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All Journal SAINSTIS El-QUDWAH Biogenesis: Jurnal Ilmiah Biologi INDONESIAN JOURNAL OF PHARMACY Jurnal Biodjati Indonesian Journal of Cardiology Berkala Penelitian Hayati
Retno Susilowati
Department Of Biology, Faculty Of Science And Technology, Maulana Malik Ibrahim Islamic State University Of Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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 1 
HABBATUS SAUDAH SEBAGAI AMELIORAN FUNGSI PANKREAS PADA MENCIT DIABETES Retno Susilowati
El-QUDWAH El-Qudwah (04-2006)
Publisher : lp2m-uin malang

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Abstract

The aims of this study are to inventory potential of Habbatus Saudah (Nigella sativa L.) to maintain pancreas B Cells, reduced blood glucose, and increases body weight diabetic mellitus patient induced by streptozotocin (STZ). STZ as antibiotic agent has a sitotoxic effect and light carcinogenic. Injection STZ cause damages Beta cells and reduce insulin secretion.  Fifteen mice 60 days old with 30-31 grams bodyweight are separate into 4 groups: Diabetic group (D), treatment group (DH), treatment control (KH) and Blanco control (K) respectively. Diabetic rats are subcutaneous injected by streptozotocin (STZ) with dose 50 mg/bw. Treatment group added habbatus saudah seed crushed 4 g/kg feed ad libitum a week after injection, for 30 days treatment. The result shows that habbatus saudah has a potential pancreas ameliorant in mice, reduce blood glucose (p 0, 01) and increase mice bodyweight (p 0, 05). Key words: Mice, Ameliorant, Diabetic, blood glucose, bodyweight, streptozotocin, Habbatus saudah, Nigella sativa L.
PENGARUH AKUT DIET ATEROGENIK TERHADAP PROFIL LIPID DAN LIPOPROTEIN-PHOSPHOLIPASE A2 Retno Susilowati
El-QUDWAH El-Qudwah (10-2010)
Publisher : lp2m-uin malang

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Abstract

Atherosclerosis is the primary cause of vascular disease is often fatal as coronary heart disease and stroke. The disease is common in chronic and critical stage, this is due partly because the method of early detection of atherosclerotic disease is less effective and clinical symptoms emerged after at this stage even more critical. Atherosclerosis is a chronic disease and occurs in old age, this causes most of atherosclerosis research conducted only on the chronic exposure for 3 months. Therefore needs to be an early marker of atherosclerosis through the observation of the major risk factors of atherosclerosis (lipid profile) in the early exposure (≤ 1 month or less) at a young age. The enzyme Lp-PLA2 is a non-conventional risk factors found in the latest, the activity produces sdLDL with the result also need to be assessed in the presence acute exposure of diet hypercholesterolemic. The research is an experimental research using mice (Mus musculus) aged 2 months with weight on average 200g, divided into two groups namely the control and treatment group of atherogenic diet. Diet treatment was given 4 weeks. At the end of the study, total cholesterol, triglycerides, LDL, HDL and apoB levels to be measured. To find the difference of these parameters, the data are tested using the test T. In addition, related atherogenic diet influence on plasma Lp-PLA2 conducted literature review and descriptive analysis of Lp-PLA2. The results showed that diet affects lipoprotein  metabolism characterized by very significance effects (p 0.01) increased levels of total cholesterol, triglycerides, LDL and significantly (p 0.05) lower HDL cholesterol in the blood of mice at exposure for 4 weeks. Atherogenic diet has not shown its impact on apoB levels, which allegedly also had influence on levels of Lp-PLA2 in plasma 4 weeks, but based on literature studies, and levels of Lp-PLA2 activity has increased the exposure of cholesterol and diabetes for a month.
Co-Authors Amalia Rizka Diana Askandar Tjokroprawiro Djanggan Sargowo Djanggan Sargowo Evika Sandi Savitri Hadya, Chorida Muhjatul Huwaida, Fadhila Isma Kholifah Holil Ma'arif Z.A, Burhan Nailirrohmah Hidayatin Rahmi Annisa Ramadhani D.A., Ria Rasjad Indra Roihatul Mutiah Sri Widyarti Taufik, Imam Tri Kustono Adi Ulfa Maynisa Rohmanningrum Weka Sidha Bhagawan Yen Yen Ari Indrawijaya