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All Journal The Indonesian Biomedical Journal Nusantara Medical Science Journal Journal of Case Reports in Dental Medicine Medica Hospitalia Neurona Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Tammasse, Jumraini
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Effectivity of Repetitive Transcranial Magnetic Stimulation Improving Depressive Symptoms and Motoric Strength Ischemic Stroke RUNTUWENE, INNEKE MAGDALENA; Akbar, Muhammad; Kurnia Bintang, Andi; Tammasse, Jumraini; Muis, Abdul; Alfian Zainuddin, Andi
Nusantara Medical Science Journal Volume 8 Issue 1, January - June 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v8i1.26490

Abstract

Introduction: Post-stroke depression often causes problems. Depression can slow motor recovery. Giving antidepressants takes one month, and thus Transcranial Magnetic Stimulation (TMS) was developed, especially repetitive Transcranial Magnetic Stimulation (rTMS). This study aims to assess the effectiveness of rTMS in improving depressive symptoms and motor strength in ischemic stroke patients. Methods:  An experimental study with a randomized pretest-posttest control group design was conducted at Wahidin Sudirohusodo Hospital and a network hospital in Makassar from August to October 2022. The treatment group received standard therapy for ischemic stroke, antidepressants, and rTMS; the control group received standard therapy for ischemic stroke and antidepressants for ten days. In this study, the Hamilton Depression Rating Scale (HDRS) and the Medical Research Council (MRC) scale were used and measured in the treatment and control groups on the first and tenth days. Results: A total of 40 subjects met the criteria and were divided into a treatment group (n = 20) and a control group (n = 20). The HDRS score in the treatment group was smaller than in the control group. The value of left extremity motor strength in the treatment group was greater than that of the control group using the Wilcoxon Test. The correlation of the HDRS score to motor strength in the treatment and control groups showed a negative correlation of the HDRS score to the left extremity using the Spearman Test.   Conclusions:  rTMS effectively improves depressive symptoms and motor strength in ischemic stroke, given standard ischemic stroke therapy, antidepressants, and rTMS.
Repetitive Transcranial Magnetic Stimulation (rTMS) as Non-Invasive Therapeutic for Post-Stroke Dysphagia: A Case Report Tammasse, Jumraini; Andi Kurnia Bintang; Muh. Iqbal Basri; M.H.Rauf, A. Ahwal; Naufal Zuhair, Muh.
Nusantara Medical Science Journal Volume 8 Issue 1, January - June 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v8i1.27392

Abstract

Introduction and importance: One of the worst complications that affects people with stroke is dysphagia. Dysphagia causes mortality through dehydration, malnutrition, aspiration pneumonia, and suffocation. For stroke survivors to have better results, post-stroke dysphagia must be adequately addressed using proven treatment methods. Presentation of case: A 64-year-old man complaints of difficulty swallowing with Gugging Swallowing Screen scoring (GUSS)= 7 (severe dysphagia) with left hemiparesis and slurred speech due to ischemic stroke on August 14th 2022. Head CT Scan found bilateral lacunar basal ganglia infarcts with brain atrophy. Patients were treated with standard ischemic stroke therapy, medical rehabilitation and repeated Transcranial Magnetic Stimulation (rTMS) procedures for 10 sessions. GUSS was carried out after the 10th session of rTMS and increased to 14 (moderate dysphagia). Discussion: By stimulating the esophagus cortex bilaterally in post-stroke dysphagia, rTMS is known to be beneficial in modulating cortical excitability and minimizing the imbalance between the hemispheres. Furthermore, it appears to be safe and well-accepted by patients. Conclusions: Our case study shows that rTMS in bilateral esophageal cortex is safe and has therapeutic potential in patients with post-stroke dysphagia.
Hubungan Intensitas Nyeri Dengan Status Fungsional Penderita Low Back Pain Zuhair, Muhammad Naufal; Tammasse, Jumraini; Aulina, Susi; Amran, Muhammad Yunus
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.935 KB) | DOI: 10.36408/mhjcm.v8i3.649

