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The Correlation of PD-L1 Overexpression With Tumor Budding In Cervical Carcinoma Lestari, Desak Putu Oki; Analysa, Analysa; Armerinayanti, Ni Wayan; Riasa, I Nyoman Putu; Artha, I Gusti Alit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1103

Abstract

Background: Several studies have proven the relationship between PD-L1, which is known as an immunotherapy target, and poor prognosis. The presence of a tumor budding (TB) group tumor outside the main tumor is also associated with a poor prognosis. The purpose of this study was to determine the relationship between PD-L1 and the grade of TB in cervical carcinoma. Methods: The design of this research is a case-control study with a retrospective approach. The sample is from a paraffin block of the primary cervical cancer tumor from the results of surgery in Balimed Denpasar Hospital between 2020 and 2023. From the statistical formula for the case-control study, a minimum sample of 15 is obtained for the case group with the criteria of high-grade TB, while 15 people were in the control group with low-grade TB. Immunohistochemistry (IHC) PD-L1 is positive if the membrane or cytoplasm is brown, and is negative if there is no brown color on the membrane or cytoplasm. Inferential statistics were used to evaluate the relationship between PD-L1 overexpression and low- and high-grade TB in cervical carcinoma using a chi-square test. Results: The results of this research revealed (p = 0.273) that there was no correlation between PD-L1 expression and high- and low-grade TB. Overexpression of PD-L1 was associated with a 2.250-fold increased risk of high-grade TB (OR = 2.250 with a 95% confidence interval of 0.103–1.915). Conclusions: The severity of TB does not correlate with PD-L1 expression. The functions of PD-L1 and other variables in the carcinogenesis of TB development are the cause of this weak association.
Empowering teachers and committees of Raudhatul Atfal Al Amin Tabanan for early cancer prevention through diverse, nutritious, balanced and food safety movement (B2SA) Analysa; Primadi, Putu; Lestari, Desak Putu Oki; Artha, I Gusti Alit; Riasa, I Nym Putu; Yusuf, M.
Transformasi: Jurnal Pengabdian Masyarakat Vol. 20 No. 2 (2024): Transformasi Desember
Publisher : LP2M Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/transformasi.v20i2.9951

Abstract

[Bahasa]: Kanker merupakan salah satu penyebab utama kematian di seluruh dunia dengan jumlah kasus yang terus meningkat. Pemahaman tentang faktor risiko, gaya hidup sehat, dan pentingnya deteksi dini dapat memainkan peran yang signifikan dalam menurunkan angka kasus kanker. Pengabdian masyarakat ini bertujuan untuk memberdayakan guru dan komite di Raudhatul Athfal (RA) Al Amin, Tabanan, dalam upaya pencegahan kanker sejak dini. Peningkatan kesadaran dan praktik hidup sehat dilakukan melalui pelatihan dan sosialisasi Gerakan B2SA (Beragam, Bergizi, Seimbang, dan Aman) serta konsep Isi Piringku. Program ini dirancang untuk membekali para pendidik dengan pengetahuan dan keterampilan dalam mengajarkan pola makan sehat serta gaya hidup yang dapat mencegah faktor risiko kanker kepada anak-anak usia dini. Kegiatan pengabdian ini dilakukan dengan metoda penyuluhan aktif dan praktik yang melibatkan mitra yaitu guru, komite sekolah dan wali murid. Program dilakukan pada sekolah (RA) yang berada di tengah kota yang di banjiri oleh kuliner modern. Penyuluhan dan praktik dilakukan dengan cara menjadikan guru RA sebagai pendidik sekaligus motivator, dan komite merupakan ujung tombak gerakan ini. Hasil evaluasi menunjukkan adanya peningkatan pengetahuan mencapai 91,3%, sedangkan peningkatan sikap mencapai 89,2%. Disimpulkan bahwa terjadi peningkatan pengetahuan dan sikap pada semua responden tentang pencegahan kanker melalui gerakan B2SA. Kata Kunci: pencegahan kanker, B2SA, isi piringku, raudhatul atfal [English]: Cancer is one of the leading causes of death worldwide, with increasing numbers of cases. Early understanding of cancer causes, risk factors, healthy lifestyles, and early detection can play a vital role in reducing the number of cancer cases. This community service aims to empower teachers and the committee at Raudhatul Athfal (RA) Al Amin, Tabanan, to prevent cancer from an early age. Increased awareness and practice of healthy living are achieved through training and socialization of the B2SA Movement (Beragam, Bergizi, Seimbang, Aman) and the concept of "Isi Piringku". This program is designed to equip educators with the knowledge and skills to teach healthy eating patterns and lifestyles that can prevent cancer risk factors in young children. This community service activity was conducted using active counseling and practical methods involving partners such as teachers, school committees, and parents. The program was conducted at a kindergarten (RA) in the city center, which is flooded with modern culinary offerings. Counseling and practice are carried out by making RA teachers both educators and motivators, and the committee is the spearhead of this movement. The results show an increase in knowledge reaching 91.3%, while the increase in attitude reached 89.2%. It is concluded that there was an increase in knowledge and attitude among all respondents regarding cancer prevention through the B2SA movement. Keywords: cancer prevention, B2SA, plan my plate, preschool