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Hubungan Polimorfisme Gen ACTN-3 (R577X) dengan Daya Ledak Otot pada Siswa Sekolah Sepakbola di Medan Hutahaean, Martina Evlyn Romauli; Tarigan, Amira Permata Sari; Ardinata, Dedi -
Jurnal Kedokteran Brawijaya Vol 30, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2018.030.02.8

Gen ACTN-3 merupakan gen yang mengkode sebuah protein sarkomer yang hampir secara keseluruhan diekspresikan dalam serat otot cepat dan menghasilkan daya ledak otot. Daya ledak (power) adalah kemampuan otot untuk mengatasi tahanan beban dengan kekuatan dan kecepatan tinggi dalam suatu gerakan yang utuh. Daya ledak merupakan komponen penting dalam olahraga sepakbola. Variasi genotif (polimorfisme) ACTN-3 (R/X) cenderung memiliki daya tahan yang lebih baik. Tujuan penelitian ini untuk menganalisis hubungan antara varian genotif ACTN-3 (polimorfisme) dan daya ledak otot. Subjek penelitian ini adalah siswa sekolah sepakbola berusia 11-14 tahun yang berjumlah 33 orang. Daya ledak otot diukur menggunakan tes standing broad jump. Varian genotif (polimorfisme) gen ACTN-3 diidentifikasi menggunakan PCR-RFLP dari sampel sel bukal. Uji Fisher Exact digunakan untuk mengetahui hubungan antara polimorfisme gen ACTN-3 dengan daya ledak otot. Hasil studi menunjukkan varian genotif ACTN-3 yang memiliki alel R cenderung menunjukkan daya ledak otot kategori diatas rata-rata dan tinggi, sementara varian genotif yang memiliki alel X lebih banyak menunjukkan daya ledak otot dalam tingkat rata-rata. Penelitian ini menunjukkan bahwa secara statistik ada hubungan signifikan antara polimorfisme gen ACTN-3 dengan daya ledak otot pada siswa sekolah sepakbola kota Medan (p<0,001) dengan kekuatan korelasi kuat (c=0,623).

The Effect of pncA Gene Mutation of Mycobacterium Tuberculosis to Transaminase and Uric Acid Serum in MDR TB Patient Yeni Vera; Bintang YM Sinaga; Dedi Ardinata; Yahwardiah Siregar
Jurnal Respirologi Indonesia Vol 38, No 3 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Bacground: The common side effects of PZA treatment is the occurrence of hepatotoxicity and blocking the secretion of uric acid. This study aims to determine the effect of the pncA gene mutation of Mycobacterium tuberculosis to serum transaminase and serum uric acid in patients with MDR TB who had receive therapy with PZA. Methods: Quasi-experimental test was conducted at MDR TB polyclinic in H. Adam Malik Medan Hospital of 25 patients with MDR TB. Mutations of genes was assessed by PCR-RFLP method and data of serum transaminase and serum uric acid retrieved from the medical records, between February until June 2015 Result: Thirtysix percent pncA gene mutation founded. Significance statistic test between mutation of pncA gene and SGOT serum in baseline Vs 4 weeks (P=0,007), baseline Vs 8 weeks (P=0,023) and uric acid serum baseline Vs 4 weeks (P=0,011). No statistically difference in SGPT serum. No correlation between pncA gene (mutation and no mutation) with transaminase serum and uric acid serum. Conclusion: Transaminase serum and uric acid elevated in MDR TB patient with mutation in pncA gene.Mutation in pncA gene have a correlation with elevated SGOT serum compared between baseline, 4 and 8 weeks. No correlation between pncA gene mutation and SGPT. Mutation in pncA gene have a correlation with uric acid serum elevated in 4 weeks. No correlation between pncA gene (mutation and no mutation) with transaminase serum and uric acid serum elevated.

