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All Journal Alchemy : Journal of Chemistry Journal of Mathematical and Fundamental Sciences Public Health of Indonesia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Journal of Fundamental and Applied Pharmaceutical Science Pharmaceutical And Biomedical Sciences Journal (PBSJ) Pharmaceutical Sciences and Research (PSR) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Kefarmasian Indonesia

Ofa Suzanti Betha

Pharmacy Department, Faculty Of Health Sciences, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Indonesia. Jl. Kertamukti No 5, Pisangan Ciputat 15419 Tangerang Selatan, Banten Indonesia

Author-ID : 336649

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Microwave-Assisted Claisen-Schmidt Condensation Reaction of Ethyl p-methoxycinnamate to Synthesize p-Methoxystyryl Ketone Derivatives and Evaluate Anti-inflammatory Activity of Synthetic Products Ismiarni Komala; Supandi Supandi; Nurmeilis Nurmeilis; Yardi Yardi; Ofa Suzanti Betha; Nurkhyati Putri Indriyani; Moethia Moethia; Muhamad Beny Setiawan; Ghilman Dharmawan; Putri Hayati Nufus; Noni Tri Utami
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 1 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.1.6

The rhizome of Kaempferia galanga has been known to contain ethyl p-methoxycinnamate (EPMC) (1) as a main component, which has anti-inflammatory properties. Previously we have reported the structural modification of EPMC (1) to form another ester, nitrostyrene, and cinnammamide derivatives and then studied their structure-activity relationships as anti-inflammatory agent. In continuing our research, in this paper, we report the microwave-assisted Claisen-Schmidt condensation of EPMC (1) to synthesize a series of p-methoxystyryl ketones followed by a study of their anti-inflammatory activity. The reaction begins with microwave-assisted cleavage oxidation of hydrolyzed product of EPMC, p-methoxycinnamic acid (2) with Ca(NO3)2 for the synthesis of p-methoxybenzaldehyde (3). Furthermore, 3 was reacted with acetophenone, ethyl methyl ketone and acetone via microwave-assisted Claisen-Schmidt condensation for the synthesis of (E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one (5a) (E)-1-(4-methoxyphenyl)pent-1-en-3-one (5b) and (E)-4-(4-methoxyphenyl)but-3-en-2-one (5c), respectively. The reaction products were characterized using spectroscopic techniques and were then tested for anti-inflammatory activity using in vitro anti-denaturation of protein assay. It was found that converting EPMC (1) to 5a and 5b reduced anti-inflammatory activity, while 5c retained anti-denaturation activity with an IC50 of 72.8 µg/ml.

Perbandingan Metode SYBR Green dan Hydrolysis Probe dalam Analisis DNA Gelatin Sapi dan Gelatin Babi Menggunakan Real Time Polymerase Chain Reaction Zilhadia Zilhadia; Afifah Nurul Izzah; Ofa Suzanti Betha
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Gelatin has a large application in the food, pharmaceutical and cosmetics industries. Gelatin is mostly derived from the skin or bone of porcine and bovine. Porcine gelatin is forbidden for Muslim and Jews. For this reason, analytical methods to detect gelatin are needed to make sure the source of gelatin. One of the analytical techniques that can differentiate bovine and porcine gelatin is Real Time Polymerase Chain Reaction (PCR). There are two popular methods of fluorescence dye, namely SYBR green and hydrolysis probe. This study was conducted to compare SYBR green and hydrolysis probe method in analyzing porcine and bovine gelatin DNA using Real Time PCR. The DNA was isolated by commercial kit. The obtained porcine and bovine gelatin DNA were 19.38 ng/μl and 13.63 ng/μl with purity were 1,566 and 1,573, respectively. Then, isolated DNA was analyzed by SYBR green and hydrolysis methods. SYBR green methods was done by annealing temperature of 65 oC for bovine primer and 60 oC for porcine primer. Therefore, hydrolysis probe methods were analyzed by annealing temperature of 60 oC for both porcine primer and bovine primer. The result showed that the hydrolysis probe was higher specificity to identify of porcine and bovine gelatin DNA than SYBR green method.

