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Machrumnizar, Machrumnizar
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Molecular Identification of Cryptococcus neoformans Isolates from House Environments of HIV-Infected Patients in an Urban Area, Indonesia: A First Report Machrumnizar, Machrumnizar; Adawiyah, Robiatul; Natriana, Tjahjani; Imran, Darma; Muslim, Mohammad; Wellyzar, Sjamsuridzal; Wahyuningsih, Retno
Makara Journal of Science Vol. 26, No. 2
Publisher : UI Scholars Hub

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Abstract

Cryptococcus neoformans isolates were previously obtained from pigeon droppings in Jakarta. This study aimed to determine another source of infection and describe the supporting niche of the fungus. The occurrence of C. neoformans was evaluated in 110 samples of decaying wood and leaves, tree hollow debris, dust, and bird droppings. Yeasts isolates were collected from 22 houses of HIV-infected patients. The isolates were identified based on culture characteristics, an assimilation test, and URA5 restriction fragment length polymorphism polymerase chain reaction. The spatial analysis was conducted in geographical information system to determine dominant house and environmental factors. Seven of the 120 isolates (5.83%) were identified as C. neoformans, corresponding to four (18.2%) houses. All isolates were from house environments of HIV-infected patients with cryptococcal meningitis. Spearman’s correlation analysis and McNemar’s test revealed a significant association between cryptococcosis in HIV-infected patients and their environment. The clinical and environmental isolates were 100% identical based on molecular techniques, indicating that the patients acquired cryptococcosis from the environment. The spatial analysis revealed that house dust, soil, and leaves were the dominant distribution factors in terms of estimating disease prevalence. This study demonstrates that the house environment is a source of infection for cryptococcosis.
SKORING CORONARY ARTERY CALSIUM PADA INDIVIDU USIA DEWASA AKHIR DAN LANSIA DENGAN HIPERTENSI Adnyana , Putu Suryabrata; Machrumnizar, Machrumnizar
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 8, Nomor 2, Juli 2023
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v8i2.15556

Abstract

Hypertension causes an increase in coronary artery calcium (CAC), which is a strong predictor of new-onset hypertension and occurrences related to atherosclerotic cardiovascular disease in people either with or without hypertension. The medical application of CAC scoring to adjust hypertension management has received slight attention and is poorly defined. In Indonesia, research on the benefits of CAC assessment for hypertension is yet very limited. This study will show the association of hypertension with CAC rating, age, and gender. This cross-sectional study used secondary data in the form of medical records from 163 patients (88 men, 75 women; range 40-70 years) at Siloam Hospital TB Simatupang. Sample collection was carried out using consecutive nonrandom sampling. Only medical records with complete physical examination results and CAC scoring will be further analyzed. The Mann-Whitney statistical test was carried out using the SPSS 25.0 program to see the relationship between CAC scoring and hypertension, with a value of p=0.002 and a significance level of p<0.05. To assess the relationship between age and gender with the incidence of hypertension, a chi square test was carried out, with each value p = 0.011 and p = 0.141 (p <0.05). The results showed a relationship between CAC scoring and hypertension in late adulthood and elderly individuals.
Monosodium Glutamat (MSG) dan Gambaran Histologis Otak: Implikasi terhadap Pembentukan Otak Mencit Tan, Suriyani; Machrumnizar, Machrumnizar; Yunus Slamet, Muhamad Andanu
Sanus Medical Journal Vol. 5 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.11335

