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All Journal Jurnal Kimia Terapan Indonesia Jurnal Farmasi Higea Indonesia Natural Research Pharmaceutical Journal (INRPJ) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Journal Of World Science Jurnal Locus Penelitian dan Pengabdian Berdikari : Jurnal Pengabdian kepada Masyarakat Al Makki Health Informatics Journal Jurnal Farmasi Galenika

Prima, Sylvia Rizky

Universitas 17 Agustus 1945 Jakarta

Author-ID : 2022789

Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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PERBANDINGAN JENIS, KOMPOSISI DAN JUMLAH PELARUT TERHADAP UJI TOTAL FLAVONOID DARI DAUN JAWER KOTOK (Plectranthus scutellarioides(L.) R.Br.) Sylvia Rizky Prima; Fetri cary munarsih; Ulia Nailis Saadah
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Tanaman Jawer Kotok (Plectranthus scutellarioides (L.) R.Br.) adalah tanaman obat tradisional yang digunakan oleh masyarakat untuk mengobati berbagai penyakit. Salah satu senyawa yang berperan penting dalam mengobati berbagai penyakit tersebut adalah senyawa flavonoid. Tujuan dari Penelitian ini adalah untuk memperoleh jenis pelarut, komposisi dan jumlah pelarut yang optimal mengahsilkan total flavonoid dari daun jawer (Plectranthus scutellarioides) (L.) R.Br. Pada penelitian ini digunakan jenis pelarut etanol dan aseton dengan komposisi perbandingan pelarut : air mulai dari 96: 4, 80:20, 70:30, 60:40 dan 50:50. Jumlah pelarut yang digunakan yaitu dengan perbandingan pelarut 5x berat sampel, 10x berat sampel dan 15x berat sampel. Metode ekstraksi yang digunakan adalah metode maserasi. Metode pengujian total flavonoid yang digunakan adalah metode kolorimertri dengan pembanding Quersetin. Dari hasil penelitian diperoleh bahwa pelarut terbaik untuk mengekstraksi total flavonoid adalah pelarut Aseton : Air (70 : 30). Berdasrakan analisa data dengan menggunakan SPPS v24, perbandingan jumlah pelarut 5x, 10 dan 15x berat sampel tidak memiliki perbedaan yang signifikan.

The Synthesis of Cinchonine Tiglat Ester Compound and Cytotoxic Test Against MCF-7 Breast Cancer Cell Ahmad Khanifudin; Gian Primahana; Sylvia Rizky Prima; Puspa Dewi Lotulung; Muhammad Hanafi
Jurnal Kimia Terapan Indonesia Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

Cinchonine is a type of cinchona alkaloid compound commonly found and/or isolated from Cinchona sp. plant. It is commonly used to treat malaria, and can potentially be used against cancer cells. In this particular study, cinchonine ester derivatives were extracted through esterification processs. Synthesized esther is aimed to gain higher lipophilicity of cinchonine so that makes it easier to pass through cell membrane. Esterification was done using DCC activator as well as DMAP catalyst with tiglic acid used to create cinchonine tiglat. Subsequent cinchonine tiglat was obtained in the form of oil with 25,28% yield. The compound obtained from the synthesis was the analyzed using LC-ESI-MS and 1H-NMR spectroscopy instrumentation. Results show that the target compound has been successfully synthesized. Its cytotoxic ability against MCF-7 breast cancer cells was tested using the Alamar Blue method. Results concluded that cinchonine tiglat ester compound has a viable cytotoxic activity with IC50 value of 1.22 ppm.

Synthesis and cytotoxicity assay using Brine Shrimp Lethality Test of Cinchonidine Isobutyrate Ester Mario Mario; Puspa Dewi Lotulung; Gian Primahana; Sylvia Rizky Prima; Muhammad Hanafi
Jurnal Kimia Terapan Indonesia Vol 19, No 1 (2017)
Publisher : Research Center for Chemistry - LIPI

This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT). Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. Cinchonidine is predicted to have anticancer activity. Synthesized ester was aimed to gain higher lipophilicity. Higher lipophilicity makes it easier for the compund to pass through cell membrane. The esterification process used DMAP as a catalyst, DCC as an activator, and isobutyric acid as a carboxilyc acid. Isobutyric acid is a type of short chained fatty acid that usually acts as an anticancer prodrugs. The product is identified by ESI-MS, FT-IR, 1H-NMR, dan 13C-NMR. Ester cinchonidine isobutyrate is gelatinous and colourless with yield of 21,77%. BSLT result showed that cinchonidine isobutyrate ester had LC50 value of 75.16 ppm which was more toxic than cinchonidine that had LC50 value of 99.2 ppm. It was proved that higher lipophilicity could increase pharmacology activity

