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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal
Sitohang, Irma Bernadette S.
Department Of Dermatology And Venereology, Faculty Of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Angka Kejadian Hiperpigmentasi Pasca Inflamasi pada Pasien Akne Vulgaris Sedang Tipe Kulit IV-V yang Diterapi Gel Benzoil Peroksida 2,5% Uji Klinis, Acak, Buta Ganda Irma Bernadette S. Sitohang; Putu Siska Virgayanti; Shannaz Nadia Yusharyahya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.995 KB) | DOI: 10.20473/bikk.V31.3.2019.71-77

Abstract

Latar belakang: Akne vulgaris (AV) merupakan peradangan kronis folikel pilosebasea dengan manifestasi klinis berupa komedo, papul, pustul, nodus dan pseudo kista yang bersifat swasirna. AV digolongkan atas tiga kategori, yaitu akne vulgaris ringan (AVR), sedang (AVS) dan berat (AVB). Rekomendasi Global Alliance dalam penanganan AVS meliputi antibiotik, asam retinoat, dengan atau tanpa benzoil peroksida (BPO). Kombinasi antibiotik dan BPO direkomendasikan untuk mengatasi masalah tersebut meskipun pada tipe kulit IV-V, hiperpigmentasi pasca inflamasi merupakan masalah yang sering dikeluhkan pada penggunaan BPO. Tujuan: Membandingkan efektivitas, efek samping dan kejadian hiperpigmentasi pasca inflamasi (HPI) pada penggunaan BPO sebagai paduan terapi lini pertama AVS pada tipe kulit IV-V Fitzpatrick. Metode: Penelitian analitik dengan desain uji klinis acak tersamar ganda membandingkan dua sisi wajah yang diberikan paduan terapi lini pertama. Sisi wajah perlakuan diberikan gel BPO 2,5% sedangkan kelompok kontrol gel plasebo. Hasil: Pada minggu ke-2,4,6,8 didapatkan penurunan persentase total lesi sebesar 51,47%, 71%, 75%, 82,84% pada kelompok BPO dan 30%, 53,75%, 62,28, 71%  pada kelompok plasebo (p<0,001) Efek samping dan kejadian HPI pada minggu ke 2,4,6 dan 8 tidak berbeda bermakna. Simpulan: Penggunaan BPO sebagai bagian dari paduan terapi lini pertama AVS lebih efektif, tidak meningkatkan efek samping ataupun kejadian HPI.
Association of zinc intake & serum zinc levels with acne severity Otami, Chintia; Chandra, Novita; Sitohang, Irma Bernadette S.
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Recent studies have suggested the relationship between diet and acne, and zinc plays a role through its anti-inflammatory mechanism. This study aimed to determine the association between zinc intake and serum zinc levels with acne severity. Methods: A comparative cross-sectional study was conducted to assess the difference in zinc intake and serum zinc levels with acne severity based on Indonesian Acne Expert Meeting (IAEM) criteria. Sixty patients with acne in Dr. Cipto Mangunkusumo General Hospital were selected. The effect of zinc intake on acne severity was analyzed via unpaired T test, whereas the effect of serum zinc levels on acne severity was examined with Mann–Whitney test. Data were further evaluated using SPSS 20.0. Results: Zinc intake in all the subjects was below the Indonesian recommended daily allowance, and the mean of zinc intake and serum zinc levels in the mild acne group was higher than that of the moderate–severe acne group. The zinc intake significantly differed between the mild and moderate–severe acne groups (p < 0.01). Likewise, serum zinc levels significantly varied between mild and moderate–severe acne group (p = 0.048). Conclusion: Although this study showed a significant difference between zinc intake and serum zinc levels with the severity of acne vulgaris, further follow-up studies should be performed to assess zinc for acne vulgaris therapy.
Case series of primary psychiatric skin disorders with multi-disciplinary approach Lusiana, Lusiana; Prayogo, Rizky Lendi; Yusharyahya, Shannaz Nadia; Sitohang, Irma Bernadette S.; Bramono, Kusmarinah
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: The incidence of psychodermatologic diseases, a group of skin abnormalities associated with psychosomatic factor, are increasing recently. About 20-40% patients with skin symptoms have concurrent psychiatric problems which are often difficult to diagnose and treat. The new classification of primary psychiatric skin disorders are delusional disorders, obsessive-compulsive and related disorders, and factitious disorders. This classification could be used for effective treatment in each patient which involves multi-disciplinary approach, including dermatology, psychiatry and other discipline if necessary. Case Illustration: The first case was a 39-year-old unmarried female, with anemia and dermatitis artefacta occurred as wound due to blade cuts. Patient was with schizoaffective depressive type and was not under regular treatment. The second case was a 61-year-old male referred with unresolved prurigo nodularis for the past 30 years. After in-depth assessment, there were delusional parasitosis and neurotic excoriations disorders. The third patient was a 50-year-old female admitted with recurrent ulcer on her face. She was aware that the lesions were intentionally manipulated by her own fingers when she was depressed. Discussion: All patients were classified as primary psychiatric skin disorders with varied skin manifestations. Symptoms usually occurred when the patient was in the depression state or low compliance for the psychotropic drugs. Patients generally had poor insight and refused to be associated with psychiatric factors. Dermato-venereologists are expected to conduct early detection and treat this disease. Conclusion: It is important to approach psychocutaneous disease in multi-disciplinary manner, especially with the psychiatrist.
Markedly clinical improvement of papulopustular rosacea with multimodality therapeutic approach: a case report Priyanto, Mufqi Handaru; Wardani, Amanda Nandi; Legiawati, Lili; Sitohang, Irma Bernadette Simbolon; Suseno, Lis Surachmiati
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/85p5m842

