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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Indonesian Journal of Biotechnology Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Ilmiah Manuntung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat JFIOnline Jurnal Peduli Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Masyarakat Bangsa Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Pharmacology and Therapy

Haafizah Dania

Faculty Of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia 55164

Author-ID : 249514

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 Âµg DAN 100 Âµg TERHADAP KEBERHASILAN KELAHIRAN INDUKSI DI RSU PKU MUHAMMADIYAH YOGYAKARTA Dania, Haafizah; Wahyono, Djoko; Retnowati, Sulistiari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripeningat pregnancy and labor induction. However, until now misoprostol dosage and administration route forinduction are various. There is no fix guide on administration and dosage of misoprostol. This researchwas intended to identify profile of misoprostol usage and effectiveness of misoprostol administrationat dosage of 50 Âµg and 100 Âµg on labor process progress of patient hospitalized in Yogyakarta PKUMuhammadiyah Hospital based on induction success. This research was non experimental research with historical cohort design. Limitation of this method was not all desired data exist in medical recordand capability of physician was not same. Subject was pregnant mothers giving birth with misoprostolinduction process in delivery room in Yogyakarta PKU Muhammadiyah Hospital from 1 January 2009to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptivelyanalytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administrationat 50 Âµg and 100 Âµg dosage on labor process progress. Research subjects who meet the inclusioncriteria in this research was 109 mothers, where 69 women (63,30%) got 50 Âµg misoprostol and 40women (36,70%) got 100 Âµg misoprostol. The results of this study indicate that the success ofinduction at 50 ug misoprostol group decreased by 89% compared with 100 ug misoprostol group (RR= 0.11), where the success of 50 ug misoprostol induction for 56 people from 69 people (81.16%),while the success induction at 100 ug misoprostol group as many as 39 people from 40 people(97.50%). The difference was statistically significant with p = 0.014 (p <0.05).

Evaluasi terapi erytropoetin pada pasien hemodialisa di rumah sakit PKU Muhammadiyah Yogyakarta Adnan, Adnan; Dania, Haafizah; Supadmi, Woro
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Most of the patients with end-stage renal disease who undergoing hemodialysis received erythropoietin (EPO) therapy for the anemia treatment. Deficiency anemia erythropoietin is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve the anemia and can improve the quality of life of patients.This study was conducted in an analytic observational with Cross Secsional design. The purpose of this study was to know there was a difference of red blood cell profile involve hemoglobin (Hb), Mean Corpusculair Volume (MCV), Mean Corpusculair Haemoglobin (MCH), Mean Corpusculair Haemoglobin Concentration (MCHC) and quality of life of CKD patients who received EPO and non EPO therapy in PKU Muhammadiyah Yogyakarta Hospital. Inclusion criteria in this study were PGK ICD N18.9 patients who were undergoing hemodialysis therapy at RS PKU Muhammadiyah Yogyakarta, outpatient, can read and understand the questionnaire, and accept to be a respondent.The results of this study showed no significant difference (p>0,05) in red blood cell (Hb, MCV, MCH, MCHC) between EPO and non EPO therapy groups. The associated of EPO with the quality of life of patients in all of KDQOL domains was p> 0.05.The conclusions of this study showed that there was no significant difference between EPO and Non EPO therapy and there was no correlation between EPO and non EPO therapy with quality of life of hemodialysis patients.

