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All Journal Indian Journal of Forensic Medicine & Toxicology Hang Tuah Medical Journal Regulate: Jurnal Ilmu Pendidikan, Hukum dan Bisnis
Lestari Dewi
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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Effectiveness of Lockdown in Reducing the Spread of COVID-19 Adyati Satya Puspita; Judya Sukmana; Lestari Dewi; Erina Yatmasari
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16656

Abstract

At the end of 2019, a mysterious outbreak appeared, forming an atypical pneumonia suspected of originatingfrom an animal market in Wuhan China. The outbreak is a new type of coronavirus which is named asCOVID-19 disease (2019 – nCoV, Novel Coronavirus). COVID 19 disease is a viral infection caused bySARS-CoV-2, namely the acute respiratory syndrome coronavirus 2 which emerged in Wuhan, China.Vaccines and antiviral drugs have not been found, meanwhile COVID-19 are prevented by using nonpharmacologicalinterventions, one of the actions taken by several countries is to create policy protocolssuch as lockdowns.The results of this study indicate that lockdown is effective in reducing the spread of COVID -19, it can beseen from the significant decrease in R0 and Rt, <1 in several countries after lockdown such as UK 0.99(0.96–1.02), Italy 0.89 (0.87–0.91), French 0.76 (0.72–0.82) and Spain 0.74 (0.71–0.78) which means thatsomeone who is infected cannot infect other people and the disease will die (disappear). The value of Rt alsoshows a consistent decline Rt to <1 (0.88) after 2 weeks of lockdown in Italy.The conclusion from this literature show that lockdowns can reduce the spread of COVID-19 which isshown by the number of incidents before and after the lockdown which has decreased to zero cases in China.The decline in cases also occurred in Europe although at the beginning of the lockdown it was not significantbut it was increasingly effective and continued to be significant after the lockdown was imposed.
The Antioxidant Effect of Noni Fruits Extract on HDL and LDL Level of Wistar Rat Induced by High Fat Diet Diah Purwaningsari; Sihning EJ Tehupuring; Nita Pranitasari; Suhailah Hayaza; Lestari Dewi; Dian Ardiana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14704

Abstract

Dyslipidemia is an important risk factor for myocardial infarction, cardiovascular diseases, and Nonalcoholic Fatty Liver (NAFLD) disorders. Inflammatory conditions, oxidative stress, and insulin resistance,as well as several risk factors for cardiovascular disease, are also risk factors for this disease. This study aimsto determine the effect of noni (Morinda citrifolia) extract on the improvement of dyslipidemia condition,based on the Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) level. This research is alaboratory experimental study with a post-test only control group design. Male Wistar rat (Rattus norvegicus)were divided into four groups: negative control group with no induction and treatment (K-), positive controlgroup given high-fat diet induction for 14 days (K+), noni extract treatment group given a high-fat diet anda noni extract at a dose of 100 mg/kg BB per day for 7 days (P1), and noni extract at a dose of 200 mg/kgBB per day for seven days (P2). Low Density Lipoprotein and High Density Lipoprotein serum levels weremeasured using the ELISA method. The results showed that there was a significant increase in LDL and adecrease in HDL in both treatment groups (P1 and P2) compared with K(+) group. Therefore, we concludethat noni extract (Morinda citrifolia) played a role as an antioxidant which can increase LDL and decreaseHDL serum levels in rats induced by a high fat diet.
Pengaruh Ekstrak Daun Kelor (Moringa oleifera L.) Terhadap Pertumbuhan Escherichia coli Pada Media Agar Nutrient AULIA CEMPAKASARI; VARIDIANTO YUDO TJAHJONO; PRAJOGO WIBOWO; LESTARI DEWI
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.402

