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All Journal Indonesia Natural Research Pharmaceutical Journal (INRPJ) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Berdikari : Jurnal Pengabdian kepada Masyarakat Pharmacy Action Journal Jurnal Ilmu Kesehatan MAKIA
Astiani, Rangki
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Journal : SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL

 1 
The Relationship Of Allergies With The Covid-19 Booster Vaccine In Communities In The Taman Sari District Area, West Jakarta In 2022 Astiani, Rangki; Luthfiana, Farisa; Ramatillah, Diana Laila; Vivian, Maria
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 8, No 2 (2023)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v8i2.7449

Abstract

In the era of the Covid-19 pandemic, various preventive measures are needed against the transmission of the corona virus, namely by wearing masks, washing hands, staying away from crowds, avoiding physical contact and byincreasing the body's immune system through vaccination, which is one of the prevention measures to reduce the transmission/transmission of Covid-19. 19 so as to reduce morbidity and mortality. The research was conducted to obtain an overview of the use of vaccination and the relationship between allergies to Booster vaccines in the Taman Sari Village Community, West Jakarta in 2022. The type of research used in this research is quantitative, namely using a cross-sectional analytical descrip- tive method. The population in this study was the people of Taman Sari Village, West Jakarta and the sample was taken as many as 124 people using a sampling technique, namely accidental sampling. From this research, results were obtained regarding the existence of a relationship between the Covid-19booster vaccine and allergies in the Taman Sari sub-district community north Jakarta.
Clinical Pharmacy Services at The Central Public Hospital "X" Luthfiana, Farisa; Astiani, Rangki; piter, piter; Sukartiningsih, Yulita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 8, No 2 (2023)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v8i2.7440

Abstract

Background: Pharmaceutical service is a direct and responsible service to patients related to pharmaceutical preparations with the aim of achieving definite results to improve the patient's quality of life.Objective: The aim is to find out how clinical pharmacy services are at “X” Hospital with eleven clinical pharmacyservice indicators based on Minister of Health Regulation Number 72 of 2016.Methods: The method used is descriptive, which aims to obtain a realistic and objective picture of pharmaceuticalservices at “X” Center General Hospital.Results: The results of the study found that eleven indicators of clinical pharmacy services were Assessment and Prescription Services, Tracing Drug Use History, Drug Reconciliation, Drug Information Services (PIO), Counseling, Visitation, Drug Therapy Monitoring (PTO), Drug Side Effects Monitoring (MESO), Evaluation Medication Use(EPO), Dispensing of Sterile Preparations, and Monitoring Blood Drug Levels (PKOD) have been carried out properly in accordance with Minister of Health Regulation No. 72 of 2016, except for PKOD because there is no request from the doctor or pharmacist's initiative to do so.
PENGARUH PENGGUNAAN OBAT GOLONGAN ANGIOTENSIN RECEPTOR BLOCKER (ARB) DAN ACE-INHIBITOR TERHADAP KADAR KALIUM PADA PASIEN HIPERTENSI DI IRNA PENYAKIT DALAM RSUP DR. M.DJAMILPADANG Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 1, No 1 (2016)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v1i1.281

