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All Journal JBIO: jurnal biosains (the journal of biosciences) Galen: Jurnal Ilmu Farmasi dan Kesehatan
Rina Yunita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Uji Diagnostik Genexpert Mtb/Rif Di Rumah Sakit Umum Pusat Haji Adam Malik Medan Elva Susanty; Zainuddin Amir; Parluhutan Siagian; Rina Yunita; Putri Chairani Eyanoer
JBIO: jurnal biosains (the journal of biosciences) Vol 1, No 2 (2015): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v1i2.2783

Abstract

Background: Cases of multidrug resistant tuberculosis (MDR TB) is increasing in number in the world and requires early detection to prevent further transmission. GeneXpert MTB/RIF is a tool that can be used for detection of rifampicin resistance, as a surrogate marker for MDR TB. This study aims to assess the sensitivity and specificity of the GeneXpert MTB/RIF in diagnosis of MDR TB. Methods: diagnostic test study was conducted at a poly MDR TB General Hospital Haji Adam Malik Medan. The subjects were all suspected MDR TB who had results positive GeneXpert MTB/ RIF with sensitive rifampin or resistant  rifampin and had a drug sensitivity test results with the proportion method Lowenstein Jensen medium. Data retrieved from the medical records, between January until December 2013. Results: founded 64 samples that had results of GeneXpert MTB/RIF test positive and had the results of drug sensitivity, 87.5% of rifampin-resistant samples were also resistant to isoniazid. The GeneXpert MTB/RIF examination showed the sensitivity of 92.86% and the specificitu of 59.09%. Conclusion: GeneXpert MTB/ RIF has a high sensitivity for diagnosing MDR TB compared the gold standard drug sensitivity testing proportion method on Lowenstein Jensen medium. This study recommends the GeneXpert MTB/RIF be used for MDR TB screening tool. Keywords: GeneXpert MTB/RIF, multidrug resistant tuberculosis, drug susceptibility test, Lowenstein Jensen medium
Uji Aktivitas Ekstrak Etanol Daun Beriang (Ploiarium elegans korth ) Secara In Vivo sebagai Antidiabetes pada Mencit Putih Jantan (Mus Musculus) Rina Yunita; Delladari Mayefis; Aprilya Sri Rachmayanti
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.116

Abstract

Diabetes melitus merupakan suatu keadaan dimana gula darah dalam keadaan tinggi atau diatas normal dan perlahan namun pasti akan merusak jaringan dalam tubuh jika tidak ditangani secara tepat. Salah satu tumbuhan yang berpotensi untuk pengobatan tradisional sebagai antidiabetes adalah Beriang (Ploiarium elegans korth). Senyawa yang terkandung dalam daun beriang adalah alkaloid, flavonoid, tannin, saponin dan triterpenoid. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak etanol daun Beriang (Ploiarium elegans korth) dalam menurunkan kadar glukosa darah pada mencit putih jantan (Mus musculus). Metode yang digunakan dalam pengujian aktivitas antidiabetes ialah tes toleransi glukosa dengan mengamati aktivitas penurunan kadar glukosa pada mencit putih Jantan (Mus musculus) dengan dosis 100 mg/kg BB, 200 mg/kg BB, dan 300 mg/kg BB yang di induksi aloksan. Hasil penelitian ini menunjukkan bahwa daun Beriang memiliki aktivitas menurunkan kadar glukosa darah pada mencit hiperglikemia dengan rata-rata persentase dosis ekstrak daun Beriang 100 mg/kgBB yaitu 30,18%, 200 mg/kgBB yaitu 35,32%, dan 300 mg/kgBB yaitu 54,57%. Dari hasil tersebut dapat dikatakan bahwa pemberian ekstrak etanol daun beriang dapat menurunkan kadar glukosa darah secara signifikan yang ditunjukkan oleh hewan uji mencit.
Co-Authors Aprilya Sri Rachmayanti Delladari Mayefis Elva Susanty Parluhutan Siagian Putri Chairani Eyanoer, Putri Chairani Zainuddin Amir