Feriawan Tan
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Molecular Docking Human Plasma Kallikrein to Prevent Acute Respiratory Distress Syndrome(ARDS) in COVID-19 Patient Feriawan Tan; Cindy ApriliaEkaPrasanty; Anna Surgean Veterini; YuaniSetiawati; Rizki Awaluddin; Fadilah Fadilah; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16860

Abstract

SARS CoV-2 infection causes various clinical manifestations ranging from mild to severe. Acute RespiratoryDistress Syndrome (ARDS) is a severe complication of COVID-19 caused by activation of the kallikreinkininsystem which produces bradykinin which is a potent proinflammatory mediator. This research is anin silico study which aims to determine the potential of active medicinal plant compounds in inhibiting thekallikrein-kinin system.Molecular docking in this study using Autodock 4.2 with Lamarckian GA criteria.Human plasma kallikrein (PDB ID: 5TJX) was docked with 70 compounds and one native ligandand analyzedusing Autodock 4.2.The smallest binding energy obtained from docking 5TJX with several compoundsin sequence, namely, xanthohumol, nafamostat, demethoxycurcumin, epicatechingallate, beta mangostin,alpha mangostin (-9.52, -9.35, -9.33, -9.28, -9.19, -9.06 kcal/mol). Therefore, the compound shows the bestpotential as a plasma kallikrein inhibitor. However, further research is still needed to determine the potentialof drugs and medicinal plant active compounds for medical treatment.
DEVELOPMENT OF E-TIBI+ AS EARLY DETECTION AND SYSTEMATIC MANAGEMENT OF TUBERCULOSIS CASES IN PLHIV Erwin Astha Triyono; Feriawan Tan; Lilis Masyfufah; Sulvy Dwi Anggraini; Maria Lucia Inge Lucida; Soedarsono; Merita Arini; Tri Pudy Asmarawati; Ariani Permatasari; Rosita Dwi Yuliandari
Journal of Vocational Health Studies Vol. 9 No. 3 (2026): March 2026 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I3.2026.199-207

Abstract

Background: HIV and TBC combinations have received global public attention in recent years. Current collaborative tuberculosis and HIV elimination strategy is not enough to eradicate these two infectious diseases. Therefore, an innovative elimination approach leveraging advancements in digital technology is urgently needed. Purpose: To evaluate the tuberculosis elimination by optimizing case finding and monitoring treatment completion through the Early Detection and Management of Tuberculosis Application System + (E-TIBI+) application based on self-assessment in the HIV population. Method: This observational cohort study was conducted in Surabaya city, East Java Province, Indonesia in the period of September - October 2024. The study population consisted of adult PLHIV who completed the E-TIBI+ self-assessment. The E-TIBI+ application is a web-based platform. Data analysis included univariate analysis in the form of frequencies for each variable and crosstab analysis with the Kendall tau-b test in E-TIBI+ application acceptance data. Result: From a total of 386 patients screened, 61 (15.80%) PLHIV were suspected of having TBC. From the 61 patients, there were 17 patients who sought diagnosis at the health facility of their choice. User acceptance of the E-TIBI+ application by PLHIV patients tends to be positive and statistically significant. Conclusion: The E-TIBI+ application demonstrates strong potential to enhance early detection and systematic monitoring of tuberculosis case management among PLHIV through digital technology.