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All Journal Journal of Case Reports in Dental Medicine Journal of Applied Science, Engineering, Technology, and Education Jurnal Ilmiah Kesehatan (JIKA) Molucca Medica Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Neurona
Bahar, Ashari
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Other

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EFEK NEUROPROTEKTIF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) DENGAN TINGKAT DEPRESI PASCA STROKE ISKEMIK : STUDI CROSS SECTIONAL Minarti, Deri Lidya; Bintang, Andi Kurnia; Akbar, Muhammad; Aulina, Susi; Bahar, Ashari; Idris, Irfan
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 3 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i3.1246

Abstract

Latar belakang dan tujuan: Brain Derived Neurotrophic Factor (BDNF) berperan penting dalam melindungi saraf, plastisitas otak, terutama setelah kerusakan sistem saraf pusat. Efek neuroprotektif BDNF dengan tingkat depresi pasca stroke iskemik perlu dikaji lebih mendalam. Penelitian ini bertujuan untuk mengetahui hubungan kadar BDNF dengan tingkat depresi pasca stroke iskemik. Metode: Penelitian ini merupakan jenis penelitian analitik observasional dengan menggunakan desain cross-sectional. Total sampel 41 orang subyek yang memenuhi kriteria inklusi. Kadar BDNF seum dukur dengan menggunakan metode ELISA. Tingkat depresi diukur menggunakan skor HDRS. Data yang terkumpul kemudian dianalisis dengan menggunakan uji statistik. Hasil: Berdasarkan hasil analisis, diperoleh p = 0,000 (p<0,05) dengan nilai r = -0,573, bahwa terdapat efek neuroprotektif kadar BDNF serum dengan tingkat depresi pasca stroke iskemik.Terdapat korelasi negatif kadar BDNF serum dengan tingkat depresi pasien pasca stroke iskemik. Kesimpulan : Terdapat efek neuroprotektif kadar BDNF serum dengan tingkat depresi pasca stroke iskemik. Semakin rendah kadar BDNF serum maka semakin berat tingkat depresi pasca stroke iskemik.
Acute ischemic stroke as a rare complication of steroid resistant nephrotic syndrome in adolescent: A case report Bahar, Ashari; Akbar, Muhammad; Basri, Muhammad I.
Journal of Case Reports in Dental Medicine Vol 4, No 3 (2022)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jcrdm.v4i3.198

Abstract

AbstractIschemic stroke is an uncommon complication of nephrotic syndrome, but must be adressed appropriately, because of the significant health impact. We reported a case of 17-years old male with sudden onset right hemiparesis. The patient was previously diagnosed with steroid resistant nephrotic syndrome (SRNS), and was treated with pulsed cyclophosphamide. Laboratory examination showed proteinuria, hypoalbuminemia and high low density lipoprotein. Axial head CT scan showed infarction in left basal ganglia and corona radiata. Digital substraction angiography (DSA) confirmed severe stenosis in the left middle cerebral artery. The patient was treated with antiplatelet, along with treatment for SRNS and hypercholestrolemia. SNRS might increase the risk of early occurrence of stroke in young adult, throught acceleration of atherosclerosis and hypercoagulable state.
Neuromuscular Taping Decompression Technique in Diabetic Painful Polyneuropathy: Impact on Pain Intensity Harun Muchsin, Achmad; Blow, David; Goysal, Yudy; Wuysang, Audry Devisanty; Tammasse, Jumraini; Bahar, Ashari; Zainuddin, Andi Alfian; Walenna, Nirwana Fitriani
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.679

