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Pengaruh Waktu Iradiasi Ultrasonik dengan Aktivasi Kalium Hidroksida terhadap Sifat Fisis Karbon Aktif dari Serbuk Karet End Life Tire Arifin, Uma Fadzilia; Adetya, Nais Pinta; Pambudi, Wisnu; Listyalina, Latifah; Ratnaningsih, Wahyu
Jurnal Teknik Kimia USU Vol. 13 No. 2 (2024): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v13i2.15549

Processing End Life Tire (ELT) rubber powder into activated carbon is an alternative for handling tire waste. One way to improve physical properties such as proximate characteristics, surface area and pore diameter of activated carbon is through chemical activation assisted by ultrasonic irradiation. This research aims to determine the effect of ultrasonic irradiation time with potassium hydroxide (KOH) activation on the quality of ELT rubber activated carbon. Activated carbon was synthesized and activated using 30% KOH at various ultrasonic irradiation times, namely 0 minutes, 15 minutes, 30 minutes, 45 minutes and 60 minutes. Based on the characterization results, activated carbon with an ultrasonic irradiation time of 30 minutes is the active carbon that has the most superior properties. The proximate characteristics of activated carbon meet the active carbon quality requirements of SNI 06â€“3730â€“1995 and have the highest surface area, namely 401.11 m2/g and pore diameter of 2.1652 nm, which is included in the mesoporous structure category so that it has the potential to be applied as an adsorbent for heavy metals from contaminated fluid.

Molecular Docking Analysis of Hydroxy Chalcones and Flavones from Anisaldehyde and Veratraldehyde as EGFR Inhibitors: Predicting Anticancer Potential Pambudi, Wisnu; Haryadi, Winarto; Matsjeh, Sabirin; Anwar, Chairil
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.8956

This study aimed to investigate the potential of hydroxy chalcone and flavone derivatives as inhibitors of the epidermal growth factor receptor (EGFR) with anticancer properties. Molecular docking simulations were conducted using Autodock Tools 1.5.6 and Discovery Studio visualizer. The EGFR protein structure with the PDB code 1M17 was utilized as the receptor, explicitly targeting the binding pocket. Redocking of the reference ligand erlotinib yielded a binding energy of -7.51 kcal mol-1 with an RMSD of 0.54 Å, confirming the accuracy of the docking protocol. The hydroxy chalcone and flavone derivatives exhibited binding energies ranging from -6.50 to -7.67 kcal mol-1 when interacting with the EGFR protein. Among the studied compounds, compound 2',5'-dihydroxy-3,4-dimethoxychalcone (1g) displayed the lowest binding energy. Interactions involving amino acids such as Met769, Ala719, Thr766, Lys721, and Glu738 were identified as crucial hydrogen bonding interactions between the ligands and the EGFR protein. These findings suggest that 2',5'-dihydroxy-3,4-dimethoxychalcone holds strong potential as a tyrosine kinase inhibitor, positioning it as a promising candidate for further development as an anticancer agent. The outcomes of the computational analysis conducted through the pkCSM online platform indicated that the chemical 2',5'-dihydroxy-3,4-dimethoxychalcone had favorable pharmacokinetic characteristics and showed low toxicity levels. Keywords: molecular docking, hydroxy chalcone, flavone, egfr, ADMET

Pengaruh Waktu Iradiasi Ultrasonik dengan Aktivasi Kalium Hidroksida terhadap Sifat Fisis Karbon Aktif dari Serbuk Karet End Life Tire Arifin, Uma Fadzilia; Adetya, Nais Pinta; Pambudi, Wisnu; Listyalina, Latifah; Ratnaningsih, Wahyu
Jurnal Teknik Kimia USU Vol. 13 No. 2 (2024): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v13i2.15549

Processing End Life Tire (ELT) rubber powder into activated carbon is an alternative for handling tire waste. One way to improve physical properties such as proximate characteristics, surface area and pore diameter of activated carbon is through chemical activation assisted by ultrasonic irradiation. This research aims to determine the effect of ultrasonic irradiation time with potassium hydroxide (KOH) activation on the quality of ELT rubber activated carbon. Activated carbon was synthesized and activated using 30% KOH at various ultrasonic irradiation times, namely 0 minutes, 15 minutes, 30 minutes, 45 minutes and 60 minutes. Based on the characterization results, activated carbon with an ultrasonic irradiation time of 30 minutes is the active carbon that has the most superior properties. The proximate characteristics of activated carbon meet the active carbon quality requirements of SNI 06â€“3730â€“1995 and have the highest surface area, namely 401.11 m2/g and pore diameter of 2.1652 nm, which is included in the mesoporous structure category so that it has the potential to be applied as an adsorbent for heavy metals from contaminated fluid.