Abstract

Hipertensi merupakan penyakit yang sering diderita oleh pasien di Irna penyakit dalam RSUP DR. M. Djamil Padang.Obat-obat yang sering diberikan ke pasien yaitu obat hipertensi golongan Angiostensin Receptor Blocker (ARB) dan ACE-inhibitor.Obat ini diketahui dapat mempengaruhi kadar kalium pasien. Sehingga peneliti melakukan penelitian tentang Kajian Penggunaan Obat Golongan ARB atau ACE-inhibitor terhadap Kadar Kalium pada Pasien Hipertensi di Irna Penyakit dalam RSUP DR. M. Djamil Padang.Penelitian ini dilakukan dari bulan Mei hingga September 2013 di Irna Penyakit Dalam RSUP DR. M.Djamil Padang. Data pasien diambil dari rekam medik dan dilakukan secara observasi prospektif dengan metode judgement sampling dan dianalisa dengan statistic Two Independent Samples Test, K-independent Sample Test dan Chi Square Test. Dalam penelitian ini dilihat kadar kalium pasien selama satu bulan. Maka didapatkan hasil 50 orang pasien hipertensi yang terdiri dari 34 orang menggunakan obat golongan ARB (candesartan), dan 16 orang golongan ACE-inhibitor (15 orang ramipril dan 1 orang kaptopril). Pada penggunaan obat golongan ARB terjadi hiperkalemia sebanyak 5 orang, hipokalemia 4 orang dan kadar kalium normal 25 orang. Pada penggunaan obat golongan ACE-inhibitor terjadi hiperkalemia sebanyak 5 orang dan kadar kalium normal 11 orang. Sehinggapenggunaan  obat golongan ARB dan ACE-inhibitor dapat mempengaruhi kadar kalium pasien hipertensi dengan pasien hiperkalemia sebanyak 10 orang (20%), hipokalemia 4 orang (8%) dan kadar kalium normal sebanyak 36 orang (72%).  Hypertension is a disease that is often suffered by patients in the department of internal medicine Irna DR. M. Djamil Padang. The drugs are often given to patients are hypertensive drug classes Angiostensin Receptor Blockers (ARBs) and ACE-inhibitors. These drugs are known to affect the patient's potassium levels. Until researchers doing research on The Drug Utilization Review ARB and ACE-inhibitors on potassium rates of Hypertension in Patients IRNA disease in RSUP DR. M. Djamil Padang. This study was conducted from May to September 2013 in the department of Internal Medicine Irna DR. M.Djamil Padang. The data is taken from the patient's medical records and conducted a prospective observational judgment sampling method and statistically analyzed with Two Independent Samples Test, K-independent Sample Test and Chi Square Test. Seen in this study potassium levels of patients, then the calculated every week for a month. Then the results obtained 50 hypertensive patients comprising  consisting of 34 men using the ARB class of drugs (candesartan), and 16 of the ACE-inhibitor (15 persons ramipril and kaptopri 1 ). On the use of the ARB class of drugs occurs by 5 people hyperkalemia, hypokalemia 4 and 25 normal potassium levels. On the use of the ACE-inhibitor drugs occurred hiperkalemia of 5 and 11 normal potassium. So the use of the drug ARB and ACE-inhibitors can affect potassium hiperkalemia hypertensive patients with a total of 10 patients (20%), hypokalemia 4 (8%) and normal potassium rates by 36 people (72%).
PENGETAHUAN MAHASISWA S1 FARMASI UNIVERSITAS 17 AGUSTUS 1945 TERHADAP CARA PENGGUNAAN ANTIBIOTIK Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 1, No 2 (2016)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v1i2.807

Abstract

Penggunaan antibiotika yang tidak rasional saat ini semakin luas dan telah menjadi masalah yang penting di seluruh dunia.Karena efek samping yang di timbulkan dari penggunaan antibiotik yang tidak rasional adalah resistensi antibiotik, suprainfeksi, toksisitas antibiotik.Sehinga waktu pengobatan pasien menjadi lebih lama, biaya pengobatan meningkat, dan menurunnya kualitas kesehatan. Penelitian ini bersifat deskriptif kualitatif dan kuantitatif dan teknik pengumpulan sample menggunakan sample random dengan menggunakan rumus Slovin. Total responden dalam penelitian ini berjumlah 192 yang terdiri dari mahasiswa semester II, IV dan VI di Universitas 17 Agustus 1945 Jakarta. Para responden dekehendaki untuk mengisi indetitas  diri dan menjawab pertanyaan-pertanyaan di lembar kuesioner. Tingkat pengetahuan terhadap penggunaan antibiotika dan frekuensi penggunaan antibiotika di analisis menggunakan uji Chi-Square. Tujuan dari penelitian ini adalah untuk melihat pengaruh tingkat pengetahuan mahasiswa Universitas 17 Agustus 1945 terhadap penggunaan antibiotik. Hasil penelitian menunjukan bahwa tingkat pengetahuan mahasiswa farmasi Universitas 17 Agustus 1945 berhubungan dengan tingkat penggunaan antibiotik, sebab hasil analisa chi-squarediperoleh nilai p-value sebesar 0,003 dan nilai chi square sebesar 11,614. Karena nilai p-value < 0,05 maka H0 ditolak, artinya terdapat hubungan antara tingkat pengetahuan dengan kualitas penggunaan antibiotik pada mahasiswa.
DRUG THERAPY IN PATIENTS WITH GRADE 4 DEXTRA HIP OSTEOARTHRITIS WITH COMORBID HYPERTENSION AND TYPE 2 DIABETES MELLITUS Astiani, Rangki; Piter, Piter; Anggraeni, Ria; Luthfiana, Farisa; Sari, Dini Permata; Ramatillah, Diana Laila; Khan, Khasif
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8977