Abstract

Background: This study aimed to evaluate the effects of neuromuscular taping decompression technique (NMT) on modifying pain scale in diabetic patients with painful distal symmetrical polyneuropathy (DSPN) at Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Using a pure experimental design with a pre-test and post-test control group method, 30 patients were included: 15 in the treatment group and 15 in the control group. The treatment group received decompression NMT on the dorsal and plantar aspects of the foot twice a week for four weeks, along with vitamin B complex supplementation. The control group received only vitamin B complex. Result: The Mann-Whitney test showed significant improvement (p <0.05) in the pain scale of the treatment group on day 28, with the Numeric Pain Rating Scale (NPRS) score being lower than that of the control group. Conclusion: This study demonstrated the significant pain-reducing effect of NMT in DSPN patients. The combination of vitamin B1, B6, and B12 supplementation with 8 NMT sessions over 28 days reduced pain to 0 on the NPRS scale. Treatment twice a week for 4 weeks, alongside vitamin B, led to near-zero pain, with pain-free results expected after 5 treatments over 17 days. NMT combined with vitamin B reduced pain approximately 2 times faster than vitamin B alone. Keywords: Diabetic Painful Distal Symmetrical Polyneuropathy, DSPN, Diabetic Neuropathic Pain, Neuromuscular Taping, NMT
Validity Test of an Alternative Method of Quantitative Pain Assessment (MAPKN) in Assessing Intensity of Nociceptive Pain, Mixed Pain, and Neuropathic Pain Gafur, Rahmi; Susi Aulina; Wuysang, Audry Devisanty; Idris, Irfan; Bahar, Ashari; Hammado, Nurussyariah; Amran, Muhammad Yunus
Journal of Applied Science, Engineering, Technology, and Education Vol. 5 No. 2 (2023)
Publisher : PT Mattawang Mediatama Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35877/454RI.asci1793

Abstract

Pain is a health problem phenomenon that most often brings patients to see a doctor. Pain intensity is the most often domain which assessed in clinical and research settings. Loeser suggests that four elements need to be considered when evaluating patients with pain. Based on the biopsychosocial approach and the concept of pain from Loeser, a pain assessment was made and called "Alternative Method of Quantitative Pain Assessment (MAPKN)". This study was conducted on 415 pain patients consisting of 163 nociceptive pain, 119 mixed pain, and 133 neuropathic pain. In the nociceptive pain group, MAPKN showed sensitivity 92.59%, specificity 96.43%, AUC 0,959 and a p value <0.001. In the mixed pain group, MAPKN showed sensitivity 98.17%, specificity 80.00%, AUC 0,836 and a p -value of 0.001. In the neuropathic pain group, MAPKN showed sensitivity 92.06%, specificity of 85.71%, AUC 0,951 and a p<0.001. The AUC value of 0.959 (96%) indicates that the diagnostic value of the MAPKN score in assessing pain intensity in the nociceptive pain group is excellent (>90%-100%). AUC value of 0.836 (83%) indicates that the diagnostic value of the MAPKN score in assessing pain intensity in the mixed pain group is good (> 80%-90%). The AUC value of 0.951 (95%) indicates that the diagnostic value of the MAPKN score in assessing pain intensity in the neuropathic pain group is excellent (>90%-100%). This is in accordance with research conducted by Eka Pranata 2004 that MAPKN has strong discriminant validity in assessing pain intensity. MAPKN is valid and has excellent diagnostic value in assessing nociceptive and neuropathic pain intensity, MAPKN is valid and has good diagnostic value in assessing mixed pain intensity.
HUBUNGAN KADAR BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) SERUM DENGAN FUNGSI KOGNITIF PENDERITA STROKE ISKEMIK Madeng, A. Arsidin Mappa; Bahar, Ashari; Akbar, Muhammad; Zainuddin, Andi Alfian; Bintang, Andi Kurnia; Kaelan, Cahyono
Molucca Medica Vol 16 No 2 (2023): VOLUME 16, NOMOR 2, OKTOBER 2023
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/10.30598/molmed.2023.v16.i2.169

