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Molecular Docking Human Plasma Kallikrein to Prevent Acute Respiratory Distress Syndrome(ARDS) in COVID-19 Patient Feriawan Tan; Cindy ApriliaEkaPrasanty; Anna Surgean Veterini; YuaniSetiawati; Rizki Awaluddin; Fadilah Fadilah; Siti Khaerunnisa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16860

SARS CoV-2 infection causes various clinical manifestations ranging from mild to severe. Acute RespiratoryDistress Syndrome (ARDS) is a severe complication of COVID-19 caused by activation of the kallikreinkininsystem which produces bradykinin which is a potent proinflammatory mediator. This research is anin silico study which aims to determine the potential of active medicinal plant compounds in inhibiting thekallikrein-kinin system.Molecular docking in this study using Autodock 4.2 with Lamarckian GA criteria.Human plasma kallikrein (PDB ID: 5TJX) was docked with 70 compounds and one native ligandand analyzedusing Autodock 4.2.The smallest binding energy obtained from docking 5TJX with several compoundsin sequence, namely, xanthohumol, nafamostat, demethoxycurcumin, epicatechingallate, beta mangostin,alpha mangostin (-9.52, -9.35, -9.33, -9.28, -9.19, -9.06 kcal/mol). Therefore, the compound shows the bestpotential as a plasma kallikrein inhibitor. However, further research is still needed to determine the potentialof drugs and medicinal plant active compounds for medical treatment.

Considering Role of Probiotic on Respiratory Disease: Is Probiotic Possible to Treat COVID-19? Eighty Mardiyan Kurniawati; Nur Anisah Rahmawati; Anna SurgeanVeterini
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14998

Background: COVID-19 is a new variant of the corona virus known as a pandemic disease. The numberof cases has increased every day around the world. Unfortunately, treatment in management has not beensatisfactory.Purpose: This study aims to examine the role of probiotics in respiratory disease and the possibility ofmanaging COVID-19 through an analysis of its function.Method: This study is a review. Quality journals until 2020 were searched in the Pubmed database forthe keywords ‘respiratory’ or ‘asthma’ or ‘pneumonia’ or ‘lung’ or ‘influenza’ and ‘COVID-19’. Compileddata includesthe author, type of study, type of probiotic, duration of intervention, target population, results,conclusion and side effects that occurredResults: We analyzed 9 experimental studies. Some studies related to respiratory disorders used theLactobacillus Sp as probiotic. One research used Fructooligosacharide as additional ingredient. The researchuse different doses and timing of interventions 14 days - 6 months. The diseases covered in this reportare asthma, pneumonia, and influenza. Probiotics can reduce symptomps, duration in hospitality risk, andquality of life.Conclusion: The ability of probiotics in the management of respiratory diseases provides hope for themanagement of COVID-19, of course, it is balanced with further research that is able to analyze cleardosages, types and roles.

Probiotics Intake as Adjunct Therapy for Infected Health-Care with SARS COV-2 Anna Surgean Veterini; Eighty Mardiyan Kurniawati; Hamzah; Subijanto Marto Soedarmo; Cita Rosita Sigit Prakoeswa; Damayanti Tinduh
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.15003

Objectives: We performed this case-control observational study to evaluate the comparison of the length ofduration of SARS COV-2 infection and the cycle threshold (Ct) value of reverse-transcriptase polymerasechain reaction (RT-PCR) nasopharynx swab between the probiotics intake (case) group and the nonprobiotics intake (control) group.Materials and Methods: Our study was a case-control study involving 15 cases and 15 controls matchfor RT-PCR positive results. The participants were healthcare consisted of registrars, consultants, andnurses. Each participant was interviewed by google forms using a structured questionnaire to collect sociodemographic characteristics, diet, therapy from a pulmonologist, and adjunct therapy.Results: The total participants consisted of 15 males and 15 females. 4 participants in the case group hadfebrile, 1 participant with anosmia, 1 participant with febrile, nausea, and vomit before they consumedprobiotics, and 9 participants without clinical complaints. One participant in the control group had feveredand cough, 14 participants without clinical complaints—1 participant with co-morbidities in the controlgroup. The data of age, duration of infection, and cycle threshold (Ct) value were in the normal distribution.Analysis results using SPSS 21.00 show no significant differences in the course of disease between the casegroup and the control group. We found 2 participants in the control group had re-infection, while there wasno re-infection in the case group.Conclusion: The present study’s finding may imply future care for the viral infection through theimmunomodulation mechanism by probiotics consumption.