STUDI PERSEPSI DOKTER TENTANG PERAN APOTEKER DALAM PELAYANAN KEFARMASIAN DI RUMAH SAKIT UMUM PUSAT (RSUP) DR. M. DJAMIL PADANG Prima, Sylvia Rizky
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 1, No 2 (2016)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v1i2.617

ABSTRACT The main of this study was to investigate physicians’expectations and experiences regarding pharrmaceutical care in hospital of DR. M. Djamil Padang. A four-part quetionnaire was hand delivered to a sample of 380 physicians practicing in hospital of DR. M. Djamil Padang. The questionnaire collected physicians’ characteristic, current expectations, actual experiences and future expectations regarding pharmaceutical care. Two hundred and two (53,16%) questionnaires were returned. In general, the mean values of physician agreement in our study showed that there is neither strong agreement nor strong disagreement with any statement regarding physicians’current expectations and future expectations of pharmacists. It is concluded that physicians as whole do not know what to expect of pharmacist. But, our study showed that with the actual experiences of Physicians with Pharmacists are still very low. Keywords: physician’s perceptions, expectations dan experience of physicians, pharmaceutical care ABSTRAK Tujuan utama penelitian ini adalah untuk menginvestigasi harapan dan pengalaman dokter terhadap peran apoteker dalam pharmaceutical care di Rumah Sakit DR. M. Djamil Padang. 4 bagian kuesioner telah berhasil diserahkan kepada 380 sampel dokter praktek di Rumah Sakit DR. M. Djmail Padang. Kuesioner berisi data karakteristik dokter, harapan dokter saat ini, pengalaman aktual dokter, dan harapan dokter terhadap peran apoteker terkait pharmaceutical care. 202 kuesioner berhasil diperoleh kembali (53,16%). Secara umum, rata-rata respon dokter untuk harapan dokter saat ini dan harapan dokter dimasa depan terhadap peran apoteker dalam pharmaceutical care tidak terlalu tinggi dan tidak terlalu rendah. Tetapi, dari hasil penelitian ini menunjukkan bahwa pengalaman aktual dokter dengan apoteker dalam hal pharmaceutical care masih sangat rendah. Kata kunci: Persepsi dokter, harapan dan pengalaman dokter, pharmaceutical care

AKTIVITAS ANTIDIABETIK TEH HERBAL KOMBINASI BUNGA TELANG (Clitoria ternatea) DAN MENIRAN (Phyllanthus niruri) PADA MENCIT (Mus muculus) YANG DIINDUKSI ALOKSAN Rabima, Rabima; Prima, Sylvia Rizky; Ikrana, Anisa Dita
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 9, No 1 (2024)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v9i1.6222

Diabetes adalah suatu penyakit gangguan metabolisme kronis yang ditandai dengan meningkatnya kadar gula darah. Bunga telang dan meniran merupakan salah satu tanaman yang memiliki aktivitas sebagai antidiabetes. Tujuan dilakukannya penelitian ini adalah untuk mengetahui aktivitas antidiabetik teh herbal kombinasi bunga telang (Clitoria ternatea) dan meniran (Phyllanthus niruri) serta persentase penurunan kadar gula darah pada mencit putih (Mus muculus) yang diinduksi aloksan. Hewan uji yang digunakan yaitu 25 mencit jantan dan dibagi menjadi 5 kelompok perlakuan yaitu kelompok negatif, kelompok positif diberi glibenklamid, dan kelompok teh herbal. Teh herbal dibuat menjadi 3 formulasi yaitu, 200 mg bunga telang dan 800 meniran, 350 mg bunga telang dan 650 mg meniran, serta 500 mg bunga telang dan 500 mg meniran. Masing-masing formulasi dikemas dalam kantong teh sebanyak 1 g dan diseduh dalam 200 ml air panas. Data dianalisis menggunakan metode One Way ANOVA. Hasil penelitian menunjukkan bahwa teh herbal kombinasi bunga telang dan meniran pada formulasi 200 mg bunga telang dan 800 mg meniran merupakan formulasi paling optimal diantara kedua formulasi lainnya. Persentase yang didapatkan yaitu sebesar 33,56% dengan selisih antara kontrol positif dan teh herbal 200 mg bunga telang dan 800 mg meniran yaitu sebesar 9,05%. Dari penelitian diatas dapat disimpulkan bahwa teh herbal kombinasi 200 mg bunga telang dan 800 mg meniran memiliki aktivitas sebagai antidiabetik yang paling baik diantara kedua formulasi lainnya.