UJI VIABILITAS MIKROENKAPSULASI Lactobacillus casei MENGGUNAKAN MATRIK NATRIUM ALGINAT Nelly Suryani; Ofa Suzanti Betha; Qurry Mawaddana
JFL : Jurnal Farmasi Lampung Vol. 8 No. 1 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Lactobacillus casei is a species that is often used as a probiotic but is not resistant to very acidic environments. Microencapsulation in this study was carried out using the extrusion method with a matrix of sodium alginate concentrations of 2%, 3%, and 4%. The three concentrations of sodium alginate were tested for their ability to protect Lactobacillus casei ATCC 393 from the effects of gastric acid simulation fluid. From the viability test, the results of enumeration of cells in the concentration of sodium alginate 2%, 3% and 4% were 3.08 x 106 colonies / gram; 7.41 x 104 colonies / gram; and 1.01 x 107 colonies / gram. The three MLNs with the three concentrations were incubated in gastric acid simulation fluid (0.08 M HCl; 0.2% NaCl; pH 1.5) for 120 minutes. The enumeration results of MLN viability after testing the gastric acid liquid at a concentration of 4% were 4.5 x 103 colonies / gram, whereas at a concentration of 2% and 3% the viability value was

Structure-Activity Relationship Study on the Ethyl p-Methoxycinnamate as an Anti-Inflammatory Agent Ismiarni Komala; Supandi Supandi; Nurhasni Nurhasni; Ofa Suzanti Betha; Eka Putri; Syarifatul Mufidah; Muhammad Fikry Awaludin; Mida Fahmi; Muhammad Reza; Nurkhayati Putri Indriyani
Indonesian Journal of Chemistry Vol 18, No 1 (2018)
Publisher : Universitas Gadjah Mada

Ethyl p-methoxycinnamate (EPMC) (1) has been isolated as a major compound from the rhizome of Kaempferia galanga together with the other compound ethyl cinnamate (2). As reported in the literature, EPMC (1) exhibited a significant in vitro and in vivo anti-inflammatory activity. In this research, we investigated the anti-inflammatory activity of compounds 1 and 2 by using anti-denaturation of heat bovine serum albumin (BSA) method. In order to analyze active sites that are responsible for the anti-inflammatory activity, therefore, it is necessary to conduct structural modification of EPMC (1). The structural modification was performed through re-esterification reaction by using conventional and assistance of the unmodified microwave oven. Evaluation of the results of the bioassay indicated that the ester and methoxy functional groups of EPMC (1) play an important role for the anti-inflammatory activity.

Deskripsi Komponen Major Metabolit Sekunder Tanaman dengan Khasiatnya Terhadap Organ Ginjal dalam Buku Al-qanun fi’l Tibb II Tri Yuliana Agustiani; Ofa Suzanti Betha; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 2 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Al-Qanun Fi’l Tibb II merupakan buku karya ilmuwan Islam yaitu Ibnu Sina yang digunakan sebagai pedoman pengobatan pada zaman keemasan islam. Penelitian ini bertujuan untuk memberikan informasi data komponen major tanaman yang berkhasiat terhadap organ ginjal dan mendeskripsikan hubungan antara komponen major metabolit sekunder tanaman dengan khasiatnya terhadap organ ginjal sesuai buku Al-Qanun Fi’l Tibb II. Penelitian dilakukan secara kualitatif dengan metode literature review melalui studi kepustakaan dan diperoleh 250 jurnal ilmiah. Hasilnya dari 44 tanaman yang berkhasiat terhadap organ ginjal terdapat senyawa metabolit sekunder terpen, flavonoid, asam fenolik, alkaloid dan tanin. Senyawa terpen merupakan metabolit sekunder terbanyak pada tanaman. Komponen major metabolit sekunder memiliki bioaktivitas terhadap organ ginjal seperti antioksidan, diuretik, anti-inflamasi, nefroprotektif, antilitiatik dan analgesik

Mutu Sediaan Serbuk Racikan Apotek-apotek di Kecamatan Tebet dan Setiabudi Alifa Nurulhusna; ofa suzanti betha; Yardi Yardi; Barita Juliano Siregar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 1 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Peresepan puyer untuk anak masih banyak dilakukan dikarenakan kemudahan pemberian dan pengaturan dosis. Pembuatan puyer di apotek pada proses pembuatannya hanya berdasarkan pada visual baik dalam pencampuran maupun pembagian kedalam bungkus puyer, hal ini dapat menyebakan heterogenitas bobot antara puyer yang satu dengan yang lainnya dan menyebabkan pemberian dosis yang tidak sama. Penelitian ini bertujuan untuk melihat dan menggambarkan mutu sediaan racikan puyer dari segi keragaman bobot dan keseragaman kadar. Evaluasi keragaman bobot dilakukan berdasarkan prosedur uji keragaman bobot kapsul keras yang tertera pada Farmakope Indonesia V menggunakan imbangan analitik dan uji keseragaman kadar dilakukan menggunakan Spektrofotometri UV-Vis. Hasil evaluasi keragaman bobot menunjukan tidak ada sampel yang memenuhi syarat keragaman bobot serta, tidak ada sampel yang memenuhi persyaratan keseragaman kadar menurut Farmakope Indonesia V.