Abstract

Pendahuluan: Stroke merupakan penyakit neurologis utama di usia dewasa, berdasarkan tingginya angka kejadian, kegawatdaruratan, penyebab utama kecacatan, dan kematian. Brain derived neurotrophic factor (BDNF) merupakan salah satu neurotrophin golongan neurotrophic. BDNF terlibat dalam perkembangan sinapsis, platisitas sinapsis, dan fungsi kognitif dan meningkat pada stroke iskemik. Sehingga perlu dilakukan analisis antara kadar BDNF dengan fungsi kognitif. Metode: Penelitian cross-sectional yang dilakukan pada 64 orang pasien stroke iskemik dengan onset 15-30 hari dengan usia 18-70 tahun. Pasien dengan gangguan fungsi kortikal luhur sebelumnya, buta huruf, afasia, Alzheimer, Parkinson dan depresi merupakan kriteria eksklusi. Usia, jenis kelamin, tingkat pendidikan, lokasi infark, kadar BDNF dan fungsi kognitif merupakan variabel yang akan dianalisis. Hasil: Tingkat pendidikan berpengaruh pada fungsi kognitif dan terdapat korelasi kuat positif bermakna antara kadar BDNF dengan fungsi kognitif. Kadar cut off BDNF ≤ 1,3 ng/mL memiliki sensitivitas 86,11% dan spesifitas 96,43% sebagai prediktor gangguan kognitif dan bermakna pada variabel memori, visuospasial dan eksekutif. Kesimpulan: BDNF serum dapat diukur untuk memprediksi terjadinya gangguan fungsi kognitif.
EFEK MEDIATOR VASCULAR CELL ADHESION MOLECULE-1 (VCAM-1) TERHADAP SEVERITAS DAN OUTCOME PASIEN STROKE ISKEMIK AKUT Assa, Christantina Pradescha; Bahar, Ashari; Akbar, Muhammad; Bintang, Andi Kurnia; Tammasse, Jumraini; Soraya, Gita Vita; Halim, Wijoyo
Molucca Medica Vol 17 No 1 (2024): VOLUME 17, NOMOR 1, APRIL 2024
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/10.30598/molmed.2024.v17.i1.16

Abstract

Introduction: Atherosclerosis is currently recognized as part of the inflammatory disease. In the acute phase, inflammation causes brain edema and expansion of ischaemic area. Vascular cell adhesion molecule 1 (VCAM-1) plays a crucial role in the inflammation mechanism immediately after cerebral damage in stroke, facilitating the migration of leukocytes across the endhothelial cells. Objective: This study aimed to establish the correlation between VCAM-1 serum levels and severity and outcomes in stroke patients. Research Methodology: It was a cross-sectional study conducted from September to November 2023 on 51 patients with acute ischemic stroke at RSUP Wahidin Sudirohusodo Makassar and other affiliated hospitals. VCAM-1 serum levels were examined using the ELISA principle. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) upon admission, and clinical outcomes were evaluated using the modified Rankin Scale (mRS) on the 30th day of onset. Results: Mann- Whitney test results showed no difference in serum VCAM-1 levels between severity groups (mild and moderate) and clinical outcome groups (good and poor). Spearman correlation test results indicated a correlation between serum VCAM-1 levels and severity (p=0.635, r=-0.068) and clinical outcomes (p=0.459, r=-0.106). Conclusion: There is no association between serum VCAM-1 levels and the severity and clinical outcomes of acute ischemic stroke patients. Recommendation: Further research is needed to explore the relationship between serum VCAM-1 levels and severity and clinical outcomes in acute ischemic stroke patients at various centers in Indonesia.
PERBANDINGAN PENGARUH TERAPI ADJUVANT CONSTRAINT INDUCED MOVEMENT THERAPY DENGAN REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION TERHADAP FUNGSI MOTORIK EKSTREMITAS ATAS PADA PASIEN STROKE ISKEMIK Tarigan, Ngalasantaru Janstar; Umbas, David Gunawan; Bintang, Andi Kurnia; Tammasse, Jumraini; Amran, Muhammad Yunus; Bahar, Ashari; Zainuddin, Andi Alfian; Halim, Wijoyo
Molucca Medica Vol 17 No 1 (2024): VOLUME 17, NOMOR 1, APRIL 2024
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/10.30598/molmed.2024.v17.i1.26