Abstract

LATAR BELAKANG : Selama pandemi, pemerintah menetapkan Skala Besar Pembatasan Sosial (PSBB) peraturan untuk mengurangi kasus infeksi COVID-19, sehingga intensitas kejadian LBP meningkat lebih dari sebelumnya karantina, mencerminkan ed the negative effect of the regulation. This is due to significant lifestyle changes such as increased time spent sitting, reduced exercise time, and the percentage of individuals reporting more stress during quarantine than before the PSBB was established. The current study reports the impact of low back pain which results in disruption of the patient's functional status due to the need for annual medical expenses and the limited visits of patients to health services, so this indicates that low back pain sufferers need to evaluate how much functional disability occurs and the factors that influence it. OBJECTIVE : To determine the relationship between pain intensity and functional status of LBP patients at the Neurology Polyclinic, RSUP Dr. Wahidin Sudirohosudo. METODE : Observasi analitik dengan pendekatan cross sectional dan teknik pengambilan sampel adalah simple random sampling. Data yang digunakan adalah kuesioner Numerical Rating Scale dan Barthel Index. Penelitian ini dilaksanakan di RSUP Dr. Wahidin Sudirohusodo selama dua bulan dimulai dari bulan Maret 2021 sampai dengan April 2021. HASIL : Pada hasil analisis data sampel menggunakan uji korelasi tau-b Kendall, nilai korelasi (-0,644) dengan nilai signifikansi hubungan (p.sig 0,000) menunjukkan adanya hubungan yang signifikan antara intensitas nyeri dengan status fungsional. KESIMPULAN : Intensitas nyeri berhubungan bermakna dengan status fungsional pasien Low Back Pain (LBP) di RSUP Dr. Wahidin Sudirohusodo Kata kunci : Low Back Pain, NRS, Barthel Index
EFEKTIVITAS TERAPI CERMIN TERHADAP PERBAIKAN MOTORIK LENGAN PASIEN STROKE ISKEMIK AKUT Machyono, Machyono; Tammasse, Jumraini; Kaelan, Cahyono; Muis, Abdul; Ganda, Idham Jaya
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 2 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i2.4

