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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Pendidikan Kimia (JPKim) Stannum : Jurnal Sains dan Terapan Kimia Arfak Chem: Chemistry Education Journal Jurna Beta Kimia
Sriwijayanti, Sriwijayanti
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Medicine & Pharmacology Public Health Social Sciences

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Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Metanol Biji Buah Pare (Momordica charantia L.) Sriwijayanti, Sriwijayanti; Situmeang, Boima; Yulianti, Nani; Susvira, Dian; Widiyanto, Holisha
Jurnal Beta Kimia Vol 4 No 1 (2024): Volume 4, Nomor 1: Mei 2024
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v4i1.15487

Abstract

Antioksidan merupakan senyawa yang dapat merangkat radikal bebas. Salah satu tanaman yang diduga dapat merangkat senyawa radikal bebas adalah biji buah pare (Momordica charantia L.). Masyarakat telah menggunakan pare sebagai makanan sehari-hari dan juga telah lama dipercaya sebagai obat tradisional untuk mengobati berbagai macam penyakit. Tujuan dari penelitian ini adalah uji skrining fitokimia dan uji aktivitas antioksidan ekstrak metanol biji buah pare. Ekstraksi dilakukan dengan menggunakan metode maserasi. Uji skrining fitokimia dilakukan dengan menggunakan berbagai reagent kimia untuk analisis senyawa golongan alkaloid, fenoli, flavonoid, tannin, triterpenoid dan steroid. Uji Aktivitas antioksidan dengan menggunakan metode DPPH. Hasil uji skrining fitokimia didapatkan bahwa ekstrak metanol biji buah pare positif mengandung senyawa golongan alkaloid, flavonoid, fenolik, triterpenoid, steroid dan tanin. Hasil uji aktivitas antioksidan didapatkan nilai IC50 sebesar 137,99 ppm yang termasuk dalam kategori sedang.
IDENTIFIKASI SENYAWA ANTIOKSIDAN DALAM FRAKSI METANOL DAUN BIDARA (Ziziphus mauritiana) Sriwijayanti, Sriwijayanti; Nasiro, Siti; Humesi, Lusi; Situmeang, Boima; Puspitasari, Puspitasari
Arfak Chem: Chemistry Education Journal Vol. 6 No. 2 (2023): Arfak Chem
Publisher : Universitas Papua, Manokwari, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30862/accej.v6i2.525

Abstract

Tumbuhan Bidara (Ziziphus mauritiana) merupakan salah satu tumbuhan yang dimanfaatkan oleh masyarakat untuk mengobati berbagai penyakit. Bidara  tumbuh didaerah yang kering dengan curah hujan yang sangat rendah. Di Indonesia, tumbuhan bidara banyak ditemukan didaerah Banten, Jawa, Madura, Bali, Sawu, Rote, Timur leste, Alor, Makasar, Bima, dan Sumba. Pada penelitian sebelumnya, ekstrak daun bidara diketahui memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk mengisolasi senyawa bioaktif dan menguji aktivitas antioksidan pada fraksi metanol daun bidara. Ekstraksi dilakukan menggunakan metode maserasi dengan pelarut metanol. Pemisahan dan pemurnian senyawa menggunakan metode kromatografi. Uji aktivitas antioksidan menggunakan metode DPPH (1,1-difenil-2-pikrihidrazin). Karakterisasi dan elusidasi struktur isolat yang mempunyai nilai % inhibisi tinggi dilakukan dengan menggunakan spektroskopi UV dan FTIR. Berdasarkan hasil uji aktivitas antioksidan fraksi 10 menghasilkan nilai % inhibisi yang tinggi yang dapat meredam radikal bebas. Hasil elusidasi struktur, senyawa yang diperoleh merupakan senyawa flavonoid.
Efektivitas Perendaman Larutan Nanas Queen Victoria sebagai Pereduksi Logam Fe pada Kerang Hijau (Perna viridis) Widiyanto, Holisha; Julianti, Julianti; Sriwijayanti, Sriwijayanti; Sari, Puspita; Situmeang, Boima; Susvira, Dian
Jurnal Beta Kimia Vol 4 No 2 (2024): Volume 4, Nomor 2: November 2024
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v4i2.18673

Abstract

Excessive Fe heavy metal contamination cause health problems for humans. One of the marine biota that is susceptible to heavy metal contamination is green mussels. Green mussels (Perna viridis) are a food that is very often consumed by humans. This Fe metal which derived with materials that are chelating agents such as citric acid, one of the fruits that contain citric acid is the Queen Victoria pineapple. The research aims to determine the effectiveness of soaking Queen Victoria pineapple solution in reduces Fe metal in green mussels. The pineapple solution immersion test was carried out with varying concentrations of 25, 50 and 75% with soaking times of 15, 30 and 45 minutes which were analyzed using inductively coupled plasma (ICP). The highest reduction results were at a concentration of 25% with a soaking time of 30 minutes, amounting to 60.58%.
The potential of methanol extract nanoemulsion from gletang flower (Tridax procumbens) as an antibacterial agent against pathogenic bacteria Sriwijayanti, Sriwijayanti; Pradana, Agrin Febrian; Fauji, Fajar Rizki; Farlina, Iin; Situmeang, Boima
Jurnal Pendidikan Kimia Vol. 16 No. 3 (2024): J. Pendidik. Kim : December 2024
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v16i3.65168

