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All Journal Jurnal Kimia Terapan Indonesia Jurnal Farmasi Higea Jurnal Ners Indonesia Natural Research Pharmaceutical Journal (INRPJ) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Journal Of World Science Jurnal Locus Penelitian dan Pengabdian Berdikari : Jurnal Pengabdian kepada Masyarakat Al Makki Health Informatics Journal Jurnal Farmasi Galenika

Prima, Sylvia Rizky

Universitas 17 Agustus 1945 Jakarta

Author-ID : 2022789

Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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PERBANDINGAN JENIS, KOMPOSISI DAN JUMLAH PELARUT TERHADAP UJI TOTAL FLAVONOID DARI DAUN JAWER KOTOK (Plectranthus scutellarioides(L.) R.Br.) Sylvia Rizky Prima; Fetri cary munarsih; Ulia Nailis Saadah
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Tanaman Jawer Kotok (Plectranthus scutellarioides (L.) R.Br.) adalah tanaman obat tradisional yang digunakan oleh masyarakat untuk mengobati berbagai penyakit. Salah satu senyawa yang berperan penting dalam mengobati berbagai penyakit tersebut adalah senyawa flavonoid. Tujuan dari Penelitian ini adalah untuk memperoleh jenis pelarut, komposisi dan jumlah pelarut yang optimal mengahsilkan total flavonoid dari daun jawer (Plectranthus scutellarioides) (L.) R.Br. Pada penelitian ini digunakan jenis pelarut etanol dan aseton dengan komposisi perbandingan pelarut : air mulai dari 96: 4, 80:20, 70:30, 60:40 dan 50:50. Jumlah pelarut yang digunakan yaitu dengan perbandingan pelarut 5x berat sampel, 10x berat sampel dan 15x berat sampel. Metode ekstraksi yang digunakan adalah metode maserasi. Metode pengujian total flavonoid yang digunakan adalah metode kolorimertri dengan pembanding Quersetin. Dari hasil penelitian diperoleh bahwa pelarut terbaik untuk mengekstraksi total flavonoid adalah pelarut Aseton : Air (70 : 30). Berdasrakan analisa data dengan menggunakan SPPS v24, perbandingan jumlah pelarut 5x, 10 dan 15x berat sampel tidak memiliki perbedaan yang signifikan.

The Synthesis of Cinchonine Tiglat Ester Compound and Cytotoxic Test Against MCF-7 Breast Cancer Cell Ahmad Khanifudin; Gian Primahana; Sylvia Rizky Prima; Puspa Dewi Lotulung; Muhammad Hanafi
Jurnal Kimia Terapan Indonesia Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

Cinchonine is a type of cinchona alkaloid compound commonly found and/or isolated from Cinchona sp. plant. It is commonly used to treat malaria, and can potentially be used against cancer cells. In this particular study, cinchonine ester derivatives were extracted through esterification processs. Synthesized esther is aimed to gain higher lipophilicity of cinchonine so that makes it easier to pass through cell membrane. Esterification was done using DCC activator as well as DMAP catalyst with tiglic acid used to create cinchonine tiglat. Subsequent cinchonine tiglat was obtained in the form of oil with 25,28% yield. The compound obtained from the synthesis was the analyzed using LC-ESI-MS and 1H-NMR spectroscopy instrumentation. Results show that the target compound has been successfully synthesized. Its cytotoxic ability against MCF-7 breast cancer cells was tested using the Alamar Blue method. Results concluded that cinchonine tiglat ester compound has a viable cytotoxic activity with IC50 value of 1.22 ppm.

Synthesis and cytotoxicity assay using Brine Shrimp Lethality Test of Cinchonidine Isobutyrate Ester Mario Mario; Puspa Dewi Lotulung; Gian Primahana; Sylvia Rizky Prima; Muhammad Hanafi
Jurnal Kimia Terapan Indonesia Vol 19, No 1 (2017)
Publisher : Research Center for Chemistry - LIPI

This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT). Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. Cinchonidine is predicted to have anticancer activity. Synthesized ester was aimed to gain higher lipophilicity. Higher lipophilicity makes it easier for the compund to pass through cell membrane. The esterification process used DMAP as a catalyst, DCC as an activator, and isobutyric acid as a carboxilyc acid. Isobutyric acid is a type of short chained fatty acid that usually acts as an anticancer prodrugs. The product is identified by ESI-MS, FT-IR, 1H-NMR, dan 13C-NMR. Ester cinchonidine isobutyrate is gelatinous and colourless with yield of 21,77%. BSLT result showed that cinchonidine isobutyrate ester had LC50 value of 75.16 ppm which was more toxic than cinchonidine that had LC50 value of 99.2 ppm. It was proved that higher lipophilicity could increase pharmacology activity