The validation of patient knowledge questionnaire for patients with diabetes mellitus and hyperlipidemia Saputri, Ginanjar Zukhruf; Dania, Haafizah; Faridah, Imaniar Noor; A, Faiza Chusnuni
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Prevalence of Diabetes Mellitus (DM) with Hyperlipidemia increased in Indonesia, where both diseases have a risk of complications towards cardiovascular disease. DM patients with hyperlipidemia require proper management to control blood sugar, total cholesterol and LDL cholesterol. Knowledge is one of the important factors in improving adherence therapy and quality of life of DM-hyperlipidemia patients, especially in controlling blood glucose level and total cholesterol levels. This study aims to develop a patient questionnaire of DM-hyperlipidemia.The study used cross sectional method. Inclusion criteria were patients aged 18 â 70 years old, diagnosed DM-Hyperlipidemia, getting at least 1 oral antidiabetic and oral anti-cholesterol. The questionnaire item of knowledge was developed based on gudeline therapy and previous research reference. Expert validation is done on Doctor who had expert in DM and clinical psychologist. The pilot test was performed on 10 healthy patients and 10 patients of DM-hyperlipidemia who had eligible inclusion criteria. Validation of questionnaire was done on 30 patients of DM-Hyperlipidemia who undergoing therapy at outpatient clinic of PKU Muhammadiyah Hospital Yogyakarta. Data collection was done by interviewing questionnaires in patients. Analysis of data using SPSS with product moment validation test and cronbach alpha to see the reliability of questionnaire.Validation results show there are some invalid items that are in questions 9, 11, 12, 15, 16 and 17, the range of questions about knowledge about hyperlipidemia, medication and general health. Re-validation without invalid item was done and obtained value r> 0.3, with value of Cronbach alpha 0,715.The DM-Hyperlipidemia patient questionnaire was valid and reliable to measure the level of knowledge of DM patients with Dysipidemia.Â Â

OPTIMALISASI PEMANFAATAN JAHE (ZINGIBER OFFICINALE) DAN ROSELLA (HIBISCUS SABDARIFA) SEBAGAI MINUMAN KESEHATAN DI MADRASAH MUALLIMIN MUHAMMADIYAH YOGYAKARTA Saputri, Ginanjar Zukhruf; Dania, Haafizah; Putranti, Widyasari
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol 2, No 2 (2018)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Sekolah berbasis asrama memiliki beberapa permaslahan terutama di bidang kesehatan. Hasil survey dan skrining kesehatan yang telah dilakukan menunjukkan tingginya prevalensi penyakit menular seperti flu, batuk pilek (16.5%) dan penyakit kulit seperti jamur, gatal, scabies (11.2%). Adanya pos kesehatan pesantren di lingkungan sekolah tersebut diharapkan dapat mengoptimalkan promosi kesehatan dalam upaya pencegahan penyakit. Hal tersebut didukung pula dengan optimalisasi pemanfaatan TOGA (tanaman obat keluarga) yang ada di setiap asrama sekolah. Lahan yang cukup luas dan tempat tinggal (asrama) siswa yang terpisah menjadi peluang dalam pengembangan penanaman TOGA, di dukung dengan pemanfaatan TOGA dalam bentuk sediaan minuman kesehatan dirasa lebih menarik dan penting untuk diupayakan sebagai salah satu kegiatan edukasi dan promosi kesehatan di lingkungan sekolah berasis asrama. Kegiatan pemberdayaan masyarakat ini bertujuan untuk melakukan pendampingan pemanfaatan TOGA dan pelatihan pemanfaatan tanaman Jahe (Zingiber officinale) dan tanaman rosella (Hibiscus sabdarifa) sebagai minuman kesehatan (syrup). Kegiatan ini meliputi dua sesi, yaitu sosialisasi hasil skrining kesehatan siswa dan edukasi kesehatan diri “swamedikasi” yang diikuti oleh pengelola madrasah, staf poskestren (perawat dan dokter), serta ibu pamong asrama (ummahat). Adapun kegiatan kedua adalah pelatihan pemanfaatan TOGA Jahe (Zingiber officinale) dan Rosella (Hibiscus sabdarifa) sebagai minuman kesehatan yang diikuti oleh 44 siswa Madrasah Mu’allimin Muhammadiyah Yogyakarta. Pengetahuan siswa sebelum dan sesudah pelatihan menunjukkan peningkatan skor rerata dari 5.56 menjadi 9.18 dengan nilai signifikansi P=0.000 (P<0.05). Hal ini menunjukkan bahwa pelatihan ini efektif dan dapat meingkatkan pengetahuan siswa Madrasah Mu’allimin Muhammadiyah Yogyakarta. Melalui pelatihan ini diharapkan siswa mampu mengaplikasikan terutama saat progam Mubaligh Hijrah yang menjadi salah satu program rutin Madrasah dalam praktek di masyarakat sekitar. Kegiatan ini diharapkan pula dapat ditindak lanjuti oleh poskestren untuk bersinergi dengan ibu pamong ataupun kantin untuk dapat mengoptimalkan TOGA di lingkungan asrama dan memulai produksi sediaan syrup kesehatan Jahe dan Rosella.