Abstract

Gletang plant is a weed that grows wild and is widely distributed in various places such as rice fields, plantations, and roadsides. Phytochemical screening of gletang flower extract using methanol revealed the presence of secondary metabolites such as alkaloids, flavonoids, steroids, phenols, terpenoids, and tannins. This study aims to formulate a nanoemulsion from the methanol extract of gletang flowers. The extraction was performed by maceration with methanol 96%. The nanoemulsion was characterized by testing its pH, % transmittance, stability, viscosity and particle size using a particle size analyzer. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coliusing the Kirby-Bauer method. The results of pH characterization, % transmittance, stability and viscosity tests met the standards. The particle size analyzer showed that the particle size ranged between 300-1000 nm. The antibacterial activity tests indicated that all three formulations showed activity against the pathogenic bacteria E. coli, with formulation 3 showing the highest activity.
The Pirdot Leaves Extract (Saurauia vulcani Korth) As Natural Antioxidant to Inhibit Oxidation Reaction of Crude Palm Oil (CPO): Ekstrak Daun Pirdot (Saurauia vulcani Korth) sebagai Antioksidan Alami untuk Menghambat Reaksi Oksidasi pada Crude Palm Oil (CPO) Musa, Weny J A; Harianja, Lokky Sardomu; Sriwijayanti, Sriwijayanti; Yulianti, Nani; Situmeang, Boima
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 2 (2024): October 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i2.4464

Abstract

The Pirdot plant (Saurauia vulcani Korth) is a wild plant that grows abundantly in tropical regions such as in North Sumatra. The active compounds found in Pirdot plant leaves are known to have good antioxidant activity. The aim of this research is to evaluate the n-hexane and methanol extracts of Pirdot plant leaves in inhibiting oxidation in crude palm oil (CPO). In this study, the Pirdot plant leaves were extracted using n-hexane (EHP) and methanol (EMP) solvents. The effectiveness of adding both extracts to the quality of CPO was tested for eight days using the parameters of free fatty acid content and peroxide value. The results of the effectiveness test for adding both extracts to CPO showed a good inhibitory effect on the oxidation reaction in CPO. The EMP extract at a concentration of 5000 ppm was more effective in maintaining the quality of CPO for 8 days, with a free fatty acid content of 3.09% and a peroxide value of 14.03 meq O2/kg.
LC-MS Analysis of Ethyl Acetate Fraction of Gandaria (Bouea macrophylla Griff.) Stem Bark and Molecular Docking Study against HER2 Protein Primawati, Junia Salsha; Sriwijayanti, Sriwijayanti; Situmeang, Boima; Safuroh, Siti; Agustin, Yuke
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.91-95

Abstract

Breast cancer is a disease that has long been a source of concern for the public due to its high mortality rate. Excessive exposure to free radicals has been identified as a potential carcinogen, thus necessitating the utilization of antioxidants to counteract the damaging effects of these molecules. Gandaria (Bouea macrophylla Griff.) is a plant that is commonly found in Java, Sumatra, Maluku, and Kalimantan. B. macrophylla is known to have strong antioxidant activity, which is correlated with anticancer activity. A part of B. macrophylla that has not been extensively researched is its stem bark. The objective of this study was to analyze the potential of the ethyl acetate fraction of B. macrophylla stem bark as an anticancer agent using in silico method. The ethyl acetate fraction of B. macrophylla stem bark was characterized by LC-MS, which revealed four major compounds: 4-hydroxy-3-(3-oxo-1-phenylbutyl)-chromen-2-one, 1-(2,5-dihydroxyphenyl)-propan-1-one, 3-ethoxy-4-hydroxybenzaldehyde, and 2-nitrobenzoic acid. Molecular docking was performed between the compounds against the HER2 protein with PDB ID 3RCD. The four compounds demonstrated binding energy values of -8.29 kcal/mol, -5.04 kcal/mol, -4.66 kcal/mol, and -4.28 kcal/mol, respectively.
The Effect of Methanol Concentrations Against Phenolic Total Content and Antioxidant of Balakacida Leaves (Chromolaena odorata) Sriwijayanti, Sriwijayanti; Firdaus, Ahmad; Situmeang, Boima; Widiyanto, Holisha; Susvira, Dian
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.239-244

Abstract

The balakacida plant with the Latin name Chromolaena odorata is a plant that lives in a tropical climate. The balakacida plant is a plant of the Asteraceae Family. Phytochemical tests on balakacida leaves showed the presence of secondary metabolites of the tannin, phenol, flavonoid, saponin and steroid groups. This study aims to extract balakacida leaves and test the total phenolic and antioxidant content. Sample extraction was carried out by the maceration method using methanol solvent. Testing of total phenolic content using the Folin Ciocalteu method, while testing of antioxidant content using the DPPH method using a UV-Vis spectrophotometer. The results showed that the concentration of methanol solvent significantly affected the acquisition of total phenolics and antioxidants. The highest total phenolic content was obtained at a methanol extract concentration of 80% of 145.64 mg GAE/g. For antioxidant content, a methanol extract concentration of 60% showed the highest activity with an average DPPH % inhibition of 59.77%. It can be concluded that a methanol extract concentration of 60% is the optimal concentration to produce balakacida leaf extract with the best antioxidant activity, although not with the highest total phenolic content.
Co-Authors Ahmad Firdaus, Ahmad Fauji, Fajar Rizki Harianja, Lokky Sardomu Humesi, Lusi iin Farlina, iin Julianti Julianti, Julianti Nani Yulianti Nasiro, Siti Pradana, Agrin Febrian Primawati, Junia Salsha Puspita Sari Puspitasari Puspitasari Safuroh, Siti Situmeang, Boima Susvira, Dian Widiyanto, Holisha Yuke Agustin