STUDI PERSEPSI DOKTER TENTANG PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI RUMAH SAKIT UMUM PUSAT (RSUP) DR. M. DJAMIL PADANG Prima, Sylvia Rizky
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 1, No 2 (2016)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v1i2.617

ABSTRACT The main of this study was to investigate physicians’expectations and experiences regarding pharrmaceutical care in hospital of DR. M. Djamil Padang. A four-part quetionnaire was hand delivered to a sample of 380 physicians practicing in hospital of DR. M. Djamil Padang. The questionnaire collected physicians’ characteristic, current expectations, actual experiences and future expectations regarding pharmaceutical care. Two hundred and two (53,16%) questionnaires were returned. In general, the mean values of physician agreement in our study showed that there is neither strong agreement nor strong disagreement with any statement regarding physicians’current expectations and future expectations of pharmacists. It is concluded that physicians as whole do not know what to expect of pharmacist. But, our study showed that with the actual experiences of Physicians with Pharmacists are still very low. Keywords: physician’s perceptions, expectations dan experience of physicians, pharmaceutical care ABSTRAK Tujuan utama penelitian ini adalah untuk menginvestigasi harapan dan pengalaman dokter terhadap peran apoteker dalam pharmaceutical care di Rumah Sakit DR. M. Djamil Padang. 4 bagian kuesioner telah berhasil diserahkan kepada 380 sampel dokter praktek di Rumah Sakit DR. M. Djmail Padang. Kuesioner berisi data karakteristik dokter, harapan dokter saat ini, pengalaman aktual dokter, dan harapan dokter terhadap peran apoteker terkait pharmaceutical care. 202 kuesioner berhasil diperoleh kembali (53,16%). Secara umum, rata-rata respon dokter untuk harapan dokter saat ini dan harapan dokter dimasa depan terhadap peran apoteker dalam pharmaceutical care tidak terlalu tinggi dan tidak terlalu rendah. Tetapi, dari hasil penelitian ini menunjukkan bahwa pengalaman aktual dokter dengan apoteker dalam hal pharmaceutical care masih sangat rendah. Kata kunci: Persepsi dokter, harapan dan pengalaman dokter, pharmaceutical care

The Impact of Pharmacist-Led Education on Patient Statisfaction in Pharmaceutical Service for Type 2 Diabetes Mellitus: A Cross Sectional Study in Two Hospital in Ambon City Ipaenim, Nurjianti; Prima, Sylvia Rizky
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4710

Type 2 Diabetes Mellitus (T2DM) is a growing public health concern that requires effective management, including patient education. Although pharmacist-led education is recognized as important in diabetes care, evidence on its impact on patient satisfaction with pharmaceutical services in resource-limited areas like Maluku Province, Indonesia, is limited. This study evaluated the effect of pharmacist-led education on patient satisfaction among T2DM outpatients in Ambon City. Using a prospective cross-sectional design, 300 patients from RSU Al Fatah and Rumkit Tk II Prof. Dr. J.A. Latumeten hospitals participated. Data were collected over three months (November 2024 to January 2025) with the Patient Satisfaction with Pharmacy Services (PSPS) questionnaire. Participants were split into two groups: one received an e-booklet plus pharmacist education (n=150), while the other received the e-booklet only (n=150). Results showed a significant improvement in satisfaction scores for the education group, from a mean of 85.84 (pretest) to 215.16 (posttest), compared to a smaller increase in the non-education group, from 130.43 to 170.57. Statistical tests (Mann-Whitney U and Wilcoxon W) confirmed significant differences (p<0.001) pre- and post-intervention, with greater improvement seen in the education group. These findings suggest pharmacist-led education substantially enhances patient satisfaction in T2DM pharmaceutical services. Integrating such education into healthcare could improve treatment adherence and outcomes. Future studies should assess long-term health impacts and cost-effectiveness.

Factors Affecting Medication Adherence and the Success of Pulmonary Tuberculosis Therapy in Several Community Health Centers in Ambon City Surtia, Surtia; Prima, Sylvia Rizky
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4713

This study examines the Factors Affecting Medication Adherence and the Success of Pulmonary Tuberculosis Therapy in Several Community Health Centers in Ambon City. Tuberculosis (TB) remains an infectious disease and a global health challenge, including in Indonesia. The success of TB therapy is highly dependent on the patient's adherence to the prescribed treatment. This study aims to analyze the factors that affect the adherence of pulmonary TB patients and their relationship with therapy success. The study design is observational with a cross-sectional approach, conducted both retrospectively and prospectively on pulmonary TB patients at several health centers in Ambon City. Data were collected through questionnaires and patient medical records. A sample of 150 respondents was selected using the purposive sampling method. The analysis was performed using the chi-square test and logistic regression. The results showed that family support, health worker support, and access to health facilities had a significant effect on patient compliance. Meanwhile, education and knowledge did not have a significant influence. The analysis also indicated a significant relationship between medication adherence and therapy success. Family support emerged as the most dominant factor influencing adherence. These findings highlight the importance of a holistic approach in TB management, particularly by strengthening social support and primary health services. Recommendations include increasing the educational role of pharmacists and implementing regular compliance monitoring. Further research is suggested to conduct longitudinal studies and explore psychosocial and cultural factors.