Abstract

Diare adalah defekasi cair lebih dari 3 kali dalam 24 jam dan merupakan penyakit yang sering terjadi di Negara dengan sanitasi buruk, dengan prevalensi tertinggi yang disebabkan oleh bakteri Escherichia coli. Ekstrak daun kelor (Moringa oleifera L.) yang banyak dijumpai di daerah tropis seperti Indonesia, diharapkan dapat efektif dalam menghambat aktivitas bakteri Escherichia coli karena menyimpan sumber metabolit sekunder yang bersifat antibakteri seperti flavonoid, tannin dan alkaloid. Penelitian ini merupakan penelitian eksperimental laboratorium dengan menggunakan bakteri Escherichia coli yang dibagi menjadi 6 kelompok perlakuan yaitu kontrol negatif, konsentrasi 25%, konsentrasi 50%, konsentrasi 75%, konsentrasi 100% dan kontrol positif yang masing-masing kelompok dilakukan 4 kali pengulangan. Hasil penelitian menunjukkan pada konsentrasi 25% memiliki diameter zona hambat 6,99 mm, pada konsentrasi 50% memiliki diameter zona hambat 7,27 mm, pada konsentrasi 75% memiliki diameter zona hambat 7,91 mm, dan pada konsentrasi 100% memiliki diameter zona hambat 8,90 mm. Pada uji Kruskal-Wallis menunjukkan adanya perbedaan signifikan dari 6 kwlompok perlakukan dengan nilai signifikasi 0,001 (p<0,05). Uji Mann-Whitney U di dapatkan bahwa kelompok control negative tidak memiliki perbedaan yang signifikan terhadap kelompok konsentrasi 25%, 50% dan 75% dengan nilai signifikasinya >0,05 (p>0,05). Hasil penelitian uji daya hambat ekstrak daun kelor kelor (Moringa oleifera L.) terhadap pertumbuhan bakteri Escherichia coli pada media agar nutrient dengan beberapa kelompok perlakuan yang berbeda telah dilakukan dan disimpulkan bahwa Ekstrak daun kelor (Moringa oleifera L.) dapat menghambat pertumbuhan bakteri Escherichia coli pada media agar.
The Role of Teachers in Improving the Ability to Recognize Number Symbols in Children Ages 4-5 years Lestari Dewi; Noviana Juni; Mufaro’ah
Regulate: Jurnal Ilmu Pendidikan, Hukum dan Bisnis Vol. 1 No. 2 (2024)
Publisher : Penerbit Hellow Pustaka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61166/regulate.v1i2.13

Abstract

This study aims to explore the role of teachers in improving the ability to recognize number symbols in children aged 4-5 years because there are still many children who cannot recognize number symbols 1-10, lack of creativity in children in recognizing number symbols 1-10, lack of curiosity in recognizing number symbols 1-10 and lack of mentioning number symbols 1-10. From the several problems above, the purpose of this study is to find out what are the roles of teachers in improving the ability to recognize number symbols, by using a qualitative descriptive research type, this research technique with data collection used is observation, interviews, documentation. After conducting the research, it can be concluded that: the role of teachers in improving the ability to recognize number symbols in children aged 4-5 years is very important, this can be assessed from: (1). The role of teachers in improving the ability to recognize number symbols is to introduce number symbols 1-10 by teaching the smallest numbers first 1-10. (2) the role of teachers in improving the ability to recognize number symbols by preparing interesting media before the learning process takes place. Inhibiting and supporting factors in increasing the ability to recognize number symbols include: (1) internal factors, factors from the child, (2) external factors, namely family and environment. Family and environment also greatly influence children in increasing their abilities.
Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.576

Abstract

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet. This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups. The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels. Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet
Co-Authors Adyati Satya Puspita ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI AULIA CEMPAKASARI Diah Purwaningsari Dian Ardiana Erina Yatmasari Indri Ngesti Rahayu Judya Sukmana Mufaro’ah Nita Pranitasari Noviana Juni PRAJOGO WIBOWO Rany Sulastri S. Soedarsono Sihning EJ Tehupuring Suhailah Hayaza VARIDIANTO YUDO TJAHJONO