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All Journal Paediatrica Indonesiana JURNAL FARMASIMED (JFM) Best Journal (Biology Education, Sains and Technology) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Malisie, Ririe Fachrina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Potential risk factors of pediatric acute respiratory distress syndrome in sepsis Saragih, Kezia Theofani; Malisie, Ririe Fachrina; Daulay, Rini Savitri; Sitepu, Bobby Ramses Erguna
Paediatrica Indonesiana Vol 64 No 3 (2024): May 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.3.2024.193-201

Abstract

Background Sepsis in children is characterized by a dysregulated host response to infection and life-threatening organ dysfunction. Pediatric acute respiratory distress syndrome (PARDS) is a severe complication of sepsis. Several known risk factors of PARDS are immunodeficiency, obesity, source of infection, and genetic factors. Objective To describe the potential risk factors of PARDS in septic children at Haji Adam Malik General Hospital, Medan, North Sumatera. Methods This descriptive study using eligible medical record data from sepsis patients aged 1 month – 18 years was conducted at Haji Adam Malik General Hospital in 2020–2022. A total sampling method was used for subject selection. Patients’ demographic and clinical characteristics, mechanical ventilation modes and parameters, laboratory results, and outcomes were collected from medical records. Patients were classified as having sepsis with PARDS if Pediatric Acute Lung Injury Consensus Conference (PALICC) criteria of ARDS was met. Results Of 112 pediatric sepsis patients, 33.9% developed PARDS. The mortality rates for PARDS was 73.7%. Of the patients with PARDS, 57.9% had immunodeficiency, 60.5% patients had an intrapulmonary infection, 39.5% had an extrapulmonary infection, and 23.7% of patients had a suspected genetic disorder. In addition, 39.5% had good nutritional status, followed by 21.1% with obese. Conclusion The majority of patients with PARDS have intrapulmonary infection and immunodeficiency. Some of patients with PARDS have suspected genetic disorders and well nourished.
Emergency Profile of Pediatric Patients Based on Pediatric Early Warning Score in the Emergency Department of the Adam Malik Hospital Danau Arta, Grace; Malisie, Ririe Fachrina; Wahyuni, Arlinda Sari; Prapiska, Fauriski Febrian; Siregar, Irma Sepala Sari
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 2 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i2.14952

Abstract

Background: High morbidity and mortality rates in pediatric patients indicate the necessity of a Pediatric Early Warning Score (PEWS) capable of early clinical deterioration identification and providing an opportunity for healthcare professionals to promptly manage patients. This study aimed to serve as foundational data and as an evaluative tool to enhance the proficiency of healthcare workers in assessing patient deterioration. Methods: This study utilized a descriptive method with a cross-sectional design and consecutive sampling technique who were treated from January to December 2022.   Results: there were 119 samples, the majority of gender was male (54.6%), the majority of the age group was 1-4 years old (37.8%), and the majority of the disease group was infection (31.1%). Both male and female majority had green PEWS (54.6%) and (45.4%), the majority of patients with an age range of 1 month to 5 years had red PEWS, the majority of infectious disease group had green PEWS, and the majority of patients with green PEWS had discharge outcome.   Conclusion: This study provides an overview of characteristics in pediatric patients and shows the majority of pediatric emergency department patients come with non-emergency conditions.  
The Quality of Life and the Hypoxia Indicator in Survivor of Pediatric Intensive Care Unit in the University of Sumatera Utara Hospital Malisie, Ririe Fachrina; Tanjung, Ika Citra Dewi
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 6 No. - (2022): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v6i-.124

Abstract

The technology development for care and management in intensive care units reduces mortality and increases survivors' survival rate and life expectancy. A significant decrease in mortality rate in patients was related to mechanical ventilation. The hypoxia degree and severity of the respiratory distress are the increase of PaO2/FiO2 ratio and decrease of oxygenation index as predictors of oxygenation sufficiency in arterial blood supply to body tissues. The critical parameter of intensive care unit survivors' quality of life is the Pediatric Quality of Life (PedsQL) Inventory score after survival from the pediatric intensive care unit (PICU). During six months of research observation, eight patients died, and 13 patients survived among 68 patients admitted to pediatric intensive care unit who have ventilatory support. The mean PaO2/FiO2 ratio (PFR) in pediatric intensive care survivors who underwent mechanical ventilation was 285, and the mean Oxygenation Index (OI) was 5.07. There was no relationship between PFR and OI with PedsQL score in this study, but we have found a significant correlation between PedsQL and the duration of mechanical ventilation and length of stay in the intensive care unit. The longer mechanical ventilation duration and length of stay in PICU, the lower the pediatric quality of life score.
Relationship Of Incidence Of Frailty With Metformin Consumption Habits In Elderly Type-2 Diabetes Mellitus Patients. Irwanto, Agus; Ardinata, Dedi; Malisie, Ririe Fachrina
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.7649