Abstract

Osteoarthritis (OA) is a chronic degenerative disease that affects the joints, especially heavy joints such as the knees and hips. OA often causes chronic pain and limited mobility, which is even more complex when accompanied by comorbid hypertension and type 2 diabetes mellitus. These comorbidities increase the risk of pharmacotherapy side effects and drug interactions, requiring a multidisciplinary approach and careful clinical pharmacy monitoring. The purpose of this report is to review the pharmacotherapy management of grade 4 OA Hip Dextra with comorbid HT and DMT2, assessing the safety, effectiveness, and role of clinical pharmacists in therapy optimization. A retrospective case study was conducted by analyzing the patient's medical records, including anamnesis, physical examination, laboratory, pharmacological therapy, and clinical response. The analysis was conducted based on the national guidelines of the Indonesian Ministry of Health, the 2021 National Formulary, PERKENI 2023, and PAPDI 2021. The patient was given combination therapy of NSAIDs, analgesics, prophylactic antibiotics, muscle relaxants, gastric protection, and supplementation for anemia. Therapeutic adjustments were made according to the patient's response and laboratory parameters. Clinical pharmacy monitoring ensures pain control, mobility, hemoglobin, and blood sugar. A multidisciplinary approach based on national guidelines has been shown to improve the safety and effectiveness of OA therapy with multiple comorbidities.
ANALYSIS OF CHEMOTHERAPY COSTS IN BREAST CANCER PATIENTS PARTICIPATING BPJS AT DHARMAIS CANCER HOSPITAL JAKARTA Piter, Piter; Astiani, Rangki; Monica, Kristin; Permatasari, Yuri
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.7773

Abstract

This study aims to find out how much chemotherapy costs for inpatient breast cancer chemotherapy patients participating in BPJS and whether there is a difference in real hospital costs compared to INA-CBGs rates. This research is a descriptive, observational study taken from secondary data, in the form of medical record data, laboratory data, INA-CBGs e-claim data and financial data on patient medical costs in accordance with the inclusion and exclusion criteria totaling 100 patient data. Data analysis uses One Sample T-test to see whether there is a significant difference between real costs and INA-CBGs rates. Based on the results of the One Sample T-test, it shows that there is a significant difference. According to the statistical results, a significance of p<0.005 was obtained in class 3 and there was no significant difference in class 1 or class 2. The average cost that breast cancer patients have to pay for each procedure chemotherapy, severity level I Rp. 7,129,348, severity level II Rp. 9,323,275 and severity level III Rp. 9,037,426.
REVIEW ARTIKEL: WAWASAN FARMAKOGENOMIK DAN BIOINFORMATIKA VARIAN GEN ACE DAN PENGARUHNYA TERHADAP RESPONS INHIBITOR ACE PADA HIPERTENSI Anggraeni, Ria; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9109

Abstract

Respons terhadap terapi antihipertensi berbasis angiotensin-converting enzyme inhibitors (ACEIs) bervariasi antar individu, yang sebagian besar dipengaruhi oleh faktor genetik. Gen ACE memiliki sejumlah polimorfisme yang dapat memengaruhi kadar enzim dan efektivitas terapi. Penelitian ini bertujuan mengeksplorasi hubungan antara variasi genetik pada gen ACE dan respons terhadap kaptopril, lisinopril, ramipril, dan enalapril pada pasien hipertensi. Penelitian ini menggunakan pendekatan bioinformatika dan farmakogenomik dengan menganalisis data dari PharmGKB, Ensembl, dan GTEx Portal. Polimorfisme genetik dianalisis untuk mengevaluasi keterkaitannya dengan efektivitas ACEI menggunakan pendekatan statistik deskriptif. Empat polimorfisme nukleotida tunggal (SNP) pada gen ACE ditemukan berasosiasi dengan respons terhadap ACEI. Varian rs4291 dan rs1799752 dikaitkan dengan efikasi kaptopril, di mana genotipe AA menunjukkan penurunan keparahan gagal ginjal. Varian rs1799752 juga terkait dengan lisinopril dan enalapril, dengan genotipe DD memberikan penurunan tekanan darah yang lebih besar. Selain itu, rs4359 dan rs4344 berkorelasi dengan efektivitas ramipril, terutama pada genotipe CC+TT dan AA+GG. Kesimpulan: Variasi genetik pada gen ACE berperan dalam menentukan respons terhadap terapi ACEI. Pendekatan farmakogenetik berpotensi meningkatkan efikasi dan keamanan pengobatan antihipertensi
Co-Authors Didit Sumardiyanto Farisa Luthfiana Firman Firman Halim, Guntoro Khan, Khasif Kristina, Eka Latief, Fahamsyah Hamdan Liandhajani, Liandhajani Monica, Kristin Muhammad Lukman Hakim, Muhammad Lukman Ningsih, Okta Via Nur Aini Budiyanti Permatasari, Yuri piter, piter Ramatillah, Diana Laila Ria Anggraeni Rizky, Permana Saidah, Andi Samor, Vania Amanda Sari, Dini Permata Seno, Kukuh Setiadi, Novan Sri Endah Susilowati Sukartiningsih, Yulita Vivian, Maria