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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Medika Kartika : Jurnal Kedokteran dan Kesehatan Indian Journal of Forensic Medicine & Toxicology Bioscientia Medicina : Journal of Biomedicine and Translational Research MEDICINUS
Indah Julianto
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Journal : MEDICINUS

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Pengaruh Astaxantine Oral terhadap Kadar Serum Tumor Necrosis Factor Alpha pada Pasien Akne Vulgaris-lores Reti Anggraeni; Niluh Widjayanti; Harijono Kariosentono; Indah Julianto; Endra Yustin; Muhammad Eko Irawanto; Prasetyadi Mawardi
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.412 KB) | DOI: 10.56951/medicinus.v33i3.73

Abstract

Background: Acne vulgaris (AV) is chronic inflammatory disease affecting the pilosebaceous unit manifested as closed and open comedones, papules, pustules, and nodules. Treatment of AV generally involves more than one drug due to multifactorial pathogenesis. Objective: This study aims to determine the efficacy of 4 mg oral astaxanthin as an adjuvant AV therapy in decreasing serum level of inflammatory marker tumor necrosis factor alpha (TNF-α). Method: This is a double-blind randomized controlled trial. Subjects were 34 patients with mild and moderate AV (Global Acne Grading System/GAGS 1-30) that were treated with combination of tretinoin 0.025% and clindamycin phosphate 1.2%. Astaxanthin was added to the treatment group and lactulose as placebo was added to the control groups, given for 4 weeks. The pretest and posttest results in both groups were analyzed statistically using nonparametric test. Results: Decrease in TNF-α serum levels occurred in both groups but significant difference compared to baseline were only found in treatment group (p=0.015). There was no significant difference in the reduction of TNF-α levels between both groups (p=0.459). Conclusion: Although the results did not show a significant difference overall, but in the treatment group, astaxanthin can significantly lower TNF-α serum levels compared to baseline.
Modalitas Terapi Vitiligo pada Anak Nathania Amelinda; Endra Yustin Ellistasari; Indah Julianto
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.106

Abstract

itiligo is a pigmentation disorder characterized by depigmented patches on skin and hair due to functional loss of melanocytes. Vitiligo in children is generally associated with other autoimmune diseases and has serious cosmetic and psychosocial impact. Treatment modalities for vitiligo in children consist of topical therapy, phototherapy, systemic therapy, and surgery. Vitiligo in children has a relatively good prognosis compared to adult cases. Repigmentation in childhood vitiligo usually happen spontaneously and relapses are rare.
Modalitas Terapi Striae Ambar Aliwardani; Putti Fatiharani Dewi; Fiska Rosita; Indah Julianto
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.124

Abstract

Striae or strechmark is a form of benign skin lesion manifested as inflammatory streaks perpendicular to the direction of skin tension which has cosmetic morbidity and possesses risk of secondary infection in severe case. Various therapeutic modalities have been introduced, such as topical therapy, physical therapy using devices, lasers, and the latest is celullar therapy using platelet-rich plasma. Such varied treatment modalities are reported to have varied results.
Co-Authors Alfina Rahma Ambar Aliwardani Arie Kusumawardani Dharmawan, Nugrohoaji Eka Devinta Novi Diana Endra Yustin Endra Yustin Ellistasari Fiska Rosita Frieda Frieda Yanuar Harijono Kariosentono Moerbono Mochtar Muhammad Eko Irawanto Nathania Amelinda Niluh Widjayanti Novan Adi Nurrachmat Mulianto Prasetyadi Mawardi Putti Fatiharani Dewi Reti Anggraeni Sesia Pradestine Suci Widhiati