Terapi Pijat Punggung Effleurage terhadap Intensitas Nyeri Akut Pasca Bedah Fraktur Tulang Panjang Lubis, Yuni Suharnida; Tanjung, Dudut; Ardinata, Dedi
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.8697

This study examines the effect of effleurage back massage therapy on the intensity of acute pain after long bone fracture surgery. This research method is true experimental with a pretest-posttest control group design. The results showed a significant difference between the NSAID and NSAID groups with effleurage with a p-value <0.05. The range of changes in VAS in the NSAID group with effleurage tended to be higher than in the NSAID group on days 3 and 4. The conclusion is that NSAIDs with effleurage are effective in reducing the intensity of acute pain in patients after long bone fracture surgery and are recommended as a nursing intervention. Independently to ease the pain intensity of fracture patients. Keywords: Effleurage, Fracture, Pain

Plasma Sirt-1 Level in Various Frailty Degree in Elderly Outpatients at Prof. Chairudin P. Lubis Hospital, Medan Fadhilah Hayati; Dedi Ardinata; Nuraiza Meutia; Ririe Fachrina Malisie; Muhammad Ichwan
International Journal of Ecophysiology Vol. 5 No. 2 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i2.13681

Frailty is a physical aging syndrome characterized by health vulnerability. Diagnosis is established incorrectly based on three or more of the five criteria: weakness, decreased walking speed, fatigue, decreased physical activity, and weight loss. Sirtuin 1 plays a role in weakness, particularly in the elderly, acting as a protective factor during weakness, and its activation could provide a novel therapeutic approach. However, research in this area is still very limited. A cross-sectional method with observation or measurement of study subjects was employed in this research, involving a total of 118 elderly subjects selected through non-probability sampling. Pearson correlation test indicates a relationship between the polymorphism genotype (rs2273773) in the SIRT1 gene and the frailty scale (p-value < 0.05), while no relationship was found between plasma SIRT1 levels and the frailty scale (p-value > 0.05). Furthermore, the F-test reveals a significant simultaneous relationship between the polymorphism genotype (rs2273773) and plasma SIRT1 levels with frailty (p-value < 0.05).

Relationship Of Incidence Of Frailty With Metformin Consumption Habits In Elderly Type-2 Diabetes Mellitus Patients. Irwanto, Agus; Ardinata, Dedi; Malisie, Ririe Fachrina
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.7649

Type 2 diabetes (T2DM) was characterised with insulin resistance and deficiency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was limitless literature and theorical that showed the relationship of metformin therapy to frailty syndrome. This study aimed to explore the possibility of metformin protective effect on frailty syndrome. This research method uses structured descriptive analysis with literature review. Article Data both original article, research article, Review article and case report are collected to be analyzed in accordance with the purpose of the title and writing of this article. Type 2 Diabetes mellitus is characterized by insulin resistance and deficiency which had happened several decades earlier, in addition to the incidence of insulin resistance will also increase. On some clinical studies that have been conducted, insulin resistance and type 2 Diabetes mellitus, it has been shown to increase the number of occurrences of frailty syndrome in old age. Conclusion Metformin was shown to have protective effect against frailty syndrome in elderly diabetic

Therapeutic potential of thymoquinone in regulating p63, claudin, and periostin in chronic rhinosinusitis with nasal polyps: An animal model study Ulfa, Loriana; Munir, Delfitri; Rambe, Andrina YM.; Farhat, Farhat; Wardani, Retno S.; Amin, Mustafa M.; Zahara, Devira; Ardinata, Dedi
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1728

