was 0,75 with an optimal cut-off value was 2,05, yielding a sensitivity of 41,67%, a specificity of 98%, and a likelihood ratio of 20,83 (p-value=0,007). In conclusion, RBA can be used as a simple and objective tool to determine the clinical outcome predictors of AIS.
Efek Restriksi Kalori dan Restriksi Kalori Mimetic pada Tikus Tua Nurliana, Nurliana; Syahrijuita, Syahrijuita; Yustisia, Ika; Kwenang, Agnes; Hardjo, Marhaen; Soraya, Gita Vita
JI-KES (Jurnal Ilmu Kesehatan) Vol. 5 No. 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.343

Abstract

AbstrakSecara global sekitar 2,3 miliar lansia mengalami overweight dan obesitas. Restriksi kalori adalah intervensi yang berpengaruh untuk memperpanjang hidup, namun sulit bagi setiap orang untuk menerapkan restriksi kalori seumur hidup. Oleh karena itu diperlukan intervensi lain yang memiliki manfaat sama dengan restriksi kalori. Penelitian ini bertujuan untuk mengetahui pengaruh restriksi kalori, dan  restriksi  kalori mimetik terhadap profil lipid tikus tua. Penelitian ini termasuk penelitian eksperimental menggunakan metode acak terkontrol dengan Pre and Post test with controlled group design. Menggunakan 18 ekor tikus dibagi menjadi 3 kelompok, A (kontrol), B (restriksi kalori), dan C (restriksi kalori mimetik) dan tiap kelompok terdiri dari 6 ekor tikus. Uji One Way Anova digunakan untuk melihat perbedaan sebelum dan sesudah intervensi. Dari hasil uji perbandingan secara keseluruhan terdapat perbedaan kolesterol, trygliserida, LDL-Cholesterol, HDL-Cholesterol serum tikus antara kelompok A,B, dan C setelah 30 hari perlakuan dengan nilai p<0.005. Dari hasil penelitian dapat disimpulkan bahwa restriksi kalori dan restriksi kalori mimetik mempengaruhi profil lipid. Kata kunci : restriksi kalori, restriksi kalori mimetik, profil lipid, penuaan AbstractGlobally around 2.3 billion elderly are overweight and obese. Calorie restriction is a powerful intervention for prolonging life, but it is difficult for everyone to implement calorie restriction for life. Therefore, other interventions are needed that have the same benefits as calorie restriction. This study aims to determine the effect of calorie restriction, and mimetic calorie restriction on the lipid profile of elderly rats and includes an experimental study using a randomized controlled method with Pre and Post test with controlled group design. Using 18 rats were divided into 3 groups, A (control), B (calorie restriction), and C (mimetic calorie restriction) and each group consisted of 6 rats. One Way Anova test was used to see the difference before and after the intervention. From the results of the overall comparison test, there were differences in cholesterol, triglycerides, LDL-Cholesterol, HDL-Cholesterol in rat serum between groups A, B, C, and D after 30 days of treatment with p < 0,005. From the results of the study it can be concluded that calorie restriction and mimetic calorie restriction affect the lipid profile. Keywords: calorie restriction, mimetic calorie restriction, intermittent fasting, lipid profile, aging
Co-Authors Andi Kurnia Bintang, Andi Kurnia Assa, Christantina Pradescha Bahar, Ashari Halim, Wijoyo Hardjo, Marhaen Kwenang, Agnes Lotisna, Mimi Muhammad Akbar NURLIANA NURLIANA Sompa, Andi Weri Suseno, Endy Syahrijuita, Syahrijuita Tammasse, Jumraini Yustisia, Ika