Abstract

Introduction Stroke is an acute disorder of cerebral perfusion or vascularization. Stroke patients commonly encounter numerous functional disorders, such as motor, psychological or behavioral disorders, where the most typical symptom is hemiparesis which greatly affects their ability to carry out daily life activities. Repetitive Transcranial Magnetic Stimulation (rTMS) is one of the interventions proposed to improve stroke recovery. Constraint-Induced Movement Therapy (CIMT) is a neurological rehabilitation treatment designed to improve upper extremity motor function after stroke Objective: This study aims to compare the effectiveness of rTMS with CIMT in improving upper extremity motor function in ischemic stroke patients. Research Methodology: This is an experimental clinical trial study with a randomized pre-test post-test control group design on 30 ischemic stroke patients at Wahidin Sudirohusodo General Hospital Makassar and other network hospitals. Repetitive Transcranial Magnetic Stimulation was carried out for 10 stimulations, CIMT was carried out for 30 days. Motor improvement was evaluated by measuring the Fugl Mayer Assessment Upper Extremity (FMA-UE) score Results: The Friedmann test showed that rTMS and CIMT provided significant changes in FMA-UE scores (p: 0.000). Mann Whitney test showed there was a significant difference in FMA-UE scores in the rTMS group compared to CIMT (p: 0.000) Conclusion: There was a significant difference in the FMA-UE score in the rTMS group compared to CIMT. Recommendation: Further research is needed with longer observation and stimulation time and looks at the effectiveness of these two therapeutic modalities through a biomarker so that more objective results can be obtained.
Serum Vascular Endothelial Growth Factor (Vegf) Levels and Alberta Stroke Program Early CT Score (Aspects) in Ischemic Stroke Patients Fakhri M, Faisal; Bahar, Ashari; Bintang, Andi Kurnia; Walenna, Nirwana Fitriani; Tammasse, Jumraini; Muis, Abdul
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 3 (2024): Volume 6 Nomor 3 Desember 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i3.679

Abstract

Stroke is the second leading cause of death and disability worldwide. Where the most common occurrence of ischemic stroke is 85% of all stroke cases. Vascular Endothelial Growth Factor (VEGF) is a dimeric glycoprotein with angiogenic and neuroprotective effects. Alberta Stroke Program Early CT Score (ASPECTS) can be used to assess the extent of acute ischemic stroke in the middle cerebral artery territory as a simple semiquantitative instrument. Method a cross-sectional study in acute ischemic stroke patients with an onset of 3-14 days. The VEGF assessed was serum VEGF and ASPECTS assessment to determine the extent of the lesion. Total ASPECT score is 10 points (normal), score > 7 (lesion area < 1/3 MCA), score < 7 (lesion area > 1/3 MCA). Of the 37 patients, the majority of patients were women (62,2%) with hypertension being the most common comorbid. All risk factors had no significant relationship to VEGF levels (p-value>0,005). There was a significant difference between the two ASPECTS categories on serum VEGF levels (p-value=0,001), A significant correlation occurred in serum VEGF levels with ASPECTS (p-value=0,000; r-0,600). Conclusion higher VEGF levels increase cerebral infarction.
Co-Authors Abdul Muis Amran, Muhammad Yunus Andi Alfian Zainuddin Andi Kurnia Bintang, Andi Kurnia Assa, Christantina Pradescha Basri, Muhammad I. Blow, David Cahyono Kaelan, Cahyono David Gunawan Umbas Fakhri M, Faisal Gafur, Rahmi Goysal, Yudy Halim, Wijoyo Hammado, Nurussyariah Harun Muchsin, Achmad IRFAN IDRIS Madeng, A. Arsidin Mappa Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Minarti, Deri Lidya Muhammad Akbar RR. Ella Evrita Hestiandari Soraya, Gita Vita Tammasse, Jumraini Tarigan, Ngalasantaru Janstar Walenna, Nirwana Fitriani Wuysang, Audry Devisanty