Abstract

EFFECTIVENESS OF MIRROR THERAPY ON RECOVERY OF ARM MOTOR FUNCTION IN PATIENTS WITH ACUTE ISCHEMIC STROKEABSTRACTIntroduction: Disability after stroke often happens and burden patients to perform their daily activity. Mirror therapy is an intervention focused on hand and leg movement of the affected side based of mirror neuron principal. This new technique using mirror is simple, affordable, and effective.Aim: To investigate the effectiveness of mirror therapy (MT) on recovery of arm motor function in patients with acute ischemic stroke.Methods: Randomized clinical trial with parallel design an patient with ischemic stroke admitted to Dr. Wahidin Sudirohusodo Hospital, Makassar, June to July 2017. Subjects were allocated into standard with mirror therapy group and standard therapy alone. Mirror therapy was done for 30 minutes everyday for 10 days. Action Research Arm Test (ARAT) at the first and the tenth day were compared using independent t test.Results: There were 32 subjects with 16 subjects in each group. Majority of subjects were men (59,4%), age 45-54 years (31,2%), had history of hypertension (81,2%), came at the third day of onset (28,1%), and a right side motor deficit (59,4%). Difference in ARAT score was higher in group receiving standard + mirror therapy than in group receiving standard therapy alone (15,56 vs 7,69).Discussion: Arm motor function recovery were significant on group receiving standard + mirror therapy compared to control after 10 days of intervention, especially grasping movement.Keywords: Action research arm test, ischemic stroke, mirror therapyABSTRAKPendahuluan: Kelumpuhan ekstremitas pascastroke merupakan masalah yang sering terjadi dan sangat mengganggu pasien dalam melakukan aktivitas sehari-hari. Terapi cermin merupakan terapi intervensi yang difokuskan pada gerakan tangan atau kaki yang paresis akibat stroke dengan prinsip mirror neuron. Teknik ini relatif baru, sederhana, murah, dan efektif dengan menggunakan bantuan cermin.Tujuan: Mengetahui efektivitas terapi cermin terhadap perbaikan motorik lengan pada pasien stroke iskemik akut.Metode: Uji klinis terandomisasi dengan desain paralel  terhadap pasien stroke iskemik akut yang dirawat di RSUP Dr. Wahidin Sudirohusodo, Makassar pada bulan Juni hingga Juli 2017. Subjek dibagi menjadi kelompok terapi yang mendapatkan tambahan terapi cermin dan kelompok kontrol yang hanya mendapatkan terapi standar. Terapi cermin dilakukan 30 menit setiap hari selama sepuluh hari. Dilakukan perbandingan skor action research arm test (ARAT) sebelum dan sesudah terapi dengan uji t tidak berpasangan.Hasil: Didapatkan 32 subjek yang masing-masing terdiri dari 16 subjek pada tiap kelompok. Mayoritas subjek adalah laki-laki (59,4%), usia 45-54 tahun (31,2%), memiliki riwayat hipertensi (81,2%), onset terbanyak pada hari ke-3 (28,1%), dan memiliki gangguan motorik pada sisi kanan (59,4%). Rerata selisih skor ARAT lebih tinggi pada kelompok terapi standar dan terapi cermin dibandingkan kelompok terapi standar saja (15,56 vs 7,69).Diskusi: Terdapat perbaikan fungsi motorik lengan yang signifikan antara kelompok dengan terapi cermin dan kelompok kontrol setelah 10 hari terapi cermin, terutama pada gerakan menggenggam (grasp).Kata kunci: Action research arm test, stroke iskemik, terapi cermin
Type 1 Arnold Chiari Malformation With Syringomyelia: A Case Report Akbar, Muhammad; Armalia, Armalia; Tammasse, Jumraini; Goysal, Yudy; Basri, Muhammad I
Journal of Case Reports in Dental Medicine Vol 3, No 3 (2021)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jcrdm.v3i3.164

Abstract

Objective: Arnold Chiari Malformation is a pathological herniation of the hindbrain through the foramen magnum into the cervical canal, characterized by herniation of the inferior cerebellar tonsils of 3-5 mm 30-70% accompanied by syringomyelia.Methods: This case presents a 16-year-old woman who came to the Neurophysiology Section of  Wahidin Sudirohusodo Hospital with complaints of weakness and numbness in her left arm since last year. It all started with pain in the back of the head and neck after a heavy sneeze three years ago, and since then, the pain has been inconsistent. The patient has gone to the doctor and was given medication, but his symptoms are not improving. Clinical manifestations get worse after the patient uses a computer or mobile phone. Physical examination revealed atrophy of the thenar and hypothenar muscles and sensory dissociation in the left arm's 5th cervical to a first thoracic dermatome. NCV and F-wave examination showed no signs of radiculopathy, plexopathy, or neuropathy. Furthermore, cervical magnetic resonance imaging (MRI) showed Arnold Chiari Malformation Type-1 with syringomyelia extending from cervical spinal cord segment-2 to thoracic-1.Result: This patient was diagnosed based on history, physical examination, nerve conduction study, and MRI spine. There was no clinical improvement after therapy.Conclusion: The clinical picture of Arnold Chiari Malformation Type-1 is so varied that it requires detailed information to diagnose.
Clinical Outcome Of Tolosa-Hunt Syndrome After Intravenous Steroid Therapy: A Case Report Bintang, Andi K.; Umbas, Juliet CG.; Basri, Muhammad I.; Tammasse, Jumraini
Journal of Case Reports in Dental Medicine Vol 3, No 3 (2021)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jcrdm.v3i3.165