Abstract

Type 2 diabetes (T2DM) was characterised with insulin resistance and deficiency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was limitless literature and theorical that showed the relationship of metformin therapy to frailty syndrome. This study aimed to explore the possibility of metformin protective effect on frailty syndrome. This research method uses structured descriptive analysis with literature review. Article Data both original article, research article, Review article and case report are collected to be analyzed in accordance with the purpose of the title and writing of this article. Type 2 Diabetes mellitus is characterized by insulin resistance and deficiency which had happened several decades earlier, in addition to the incidence of insulin resistance will also increase. On some clinical studies that have been conducted, insulin resistance and type 2 Diabetes mellitus, it has been shown to increase the number of occurrences of frailty syndrome in old age. Conclusion Metformin was shown to have protective effect against frailty syndrome in elderly diabetic
Thoracic CT Scan Image in Transudate and Exudate Pleural Effusion Cases at Haji Adam Malik General Hospital Medan in January - September 2024 Lokman, Yovita Belva; Putra, Dedy Dwi; Tarigan, Setia Putra; Malisie, Ririe Fachrina
Journal of Society Medicine Vol. 3 No. 12 (2024): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v3i12.185

Abstract

Introduction: Pleural effusion is the most common pleural disease, typically diagnosed through thoracentesis. However, thoracentesis carries risks of complications. Chest CT scans offer a non-invasive alternative to assess pleural effusion and distinguish between exudate and transudate types. Methods: This retrospective cross-sectional study was conducted on patients with pleural effusion at Haji Adam Malik General Hospital, Medan. A total of 80 patients were included. Statistical analysis was performed to evaluate the correlation between demographic, clinical, and thoracic CT findings with the type of pleural effusion. The Mann-Whitney test determined the efficacy of attenuation values in differentiating exudate and transudate. Results: Of the 80 patients, 57 (71.3%) had exudative pleural effusion and 23 (28.7%) transudative. The sample comprised 43 males (53.8%) and 37 females (46.3%), with a mean age of 48.44 ± 18.532 years (range: 2–84 years). Significant correlations were found between the etiology of pleural effusion and pleural nodules with effusion type (p = 0.000 and p = 0.023, respectively). No significant correlations were observed between age, gender, or other CT findings with effusion type (p > 0.05). Attenuation values on CT scans effectively distinguished exudative from transudative effusion (p = 0.000). A cutoff attenuation value of 17.5 Hounsfield Units (HU) demonstrated an AUC of 0.887, with 84.2% sensitivity and 82.6% specificity. Conclusions: Thoracic CT scans are effective for differentiating exudative and transudative pleural effusion. Significant differences were identified in etiology, pleural nodules, and attenuation values, supporting the use of CT imaging as a non-invasive diagnostic method
A Review: Propolis As An Antiinflammatory Adjunct Therapy in Chronic Kidney Disease Depari, Elpiani; Malisie, Ririe Fachrina
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2613

Abstract

Chronic Kidney Disease (CKD) is a disease with abnormalities of the structure and function of kidney that last for at least 3 months and has an impact on health. Inflammation is a progression factor and outcome of CKD. Diabetes, hypertension, cardiovascular disease, exposure to environmental pollution and use of nephrotoxic drugs develop into CKD through inflammation. Inflammation in CKD caused complications in cardiovascular disease, bone mineral disorders, anemia and immune disorders, as well as reducing the patient's quality of life. Cardiovascular complications are the main cause of CKD patients’ death. Renal replacement therapy such as hemodialysis is not effective enough to overcome the inflammation, because unable to remove intermediate molecules and protein-bound molecules, the majority of which are inflammatory markers such as cytokines, namely TNF-?, IL-1, IL-6 and others. Propolis, a natural bee resin product, has anti-inflammatory effects, because it contains many bioactive phytochemicals such as flavonoids, phenolic acids, esters, diterpenes, aromatic aldehydes, amino acids, fatty acids, vitamins and minerals. It inhibits the production and release of cytokines through inhibiting NF-kB (nuclear factor kappa Beta) activity, reducing COX-2 expression and inhibiting nitric oxide (NO). Many clinical trials of propolis in CKD have been carried out and reported safe and beneficial, including in patients undergoing dialysis. Propolis has been proven able to reduce several inflammatory markers, such as TNF-?, interleukin and others. It has great potential as a safe additional therapy in CKD patients, both dialysis and non-dialysis.
Co-Authors Agus Irwanto Ardinata, Dedi - Bobby Ramses Erguna Sitepu Danau Arta, Grace Dedy Dwi Putra, Dedy Dwi Depari, Elpiani Fauriski Febrian Prapiska, Fauriski Febrian Irma Sepala Sari Siregar Lokman, Yovita Belva Rini Savitri Daulay, Rini Savitri Saragih, Kezia Theofani Tanjung, Ika Citra Dewi Tarigan, Setia Putra Wahyuni, Arlinda Sari