PENGARUH PEMBERIAN PATIENT INFORMATION LEAFLET (PIL) DAN SMS MOTIVASI TERHADAP PENGETAHUAN DAN KEPATUHAN PASIEN DM DENGAN DISLIPIDEMIA Dania, Haafizah; Saputri, Ginanjar Zukhruf; Faridah, Imaniar Noor
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Diabetes mellitus(DM) and dyslipidemia are high prevalence diseases which also as one of risk factors for coronary heart disease. Knowledge and adherence are important factors in the treatment of DM-dyslipidemia either to control blood glucose and cholesterol or to prevent from complications. Education is one of the ways to increase knowledge and adherence. The aim of this research is to determine the impact of intervention (Patient Information Leaflet (PIL) and motivation messages by SMS) to knowledge and adherence of DM-dyslipidemia patients in PKU Muhammadiyah Yogyakarta Hospital. This research is a quasi experimental study with analytical quantitative. The data taken from February 2016 to April 2017 at PKU Muhammadiyah Yogyakarta Hospital. Inclusion criterias in this research are patient with age more than 18 years old, with diagnosed by DM-dyslipidemia, using 1 or more of DM and dyslipidemia medicine, not deaf, and cooperative. Interventions that given to the patients are Patient Information Leaflet (PIL) and motivation messages by SMS which routinely given in a week after first we met. Knowledge is assessed using questionnaire and adherence is assesed using pill count method. The data that need analyzed are characteristic patients and the impact of intervention using Wilcoxon and paired t-test. The result of intervention in 56 patients showed the increasing number of patient that have good knowledge after intervention, from 58,9% to 71,4%, otherwise it not differ significantly (p 0.071). Other than that, the adherence also increased that showed from the patients who have adhere category after intervention, from 58,93% to 91.07% and it differ significantly with p 0.001 (p<0.05). Diabetes mellitus(DM) and dyslipidemia are high prevalence diseases which also as one of risk factors for coronary heart disease. Knowledge and adherence are important factors in the treatment of DM-dyslipidemia either to control blood glucose and cholesterol or to prevent from complications. Education is one of the ways to increase knowledge and adherence. The aim of this research is to determine the impact of intervention (Patient Information Leaflet (PIL) and motivation messages by SMS) to knowledge and adherence of DM-dyslipidemia patients in PKU Muhammadiyah Yogyakarta Hospital. This research is a quasi experimental study with analytical quantitative. The data taken from February 2016 to April 2017 at PKU Muhammadiyah Yogyakarta Hospital. Inclusion criterias in this research are patient with age more than 18 years old, with diagnosed by DM-dyslipidemia, using 1 or more of DM and dyslipidemia medicine, not deaf, and cooperative. Interventions that given to the patients are Patient Information Leaflet (PIL) and motivation messages by SMS which routinely given in a week after first we met. Knowledge is assessed using questionnaire and adherence is assesed using pill count method. The data that need analyzed are characteristic patients and the impact of intervention using Wilcoxon and paired t-test. The result of intervention in 56 patients showed the increasing number of patient that have good knowledge after intervention, from 58,9% to 71,4%, otherwise it not differ significantly (p 0.071). Other than that, the adherence also increased that showed from the patients who have adhere category after intervention, from 58,93% to 91.07% and it differ significantly with p 0.001 (p<0.05). Diabetes mellitus(DM) and dyslipidemia are high prevalence diseases which also as one of risk factors for coronary heart disease. Knowledge and adherence are important factors in the treatment of DM-dyslipidemia either to control blood glucose and cholesterol or to prevent from complications. Education is one of the ways to increase knowledge and adherence. The aim of this research is to determine the impact of intervention (Patient Information Leaflet (PIL) and motivation messages by SMS) to knowledge and adherence of DM-dyslipidemia patients in PKU Muhammadiyah Yogyakarta Hospital. This research is a quasi experimental study with analytical quantitative. The data taken from February 2016 to April 2017 at PKU Muhammadiyah Yogyakarta Hospital. Inclusion criterias in this research are patient with age more than 18 years old, with diagnosed by DM-dyslipidemia, using 1 or more of DM and dyslipidemia medicine, not deaf, and cooperative. Interventions that given to the patients are Patient Information Leaflet (PIL) and motivation messages by SMS which routinely given in a week after first we met. Knowledge is assessed using questionnaire and adherence is assesed using pill count method. The data that need analyzed are characteristic patients and the impact of intervention using Wilcoxon and paired t-test. The result of intervention in 56 patients showed the increasing number of patient that have good knowledge after intervention, from 58,9% to 71,4%, otherwise it not differ significantly (p 0.071). Other than that, the adherence also increased that showed from the patients who have adhere category after intervention, from 58,93% to 91.07% and it differ significantly with p 0.001 (p<0.05).