Abstract

Introduction: Rosacea is a chronic inflammatory skin disease that mainly affects the central area of the face. There are four subtypes, and they may progress between subtypes or span multiple subtypes. Due to its long course of the disease, optimum treatments are needed to control the disease progression. Case: We reported rapid improvement of combining topical metronidazole, doxycycline, and light emitting diode for treating a patient with papulopustular rosacea in a 44-years-old woman, a week from the initial therapy. Discussion: Therapeutic approaches to rosacea mainly focus on controlling the symptoms with anti-inflammatory agents. More recently, photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative or an adjuvant therapy to conventional treatment through their synergic mechanism between therapeutic modalities. Conclusions: This combination treatment may be effective for treating papulopustular rosacea without any side effects.
Adjuvant therapies of acne: review of literatures Randy Satria Nugraha Rusdy; Lili Legiawati; Irma Bernadette Simbolon Sitohang; Sondang Marisi Holong Aemilia Pandjaitan Sirait
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 5 No. 1 (June 2022)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/bekrds92

Abstract

Acne is a chronic inflammatory disorder affecting pilosebaceous unit with various clinical manifestation from comedone, papule, pustule, to nodule and cyst. Choice of treatment is based on acne severity. Prolong antibiotic use along with restriction of isotretinoin use in Indonesia can be a challenge in managing acne. A lot of treatment options from topical agent, systemic medication, comedone extraction, intralesional corticosteroid injection, chemical peeling, light and laser-based therapy, as well as diet modification can be used as an adjuvant to improve acne. Review of literatures was performed to present recent evidence toward the effectivity of adjuvant therapy as a part of acne management.
MICRO AND NANO-AUTOLOGOUS FAT TRANSFER UNTUK TATA LAKSANA LIPODISTROFI WAJAH PADA LUPUS ERITEMATOSUS SISTEMIK Batubara, Irwan Saputra; Suseno, Lis Surachmiati; Sitohang, Irma Bernadette; Legiawati, Lili
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.404

Abstract

Introduction: Lipodystrophy in systemic lupus erythematosus (SLE) causes deformity and psychological problem for patients. The recommended treatment is autologous fat transfer (AFT) because of its effectiveness. Case: A 19-year-old woman with facial lipodystrophy due to SLE was treated with AFT. Fat tissue was aspirated from the lateral side of the left thigh and then processed into microfat and nanofat using the Luer-Lok connectors. The total volume of fat injected was 28 mL with a significant improvement of skin contour. She was satisfied with the results. There were no postoperative complications. She is still under monitoring for the next six months to assess AFT retention. Discussion: There are various modifications of the AFT technique to improve outcomes and avoid complications. Microfat aims to fill the volume loss, whereas nanofat is beneficial to improve skin contours. The main drawback of AFT is the unpredictable retention of fat volume. Patient factors, fat processing methods, and AFT technique play a role in post-AFT retention. Although extremely rare, fat embolization can occur during AFT which can be fatal. Injection with a blunt cannula, use of vasoconstrictors, and mapping of facial vascularization may reduce the risk of fat embolization. Conclusion: Autologous fat transfer is recommended for lipodystrophy because it is easy to perform, inexpensive, and non-immunogenic. Dermato-venereologists have an important role in the management of lipodystrophy due to SLE.
Comparing Sodium Fusidate and Petrolatum for Electrosurgery-related Wound Healing: A Double-blind Randomized Controlled Trial Parrol, Firman; Wibawa, Larisa Paramitha; Sitohang, Irma Bernadette Simbolon; Saldi, Siti Rizny Fitriana
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Electrosurgery is a common surgical technique used to treat skin tumors. This procedure produces necrotic skin, which might impair the wound healing process, prompting physicians to prescribe topical antibiotics to prevent infection. This study aims to analyze the efficacy of sodium fusidate ointment compared to petrolatum for wound healing after electrosurgery. Methods: We conducted a double-blind, randomized, controlled study with a within-person design. The inclusion criteria were adult subjects with seborrheic keratosis or acrochordon with a size of 4 mm to 10 mm on the face and neck, with a minimum of 2 lesions. Electrodessication was performed on the subject lesions. The patients were then randomized to receive and sodium fusidate ointment or petrolatum. Follow-up was done for up to 14 days, during which wound healing score, erythema, edema, crusts, re-epithelialization, incidence of infection, and subjective symptoms were assessed. This study is registered in ClinicalTrials.gov (NCT05353374). Results: Twenty-two subjects with 90 wounds were enrolled. The subjects had a mean age of 48.18 ± 11.25 years old and 86.4% of them had seborrheic keratosis. Statistical analysis revealed no significant difference in erythema, edema, crusts, re-epithelialization, infection, subjective symptoms, and total wound healing score appearance on days 3, 7, and 14 following the procedure. Conclusion: Both sodium fusidate ointment and petrolatum showed similar efficacy for wound healing after electrosurgery.
Co-Authors Aida S.D. Hoemardani Batubara, Irwan Chandra, Dian Novita Chandra, Novita Chintia Otami Effendi, Evita Fathan, Hafizah Kusmarinah Bramono Larisa Paramitha Levina Chandra Lili Legiawati Lusiana Lusiana Lusiana Lusiana Mardiastuti Mardiastuti Otami, Chintia Parrol, Firman Prayogo, Rizky Lendi Priyanto, Mufqi Handaru Putu Siska Virgayanti Rajesh Balkrisnan Randy Satria Nugraha Rusdy Rizky Lendl Prayogo Rubby Aditya Saldi, Siti Rizny Fitriana Shannaz Nadia Yusharyahya Sirait, Sondang Panjaitan Suseno, Lis Surachmiati Wardani, Amanda Nandi