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The effects of vitamin D on chronic wounds Priyanto, Mufqi Handaru; Miranda, Eliza; Yusharyahya, Shannaz Nadia; Legiawati, Lili; Novianto, Endi; Bramono, Kusmarinah; Krisanti, Roro Inge Ade
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Wounds that fail to proceed through the normal healing process are referred to as chronic wounds, also known as ulcers. Chronic wounds have immeasurable biological, psychological, social, and economic effects, bringing tremendous challenges for patients, doctors, healthcare providers, and healthcare systems. Discussion: This condition is associated with a variety of comorbidities and complex etiologies. The global incidence of chronic wounds is expected to increase with longer life expectancy. Thus, a holistic approach is necessary, such as proper wound management, proper control of comorbidities, and provision of adequate nutrition, including vitamin D supplementation. Vitamin D is an essential pro-hormone for cell differentiation, proliferation, and growth. It affects the skin’s immune response, and is therefore thought to promote wound healing and tissue repair. Many studies have been published on the association between low vitamin D levels and chronic wounds. However, whether or not vitamin D supplementation directly contributes to wound healing still needs to be elucidated. Conclusion: Despite the many reports on vitamin D as an adjuvant treatment for chronic wounds, further large-scale clinical studies are needed to cement the role of vitamin D as an effective standard therapy for chronic wound healing.
Markedly clinical improvement of papulopustular rosacea with multimodality therapeutic approach: a case report Priyanto, Mufqi Handaru; Wardani, Amanda Nandi; Legiawati, Lili; Sitohang, Irma Bernadette Simbolon; Suseno, Lis Surachmiati
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/85p5m842

Abstract

Introduction: Rosacea is a chronic inflammatory skin disease that mainly affects the central area of the face. There are four subtypes, and they may progress between subtypes or span multiple subtypes. Due to its long course of the disease, optimum treatments are needed to control the disease progression. Case: We reported rapid improvement of combining topical metronidazole, doxycycline, and light emitting diode for treating a patient with papulopustular rosacea in a 44-years-old woman, a week from the initial therapy. Discussion: Therapeutic approaches to rosacea mainly focus on controlling the symptoms with anti-inflammatory agents. More recently, photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative or an adjuvant therapy to conventional treatment through their synergic mechanism between therapeutic modalities. Conclusions: This combination treatment may be effective for treating papulopustular rosacea without any side effects.
PIODERMA FASIALE: DERMATOSIS AKIBAT INFEKSI ATAU AKIBAT ETIOLOGI LAIN? SUATU KASUS JARANG Priyanto, Mufqi Handaru; Miranda, Eliza; Sirait, Sondang Pandjaitan; Menaldi, Sri Linuwih SW
Media Dermato-Venereologica Indonesiana Vol 51 No 1 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i1.261

Abstract

Pioderma fasiale merupakan kondisi kelainan kulit yang jarang terjadi. Kelainan ini secara klasik ditandai dengan munculnya erupsi inflamatori berupa papul, pustul, nodul, bahkan kista pada wajah, terutama mengenai perempuan usia 15-46 tahun. Kondisi tersebut saat ini disebut sebagai rosasea fulminan, suatu varian rosasea yang berat dengan etiologi yang belum diketahui jelas sampai sekarang. Diduga terdapat hubungan antara pioderma fasiale dengan faktor imunologi, hormonal, dan vaskular. Dilaporkan satu kasus yang sepengetahuan penulis belum pernah dilaporkan di Indonesia. Perempuan usia 15 tahun dalam terapi lupus eritematosus sistemik, datang dengan erupsi pustul multipel di atas plak eritematosa disertai beberapa telangiektasis pada wajah. Kondisi ini awalnya dipikirkan sebagai suatu pioderma yang membaik dengan antibiotik sistemik  amoksisilin/asam klavulanat, namun mengalami rekurensi. Kultur dari pustul tidak didapatkan pertumbuhan isolat bakteri, dan biopsi jaringan menunjukkan sebukan sel polimorfonuklear di sekitar pembuluh darah, jaringan interstitial, dan folikel rambut. Pasien kemudian diterapi dengan kombinasi asam retinoat dan eritromisin topikal yang memberikan respons sangat baik dalam 3 minggu sejak dimulainya terapi.