Phytochemical Screening Of Saponin And Antibacterial Activity Of 96% Ethanol Extract Of Costus Speciosus Against E. Coli And S. Aureus Prasasty, Vony Intan; Prima, Sylvia Rizky; Damayantie, Wury
Al Makki Health Informatics Journal Vol. 3 No. 4 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i4.56

This study aims to explore the content of secondary metabolite compounds, especially saponins, and to examine the antibacterial activity of ethanol extract of 96% of unsalted pacing leaves (Costus speciosus) against Escherichia coli and Staphylococcus aureus bacteria. Extraction was carried out by maceration method using 96% ethanol solvent, followed by qualitative phytochemical tests to detect the presence of bioactive compounds. The antibacterial activity test was carried out using the disc diffusion method with various concentrations of extracts (5%, 10%, 20%, 40%, and 80%). The results of phytochemical screening showed that the extract contained saponins, alkaloids, tannins, and triterpenoid compounds, while flavonoids were not detected. Antibacterial tests showed that the extract had concentration-dependent increased bacterial growth inhibition activity, with the highest inhibition zone recorded at 80% concentrations against both test bacteria. The Minimum Inhibitory Concentration (MIC) is set at a concentration of 5%, although significant effectiveness is seen starting at concentrations of 10% and above. Based on these findings, it can be concluded that ethanol extract of 96% unsalted pacing leaves has potential as a natural antibacterial agent, which can be further developed as a candidate for local plant-based phytopharmaceuticals. These findings also make a scientific contribution to the utilization of biological resources in supporting alternative medicine in the era of antibiotic resistance.

SKRINING DAN OPTIMALISASI VITAMIN D PADA IBU HAMIL DALAM PENCEGAHAN STUNTING DI RW 06 KEBON BAWANG, JAKARTA UTARA Ramatillah, Diana Laila; Prima, Sylvia Rizky; Susilowati, Sri Endah; fitriani, Fitriani; Lestari, Mega; Ghassani, Fatiha Azka; Luthfiana, Farisa; Darsono, Michelle; Sumardiyanto, Didit
BERDIKARI Vol 8, No 2 (2025): Jurnal Berdikari
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/berdikari.v8i2.8871

Stunting masih menjadi masalah kesehatan masyarakat di Indonesia yang berdampak pada kualitas sumber daya manusia di masa depan. Vitamin D berperan penting dalam metabolisme kalsium, sistem imun, serta pertumbuhan janin, sehingga kekurangannya pada ibu hamil dapat meningkatkan risiko stunting pada anak. Program pengabdian masyarakat ini bertujuan meningkatkan pengetahuan ibu hamil mengenai peran vitamin D dalam pencegahan stunting melalui edukasi gizi berbasis komunitas. Kegiatan dilaksanakan di RW 06 Kebon Bawang, Jakarta Utara, dengan melibatkan 50 responden ibu hamil. Metode yang digunakan meliputi skrining dasar kesehatan, penyuluhan dengan media booklet, leaflet, poster, dan video, pelatihan kader Posyandu, serta penerapan teknologi tepat guna berupa alat pemanggang kacang kedelai. Evaluasi dilakukan dengan membandingkan hasil pre-test dan post-test. Hasil menunjukkan peningkatan pengetahuan rata-rata dari 55% menjadi 84%, dengan peningkatan tertinggi pada pemahaman mengenai kedelai sebagai sumber vitamin D (dari 46% menjadi 80%). Program ini juga menghasilkan media edukasi, pelatihan kader, dan inovasi teknologi sederhana yang dapat dimanfaatkan secara berkelanjutan. Temuan ini menunjukkan bahwa pendekatan partisipatif berbasis komunitas efektif untuk meningkatkan pengetahuan ibu hamil dan mendukung upaya pencegahan stunting di wilayah perkotaan padat penduduk.

