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All Journal Journal of Case Reports in Dental Medicine Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Neurona
Bahar, Ashari
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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EFEK NEUROPROTEKTIF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) DENGAN TINGKAT DEPRESI PASCA STROKE ISKEMIK : STUDI CROSS SECTIONAL Minarti, Deri Lidya; Bintang, Andi Kurnia; Akbar, Muhammad; Aulina, Susi; Bahar, Ashari; Idris, Irfan
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 3 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i3.1246

Abstract

Latar belakang dan tujuan: Brain Derived Neurotrophic Factor (BDNF) berperan penting dalam melindungi saraf, plastisitas otak, terutama setelah kerusakan sistem saraf pusat. Efek neuroprotektif BDNF dengan tingkat depresi pasca stroke iskemik perlu dikaji lebih mendalam. Penelitian ini bertujuan untuk mengetahui hubungan kadar BDNF dengan tingkat depresi pasca stroke iskemik. Metode: Penelitian ini merupakan jenis penelitian analitik observasional dengan menggunakan desain cross-sectional. Total sampel 41 orang subyek yang memenuhi kriteria inklusi. Kadar BDNF seum dukur dengan menggunakan metode ELISA. Tingkat depresi diukur menggunakan skor HDRS. Data yang terkumpul kemudian dianalisis dengan menggunakan uji statistik. Hasil: Berdasarkan hasil analisis, diperoleh p = 0,000 (p<0,05) dengan nilai r = -0,573, bahwa terdapat efek neuroprotektif kadar BDNF serum dengan tingkat depresi pasca stroke iskemik.Terdapat korelasi negatif kadar BDNF serum dengan tingkat depresi pasien pasca stroke iskemik. Kesimpulan : Terdapat efek neuroprotektif kadar BDNF serum dengan tingkat depresi pasca stroke iskemik. Semakin rendah kadar BDNF serum maka semakin berat tingkat depresi pasca stroke iskemik.
Acute ischemic stroke as a rare complication of steroid resistant nephrotic syndrome in adolescent: A case report Bahar, Ashari; Akbar, Muhammad; Basri, Muhammad I.
Journal of Case Reports in Dental Medicine Vol 4, No 3 (2022)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jcrdm.v4i3.198

Abstract

AbstractIschemic stroke is an uncommon complication of nephrotic syndrome, but must be adressed appropriately, because of the significant health impact. We reported a case of 17-years old male with sudden onset right hemiparesis. The patient was previously diagnosed with steroid resistant nephrotic syndrome (SRNS), and was treated with pulsed cyclophosphamide. Laboratory examination showed proteinuria, hypoalbuminemia and high low density lipoprotein. Axial head CT scan showed infarction in left basal ganglia and corona radiata. Digital substraction angiography (DSA) confirmed severe stenosis in the left middle cerebral artery. The patient was treated with antiplatelet, along with treatment for SRNS and hypercholestrolemia. SNRS might increase the risk of early occurrence of stroke in young adult, throught acceleration of atherosclerosis and hypercoagulable state.
Neuromuscular Taping Decompression Technique in Diabetic Painful Polyneuropathy: Impact on Pain Intensity Harun Muchsin, Achmad; Blow, David; Goysal, Yudy; Wuysang, Audry Devisanty; Tammasse, Jumraini; Bahar, Ashari; Zainuddin, Andi Alfian; Walenna, Nirwana Fitriani
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.679

Abstract

Background: This study aimed to evaluate the effects of neuromuscular taping decompression technique (NMT) on modifying pain scale in diabetic patients with painful distal symmetrical polyneuropathy (DSPN) at Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Using a pure experimental design with a pre-test and post-test control group method, 30 patients were included: 15 in the treatment group and 15 in the control group. The treatment group received decompression NMT on the dorsal and plantar aspects of the foot twice a week for four weeks, along with vitamin B complex supplementation. The control group received only vitamin B complex. Result: The Mann-Whitney test showed significant improvement (p <0.05) in the pain scale of the treatment group on day 28, with the Numeric Pain Rating Scale (NPRS) score being lower than that of the control group. Conclusion: This study demonstrated the significant pain-reducing effect of NMT in DSPN patients. The combination of vitamin B1, B6, and B12 supplementation with 8 NMT sessions over 28 days reduced pain to 0 on the NPRS scale. Treatment twice a week for 4 weeks, alongside vitamin B, led to near-zero pain, with pain-free results expected after 5 treatments over 17 days. NMT combined with vitamin B reduced pain approximately 2 times faster than vitamin B alone. Keywords: Diabetic Painful Distal Symmetrical Polyneuropathy, DSPN, Diabetic Neuropathic Pain, Neuromuscular Taping, NMT
Co-Authors Andi Alfian Zainuddin Andi Kurnia Bintang, Andi Kurnia Basri, Muhammad I. Blow, David Goysal, Yudy Harun Muchsin, Achmad IRFAN IDRIS Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Minarti, Deri Lidya Muhammad Akbar RR. Ella Evrita Hestiandari Tammasse, Jumraini Walenna, Nirwana Fitriani Wuysang, Audry Devisanty