Mutu Sediaan Racikan Puyer di Kecamatan Ciputat Timur Ofa Suzanti Betha; Yardi Yardi; Yetika Alvionita; Zilhadia Zilhadia; Barita Juliano Siregar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 1, No 1 (2019)
Publisher : UIN Syarif Hidayatullah Jakarta

Peracikan obat merupakan salah satu dari bentuk pelayanan kefarmasian yang menjadi tanggung jawab seorang apoteker di apotek dan sarana pelayanan kefarmasian lainnya. Proses peracikan yang baik akan menghasilkan sediaan yang bermutu, aman dan efektif. Sediaan obat termasuk sediaan hasil peracikan harus terjamin mutu dan keamanannya. Di Indonesia khususnya belum terdapat prosedur dan standar mutu sediaan racikan.Penelitian ini bertujuan melakukan evaluasi mutu puyer hasil racikan apotek di kecamatan Ciputat yaitu keseragaman sediaan. Sediaan puyer disampling dari semua apotek (8 apotek) yang terdapat di wilayah kecamatan Ciputat Timur. Analisa yang dilakukan adalah keragaman bobot dan keseragaman kandungan. Penetapan keragaman bobot dilakukan menggunakan timbangan analitik dan keseragaman kandungan menggunakan Spektrofotometer UV-Vis. Hasil dari penelitian ini menunjukkan bahwa, sediaan racikan puyer dari 8 apotek di kecamatan Ciputat Timur tidak memenuhi uji keragamanan bobot dan keseragaman kandungan menurut Farmakope Indonesia V.

Amobilisasi Sel Lactobacillus Acidophilus FNCC116 Untuk Demineralisasi Limbah Kulit Udang Dalam Pengolahan Kitin Betha, Ofa Suzanti; Setyahadi, Siswa; Suryadi, Herman
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Chitin, a homopolimer, is the most abundant renewable natural resources after cellulose. Chitin and its derivatives hold many applications in agriculture, textile, pharmacy and medic. Chitin that extracted from waste shrimp shells by biological fermentation has better quality than chemical procees. Demineralization of chitin by biological procees use lactic acid as product of fermentation. Deproteinization of chitin use proteolytic activity of enzyme that produce by bacteria in fermentation. Lacto-bacillus acidophilus FNCC116 has been immobilized by entrapment methods and 2% sodium alginate in 0,2 M CaCl2 as the matric . The ability of immobilized Lacto-bacillus acidophilus FNCC116 cell in fermentation was tested. The fermentation that was carried out in medium which consist of 6% glukosa, 1,5% yeast extract, 0,003% MnSO4 0,003% FeSO4.7H2O, 0,02% MgSO4.7H2O and has been producted 2,24% lactic acid. Demineralization of waste shrimp shell with 30% immobilized Lactobacillus acidophilus FNCC116 cell has successfully decreased ash content tol 1,18% and produced lactic acid maximum 2.24%. Immobilization of Lactobacillus acidophilus FNCC116 cell promised an efficient method in bioproceesing of chitin recovery.

Diferensiasi Gelatin Sapi dan Gelatin Babi pada Gummy Vitamin C Menggunakan Metode Kombinasi Spektroskopi Fourier Transform Infrared (FTIR) dan Principal Component Analysis (PCA) Zilhadia, Zilhadia; Kusumaningrum, Farida; Betha, Ofa Suzanti; Supandi, Supandi
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Gelatin is a polypeptide obtained by partial hydrolysis of collagen derived from skin and bones of bovine and porcine. It has an essential component for the manufacture of gummy vitamin C as a gel-forming agent. The porcine gelatin is haram for moslems. This study was conducted to differentiate bovine gelatin and porcine gelatin in vitamin C gummy by using Fourier Transform Infrared (FTIR) combined with PCA. Gelatin was extracted from vitamin C gummy by using acetone at -20ºC and analyzed at wave number 4000-750 cm-1. The spectrum of both bovine and porcine gelatin extract from vitamin C gummy have almost the same number absorption that can not be distinguished. Therefore, the spectrum was analyzed by PCA. PCA result, represented with the plot score, showed that both bovine and porcine gelatin extracted has a clear dictinction. PCAcombined FTIR could differentiate of them. This study obtained that the commercial vitamin C gummy contained bovine gelatin.