IDENTIFIKASI KANDUNGAN KIMIA DENGAN GC-MS DARI FRAKSI UMBI BAWANG BATAK (Allium chinense G.Don) Prima, Sylvia Rizky
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 9, No 2 (2024)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v9i2.7663

Batak onions (Аllium chinense G. Don) are an onion that local from Samosir Island, North Sumatera. This plant is used empirically as a cooking spice. Previous research reported that this plant has several bioactivities such as antimicrobial. This research aims to determine the chemical content of several fractions of Batak onion bulbs using the Gаѕ Сhrоmаtоgrарhy Mаѕѕ Ѕресtrоmеtry (GС-MЅ) method. Extraction was carried out using a maceration technique and continued with a fractionation process using the solvents n-hexane, ethyl acetate and butanol. The results of the analysis showed that the compound content of several of the onion tuber fractions was 13 compounds obtained h from the n-Hexane fraction, 9 compounds obtained from the ethyl acetate fraction, and having 7 y compounds which is obtained from the butanol fraction. Oleic acid compound is the most dominant compound contained in Batak onion bulbs from local Samosir island, with the percentage of its content in the n-hexane, ethyl acetate and butanol fractions being 22.05%, 52.42% and 59.38%, respectively.

Exploration and Antimicrobial Activity Test of Secondary Metabolites from Endophytic Fungi of Curcuma Zedoaria from West Nusa Tenggara Mario, Mario; Rizky Prima, Sylvia; Primahana, Gian
Journal of World Science Vol. 4 No. 9 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i9.1505

Antibiotic resistance has become a significant public health issue in Indonesia, prompting the search for alternative antimicrobial agents from natural sources. Endophytic fungi symbiotically living inside medicinal plants such as Curcuma zedoaria (temu putih) have the potential to produce bioactive secondary metabolites that could serve as new antibacterial agents. This study aimed to isolate endophytic fungi from the rhizome of temu putih originating from West Nusa Tenggara (NTB), evaluate the antibacterial activity of isolates grown on Potato Dextrose Broth (PDB) and Yeast Malt Broth (YMB), and identify as well as elucidate the structure of the secondary metabolite compounds produced. This experimental comparative study involved isolation of endophytic fungi by surface sterilization, culturing on PDB and YMB media, extraction with ethyl acetate, and antibacterial testing against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 8739 using the microdilution method. Metabolite profiling was performed using HPLC-DAD, preparative HPLC for fractionation, LC-HRMS for molecular mass identification, and NMR spectroscopy for structural elucidation. Five endophytic fungal isolates were successfully obtained from the temu putih rhizome. Antibacterial activity was stronger in isolates cultured on PDB compared to YMB. From isolate TP 3 cultured in PDB, several secondary metabolite fractions were isolated, with fraction 4 (F4) containing linoleic acid as the pure compound. F4 demonstrated a Minimum Inhibitory Concentration (MIC) of 200 µg/mL against S. aureus, comparable to the TP 3 PDB isolate, while against E. coli, F4 showed MIC > 200 µg/mL and TP 3 PDB isolate showed an MIC of 100 µg/mL.

The Impact of Pharmacist-Led Education on Patient Statisfaction in Pharmaceutical Service for Type 2 Diabetes Mellitus: A Cross Sectional Study in Two Hospital in Ambon City Ipaenim, Nurjianti; Prima, Sylvia Rizky
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4710