Sensitivity and Specificity Comparison Between APFEL, KOIVURANTA, and SINCLAIR Score As PONV Predictor In Post General Anesthesia Patient M Yusuf Gunawan; Arie Utariani; Maulydia Maulydia; Anna Surgean Veterini
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i1.2826

ABSTRACTBackground: Post Operative Nausea Vomiting (PONV) are the two most common and unpleasant side effects after anesthesia and surgery. Without proper prophylactic administration, the PONV incidence is currently around 20% -30% in normal patients and 70% in high-risk patients (Butterworth et al., 2013). Recently, many PONV predictor scores have been used to determine the PONV severity and prophylactic administration. Objective: To compare the scores of Apfel, Koivuranta, and Sinclair as predictors of PONV in adult patients after general anesthesia at RSUD Dr. Soetomo. Methods: A cross-sectional study design conducted in 100 patients who underwent elective surgery under general anesthesia at RSUD Dr. Soetomo Surabaya. Patients who meet the criteria will be recorded in the clinical research form and being followed to evaluate the assessment using Apfel, Koivuranta, and Sinclair scores when the patient is in the recovery room and the ward. A diagnostic test is performed to assess the accuracy between these scores. Results: In this study, the prevalence of PONV after general anesthesia in elective surgery at GBPT RSUD Dr Soetomo Surabaya is 26%. The Apfel score obtained has a sensitivity value of 79.5%, a specificity of 45.9% with an AUC value of 0.701. The Koivuranta score has a sensitivity value of 96.2%, a specificity of 27% with an AUC value of 0.628. The Sinclair score has a sensitivity value of 73.1%, a specificity of 48.6% with an AUC value of 0.619. Conclusion: Apfel's score is more accurate PONV prediction score and has a simpler score determination variable. Keywords : PONV, predictor score, apfel score, koivuranta score, sinclair score, general anesthesia.

The Difference of Results in Abdomen and Anus Area Measurement With Non-Contact Infrared Thermometer Anna Surgean Veterini; Nancy Margarita Rehatta; Hamzah Hamzah; Widijiati Widijiati; Sarmanu Sarmanu; Subijanto Marto Soedarmo; Widodo Jatim Pudjirahardjo; Annis Catur Adi; Heni Rachmawati; I Ketut Sudiana
Jurnal Veteriner Vol 22 No 2 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Study about sepsis is chalenging to get the right therapeutic method. One clinical signs of the sepsis mice model is changes in body temperature. An easy way to examine body temperature is using infrared non-contact thermometer. The aim of this study is to compare the body temperature obtained from infrared non-contact thermometer at the abdomen and anus area. We used male Mus musculus mice, body weight of 25–30 grams, were divided into 2 groups (control and treated groups). In the control group, mice were injected with NaCl 0.9% solution, with the amount of NaCl volume equal to LPS. In the treated group, mice were injected with 2.5 mg/kgBW of LPS intraperitoneally. Body temperature measurement was measured in abdomen (tabd) and anus (tan) area. Body temperature was measured at 8th and 24th hour after LPS or NaCl injection. Body temperature value result using tabd was higher than tan. LPS injection to mice produced an increase in body temperature but was not significant when compared to the control group (8th and 24th hour). The mean difference between tabd and tan in 8th hour control groups respectively were 2.12oC. The mean difference between tabd and tan in 24th hour control groups 4.6oC. The mean difference in treated groups (8th hour) was 4.66oC, while it was 4.77oC in the 24th hour treated groups. LPS could caused vasodilation of the vessels, the measurement area of non contact-infrared thermometer will be the most important factor to be considered; tan may closer to the physiology condition.

Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.

Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.61

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.