Profil Metabolomik dan Studi Molecular Docking Senyawa Aktif Eco Enzyme dari Kulit Buah Jeruk Nipis dan Kulit Buah Manggis Sebagai Kandidat Antibakteri Untuk Formulasi Hand Sanitizer Alami Putu Irwan Mambre Wipranata; Sylvia Rizky Prima; Iyan Hardiana
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.55921

Latar belakang penelitian ini adalah potensi eco enzyme hasil fermentasi limbah kulit jeruk nipis (Citrus aurantiifolia) dan kulit manggis (Garcinia mangostana) sebagai sumber antibakteri alami. Pendekatan integrasi metabolomik dan molecular docking digunakan untuk mempercepat identifikasi senyawa aktif dalam pengembangan hand sanitizer alami yang aman dan efektif. Penelitian bertujuan menilai potensi antibakteri eco enzyme melalui pemetaan metabolomik, uji in silico, dan verifikasi in vitro. Limbah kulit difermentasi selama ±3 bulan, kemudian dikarakterisasi secara organoleptik dan pH. Profil kimia dianalisis menggunakan LC-HRMS, dan kandidat senyawa didocking terhadap DNA gyrase E. coli serta PBP2a S. aureus. Aktivitas antibakteri diuji dengan metode difusi cakram pada MHA (37 °C, 18–24 jam), termasuk pada formulasi hand sanitizer berbasis etanol, gliserol, H₂O₂, dan air dengan variasi kadar eco enzyme. Mutu fisik sediaan juga dievaluasi. Data dianalisis menggunakan ANOVA/regresi dan analisis jalur sederhana. Hasil LC-HRMS mengidentifikasi 35 senyawa, seperti xanthone dan limonene. Uji in silico menunjukkan dua senyawa dengan afinitas pengikatan tertinggi terhadap target enzim, mengindikasikan potensi inhibisi secara teoritis.

Mikroorganisme Adaptif dalam Ekstrak dan Minuman Sebagai Sumber Senyawa Bioaktif: Review Artikel Meinanda Grabilia; Sylvia Rizky Prima
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56033

Fermentasi merupakan proses bioteknologi yang berperan penting dalam meningkatkan kualitas sensori, keamanan, serta nilai fungsional pangan dan minuman. Perkembangan penelitian terbaru menunjukkan bahwa mikroorganisme adaptif seperti bakteri asam laktat, khamir, bakteri asam asetat, dan komunitas simbiotik pada kombucha mampu menghasilkan berbagai senyawa bioaktif melalui mekanisme respons terhadap tekanan lingkungan fermentasi. Artikel ini bertujuan untuk menganalisis secara sistematis peran mikroorganisme adaptif dalam ekstrak tanaman dan minuman fermentasi sebagai sumber senyawa bioaktif berdasarkan 25 studi ilmiah periode 2019–2025. Metode yang digunakan adalah systematic literature review dengan penelusuran pada database terindeks internasional. Hasil kajian menunjukkan bahwa adaptasi mikroba terhadap kondisi seperti pH rendah, tekanan osmotik, dan keterbatasan nutrien memicu perubahan jalur metabolisme yang menghasilkan metabolit sekunder bernilai biologis tinggi, antara lain polifenol terkonversi, asam organik, peptida bioaktif, eksopolisakarida, vitamin B, serta gamma-aminobutyric acid (GABA). Senyawa-senyawa tersebut terbukti memiliki aktivitas antioksidan, antimikroba, antiinflamasi, imunomodulator, serta potensi probiotik. Selain itu, interaksi sinergis antar mikroorganisme dalam sistem fermentasi campuran, seperti pada kombucha dan kefir, turut memperkuat pembentukan bioaktivitas produk akhir. Penelitian ini menegaskan bahwa fermentasi tidak hanya berfungsi sebagai metode pengawetan tradisional, tetapi juga sebagai strategi inovatif dalam pengembangan pangan fungsional dan nutraseutikal berbasis mikroorganisme adaptif. Temuan ini memberikan landasan ilmiah bagi optimalisasi proses fermentasi untuk meningkatkan kualitas dan manfaat kesehatan produk berbasis ekstrak dan minuman fermentasi.

Co-Authors Ahmad Khanifudin Anisa Dita Ikrana Damayantie, Wury Darsono, Michelle Didit Sumardiyanto Farisa Luthfiana Fetri cary munarsih Fitriani Fitriani Ghassani, Fatiha Azka Gian Primahana Gian Primahana Gian Primahana Ipaenim, Nurjianti Iyan Hardiana Mario Mario Mario Mario Mega Lestari Meinanda Grabilia Muhammad Hanafi Muhammad Hanafi Muhammad Rizaldi Prasasty, Vony Intan Puspa Dewi Lotulung Puspa Dewi Lotulung Putu Irwan Mambre Wipranata Rabima Rabima Ramatillah, Diana Laila Sri Endah Susilowati Surtia, Surtia Ulia Nailis Saadah

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