Abstract

Abstract BACKGROUND The sodium salt of glutamic acid, monosodium glutamate (MSG), is a white crystalline compound (glutamic acid). MSG was first produced in large quantities in early 1963 by Korea and Japan which then spread to other countries, including Indonesia. The medical profession is concerned about the detrimental consequences of MSG because of its widespread and uncontrolled consumption. The histological differences between the cerebellum of MSG-treated and MSG-free rats are of interest to researchers. METHOD The Post Test-Only Control Group design was used in this study and used data collected for 14 days. This study used 30 male mice of the Swiss Webster type (Mus Musculus) which were reared as pure strains through inbreeding. Mice taken were 8 weeks old weighing 20 – 40 grams and divided into three groups, each consisting of nine mice with one tail in reserve for each group. One group as a control and two groups will receive MSG orally, each at a dose of 3 mg and 8 mg. Termination of mice was carried out by means of dislocation of the cervical vertebrae and continued with preparation of mice brain tissue preparations. Data analysis, which was obtained from observing the histological appearance of the mouse brain, used the Paired-Sample T test in the SPSS (Statistical Product and Service Solutions) version 20.0 for Windows with a significance level of 0.05. RESULTS In this study, there was no difference in the histological appearance of the brain cerebellum of mice in the control group and the administration of 3 mg and 8 mg of MSG. However, there was a greater increase in body weight in mice given 3 mg of MSG compared to the group given 8 mg of MSG and controls, the average weight gain was 2.87 mg. CONCLUSION After observing through a microscope on the brain preparations of control mice, MSG 3 mg and MSG 8 mg, no difference in histological appearance was found. But giving MSG to mice affects weight gain.   Abstrak LATAR BELAKANG Garam natrium dari asam glutamat, monosodium glutamat (MSG), adalah senyawa kristal putih (asam glutamat). MSG pertama kali diproduksi dalam jumlah besar pada awal tahun 1963 oleh Korea dan Jepang yang kemudian menyebar ke negara lain, termasuk Indonesia. Profesi medis prihatin dengan konsekuensi merugikan dari MSG karena konsumsinya yang meluas dan tidak terkendali. Perbedaan histologis antara otak kecil tikus yang diberi MSG dan bebas MSG adalah hal yang menarik untuk diketahui. METODE Desain Post Test-Only Control Group digunakan dalam penelitian ini dan menggunakan data yang terkumpul selama 14 hari. Penelitian ini menggunakan 30 ekor mencit jantan jenis Swiss Webster (Mus Musculus) yang dipelihara sebagai galur murni melalui perkawinan sedarah. Mencit yang diambil berumur 8 minggu dengan berat 20 – 40gram dan dibagi menjadi tiga kelompok, masing-masing terdiri atas sembilan ekor mencit dengan cadangan satu ekor untuk setiap kelompok. Satu kelompok sebagai kontrol dan dua kelompok akan menerima MSG secara oral, masing-masing dengan dosis 3 mg dan 8 mg. Terminasi mencit dilakukan dengan cara dislokasi vertebra servikal dan dilanjutkan pembuatan preparat jaringan otak mencit. Analisis data, yang diperoleh dari pengamatan gambaran histologis otak mencit, menggunakan Paired-Sample T test pada program SPSS (Statistical Product and Service Solutions) versi 20.0 for Windows dengan tingkat kemaknaan 0,05. HASIL Pada penelitan ini tidak ditemukan adanya perbedaan pada gambaran histologis cerebellum otak mencit pada kelompok kontrol dan pemberian MSG 3 mg dan 8 mg. Namun, terdapat peningkatan berat badan lebih banyak pada mencit yang diberikan MSG 3 mg dibandingkan dengan kelompok yang diberikan MSG 8 mg dan kontrol, rata-rata kenaikan berat badan sebesar 2,87 mg. KESIMPULAN Setelah dilakukan pengamatan melalui mikroskop pada preparat otak mencit kontrol, MSG 3 mg dan MSG 8 mg, belum ditemukan perbedaan gambaran histologis. Tetapi pemberian MSG pada mencit mempengaruhi pertambahan berat badan.
Tuberculosis treatment outcomes and associated factors: A retrospective study in West Nusa Tenggara, Indonesia Meiyanti, Meiyanti; Bachtiar, Adang; Kusumaratna, Rina K.; Alfiyyah, Arifah; Machrumnizar, Machrumnizar; Pusparini, Pusparini
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1660

Abstract

Successfully treating tuberculosis (TB) could significantly help reduce its spread. The aim of this study was to identify factors associated with successful TB treatment. A retrospective study was conducted in West Nusa Tenggara, Indonesia, using data from the National TB Information System (SITB) covering patients from January 1 to December 31, 2022. Patients were classified into two groups: those with successful treatment outcomes (cured or completed treatment) and those with unsuccessful outcomes (including treatment failure, loss to follow-up, or death). Univariate and multivariate logistic regression analyses were performed to identify factors associated with treatment outcomes, providing odds ratios (OR) and adjusted odds ratios (aOR) with 95% confidence intervals (CIs). A total of 2,225 TB patients (1,382 males and 843 females) were included in the study. Of these, 2,048 (92.1%) achieved successful treatment outcomes. Univariate analysis indicated that older age (OR: 0.47; 95%CI: 0.28–0.78) and a high number of AFB in sputum smears (OR: 0.23; 95%CI: 0.09–0.66) were associated with a higher likelihood of unsuccessful TB treatment. In contrast, having no HIV infection (OR: 13.44; 95%CI: 6.22–29.08), clinical TB cases (diagnosed clinically rather than bacteriologically) (OR: 1.50; 95%CI: 1.04–2.20) and longer duration of TB treatments were associated with successful treatment outcomes. Multivariate analysis suggested that the TB treatment durations of 4–6 months (aOR: 1256.95; 95%CI: 431.89–3658.19) and 7–12 months (aOR: 575.5; 95%CI: 99.1–3342.06) were associated with a significantly higher likelihood of success compared to durations of 0–3 months. In conclusion, this study highlights that a minimum treatment duration of three months was crucial for increasing the likelihood of successful TB treatment. These findings emphasize the importance of comprehensive support programs to ensure adherence to treatment guidelines and improve outcomes.
Trematoda Darah: Schistosomiasis pada Sistem Saraf Pusat Yuliana, Yuliana; Machrumnizar, Machrumnizar
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