Anesthesia Services for Children's Radiotherapy During Pandemic COVID-19 in 2020: Experience from East Indonesia Anna Surgean Veterini; Herdiani Sulistyo Putri; Ulinta Purwati Pasaribu
JAI (Jurnal Anestesiologi Indonesia) Vol 14, No 2 (2022): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.41926

Background: The global COVID-19 pandemic has significantly strained the healthcare sector, with overwhelmed health services in affected countries worldwide. Despite the need to sustain vital oncology treatments, particularly for children, radiotherapy practitioners are unsure how to treat during the pandemic. At the same time, several anesthesia procedures may increasingly expose anesthesia providers to COVID-19. The challenging services for handling oncology cases in children at Dr. Soetomo Hospital during the COVID-19 pandemic can be carried out properly with various adjustments. Objective: The purpose of this study was to describe how the radiotherapy center in East Indonesia responds to the challenge in this pandemic era.Method: During 2020, we gathered information by using administrative datasets on the number of patients, the types of anesthesia services provided, and undesired events in the radiotherapy room. We use descriptive statistics to describe what is going on in our data.Result: The total number of patients who underwent radiotherapy was 12, with 188 sessions, and uncooperative children received midazolam and propofol during the procedure. The result showed that there was no untoward incident in 2020.Conclusion: Therefore, it indicates that we provided relatively safe sedation services for children's radiotherapy.

Kontrol Edukasi Video Visual Smartphone Berbasis Selfcare terhadap Kecemasan dan Tekanan Darah Pasien Endoskopi dengan Pelayanan Anestesiologi Slamet Mustofa; Sriyono Sriyono; Anna Surgean Veterini
Journal of Telenursing (JOTING) Vol 5 No 1 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i1.4887

This study aims to analyze the effect of self-care-based smartphone visual video education on the anxiety level and blood pressure of endoscopic patients with anesthesiology services. This research method uses a quasy experiment (pre-post test with control group design). The results showed that there were differences between the treatment and control groups. There were significant differences in anxiety (p=0.000), systolic blood pressure (p=0.011), and diastolic blood pressure (p=0.042). In the intervention group, there was a significant effect of smartphone visual video education on anxiety (p=0.000), systolic blood pressure (0.042), and diastolic blood pressure (p=0.008). In conclusion, self-care-based smartphone graphic video education affects the anxiety and blood pressure of endoscopic patients with anesthesiology services. Keywords: Education, Endoscopy, Anxiety, Blood Pressure, Video

EFFECTS OF CONSUMING BISCUITS MADE FROM MORINGA OLEIFERA LEAF ON BODY WEIGHT AND HEIGHT OF CHILDREN UNDER FIVE IN BANGKALAN, MADURA ISLAND Anna Surgean Veterini; Enny Susanti; Meity Ardiana; Annis Catur Adi; Heni Rachmawati
Media Gizi Indonesia Vol. 18 No. 2 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v18i2.150-156

One of the efforts to maintain childrenâ€™s nutritional status is to prevent weight faltering, which was formerly known as failure to thrive. Unresolved weight faltering will cause several problems, such as growth failure, stunting, decreased IQ, morbidity, and mortality in children. Stunting is one of the big problems that occur in Indonesia. One of the continuous strategies to prevent weight faltering is through food supplementation, such as consuming moringa leaf which is high in protein in the form of biscuits. This study aims to determine the effects of consuming biscuits made from Moringa oleifera leaf on children's growth in Bangkalan, Indonesia. This study used experimental research method for two months. The sample was drawn using consecutive sampling technique. The subjects in this study were 31 children under five whose weight and height were not according to age. Before moringa biscuits were distributed, childrenâ€™s body weight and height were measured. The nutritional status was evaluated every month for two months. The parameters measured were weight gain and height increase. The results were analyzed using univariate and multivariate tests on SPSS. After giving moringa oleifera biscuits for two months at the Village Health Post (Pos Kesehatan Desa/Poskesdes) of Bangkalan, childrenâ€™s body weight increased by 0.35 kg per month and their height increased by 0.65 cm per month. The distribution of biscuits can be continued to preventing stunting.

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