Article Per Year (5 Year)
p-Index From 2020 - 2025
1.431
P-Index
This Author published in this journals
All Journal BALI MEDICAL JOURNAL (BMJ) Medicina INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Medical Journal of Indonesia MNJ (Malang Neurology Journal) Bali Journal of Anesthesiology The Indonesian Journal of Infectious Diseases Callosum Neurology Journal : Jurnal Berkala Neurologi Bali ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Kedokteran Neurosains Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Archives of Biomedical Research (InABR) Cermin Dunia Kedokteran Magna Neurologica Neurona
Raka-Sudewi A. A.
Udayana University, Bali-Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

 1 
FLOUXETINE IMPROVED INTRAVAGINAL EJACULATORY LATENCY TIME THROUGH DECREASED LEVELS OF INTERFERON-GAMMA AND INCREASED LEVELS OF SEROTONIN IN PATIENT WITH PREMATURE EJACULATION I M., Nyandra; W, Pangkahila; A. A., Raka-Sudewi; I N. A., Bagiada
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 6 No 2 (2012): Indonesian Journal of Biomedical Sciences
Publisher : Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.199 KB)

Abstract

Pathophysiology of premature ejaculation (PE) is very complex because it is associated with many factors, which can be grouped into biological factors and psychological factors. Various diseases have been found correlate between psychological factors and biological factors through cytokines, one of which is IFN-g (IFN-g). IFN-g affect indolamine dioxygenase enzyme (IDO) and decrease levels of serotonin. Low levels of serotonin leads to PE. The purpose of this study was to prove the relationship of serotonin and IFN-g in pathophysiology of PE. This study was designed as a pretest-posttest double-blind cross-over control group design. Patients with PE were divided into 2 groups: control group and treatment group. Treatment group received flouxetine 20 mg for 30 days. Then the control and treatment groups were crossed after passing a 14-days washout period. Previously as a control group to treatment group and received flouxetine 20 mg per day for 30 days. Before and after treatment in each group was examined the levels of serotonin and IFN-g. Of the 26 subjects, each group there was 13 subjects. Flouxetine 20 mg per day for 30 days increased serotonin levels were significantly (p < 0.05), and decreased levels of IFN-g were significantly (p < 0.05). Increased levels of serotonin and decreased levels of IFN-g was significantly associated with improvements (intravaginal ejaculatory latency time) ejaculation in PE patient. From these results it can be concluded that PE occurs because decreased levels of serotonin. Decreased levels of serotonin are associated with increased levels of IFN-g. Keywords: PE, Serotonin, IFN-g.
HIGH PLASMA TNF-? LEVELS AND MONONUCLEAR CELLS iNOS AND TNF-? EXPRESSION AS RISK FACTORS FOR PAINFUL DIABETIC NEUROPATHY Eko Purwata, Thomas; Suastika, Ketut; Raka Sudewi, A. A.; Widjaja, Djoenaidi
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 2 Juli 2010
Publisher : Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.818 KB)

Abstract

Painful Diabetic Neuropathy (PDN) is one of the most common and annoyingcomplications of diabetes mellitus. The pathogenesis of PDN is complex and still unclear.Recently it has become clear that nitric oxide (NO) and proinflammatory cytokines playan important role in the pathogenesis and maintenance of pain in PDN. Based on thisphenomenon, this study was conducted to investigate whether the cytokine tumornecrosis factor-alpha (TNF-?) and NO, in this case inducible Nitric Oxide Synthase(iNOS), play a role in PDN pathogenesis.The study was carried in two steps. The first step was a cross sectional and thesecond step was a case-control study. The study was performed in 110 type-2 diabeticpatients. The plasma TNF-? levels were determined by ELISA while the expression ofTNF-? and iNOS in mononuclear cells were analyzed immunohistochemically.Of 110 subjects, 59 patients suffered from Painful DN (case) and the remaining51 patients were Painless DN (control). Cross sectionally, plasma TNF-? levels andimmunoreactivity for iNOS and TNF-? were higher in patients with more severe pain inthe Visual Analog Scale (VAS). There were statistically significant differences (p <0.05) between mild and severe pain in regard to TNF-? level (15.24 pg/ml ± 5.42 vs.20.44 pg/ml ± 10.34 ); to iNOS immunoreactivity (9.72 % ± 8.61 vs. 15.6% ± 11.84); andto TNF-? immunoreactivity (13.0 % ± 9. 48 vs. 20.44% ± 11.75).The case control study showed that TNF-? had an odd ratio of 5.053 [CI 95%(2.241-11.392); p < 0.001]. TNF-? immunoreactivity of 4.125 [CI 95% (1.805-9.425); p< 0.001]; and iNOS immunoreactivity of 3.546 [CI 95% (1.613-7.795); p = 0.002]. There were correlations between TNF-? level, TNF-? and iNOS immunoreactivity andVAS with coefficient correlation: 0.330; 0.285 and 0.275 (p < 0.05) respectively.It is concluded that Diabetic Neuropathy patients with high TNF-? levels, iNOSand TNF-? immunoreactivity of mononuclear cells have higher risk for painful DN thanpainless DN. The higher TNF-? level, iNOS and TNF-? immunoreactivity the moresevere was the pain. This supports the hypothesis that TNF-? and iNOS have role inPDN pathogenesis. The results of this research could be applied as a basic for furtherresearch in pursuit of better management of PDN.
Co-Authors Adinda Putra Pradhana Agung Bagus S. Satyarsa Agus Eka Darwinata Akira Ito Anak Agung Bagus Ngurah Nuartha Anak Agung Ngurah Subawa Angelia Carolin Bagiada I N. A. Christine Ekawati, Christine Christopher Ryalino Cokorda Istri Dyah Sintarani Sintarani Dedi Silakarma Desak Gde Diah Dharma Santhi Dewa Ngurah Suprapta Djoenaidi Widjaja Ernesta Ginting F. S. Wignall Ge Aris Geson Ginting, Ernesta Gitari, Ni Made I Dewa Made Sukrama I Gde Raka Widiana I Gede Ketut Sajinadiyasa I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Kade Mahardika I Ketut Suastika I Made Jawi I Nyoman Adi Putra I Putu Eka Widyadharma I Wayan Niryana I Wayan Putu Sutirta Yasa I. B. P. Dwija Ida Ayu Jasminarti Dwi Kusumawardani Ida Ayu Sri Wijayanti Ida Bagus Ngurah Rai Imelda, Yuliana Monika Ivan Elisabeth Purba K. Subrata K. Wirasandhi Kade Agus Sudha Naryana Kazuhiro Nakaya M Wiryana Made Nyandra Made Wiryana N ADIPUTRA, N N. K. Susilarini NFN Moestikaningsih Ni Luh Putu Eka Arisanti Ni Made Adi Tarini Ni Made Susilawathi Ni Nengah Dwi Fatmawati Ni Nyoman Sri Budayanti Ni Putu Sriwidyani Ni Wayan Candrawati Oka Adnyana Pangkahila W Paramita, Dyah Pradnya Pramitasuri, Tjokorda Istri Pusaka, Semerdanta Putra Martin Widanta IGN Putu Yogi Pramana Sanjaya, Feliani Senja Decy Ningrum Sri Maliawan Sukmawati, Ni Made Dewi Dian Suryapraba, Anak Agung Ayu Susilawathi, Ni Made Thomas Eko Purwata Tjokorda Gde Agung Senapathi Tjokorda Gde Bagus Mahadewa Tjokorda Istri Pramitasuri Toni Wandra Vania, Aurelia Widanta IGN, Putra Martin Yasuhito Sako Yuliana Monika Imelda