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Abstract

Schistosomiasis (bilharzia) is a disease caused by blood trematode worms of the genus Schistosoma, which can be acute or chronic. There are five species of Schistosoma (S. japonicum, S. mansoni, S. intercalatum, S. Mekongi, and S. haematobium) known to infect humans, which are distributed across a wide geographic range. Severe clinical symptoms of schistosomiasis infection on the central nervous system (CNS) are caused by the deposition of eggs when adult worms migrate abnormally to the brain or spinal cord. As a result, radiculopathy, myelopathy, increased intracranial pressure, and clinical sequelae occur. Each species shows different tendencies for atopic infections and clinical symptoms. The most common neurological symptom associated with Schistosoma mansoni or S. haematobium infections is myelopathy, while severe encephalitis is more likely to be caused by S. japonicum infections. The symptoms of encephalopathy can manifest as headache, vision disturbances, delirium, convulsions, motor limitations, and ataxia. Spinal abnormalities may lead to backache, lower limb radiating discomfort, muscular weakness, loss of sensation, and urinary impairment. Histopathological analysis, which shows granulomas and Schistosoma eggs, is necessary for a definitive diagnosis. Current management involves surgical procedures, steroids, and schistosomicide drugs. Corticosteroids are administered in the acute stage, and praziquantel is given after the female worm begins to lay eggs. If medical intervention fails to relieve compression or medullary degeneration, surgery should be postponed in some instances. The earlier a diagnosis is identified and proper therapy begins, the better the patient's outcome.
The Double Burden: A Bibliometric Analysis on Tuberculosis with Diabetes Mellitus Comorbidity Machrumnizar, Machrumnizar; Bachtiar, Adang; K. Kusumaratna, Rina
Jurnal Kesehatan Masyarakat Vol. 21 No. 1 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v21i1.10742

Abstract

Many studies have been conducted independently and collaboratively to find effective ways to control TB. However, the prevalence of TB continues to increase, especially in low- and middle-income countries. This study highlights the breadth of research conducted worldwide and collaborative networks over the past decade. Between 2003 and 2023, 410 research articles on TB with comorbid diabetes were analyzed using the Scopus database, with an annual growth rate of 7.18%, reaching its peak in 2022. The keywords “tuberculosis” and “diabetes mellitus” were found to have a total link strength of 2895 and 3101, respectively. The most published articles on TB-DM were published in the International Journal of Tuberculosis and Lung Disease (23). Babu, Subash (23) authored the most TB-DM article publications. The National Institute for Research in Tuberculosis is the most productive affiliation (12), making India the country with the most published articles. Still, the Netherlands led in average article citations (32.8%), and the United States has the most collaborative link country (324). Visualization of the co-occurrence and co-authorship networks was conducted using R-Studio and VOS-Viewer. The study highlights the rising tuberculosis and diabetes incidence, identifies research trends, disparities, and bidirectional control innovations, providing valuable insights for policy recommendations.
PERBEDAAN FAKTOR FISIOLOGIS ANTARA PEMAKAIAN MASKER KN95 DAN NON-KN95 PADA KOMUNITAS SEPEDA USIA PRODUKTIF Lateefa, Andrienne Zayna; Machrumnizar, Machrumnizar
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 3 (2025): DESEMBER 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i3.51021