Abstract

Objectives: Tolosa-Hunt syndrome (THS) is caused by an idiopathic inflammatory process in the cavernous sinus, superior orbital fissure, or orbit. THS is a rare disease. The main clinical symptoms are ophthalmoplegic pain, accompanied by ipsilateral headache, paresis of one or more ipsilateral III, IV, and or VI cranial nerves, MRI or biopsy abnormalities, and cannot be categorized as other diseases. THS resolves adequately with corticosteroids within 24-72 hours of therapy.Methods: Male, 53 years old, was admitted for painful right ophthalmoplegia, constant onset, two weeks, ipsilateral headache, accompanied by diplopia and right eyelid ptosis.  There was no history of fever, trauma, or similar illness. Neurological examination showed exotropia due to paresis of the right III and IV cranial nerves. Analgesics can not relieve the pain. Laboratory findings, CT angiography, and brain MRI were normal.Result: There was clinical improvement within 24 hours after initiation of methylprednisolone followed by tapering-off oral prednisone.Conclusion: THS is a diagnosis of exclusion and must be distinguished from other causes of painful ophthalmoplegia. Careful follow-up is required to diagnose THS. The diagnosis should not depend on MRI alone but should be adjusted according to clinical findings and therapeutic response.
MLC 901 Decreases HSP-70, MMP-9, Cerebral Infarction Volume and Functional Outcome in Acute Ischemic Stroke Rat Model Hunaifi, Ilsa; Bintang, Andi Kurnia; Tammasse, Jumraini; Wahid, Isra'; Hatta, Mohammad; Islam, Andi Asadul; Zainuddin, Andi Alfian; Sugianto, Paulus
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3610

Abstract

BACKGROUND: Acute ischemic stroke (AIS) is usually treated with thrombolysis, however the percentage of patients receiving this therapy is not quite low. Therefore, it is necessary to find alternative therapy using neuroprotective agent such as Moleac (MLC) 901. Heat shock proteins (HSP)-70 and matrix metalloproteinase (MMP)-9 are usually related to AIS due to the triggered stroke-induced physiological stress. However, the effect of MLC 901 on Hsp70 mRNA expression, HSP-70 and MMP-9 remains unclear. This study was conducted to determine the effect of MLC 901 on those three parameters in relation to cerebral infarction volume and functional outcomes in an AIS model.METHODS: Rats were induced with AIS using unilateral common carotid artery occlusion (UCAO) and received three different treatments: 43.2 mg/200 gBW MLC 901, 21.6 mg/200 gBW MLC 901, and sodium carboxymethyl cellulose (CMC-Na), that were administered orally for 14 days. HSP-70 and MMP-9 protein levels were assessed using enzyme-linked immunosorbent assay (ELISA), and Hsp70 mRNA expression was assessed using quantitative real-time polymerase chain reaction (qRT-PCR). Foot fault scores for evaluation functional outcome and infarction volume were assessed by ImageJ.RESULTS: AIS-induction increased HSP-70, MMP-9, and Hsp70 mRNA expression within 24-48 h. MMP-9, HSP-70 , and Hsp70 mRNA expression were reduced by MLC 901. MLC 901 at dose of 43.2 mg/200 gBW and 21.6 mg/200 gBW were effective in reducing these levels compared to the control. MLC 901 improved functional outcomes and decreased cerebral infarction volume. Moreover, a dosage of 43.2 mg/200 gBW was more effective in reducing Hsp70 mRNA expression and HSP-70, improving functional outcomes, and reducing cerebral infarction volume than a dosage of 21.6 mg/200 gBW, but not MMP-9 protein.CONCLUSION: MLC 901 effectively decreased Hsp70 mRNA expression, HSP-70 and MMP-9 protein levels, infarct volume, and functional outcomes. MLC 901 could be a potential therapeutic agent for AIS.KEYWORDS: MLC 901, HSP-70, MMP-9, acute ischemic stroke
Neuromuscular Taping Decompression Technique in Diabetic Painful Polyneuropathy: Impact on Pain Intensity Harun Muchsin, Achmad; Blow, David; Goysal, Yudy; Wuysang, Audry Devisanty; Tammasse, Jumraini; Bahar, Ashari; Zainuddin, Andi Alfian; Walenna, Nirwana Fitriani
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 3 (2025): Vol 41 No 3 (2024): Volume 41, No 3 - Juni 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i3.679

