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All Journal Sari Pediatri JOURNAL LA MEDIHEALTICO AKSONA Asian Journal of Health Research Prominentia Medical Journal
Nugraheni, Pramita Anindya
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Asian Journal of Health Research

 1 
Diagnostic and Treatment Challenges of Recurrent Tuberculosis in Patient with Drug-Induced Hepatotoxicity: A Case Report Devanda, Kasilda Pasha; Avelline, Kendraadine Dheayu; Lauwis, Keziah Queency; Kharizmatika; Hayati, Khofifah Bela Rachmanu; Adiwinoto, Ronald Pratama; Nugraheni, Pramita Anindya; Rasyida, Annisa Ullya
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.195

Abstract

Introduction: Pulmonary tuberculosis (TB) remains one of the most significant global health challenges, especially complicated by cases with incomplete treatment histories. The recurrence of TB poses diagnostic and therapeutic dilemmas that significantly impact patient outcomes. Case Presentation: We report a case of a 57-year-old female patient presenting with recurrent pulmonary TB after an incomplete treatment course. The patient's history revealed gaps in adherence to the prescribed TB regimen, leading to multiple relapses. In this study, we found that patients undergoing TB treatment may experience liver damage as a result of the TB medication, also known as DIH. Comprehensive diagnostic procedures, including chest radiography, sputum culture, and molecular testing, confirmed recurrent TB. The patient's clinical manifestations, treatment plan, and response to therapy are detailed. Conclusion: Recurrent TB is common, particularly in older adults, and is influenced more by environmental factors than occupation. Additionally, ATT poses risks of hepatotoxicity, especially in malnourished patients, underscoring the importance of managing side effects and addressing factors like malnutrition to prevent complications and improve outcomes. This case underscores the importance of complete adherence to TB treatment regimens and highlights the challenges in managing recurrent TB. It emphasizes the need for robust follow-up, patient education strategies, early diagnosis, and prompt intervention to prevent recurrence and enhance patient outcomes.
A Rare Pediatric Case of Dengue Hemorrhagic Fever with Encephalopathy and Suspected Subdural Hemorrhage Cempakasari, Aulia; Rahmawati, Tiara; Arifin, Alief Qobidh Al Bashor; Syahputri, Dewi; Hutami, Firdha Yekti; Prameswari, Renata; Nugraheni, Pramita Anindya; Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.262

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is a severe arboviral infection that rarely leads to neurological complications. Dengue encephalopathy, often secondary to metabolic disturbances or shock, presents a significant diagnostic and management challenge in the pediatric population. Case Presentation: We report the case of a 4-year-3-month-old obese girl presenting with fever, gastrointestinal symptoms, and progressively decreasing consciousness (apathetic). Diagnosis of DHF was confirmed by a positive NS1 antigen test, severe thrombocytopenia (nadir 14,000/µL), and hemoconcentration with pleural effusion. Hepatic involvement was noted (SGOT 117.81 U/L). Neurological involvement was characterized by clinical encephalopathy, and a head CT scan revealed hyperdense lesions suspecting subdural hemorrhage (SDH). The patient required multidisciplinary management in the Intensive Care Unit (ICU) for supportive fluid therapy, inotropic support (Dobutamine), and platelet transfusion. The patient showed marked clinical improvement and was discharged on day nine. At a two-week post-discharge follow-up, she demonstrated full cognitive and motor recovery with no neurological sequelae Conclusion: This case highlights the critical need for clinical vigilance for rare, simultaneous neurological complications (encephalopathy and suspected SDH) in pediatric DHF. It underscores that early diagnosis and aggressive, multidisciplinary supportive care can lead to complete recovery even in severe presentations.
Co-Authors Adnyana , I Made Dwi Mertha Agustin, Renny Arifin, Alief Qobidh Al Bashor Avelline, Kendraadine Dheayu Cempakasari, Aulia Devanda, Kasilda Pasha Hadi, Rifqi Athaya Vinanta Hayati, Khofifah Bela Rachmanu Hendrawan, Michelle Herdiyantini, Mita Hutami, Firdha Yekti Kharizmatika Lauwis, Keziah Queency Miranda, Stefani Novitania, Milleniawati Putri Oktavia, Reza Mardiana Ayu Putri, Fransisca Dian Nathania Rahmawati, Tiara Rantika, Rheina Hasna Rasyida, Annisa Ullya Renagupita, Melani Sinastri Renata Prameswari Risma Risma, Risma Ronald Pratama Adiwinoto Setiabudi, Martin Panglipuringtyas Syahputri, Dewi UNTARI, NI KOMANG SRI DEWI Utami, Rina Mega Widisaputro, Michael Deni