Quality Evaluation of Bioplastic from Glutinous Rice Starch Reinforced with Bamboo Leaf Powder Arifin, Uma Fadzilia; Adetya, Nais Pinta; Pambudi, Wisnu; Ratnaningsih, Wahyu
CHEESA: Chemical Engineering Research Articles Vol. 5 No. 2 (2022)
Publisher : Universitas PGRI Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/cheesa.v5i2.14235.82-91

Plastics are widely used in various aspects of life due to their variety of superior properties. However, they contribute a negative impact on the environment, which leads to the search for an alternative solution such as the production of bioplastics as biodegradable plastics. Therefore, this study aims to evaluate the psycho-mechanic quality of bioplastic from glutinous rice starch reinforced with bamboo leaf powder. The bioplastic synthesis process was carried out using 0, 1, 3, 5, and 7% (w/w) variations of bamboo leaf powder on glutinous rice starch, respectively. The results showed that the best bioplastic composition was the addition of 3% (w/w) bamboo leaf powder to glutinous rice starch. This indicated that the addition of bamboo leaf powder in bioplastics can enhance the thickness, hardness, and tensile strength significantly. Meanwhile, the value of density, water vapor transmission rate, and elongation showed a slight increase, and the bioplastic also degraded more than 70% for 7 days.

Increasing Antioxidant Activity and Organoleptic Properties of Soursop Leaf Tea (Annona muricata Linn.) by Adding Cinnamon Powder (Cinnamomum burmanni) Indarto, Indarto; Astuti, Salima Duwi; Rudini, Mahmud; Pambudi, Wisnu
Biosfer: Jurnal Tadris Biologi Vol 11 No 2 (2020): Biosfer: Jurnal Tadris Biologi
Publisher : UNIVERSITAS ISLAM NEGERI RADEN INTAN LAMPUNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/biosfer.v11i2.7285

Soursop leaf tea is a health drink that contains steroid compounds, terpenoids, flavonoids, kumari, tannins, and alkaloids. The flavonoids and tannins in soursop leaves act as antioxidants. Since it has an unpleasant aroma, cinnamon is added to add scent and flavor. This study aimed to determine the effect of cinnamon powder on the soursop leaf tea's antioxidant activity. This study employed the completely randomized design method (CRD) with two factors: the soursop leaves and cinnamon powder concentrations. This study consisted of four treatments, namely SP0 (100% soursop leaves), SP1 (90% soursop leaves and 10% cinnamon powder), SP2 (80% soursop leaves and 20% cinnamon powder), and SP3 (70% soursop leaves and 30% cinnamon powder) within three repetitions. The proximate test was focused on antioxidant activity analyzed by ANOVA at α = 5%. The organoleptic test covered the color, taste, aroma, and other overall preferences by qualitative descriptive tests. The results showed that the highest antioxidant (29.19%) could be found in the SP3 sample (70% soursop leaves and 30% cinnamon powder), while the preferred organoleptic test was the SP2 sample.

PEMBERDAYAAN MASYARAKAT DALAM PENGELOLAAN SAMPAH DENGAN MENERAPKAN TEKNOLOGI PIROLISIS PLASTIK DI BANK SAMPAH SIDOMULYO MAJU BAMBANGLIPURO Listyalina, Latifah; Syahbani, Muhammad Wahyu; Ratnaningsih, Wahyu; Saputra, Andri; Satwikanitya, Pani; Ellianto, Mario Sarisky Dwi; Suharyanto, Suharyanto; Pambudi, Wisnu
Charity : Jurnal Pengabdian Masyarakat Vol. 7 No. 2 (2024): Charity-Jurnal Pengabdian Masyarakat
Publisher : PPM Universitas Telkom

Show Abstract | Download Original | Original Source | Check in Google Scholar

Keberadaan sampah merupakan suatu hal yang mempunyai banyak dampak negatif pada manusia dan lingkungan sekitar, khususnya sampah plastik yang merupakan material yang sulit terurai di alam. Bank Sampah Sidomulyo Maju merupakan bank sampah yang terletak di Desa Sidomulyo, Bambanglipuro, Bantul. Berdasarkan informasi yang di peroleh dari website dan perangkat desa Sidomulyo, kegiatan yang saat ini berjalan di bank sampah Sidomulyo Maju adalah aktivitas pengumpulan dan pemilahan jenis sampah komunal yang dihasilkan oleh masyarakat setempat. Selaras dengan Program yang dicanangkan oleh Pemerintah Bantul “Bantul Bebas Sampah 2025” dan Program Tri Dharma Perguruan Tinggi, diberikan Pelatihan Pembuatan Minyak Pirolisis dari Sampah Plastik kepada masyarakat dan anggota Bank Sampah Sidomulyo Maju di Desa Sidomulyo, Bambanglipuro, Bantul. Pelatihan yang dilakukan diharapkan dengan semangat pengabdian yang disusun oleh Perguruan Tinggi, yakni mengharapkan terjadinya transfer ilmu dan kemanfaatan dari civitas akademika kepada masyarakat luas.

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