TINGKAT PENGETAHUAN PENGGUNAAN OBAT BEBAS DAN OBAT BEBAS TERBATAS UNTUK SWAMEDIKASI PADA MASYARAKAT RW 8 MOROBANGUN JOGOTIRTO BERBAH SLEMAN YOGYAKARTA Hidayati, Ana; Dania, Haafizah; Puspitasari, Murtyk Dyahajeng
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.577 KB)

Currently, there are developed illnesses that encourage humans to do their own alternative medication. In 2002, an estimated shows that 92% of people in the world choose the alternative medication namely self medication, by using over the counter medicine including free and limited, however the level of knowledge in using this medication is still poor, then it is possible to make a mistake. Therefore, this research aims to find out the level of knowledge in using over the counter medicine including free and limited for self medication of society in RW 08, Morobangun, Jogotirto, Berbah, Sleman, Yogyakarta. This study belongs to descriptive observational to find out the subject characteristic, the level of knowledge and the description of the kind of medicine used by society of RW 08 Morobangun. The sample used in this study is the people who lived in Rw 08 Morobangun, Jogotirto, Berbah, Sleman, Yogyakarta. The data was taken from the interview with the patient by using the questionnaire. The sample collecting technique was nonrandom sampling and the method was accidental sampling with the number of the respondents were 175. The result showed that 175 respondents in RW 08 Morobangun, Jogotirto, Berbah, Sleman, Yogyakarta used self medication of over the counter medicine including free and limited only for their ailment. The level of knowledge in using over the counter medicine including free and limited for self medication of society in RW 08 Morobangun, Jogotirto, Berbah, Sleman, Yogyakarta showed that 42.9% reached the good category and 57,1% reached the sufficient category of 175 respondents. The conclusion of this study is the level of knowledge in using over the counter medicine including free and limited for self medication of society in RW 08 showed that most of the respondents achieved the sufficient category with 100 respondents (57,1%).

HUBUNGAN ANTARA PENGETAHUAN DENGAN LUARAN TERAPI PADA PASIEN DIABETES MELLITUS TIPE 2-DISLIPIDEMIA Faridah, Imaniar Noor; Dania, Haafizah; Saputri, Ginanjar Zukhruf; A, Faiza Chusnuni
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.678

Diabetes mellitus and dyslipidemia are non communicable disease which those prevalence increased significantly.Those are risk factors of cardiovascular disease. A good knowledge is important to enhance the awareness of disease, so that the target of outome therapy can be achieved. The aim of this research are to describe the patient?s knowledge about the disease and to know the relationship between patient?s knowledge and outcomes therapy (HbA1c and total cholesterol). This research is an observational analytic study with cross setional design. The data taken prospectively from diabetes patients in PKU Muhammadiyah Hospital around September to December 2016. Sample who met the inclusion criterias were patient who diagnosed with diabetes mellitus-dyslipidemia, aged over 18 years old, have a HbA1c and total cholesterol data and using minimal 2 drugs, antidiabetic and anticholesterol. The datas are the knowledge data which taken using validated questionnaire and the outcomes therapy which taken from patient?s medical data. Linear regression analysis is done to know the relationship between knowledge and outcome therapy. Around 37 patients who participated in this research were below 60 years old (64.9%), mostly female (59.5%), and have en education more than 9 years (86.5%). Besides that, only 62.2% patient who achieved the target of HbA1c, and only 56.8% patient who achieved the target of total cholesterol. Furthermore, based on linear regression analysis showed that there was no relationship between knowledge and outcome therapy either HbA1c or total cholesterol (sig 0.893 and 0.292).

