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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Sciences of Pharmacy
Kuntana, Yasmi Purnamasari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Medicine & Pharmacology Public Health

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Histological Structure of Male Wistar Rats’ Stomach Fed with Yam Tuber Flour Supplementation Permana, Andre Dian; Kuntana, Yasmi Purnamasari; Malini, Desak Made
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 3 (2023): October 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i3.7166

Abstract

A residential rat might harm human health because it acts as a disease reservoir. It has been many efforts to control this rate using synthetic rodenticide. Nevertheless, synthetic rodenticides broke the environment and made rats resistant. Yam (Dioscorea hispida) tube application on rat’s bite could solve the problem. This study evaluated the histology of male Wistar rats (Rattus norvegicus) fed with bite block supplemented with different yam tuber flour concertation to control residential rat populations. Five different treatments were applied with five replications. The treatments were negative control and brodifacoum 0.005% (positive control), 30%, 50%, and 70% of yam tuber flour. The results show that yam tuber supplementation caused damage to male Wistar rat stomachs, as indicated by mucosal erosion and the presence of inflammatory cells. The statistical test indicated that stomach damage significantly differed among treatments, with the severest damages caused by 50% yam tuber supplementation. It could be concluded that the rat’s bite containing yam tuber flour caused stomach damage, and the feed bite containing 70% yam tuber flour was the most effective. This result proved that yam tuber has good potential as a natural rodenticide to control residential rat populations.
Histological Structure of Male Wistar Rats’ Stomach Fed with Yam Tuber Flour Supplementation Permana, Andre Dian; Kuntana, Yasmi Purnamasari; Malini, Desak Made
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 3 (2023): October 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i3.7166

Abstract

A residential rat might harm human health because it acts as a disease reservoir. It has been many efforts to control this rate using synthetic rodenticide. Nevertheless, synthetic rodenticides broke the environment and made rats resistant. Yam (Dioscorea hispida) tube application on rat’s bite could solve the problem. This study evaluated the histology of male Wistar rats (Rattus norvegicus) fed with bite block supplemented with different yam tuber flour concertation to control residential rat populations. Five different treatments were applied with five replications. The treatments were negative control and brodifacoum 0.005% (positive control), 30%, 50%, and 70% of yam tuber flour. The results show that yam tuber supplementation caused damage to male Wistar rat stomachs, as indicated by mucosal erosion and the presence of inflammatory cells. The statistical test indicated that stomach damage significantly differed among treatments, with the severest damages caused by 50% yam tuber supplementation. It could be concluded that the rat’s bite containing yam tuber flour caused stomach damage, and the feed bite containing 70% yam tuber flour was the most effective. This result proved that yam tuber has good potential as a natural rodenticide to control residential rat populations.
Gambaran Morfologis Ginjal Ayam yang Diberi Ransum Mengandung Temulawak Serta Pengaruhnya terhadap Bobot Badan Alipin, Kartiawati; Fadilah, Ardi Mufarriz; Kuntana, Yasmi Purnamasari
Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) 2016: Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (722.537 KB)

Abstract

Temulawak merupakan tanaman obat asli Indonesia yang mempunyai khasiat sebagai antibakteri yang dapat digunakan sebagi antibiotik alami dalam mencegah maupun mengobati penyakit. Pemanfaatan temulawak tidak hanya untuk manusia namun dapat digunakan sebagai pencegah penyakit pada ayam broiler, hal ini dilakukan dengan tujuan sebagai alternatif pengganti penggunaan antibiotik selama pemeliharaan ayam. Tujuan penelitian ini dilakukan untuk mengetahui pengaruh kurkuminoid temulawak (Curcuma xanthorrhiza Roxb.) terhadap organ ginjal ayam broiler dilihat dari struktur morfologis serta pengaruhnya terhadap bobot badan. Metode penelitian secara eksperimental dengan rancangan acak lengkap yang terdiri dari empat perlakuan dan enam ulangan yaitu R0 (kontrol), R1 (37 mg kurkuminoid /kg ransum), R2 (74mg kurkuminoid/kg ransum) dan R3 (111 mg kurkuminoid/kg ransum). Perlakuan diberikan terhadap ayam broiler umur empat hari hingga lima minggu secara adlibitum. Hasil penelitian menunjukkan pemberian kurkuminoid temulawak pada semua dosis perlakuan berpengaruh terhadap struktur morfologis ditandai dengan adanya perubahan warna pada ginjal. Kesimpulan penelitian adalah walaupun pemberian kurkuminoid temulawak berpengaruh terhadap morfologis ginjal ayam namun masih dalam batas normal karena bobot badan ayam broiler mengalami peningkatan dibandingkan dengan kontrol.
Differential Regulation of Slc40a1, Fth1, and Hmox1 by Deferasirox in Splenic Iron Overload Wibowo, Annisa Maharani; Kuntana, Yasmi Purnamasari; Arrizqiani, Tanendri; Safitri, Ratu
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404386

Abstract

Iron overload, often arising from repeated transfusions in thalassemia major, disrupts iron homeostasis and induces oxidative stress. Deferasirox is a widely used oral chelator, yet its effects on splenic iron-regulatory gene expression remain unclear. This study investigated the impact of deferasirox on ferritin heavy chain (Fth1), ferroportin (Slc40a1), and heme oxygenase-1 (Hmox1) expression in a rat model of splenic iron overload. Eighteen male Wistar rats were randomly assigned into three groups (n = 6 each): normal (N), iron dextran-induced overload without treatment (KN), and iron overload treated with deferasirox (KP). Gene expression was quantified by real-time PCR using the 2−ΔΔCT (Livak) method, with statistical analysis performed via one-way ANOVA and Tukey’s post hoc test. Iron overload significantly upregulated Fth1 (2.26-fold) and Slc40a1 (1.72-fold) versus controls (p < 0.05). Deferasirox treatment reduced Fth1 (3.28-fold decrease) and Slc40a1 (1.15-fold reduction) relative to untreated overload, though not significantly (p > 0.05). In contrast, Hmox1 expression markedly increased (55.25-fold, p < 0.05) following deferasirox administration. These results indicate that deferasirox selectively modulates splenic iron-regulatory genes, suggesting both chelation and adaptive stress-response mechanisms, thereby supporting its therapeutic role in managing iron overload.
Co-Authors Arrizqiani, Tanendri Desak Made Malini Fadilah, Ardi Mufarriz Kartiawati Alipin Permana, Andre Dian Ratu Safitri Wibowo, Annisa Maharani