Abstract

Background: This study aimed to evaluate the effects of neuromuscular taping decompression technique (NMT) on modifying pain scale in diabetic patients with painful distal symmetrical polyneuropathy (DSPN) at Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Using a pure experimental design with a pre-test and post-test control group method, 30 patients were included: 15 in the treatment group and 15 in the control group. The treatment group received decompression NMT on the dorsal and plantar aspects of the foot twice a week for four weeks, along with vitamin B complex supplementation. The control group received only vitamin B complex. Result: The Mann-Whitney test showed significant improvement (p <0.05) in the pain scale of the treatment group on day 28, with the Numeric Pain Rating Scale (NPRS) score being lower than that of the control group. Conclusion: This study demonstrated the significant pain-reducing effect of NMT in DSPN patients. The combination of vitamin B1, B6, and B12 supplementation with 8 NMT sessions over 28 days reduced pain to 0 on the NPRS scale. Treatment twice a week for 4 weeks, alongside vitamin B, led to near-zero pain, with pain-free results expected after 5 treatments over 17 days. NMT combined with vitamin B reduced pain approximately 2 times faster than vitamin B alone. Keywords: Diabetic Painful Distal Symmetrical Polyneuropathy, DSPN, Diabetic Neuropathic Pain, Neuromuscular Taping, NMT
Characteristics of Cognitive Status in Sub-Population of Sub-Acute Stage of Ischemic Stroke Patients in West Nusa Tenggara, Indonesia Harahap, Herpan Syafii; Akbar, Muhammad; Tammasse, Jumraini; Bintang, Andi Kurnia; Zainuddin, Andi Alfian
Kesmas Vol. 16, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cognitive decline is a significant complication that affects most stroke survivors. Early detection of cognitive decline in ischemic stroke patients and identification of risk factors improves their clinical outcomes. This study aimed to determine the characteristics of cognitive status in the sub-acute phase of ischemic stroke. A cross-sectional study was conducted on 89 sub-acute ischemic stroke patients in three hospitals in West Nusa Tenggara recruited consecutively from August 2019 to April 2020. The data collected were demographic and clinical characteristics, cognitive status, and functional outcome. The association between clinical and demographic characteristics and cognitive decline was analyzed using logistic regression. In addition, the relationship between cognitive status and functional outcomes of these patients was examined using the chi-square test. This study revealed that the prevalence of cognitive decline in these subjects was 71.9%. Multiple logistic regression showed that age was the only characteristic associated with cognitive decline in the subjects (OR = 5.12,95% CI = 1.08-24.28). Furthermore, the frequency of cognitive decline in these subjects was significantly associated with functional outcomes (p-value =0.014). Thus, there was a high prevalence of cognitive decline in sub-acute ischemic stroke patients associated with increasing age and poor functional outcomes.
Co-Authors Abdul Muis Alfian Zainuddin, Andi Amran, Muhammad Yunus Andi Alfian Zainuddin Andi Asadul Islam Andi Kurnia Bintang Andi Kurnia Bintang, Andi Kurnia Armalia, Armalia Bahar, Ashari Basri, Muhammad I Basri, Muhammad I. Bintang, Andi K. Blow, David Cahyono Kaelan, Cahyono Goysal, Yudy Harun Muchsin, Achmad Hatta, Mohammad Herpan Syafii Harahap Idham Jaya Ganda, Idham Jaya Ilsa Hunaifi, Ilsa Kurnia Bintang, Andi M.H.Rauf, A. Ahwal Machyono, Machyono Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Muh. Iqbal Basri Muhammad Akbar Naufal Zuhair, Muh. Paulus Sugianto, Paulus RR. Ella Evrita Hestiandari RUNTUWENE, INNEKE MAGDALENA Umbas, Juliet CG. Wahid, Isra' Walenna, Nirwana Fitriani Wuysang, Audry Devisanty Zuhair, Muhammad Naufal