Diferensiasi Gelatin Sapi dan Babi pada Cangkang Kapsul Keras Menggunakan metode Kombinasi Kromatografi Cair Kinerja Tinggi dan Kemometrik Zilhadia Zilhadia; Fathmah Syafiqoh; Ofa Suzanti Betha
Jurnal Sains Farmasi & Klinis Vol 9, No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022
Publisher : Fakultas Farmasi Universitas Andalas

Gelatin sapi dan babi merupakan bahan utama pembuatan cangkang kapsul keras. Gelatin babi tidak boleh dikonsumsi oleh Muslim sehingga perlu dilakukan analisis pembeda gelatin sapi dan babi. Tujuan penelitian ini adalah untuk mendiferensiasi gelatin sapi dan babi pada cangkang kapsul keras menggunakan metode kombinasi Kromatografi Cair Kinerja Tinggi (KCKT) dan Kemometrik menu Principal Komponen Analisis(PCA). Gelatin di ekstraksi dari cangkang kapsul keras dan langsung dihidrolisis menggunakan teknik hidrolisis asam, diinjeksikan ke dalam alat KCKT dan tinggi puncak kromatogram setiap asam amino penyusun gelatin dianalisis. Hasil penelitian menunjukkan bahwa asam amino penyusun gelatin dapat dipisahkan dengan baik oleh KCKT. Gelatin standar dan gelatin dari cangkang kapsul dengan sumber hewan yang sama memiliki komposisi asam amino yang sama. Dengan demikian, PCA dapat mengklasifikasikan sumber gelatin pada cangkang kapsul simulasi. Namun penelitian ini belum berhasil mengidentifikasi sumber gelatin cangkang kapsul komersial

Co-Authors Abdi Wira Septama Addina Syahida Afifah Nurul Izzah Akhsani, Luthfia Wikhdatul Alifa Nurulhusna Amelia, Puteri Annisa Triana Yusman Anwar, Vidia Arliani Azzahra, Afifah Nurnishrina Barita J. Siregar Bayyinah Bayyinah Bayyinah, Bayyinah Boy Reynaldi Noor Djamain, Nelly Suryani Eka Putri Estu Mahanani Dhilasari Fakhrun Nisa' Farida Kusumaningrum Fathmah Syafiqoh Ghilman Dharmawan Herdini Herdini , Herdini Herman Suryadi Ismiarni Komala Komala, Ismiarni Kusumaningrum, Farida Maulina Handayani Mida Fahmi Mochamad Iqbal Nurmansyah Moethia Moethia Mufidah, Syarifatul Muhamad Beny Setiawan Muhammad Fikry Awaludin Muhammad Reza Munfarikhatin, Atina Nelly Suryani Nelly Suryani Nisa', Fakhrun Noni Tri Utami Nurhasni Nurhasni Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhayati Putri Indriyani Nurkholiza, Zahara Faiziah Nurkhyati Putri Indriyani Nurmeilis Nurmeilis Putri Hayati Nufus Qurry Mawaddana RAHMAT, DENI Rurynta Ferly Shavira Sabrina Dahlizar Saibi, Yardi Yardi Sangadji, Sarah Nahdah Zhaafirah Sarah Nahdah Zhaafirah Sangadji Siregar, Barita Juliano Siswa Setyahadi Siswa Setyahadi Sofa Fajriah Suci Ahda Novitri Supandi Supandi Supandi Supandi Supandi Supandi Supandi suryani, nelly Syafiqoh, Fathmah Tengku Riza Zarzani N Tri Yuliana Agustiani Ummi Habibah Wafa Wafa Yardi Yardi Yardi Yardi Yetika Alvionita Yuni Anggraeni Yuni Anggraeni Zilhadia Zilhadia Zilhadia

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