Validation of diabetes mellitus patient behavior questionnaire in primary health care service Ginanjar Zukhruf Saputri; Akrom Akrom; Haafizah Dania; Okta Muthia S
International Journal of Public Health Science (IJPHS) Vol 8, No 4: December 2019
Publisher : Intelektual Pustaka Media Utama

This study aimed to develop and validation a questionnaire as measurement instrument for knowledge and adherence behavior of DM patients in primary health care. Cross sectional study design was conducted in diabetes mellitus patient. Inclusion criteria were patients in the age group 18-65 years, diagnosed with DM, receiving at least one oral antidiabetic medication. Questionnaire questions for behavioral item were developed based on Diabetes Mellitus management guidelines and references to previous studies. Evaluation and validation by expert was carried out on diabetes mellitus experts and clinical psychologists. The pilot study was conducted on 10 healthy patients and 10 patients with diabetes who enrolled inclusion criteria. Questionnaire validation test was conducted with 41 DM outpatient at PKU Muhammadiyah Hospital in Yogyakarta. Collecting data by interviewing patients based on questionnaire. Statistical analysis was performed using SPSS with Pearson correlation coefficients for validation test and Cronbach alpha coefficients for reliability test of the questionnaire. Adherence behavior questionnaire consists of 12 question items, which are divided into three domains: cognitive, affective, and psychomotor domains. Validation results showed 12 valid items where the pearson correlation value was>0.308 (n=41). Cronbach alpha as reliability test results showed 0.78. This result showed a questionnaire were valid and reliable in Diabetes Mellitus patients. This instrument would be use in primary health care for measuring adherence behavior of DM patients.

Adverse Event Sindroma Metabolik Kombinasi Terapi Risperidon dan Klozapin pada Pasien Skizofrenia di Rumah Sakit Jiwa Magelan Gilang R. Al Farizi; Dyah A. Perwitasari; Haafizah Dania; Melisa I. Barliana; Santi Yuliani
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.159