Abstract

Penggunaan masker merupakan salah satu upaya pencegahan infeksi COVID-19, namun pemakaiannya saat berolahraga berpotensi menurunkan suplai oksigen dan menimbulkan hipoksia. Penelitian ini bertujuan untuk mengetahui perbedaan faktor fisiologis antara penggunaan masker KN95 dan non-KN95 pada komunitas pesepeda usia produktif. Penelitian eksperimental ini dilakukan pada anggota komunitas sepeda berusia 15–64 tahun yang rutin berolahraga, dengan eksklusi pada subjek yang memiliki penyakit jantung, asma, PPOK, pneumonia, kebiasaan merokok, serta konsumsi alkohol atau opioid. Peserta dibagi secara acak ke dalam dua kelompok, yaitu kelompok masker KN95 (KN95, KF94) dan kelompok non-KN95 (masker kain, masker medis). Parameter fisiologis yang diukur meliputi heart rate, respiratory rate, dan saturasi oksigen. Analisis data dilakukan menggunakan uji t independen dan Mann–Whitney dengan bantuan perangkat lunak SPSS. Sebanyak 32 responden berpartisipasi dengan rata-rata usia 34,09 ± 8,8 tahun dan proporsi laki-laki sebesar 62,5%. Hasil penelitian menunjukkan bahwa kelompok masker KN95 memiliki heart rate yang lebih tinggi dibandingkan kelompok non-KN95 (135,75 ± 11,63 bpm vs 121,31 ± 13,35 bpm; p=0,003) serta respiratory rate yang lebih tinggi (33,50 ± 5,59 vs 28,38 ± 5,33; p=0,013). Selain itu, saturasi oksigen pada kelompok KN95 lebih rendah dibandingkan non-KN95 (96% vs 97%; p=0,025). Dapat disimpulkan bahwa terdapat perbedaan signifikan antara penggunaan masker KN95 dan non-KN95 pada komunitas pesepeda usia produktif, di mana pemakaian masker KN95 meningkatkan heart rate dan respiratory rate serta menurunkan saturasi oksigen setelah aktivitas fisik sedang.
Impact of co-epidemic tuberculosis and diabetes mellitus on health-related quality of life: A review Machrumnizar, Machrumnizar; Muyana, Nana; Bachtiar, Adang; Kusumaratna, Rina Kurniasri; Suyanto, Jipri
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 4: Desember 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i4.2088

Abstract

The high comorbidity rate between diabetes mellitus and tuberculosis has a significant impact on the patient's health-related quality of life and eradication of tuberculosis program outcomes, especially in lower-middle-income countries that bear a "double disease burden". This review outlines the health-related quality of life of tuberculosis patients with diabetes. The search, selection, and article collection procedures were unmethodical. The retrieved articles were open-access and full-text in English. Health-related quality of life includes physical, psychological, social, and environmental domains. Health-related quality of life in diabetes, tuberculosis, and tuberculosis-diabetes comorbid patients experienced negative changes in all domains. Commonly used health-related quality-of-life measures can be generic or disease-specific. This review also highlights the importance of collaborative tuberculosis and diabetes management supported by the community, health workers, and stakeholders. Finally, this collaborative management support will enhance patient health-related quality of life and contribute to the accomplishment of the tuberculosis elimination program.
PENYULUHAN KESEHATAN DEMAM BERDARAH DENGUE DI MASA PANDEMI COVID-19 Tan, Suriyani; Yuliana, Yuliana; Devita, Arleen; Machrumnizar, Machrumnizar
JUARA: Jurnal Wahana Abdimas Sejahtera Volume 4, Nomor 1, Januari 2023
Publisher : Jurusan Teknik Lingkungan Fakultas Arsitektur Lanskap dan Teknologi Lingkungan, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/juara.v4i1.13734

Abstract

Dengue Hemorrhagic Fever (DHF) is caused by the dengue virus and is still a public health problem today, especially in urban areas. The death rate caused by this disease is very high if not treated immediately. Dengue virus is mainly transmitted by female mosquitoes Aedes aegypty and Aedes. albopictus. Aedes spp mosquitoes are mosquitoes that have the ability to reproduce quickly because the eggs of these mosquitoes can live in dry conditions. Indonesia implements the Jumantik program (Larva Monitoring staff) as a way of eradicating mosquitoes. However, with the current implementation of PSBB (Large-Scale Social Restrictions) in DKI Jakarta, this program has become a bit difficult to implement. This counseling was carried out as part of increasing public literacy in understanding dengue fever from symptoms to prevention at the household level, so that people became aware of this disease even in the midst of the Covid-19 pandemic. The counseling was conducted online and prior to the counseling, an initial survey of understanding about DHF was conducted and a final survey was conducted after the counseling to assess the level of public understanding about DHF. The results achieved in the form of benefits, especially for the community, namely residents understand about dengue fever and its prevention through eradicating mosquito larvae in their respective homes, which in turn can reduce the number of dengue cases in Jakarta.
Co-Authors Adang Bachtiar Adnyana , Putu Suryabrata Alfiyyah, Arifah Devita, Arleen Imran, Darma K. Kusumaratna, Rina Kusumaratna, Rina Kurniasri Lateefa, Andrienne Zayna Meiyanti Meiyanti, Meiyanti Muslim, Mohammad Muyana, Nana Natriana, Tjahjani Pusparini Pusparini Retno Wahyuningsih Rina K. Kusumaratna, Rina K. Robiatul Adawiyah Suriyani Tan, Suriyani Suyanto, Jipri WELLYZAR SJAMSURIDZAL Yuliana Yuliana Yunus Slamet, Muhamad Andanu