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All Journal Jurnal EduHealth
Zakiyah, Wildani
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Health Professions Public Health Veterinary

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Article Review: Analysis Of Artificial Sweetness In Food And Beverages: English Zakiyah, Wildani; Nurul Sa'adah, Cantika; Prasetyo, Fajar; Febiola Lubis, Christina; Lina Nurfadhila; Marsah Rahmawati Utami
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.02 KB)

Abstract

Artificial sweeteners are substances added to food and beverages with the aim of giving a sweet taste, having no nutritional value. The types of artificial sweeteners allowed by the Minister of Health are Cyclamate, Saccharin, Aspartame and Sorbitol. The method used in this paper is a literature review study. The total journals used in this article review are 14 journals. In several studies, the levels of artificial sweeteners contained in related foods are still within the limits permitted by the government, but in some studies there are still foods whose levels of artificial sweeteners exceed the permitted limits.
Literature Review : Study of molecular mechanism level of NSAID class of drugs as COX-2 inhibitors Zakiyah, Wildani; Sukma Wibowo, Sepvia Putri; Elyyana, Nina; Nur Darmawan, Shiyami Aulia; Lestari, Sepiyani Ayu; Sa'diyyah, Nur; Malau, Jekmal; Mulki, Munir Alinu
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.745 KB)

Abstract

NSAIDs (Non-Steroid Anti-Inflammatory Drugs) are drugs that can treat pain and inflammation. The therapeutic effect of NSAIDs as anti-inflammatory analgesics is that they have the ability to inhibit the biosynthesis of prostaglandins which are pain mediators. This prostaglandin has a major role in inhibiting the COX enzyme (cyclooxygenase) in which COX has two isoforms, namely COX1 isoenzyme (non-selective) and COX2 isoenzyme (selective). Tricyclic COX-2 selective inhibitors work by blocking COX-2. COX-2 binds to PD-L1 via the PGE2 pathway and affects macrophages in suppressing myeloid. COX-2 has functions including producing reactive oxygen species that are responsible for DNA damage, activating substances that deviate from intracellular pathways such as the MAPK and PI3 K/AKT pathways, activating STAT3, inducing Bcl-2, and producing growth factors including growth factors. epidermal (EGF)) and fibroblast growth factor (FGF).
Co-Authors Agustin, Annastya Eka Elyyana, Nina Farikha, Siti Fauziah, Anisa Febiola Lubis, Christina Jekmal Malau Lestari, Sepiyani Ayu Lina Nurfadhila Maharani, Dhavina Marsah Rahmawati Utami Mukti, Galih Ibnu Munir Alinu Mulki Nur Darmawan, Shiyami Aulia NURLAELA NURLAELA Nurul Sa'adah, Cantika Prasetyo, Fajar Sa'diyyah, Nur Sakina, Irene Virda Saula, Lely Sulfiani Sukma Wibowo, Sepvia Putri