Kombinasi risperidon dan klozapin pada pasien skizofrenia dapat menyebabkan adverse drug event peningkatan body mass index (BMI), tekanan darah sistolik, dan tekanan darah diastolik seiring lamanya terapi. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara durasi kombinasi terapi risperidon dan klozapin dengan peningkatan BMI, tekanan darah sistolik, dan tekanan darah diastolik pada pasien skizofrenia. Metode yang digunakan adalah studi kohort retrospektif periode Februari–Mei 2019 pada 59 pasien skizofrenia rawat inap di Rumah Sakit Jiwa Magelang. Subjek dibagi ke dalam 2 kelompok durasi terapi <8 minggu (48 pasien) dan ≥8 minggu (11 pasien). Pengukuran BMI, tekanan darah sistolik, dan tekanan darah diastolik dilakukan pada hari pertama rawat inap dan saat konsultasi rawat jalan yang disesuaikan dengan cut-off point NCEP-ATP III modifikasi BMI populasi Asia Tenggara. Kuesioner terstruktur digunakan untuk mengukur kalori intake dan aktivitas fisik yang diperoleh dari catatan medis pasien. Hasil uji bivariat menunjukkan hubungan bermakna secara klinik antara BMI saat pertama rawat inap dan saat rawat jalan pada kelompok durasi terapi ≥8 minggu, 22,41±2,98 kg/m2 vs 25,2±6,80 kg/m2 (p=0,023, –2,75 (–5,12–(–0,39)), namun tidak ada hubungan bermakna pada tekanan darah sistolik 117±11,73 mmHg vs 118±15,42 mmHg (p=0,797, 95%CI –1,07 (–9,41–7,26) dan tekanan darah diastolik 76±7,86 mmHg vs 73±8,48 mmHg (p=0,192, 95%CI 3,52 (–1,81–8,86) antara kedua kelompok. Faktor usia, jenis kelamin, status merokok, dosis, komedikasi, intake kalori, dan aktivitas fisik tidak menunjukkan hubungan bermakna dengan peningkatan BMI, tekanan darah sistolik, dan tekanan darah diastolik.Kata kunci: Kombinasi terapi risperidon dan klozapin, metabolik, skizofrenia Adverse Events of Risperidone and Clozapine Combination Therapy on Schizophrenic Patients at Magelang Mental HospitalAbstractThe adverse drug effect of risperidone and clozapine combination therapy possibly increases the BMI, systolic and diastolic blood pressures of mental victims. This study aimed at determining the relationship between the duration of risperidone and clozapine combination therapy and increase in body mass index (BMI), systolic and diastolic blood pressures of schizophrenic patients. The correlation was obtained using the cohort retrospective method on 59 schizophrenic inpatients at Magelang Mental Hospital from February–May 2019. Participants were grouped into 2 categories, termed <8 and ≥8 weeks with 48 and 11 persons, respectively. Subsequently, patients’ BMI, systolic and diastolic blood pressures were measured during the first day of hospitalization and outpatient consultations, based on NCEP-ATP III cut off-point with the modification of Southeast Asian population’s BMI. Structured questionnaires were used to evaluate calory intake and physical activity as well as generate respondents’ medical records. The bivariate analysis results showed a significant relationship between BMI increase at initial hospitalization and during outpatient consultation on group ≥8 weeks therapy, 22.41±2.98 kg/m2 vs 25.2±6.80 kg/m2 (p=0.023, –2.75 (–5.12–(–0.39)). However, there is no major correlation occurred in systolic 117±11.73 mmHg vs 118±15.42 mmHg (p=0.797, 95%CI –1.07 (–9.41–7.26)) and diastolic blood pressures 76±7.86 mmHg vs 73±8.48 mmHg (p=0.192, 95% CI 3.52 (–1.81–8.86)) for both groups. Furthermore, age, gender, smoking status, dosage, co-medication, calory intake and physical activity indicated no substantial variations, in terms of the increase in BMI, systolic and diastolic blood pressures among two categories. Keywords: Metabolic syndrome, risperidone and clozapine combination therapy, schizophrenia

Atypical Antipsychotic Induced Weight Gain in Schizophrenic Patients Tetie Herlina; Dyah A. Perwitasari; Haafizah Dania; Santi Yuliani; Melisa I. Barliana
Indonesian Journal of Clinical Pharmacy Vol 10, No 1 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.1.57

