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All Journal EKSAKTA: Journal of Sciences and Data Analysis Jurnal Kesehatan Bakti Tunas Husada Sciences of Pharmacy Jurnal Farmasi Galenika
Tanendri Arrizqiyani, Tanendri
Program Studi DIII Analis Kesehatan STIKes Bakti Tunas Husada Tasikmalaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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UJI EFEKTIVITAS LOSION BIJI PALA (Myristica fragrans) SEBAGAI REPELLENT NYAMUK Culex sp Arrizqiyani, Tanendri
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 20, No 1 (2020)
Publisher : STIKes Bakti Tunas Husada Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v20i1.561

Abstract

Lethal Concentration (LC50) of Myristicin (Myristica fragrans Houtt) on Larva Aedes aegypti Instar III Arrizqiyani, Tanendri; Mardiana, Ummy; Hidana, Rudy; Nurhamidah, Siti
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 5, ISSUE 2, October 2024
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol5.iss2.art7

Abstract

Myristicin is an active substance that can be found in nutmeg plants. The purpose of this study was to determine the LC50 myristicin against larval instar III of Aedes aegypti. The method used is the experimental method. The samples used were myristicin isolates with varying concentrations of 5 ppm, 10 ppm, 15 ppm, and 20 ppm against Aedes aegypti instar III larvae. The parameters observed were LC50 Aedes aegypti larvae for 24 hours. The results obtained are based on calculations using IBM SPSS Statistics 22.0 using the probit formula it is known that LC50 isolate myristicin which can kill larvae at 12 hours is 10 ppm and the positive control is 10 ppm. These results are better when compared with results in other studies with LC50 of 111,002 ppm and positive control at 24 hours. Based on the results of research that has been done, it can be concluded that the LC50 isolate of Myristicin (Myristica fragrants Houtt) against Aedes aegypti Instar III larvae at the 12th hour is 10 ppm.
PENGARUH EKSTRAK ETANOL DAUN PEGAGAN (Centella asiatica) TERHADAP PERTUMBUHAN Escherichia coli SECARA IN VITRO Khusnul, Khusnul; Anggraeni, Rima; Arrizqiyani, Tanendri
JURNAL FARMASI GALENIKA Vol 8 No 1 (2021): Jurnal Farmasi Galenika Vol 8 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v8i1.185

Abstract

Daun pegagan (Centella asiatica) merupakan salah satu tanaman liar yang memiliki daerah penyebaran sangat luas. Tanaman ini banyak dimanfaatkan sebagai tanaman untuk mengobati diare. Diare dapat bersifat akut atau kronis, penyebabnya selain racun juga higienis dan sanitasi lingkungan serta infeksi bakteri patogen seperti Escherichia coli. Namun, daun pegagan yang memiliki potensi sebagai antibakteri dengan jumlahnya yang banyak, belum diteliti oleh peneliti yang menguji potensi daun pegagan terhadap pertumbuhan bakteri Escherichia coli. Tujuan dari penelitian ini untuk mengetahui pengaruh kemampuan daya hambat ekstrak etanol daun pegagan (Centella asiatica) terhadap pertumbuhan Escherichia coli. Uji daya hambat ekstrak etanol daun pegagan dilakukan dengan metode Kirby-Bauer. Daun pegagan di ekstraksi dengan cara maserasi menggunakan etanol 70%. Konsentrasi ekstrak yang digunakan adalah 100%, 90%, 80%, 70%, 60%,50%, 40%, dan 30%. Hasil yang di amati berupa zona hambat. Hasil penelitian menunjukkan bahwa ekstrak daun pegagan (Centella asiatica) berpengaruh terhadap pertumbuhan bakteri Escherichia coli.
UJI LARVASIDA MIRISTISIN (Myristica fragrans Houtt) TERHADAP Aedes aegypti INSTAR III Arrizqiyani, Tanendri; Nurhamidah, Siti
JURNAL FARMASI GALENIKA Vol 8 No 1 (2021): Jurnal Farmasi Galenika Vol 8 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v8i1.188

Abstract

Demam berdarah dengue (DBD) disebabkan oleh virus dengue yang masih banyak menimbulkan kematian. Untuk memutus mata rantai penyebaran penyakit DBD dilakukan melalui penggunaan larvasida alami yang berasal dari tanaman pala. Salah satu zat aktif dari tanaman pala yaitu miristisin yang diduga memiliki aktivitas psikofarmakologis sebagai insektisida. Penelitian ini menggunakan metode eksperimen dengan tujuan untuk mengetahui LC50 dari miristisin dengan variasi konsentrasi 5, 10, 15, dan 20 ppm. Objek yang digunakan yaitu larva Aedes aegypti instar III. Berdasarkan hasil penelitian yang telah dilakukan, maka dapat disimpulkan bahwa konsentrasi miristisin (Myristica fragrans Houtt) yang dapat membunuh larva Aedes aegypti Instar III berdasarkan LC50 yaitu pada konsentrasi 11,655 ppm pada jam ke-12 dan 15,230 ppm pada jam ke-24.
Effect of Deferiprone on Hepatic Expression of Hamp, Ftl, and Tfr1 Genes in an Iron-Overloaded Rat (Rattus norvegicus) Model Salsabila, Nadhila Hasna; Kuntana, Yasmi Purnamasari; Arrizqiyani, Tanendri; Safitri, Ratu
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404387

Abstract

Iron overload is linked to progressive impairment of organ function, with the liver being the primary site of deposition due to the lack of a physiological route for iron elimination. The maintenance of systemic iron balance depends on key regulatory proteins, including hepcidin (Hamp gene), ferritin light chain (Ftl gene), and transferrin receptor 1 (Tfr1 gene). This study tested the hypothesis that Deferiprone (DFP), an oral iron chelator, modulates the hepatic expression of Hamp, Ftl, and Tfr1 genes in an iron-overloaded rat model. Eighteen male Wistar rats (150-200 g) were randomly assigned into three groups: Normal (N), Negative Control (NC; induced with Iron Dextran), and Treatment (T; Iron Dextran + DFP). Iron overload was induced via intravenous injection of Iron Dextran (120 mg/kg BW) over 15 days at 3-day intervals, while DFP was administered orally (100 mg/kg BW) in three divided doses for 28 consecutive days. Gene expression was assessed using RT-PCR, and relative quantification was performed using the Livak method. The iron-overloaded rats showed marked upregulation of Hamp and Ftl and downregulation of Tfr1. Administration of DFP significantly reversed these alterations, decreasing Hamp and Ftl levels while restoring Tfr1 expression to levels comparable to normal controls. These results highlight the potential role of DFP in modulating hepatic iron-regulatory genes under iron overload conditions. 
Co-Authors Anggraeni, Rima Khusnul, Khusnul Meliansyah, Mila Nurhamidah, Siti Ratu Safitri RUDY HIDANA, RUDY Salsabila, Nadhila Hasna Sri Sumiati Yasmi Purnamasari Kuntana