High recurrence rate and the necessity for repeated surgical interventions contribute to the chronicity and treatment-resistant nature of chronic rhinosinusitis with nasal polyps (CRSwNP). Thymoquinone, known for its protective effects on epithelial integrity, has not been previously explored in CRSwNP. The aim of this study was to investigate the therapeutic potential of thymoquinone to restore epithelial integrity by assessing p63 transcription factor and claudin protein expressions, as well as periostin mRNA expression in an animal model. An in vivo study using post-test-only control group design was conducted in which male Wistar rats were randomly assigned to three groups, each consisting of 10 animals: healthy group, CRSwNP group, and thymoquinone-treated group for three weeks. Immunohistochemistry was used to analyze the p63 and claudin protein expressions, while periostin mRNA expression was quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR). This study found that thymoquinone significantly reduced p63 transcription factor expression compared to the untreated CRSwNP group (p=0.009). Claudin protein expression was significantly higher in thymoquinone-treated group compared to CRSwNP group (p=0.007), indicating improved epithelial barrier function. Periostin mRNA expression showed no significant difference between healthy and thymoquinone-treated groups (p=0.564), but a significant decrease was observed in CRSwNP group compared to thymoquinone-treated group (p=0.000) and between the healthy and CRSwNP groups (p=0.002), suggesting attenuation of tissue remodeling and inflammation. In conclusion, thymoquinone could enhance sinonasal epithelial barrier integrity in CRSwNP by downregulating p63 transcription factor, upregulating claudin protein expression, and reducing periostin mRNA expression. These findings emphasize the potential of thymoquinone as a therapeutic agent to mitigate inflammation and tissue remodeling in CRSwNP, warranting further investigation as a novel treatment option.

The relationship between pain intensity and sleep quality in various type of elective postoperative patients at Prof. Dr. Chairuddin P. Lubis USU Medan Hospital Tarigan, Randi Joel Oktavianus; Lubis, Andriamuri Primaputra; Ardinata, Dedi; Ketaren, Aga Shahri Putera
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 2 (2025): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i2.2659

Background: Postoperative pain arises after surgery and includes acute pain that needs to be treated immediately. The postoperative phase must always be observed because it relates to the patient's recovery process. The prevalence of postoperative pain varies widely around the world, with the United States at 86%, Europe at 70%, and China at 48.7%. The prevalence of postoperative pain in Indonesia has not been studied as a whole.Objectives: The research aims to analysed the relationship between pain intensity and sleep quality in elective postoperative patients at Prof. dr. Chairuddin P. Lubis USU Medan Hospital.Methods: The research used an analytical observation using a cross-sectional approach with a consecutive sampling design. Respondents' data was collected only once and simultaneously using the Numeric Pain Rating Scale (NRS) and Pittsburgh Sleep Quality Index (PSQI) questionnaires. The data will be analysed using the Statistical Package for the Social Sciences (SPSS), including Somers'd test.Results: Based on the analysis of 125 respondents' data, the highest experienced pain intensity by patients was moderate pain intensity with 49,6%, mild pain intensity with 38,4%, and severe pain intensity 12%. In the sleep quality, the poor sleep quality group was the highest, with 54,4% and the good sleep quality group 45,6%. Respondents in this research were majority aged 26–35 years with 37 respondents. This analysis shows a significant relationship and very strong correlation between pain intensity and sleep quality (p-value <0,001 and r = 0,789).Conclusion: There is a relationship between pain intensity and sleep quality in elective postoperative patients at Prof. dr. Chairuddin P. Lubis USU Medan Hospital.

Anti-inflammatory and Anti-infertility Effects of Ethanol Extract of Turmeric (Curcuma longa) in Male Wistar Rats with Type 2 Diabetes Mellitus Induced by Streptozotocin-Nicotinamide-High Fat Diet Vivian, Vivian; Lim, Hadyanto; Siahaan, Jekson Martiar; Anto, Endy Juli; Ilyas, Syaffrudin; Ardinata, Dedi
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.891

Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with chronic inflammation and male reproductive dysfunction. The ethanol extract of turmeric (Curcuma longa) has demonstrated potential as an alternative therapeutic agent due to its anti-inflammatory and reproductive restorative properties. This study aims to analyze the anti-inflammatory and anti-infertility effects of the ethanol extract of Curcuma longa in male Wistar rats with T2DM induced by a streptozotocin-nicotinamide-high fat diet (STZ-NA-HFD). Subjects and Method: Thirty male Wistar rats were randomized into six groups (n=5): normal control (K1), diabetic control (K2), positive control (T2DM + metformin 45 mg/kgBW, K3), and three treatment groups receiving Curcuma longa extract at doses of 50 mg/kgBW (K4), 100 mg/kgBW (K5), and 150 mg/kgBW (K6). Diabetes was induced with STZ (55 mg/kgBW) and nicotinamide (120 mg/kgBW). Blood glucose, IL-6, testosterone levels, sperm count, and sperm motility were evaluated after 21 days of treatment. Results: The turmeric extract significantly reduced blood glucose levels (p<0.001) and IL-6 concentrations from 574.06±68.99 to 214.06±78.71 ng/mL at a dose of 150 mg/kgBW (p<0.001). Normal sperm motility increased significantly at 150 mg/kgBW (20.0±2.55%) compared to the diabetic control (8.40±2.07%) (p=0.008). Conclusion: The ethanol extract of Curcuma longa demonstrated significant anti-inflammatory activity by reducing IL-6 levels and improving glycemic control. Its anti-infertility effect was reflected by enhanced sperm motility, particularly at the 150 mg/kgBW dose. These findings indicate that Curcuma longa possesses potential as an adjuvant therapy for the management of T2DM and its associated complications.

Relationship Of Incidence Of Frailty With Metformin Consumption Habits In Elderly Type-2 Diabetes Mellitus Patients. Irwanto, Agus; Ardinata, Dedi; Malisie, Ririe Fachrina
BEST Journal (Biology Education, Sains and Technology) Vol 6, No 2 (2023): September 2023
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v6i2.7649

Type 2 diabetes (T2DM) was characterised with insulin resistance and deficiency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was limitless literature and theorical that showed the relationship of metformin therapy to frailty syndrome. This study aimed to explore the possibility of metformin protective effect on frailty syndrome. This research method uses structured descriptive analysis with literature review. Article Data both original article, research article, Review article and case report are collected to be analyzed in accordance with the purpose of the title and writing of this article. Type 2 Diabetes mellitus is characterized by insulin resistance and deficiency which had happened several decades earlier, in addition to the incidence of insulin resistance will also increase. On some clinical studies that have been conducted, insulin resistance and type 2 Diabetes mellitus, it has been shown to increase the number of occurrences of frailty syndrome in old age. Conclusion Metformin was shown to have protective effect against frailty syndrome in elderly diabetic

Effectiveness of virtual reality positive self-talk on changes in brain wave activity among patients with breast cancer undergoing chemotherapy: a randomized controlled trial Harahap, Ikhsanuddin Ahmad; Nasution, Azizah; Harahap, Urip; Ardinata, Dedi
Jurnal Ners Vol. 21 No. 1 (2026): VOLUME 21 ISSUE 1 (FEBRUARY 2026)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v21i1.78907

Introduction: Patients with breast cancer undergoing chemotherapy often experience pain, cognitive impairments, and changes in brainwave activity. This study evaluated the efficacy of Virtual Reality Positive Self-Talk (VR-PST) on changes in brain wave activity in breast cancer patients undergoing chemotherapy. Methods: A single-blind randomized controlled clinical trial was conducted involving 92 patients with breast cancer undergoing chemotherapy, who were randomly assigned to the VR-PST intervention group (n = 46) and the control group (n = 46). Participants in the VR-PST group received five intervention sessions conducted over a two-week period, consisting of structured cognitive self-talk presented in a virtual reality environment (VR-PST), while the control group received standard care. Brain wave activities in both groups were measured using the Muse 2 electroencephalographic (EEG) device before and after the intervention. Results: There were shifts in brain waves from delta to alpha waves in both groups, indicating relaxation; however, the VR-PST group showed a more dominant increase in beta waves. The VR-PST group demonstrated a trend toward greater cognitive activation; however, Fisher’s Exact Test showed that the difference between the groups was not statistically significant (p = 0.052). Conclusions: Although the difference was not statistically significant, the observed trend of increased beta-wave activity in the VR-PST group suggests a possible enhancement of cognitive activation. However, this finding should be interpreted with caution, and further studies are required to confirm this effect.

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