Atypical antipsychotics are widely prescribed and have the potential to cause weight gain, which may result in the development of metabolic syndrome. Also, it is important to monitor the use of atypical antipsychotic for metabolic disturbance. The purpose of this study is to determine the side effects of atypical antipsychotics in increasing body weight in schizophrenia patients after 4 weeks of use. Furthermore, a retrospective design was conducted and data were collected based on consecutive sampling in 80 adult psychiatric inpatients (20 women and 60 men) with initial diagnoses of schizophrenia and with the same daily nutrition. The patients were hospitalized from January to March 2019, within the term (over 4 weeks) of initiation atypical antipsychotic. The patient body weight was collected before and 4 weeks after the treatment of atypical antipsychotic. The results showed that patients (20 women and 60 men) receiving atypical antipsychotic had a mean age of 35.6 years and a percentage of 70% women and 56% men had a weight gain of 1–5 kg over 4 weeks. The mean weight observed among our subjects increased from 57.55±10.743 kg to 59.83±12.205 kg after initiating treatment (p=0.001). However, the dual combination of atypical antipsychotics risperidone and clozapine are the most widely atypical antipsychotic used with a percentage equal to 91.25%, 3.75% clozapine, and 5% risperidone. Furthermore, it can be concluded that atypical antipsychotics use for at least 4 weeks can cause weight gain in schizophrenic patients. Pharmacist and doctors are recommended to monitor the metabolic side effects due to the atypical antipsychotic use. Keywords: Atypical antipsycotic, schizophrenia, weight gain Antipsikotik Atipikal Menginduksi Peningkatan Berat Badan pada Pasien Skizofrenia AbstrakAntipsikotik atipikal banyak diresepkan dan berpotensi menyebabkan kenaikan berat badan yang dapat menyebabkan sindrom metabolik. Ada kebutuhan klinis yang mendesak untuk memantau penggunaan antipsikotik atipikal terhadap gangguan metabolisme. Penelitian ini bertujuan untuk mengetahui efek samping antipsikotik atipikal dalam meningkatkan berat badan pada pasien skizofrenia setelah pemakaian 4 minggu. Melalui desain retrospektif, data dikumpulkan dengan consecutive sampling pada 80 pasien rawat inap psikiatri dewasa (20 wanita dan 60 pria) dengan diagnosis awal skizofrenia dan dengan pengaturan nutrisi harian yang sama. Pasien dirawat di rumah sakit sejak Januari 2019 sampai dengan Maret 2019, dalam jangka menengah (lebih dari 4 minggu) pemberian antipsikotik atipikal. Data berat badan pasien dicatat sebelum dan 4 minggu sesudah pemakaian antipsikotik atipikal. Pasien (20 wanita dan 60 pria) yang menerima antipsikotik atipikal memiliki usia rata-rata 35,6 tahun, semua pasien dengan persentase 70% wanita dan 56% pria memiliki kenaikan berat badan 1–5 kg selama periode 4 minggu. Berat rata-rata yang diamati di antara subyek meningkat dari 57,55±10,743 kg menjadi 59,83±12,205 kg setelah memulai pengobatan (p=0,001). Antipsikotik atipikal yang paling banyak digunakan adalah kombinasi antipsikotik atipikal risperidon clozapin dengan persentase sebesar 91,25%, clozapin 3,75%, risperidon 5%. Kami menyimpulkan bahwa penggunaan antipsikotik atipikal selama setidaknya 4 minggu dapat menyebabkan penambahan berat badan pada pasien skizofrenia. Apoteker dan dokter direkomendasikan untuk memantau efek samping metabolik akibat penggunaan antipsikotik atipikal.Kata kunci: Antipsikotik atipikal, peningkatan berat badan, skizofrenia

Co-Authors A, Faiza Chusnuni A, Faiza Chusnuni Adnan Adnan Adnan, Adnan Akrom, Akrom Ana Hidayati Athika Darumas Putri Baroroh, Faridah Bayu Tri Murti Bramadi Arya Cheung, Rocky Denys Chichi Kusumastuti Dewi Wulandari Djoko Wahyono Dyah A. Perwitasari Dyah A. Perwitasari Dyah A. Perwitasari Dyah Aryani Perwitasari Faiza Chusnuni A Fatimah, Salma Auliya Feangi, Yanti Fitriani Gilang R. Al Farizi Gina Noor Djalilah Herlina, Tetie Imaniar N. Faridah Imaniar N. Faridah Imaniar Noor Faridah Islami, Safira Nur Khansa F. Rahmah Khoirunnisa M. Jannah Lalu Muhammad Irham Lamhot B Simanjuntak Maliza, Rita Melisa I. Barliana Melisa I. Barliana Melisa I. Barliana Menit Ardhiani Menit Ardhiani Miftahul Afwansyah Moch. Saiful Bachri Mufidah, Syarifatul Muhammad Fathurrahman Mutmainnah Siradjuddin Ni Made Ary Sarasmita Okta Muthia S Pradika, Jaka Pratama, Kharisma Puspitaningrum, Anisa Nova Puspitasari, Murtyk Dyahajeng Puspitasari, Murtyk Dyahajeng Retnowati, Sulistiari Rezadhini, Melodia Rizky Abdulah Rizky, Muhammad Arif Santi Yuliani Santi Yuliani Saputri, Ginanjar Zukhruf Sari, Prita Anggraini Kartika Siswandi Suhendra, Gugun Sulistiari Retnowati Sundari, Trias Kania Susi Ari Kristina Utomo, Adhitya Ilham Mukti Wahyono, Djoko Wahyu Rahmatulloh Widyasari Putranti Wigatiningtyas, Ariska Wirawan Adikusuma Woro Supadmi

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