Type 2 Diabetes Mellitus (T2DM) is a growing public health concern that requires effective management, including patient education. Although pharmacist-led education is recognized as important in diabetes care, evidence on its impact on patient satisfaction with pharmaceutical services in resource-limited areas like Maluku Province, Indonesia, is limited. This study evaluated the effect of pharmacist-led education on patient satisfaction among T2DM outpatients in Ambon City. Using a prospective cross-sectional design, 300 patients from RSU Al Fatah and Rumkit Tk II Prof. Dr. J.A. Latumeten hospitals participated. Data were collected over three months (November 2024 to January 2025) with the Patient Satisfaction with Pharmacy Services (PSPS) questionnaire. Participants were split into two groups: one received an e-booklet plus pharmacist education (n=150), while the other received the e-booklet only (n=150). Results showed a significant improvement in satisfaction scores for the education group, from a mean of 85.84 (pretest) to 215.16 (posttest), compared to a smaller increase in the non-education group, from 130.43 to 170.57. Statistical tests (Mann-Whitney U and Wilcoxon W) confirmed significant differences (p<0.001) pre- and post-intervention, with greater improvement seen in the education group. These findings suggest pharmacist-led education substantially enhances patient satisfaction in T2DM pharmaceutical services. Integrating such education into healthcare could improve treatment adherence and outcomes. Future studies should assess long-term health impacts and cost-effectiveness.

Factors Affecting Medication Adherence and the Success of Pulmonary Tuberculosis Therapy in Several Community Health Centers in Ambon City Surtia, Surtia; Prima, Sylvia Rizky
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4713

This study examines the Factors Affecting Medication Adherence and the Success of Pulmonary Tuberculosis Therapy in Several Community Health Centers in Ambon City. Tuberculosis (TB) remains an infectious disease and a global health challenge, including in Indonesia. The success of TB therapy is highly dependent on the patient's adherence to the prescribed treatment. This study aims to analyze the factors that affect the adherence of pulmonary TB patients and their relationship with therapy success. The study design is observational with a cross-sectional approach, conducted both retrospectively and prospectively on pulmonary TB patients at several health centers in Ambon City. Data were collected through questionnaires and patient medical records. A sample of 150 respondents was selected using the purposive sampling method. The analysis was performed using the chi-square test and logistic regression. The results showed that family support, health worker support, and access to health facilities had a significant effect on patient compliance. Meanwhile, education and knowledge did not have a significant influence. The analysis also indicated a significant relationship between medication adherence and therapy success. Family support emerged as the most dominant factor influencing adherence. These findings highlight the importance of a holistic approach in TB management, particularly by strengthening social support and primary health services. Recommendations include increasing the educational role of pharmacists and implementing regular compliance monitoring. Further research is suggested to conduct longitudinal studies and explore psychosocial and cultural factors.

Phytochemical Screening Of Saponin And Antibacterial Activity Of 96% Ethanol Extract Of Costus Speciosus Against E. Coli And S. Aureus Prasasty, Vony Intan; Prima, Sylvia Rizky; Damayantie, Wury
Al Makki Health Informatics Journal Vol. 3 No. 4 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i4.56

This study aims to explore the content of secondary metabolite compounds, especially saponins, and to examine the antibacterial activity of ethanol extract of 96% of unsalted pacing leaves (Costus speciosus) against Escherichia coli and Staphylococcus aureus bacteria. Extraction was carried out by maceration method using 96% ethanol solvent, followed by qualitative phytochemical tests to detect the presence of bioactive compounds. The antibacterial activity test was carried out using the disc diffusion method with various concentrations of extracts (5%, 10%, 20%, 40%, and 80%). The results of phytochemical screening showed that the extract contained saponins, alkaloids, tannins, and triterpenoid compounds, while flavonoids were not detected. Antibacterial tests showed that the extract had concentration-dependent increased bacterial growth inhibition activity, with the highest inhibition zone recorded at 80% concentrations against both test bacteria. The Minimum Inhibitory Concentration (MIC) is set at a concentration of 5%, although significant effectiveness is seen starting at concentrations of 10% and above. Based on these findings, it can be concluded that ethanol extract of 96% unsalted pacing leaves has potential as a natural antibacterial agent, which can be further developed as a candidate for local plant-based phytopharmaceuticals. These findings also make a scientific contribution to the utilization of biological resources in supporting alternative medicine in the era of antibiotic resistance.

Co-Authors Ahmad Khanifudin Damayantie, Wury Darsono, Michelle Didit Sumardiyanto Farisa Luthfiana Fetri cary munarsih Fitriani Fitriani Ghassani, Fatiha Azka Gian Primahana Gian Primahana Ikrana, Anisa Dita Ipaenim, Nurjianti Mario Mario Mario Mario Mega Lestari Muhammad Hanafi Muhammad Hanafi Prasasty, Vony Intan Primahana, Gian Puspa Dewi Lotulung Puspa Dewi Lotulung Rabima, Rabima Ramatillah, Diana Laila Sri Endah Susilowati Surtia, Surtia Ulia Nailis Saadah

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