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All Journal Nusantara Medical Science Journal Indonesian Journal of Cardiology Jambura Medical and Health Science Journal Cermin Dunia Kedokteran
Muzakkir, Akhtar Fajar
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Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Right Ventricle Free Wall Longitudinal Strain in Cancer Patients Following Chemotherapy Ghaznawie, Aussie Fitriani; Muzakkir, Akhtar Fajar; Fathlina, F.; Mappahya, Ali Aspar; Alkatiri, Abdul Hakim; Zainuddin, Andi Alfian; Prihantono, Prihantono
Nusantara Medical Science Journal Volume 8 Issue 1, January - June 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v8i1.26648

Abstract

Introduction: The survival rate of cancer patients was high due to chemotherapy, but it can cause cardiotoxicity and increase morbidity and mortality. Most studies on cancer therapy-related cardiac dysfunction (CTRCD) focus more on the left ventricle. This study assesses chemotherapy's effect on the right ventricle, namely the right ventricle free wall longitudinal strain (RVFWLS). Methods: This study is a prospective cohort conducted from January to December 2022 on thirty-four cancer patients undergoing chemotherapy at Dr Wahidin Sudirohusodo Hospital Makassar. The RVFWLS was assessed before and after chemotherapy using echocardiographic. Result: The RVFWLS value after one cycle chemotherapy decreased compared pre-chemotherapy (4.40±4.84; p=0.001). Conclusion: The effect of chemotherapy is a decrease the RVFWLS value after the first cycle of chemotherapy. It should be considered for echocardiographic evaluation, especially the RVFWLS value every cycle of chemotherapy.
Management of Acute Coronary Syndrome Indonesia : Insight from One ACS Multicenter Registry Juzar, Dafsah Arifa; Muzakkir, Akhtar Fajar; Ilhami, Yose Ramda; Taufiq, Nahar; Astiawati, Tri; R A, I Made Junior; Pramudyo, Miftah; Priyana, Andria; Hakim, Afdhalun; Anjarwani, Setyasih; Endang, Jusup; Widyantoro, Bambang
Jurnal Kardiologi Indonesia Vol 43 No 2 (2022): Indonesian Journal of Cardiology: April - June 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1406

Abstract

Background Acute coronary syndrome (ACS) is a life-threatening disorder which contributes to high morbidity and mortality in the world. Registry of ACS offers a great guidance for improvement and research. We collated a multicentre registry to gain information about demographic, management, and outcomes of ACS in Indonesia. Methods IndONEsia Acute Coronary Syndrome Registry (One ACS Registry) was a prospective nationwide multicenter registry with 14 hospitals participating in submitting data of ACS via standardized electronic case report form (eCRF). Between July 2018 and June 2019, 7634 patients with ACS were registered. This registry recorded baseline characteristics; onset, awareness, and transfer time; physical examination and additional test; diagnosis; in-hospital medications and intervention; complications; and in-hospital outcomes. Results Nearly half of patients (48.8%) were diagnosed with STE-ACS. Most prevalent risk factors were male gender, smoking, hypertension. Patients with NSTE-ACS tended to have more concomitant diseases including diabetes mellitus, dyslipidemia, prior AMI, HF, PCI, and CABG. Majority of ACS patients in our registry (89.4%) were funded by national health coverage. Antiplatelet, anticoagulant, antihypertensive, and statins were prescribed as 24-hours therapy and discharge therapy; however presription of potent P2Y12 inhibitor was low. More STE-ACS patients underwent reperfusion therapy than non-reperfusion (65.2% vs. 34.8%), and primary PCI was the most common method (45.7%). Only 21.8% STE-ACS patients underwent reperfusion strategy within 0-3 hours of onset. Invasive strategy performed in 17.6% of NSTE-ACS patients, and only 6.7% performed early (within <24 hours). Patients underwent early invasive strategy had a shorter median LoS than late invasive strategy (P<0.001). A shorter median LoS also found in intermediate and low risk patients. Mortality rate in our ACS patients was 8.9%; STE-ACS patients showed higher mortality than NSTE-ACS (11.7 vs. 6.2%). Conclusion Our registry showed a comparable proportion between STE- and NSTE-ACS patients, with male gender predominant in middle age. Both STE- and NSTE-ACS sharing the same risk factors. We need an improvement in referral time, especially in patients with STE-ACS. Evidence from our registry showed that there are two issues that need to be addressed in order to improve ACS outcomes: optimal and adequate medical treatment and invasive strategy. This article has a related Erratum.
The IndONEsia ICCU Registry Juzar, Dafsah Arifa; Bagaswoto, Hendry Purnasidha; Muzakkir, Akhtar Fajar; Habib, Faisal; Astiawati, Tri; Prasetya, Indra; Wirawan, Hendy; Ilhami, Yose Ramda; Djafar, Dewi Utari; Sungkar, Safir; Danny, Siska Suridanda
Jurnal Kardiologi Indonesia Vol 44 No 4 (2023): Indonesian Journal of Cardiology: October - December 2023
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1603

Abstract

Introduction: Patients in the Intensive Cardiovascular Care Unit (ICCU) often present with cardiovascular disease (CVD) issues accompanied by various non-cardiovascular conditions. However, a widely applicable scoring system to predict patient outcomes in the ICCU is lacking. Therefore, developing and validating scores for predicting ICCU patient outcomes are warranted. The aims of the IndONEsia ICCU (One ICCU) registry include developing an epidemiological registry of ICCU patients and establishing a multicentre research network to analyse patient outcomes. Methods and results: This nationwide multicenter cohort protocol will capture data from patients receiving cardiovascular critical care treatment in 10 Indonesian hospitals with ICCU facilities. Recorded data will encompass demographic characteristics, physical examination findings at hospital and ICCU admission, diagnoses at ICCU admission, therapy, intervention, complications on days 3 and 5 of in-ICCU care, in-hospital outcomes, and 30-day outcomes. Conclusion: The One ICCU is a large, prospective registry describing the care process and advancing clinical knowledge in ICCU patients. It will serve as an investigational platform for predicting the mortality of ICCU patients.
Menjembatani Kesenjangan dalam Manajemen Dislipidemia di Indonesia Melalui Strategi ACS Europath: Analisis Antonius, Richard; Muzakkir, Akhtar Fajar
Cermin Dunia Kedokteran Vol 52 No 4 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i4.1384

Abstract

Dyslipidemia is a significant global public health concern, particularly in Indonesia. Current dyslipidemia guidelines stated the management should be done with a combination of lifestyle and pharmacological interventions. Treatment with lipid lowering agents should be initiated early for better prognostic benefit. ACS Europath IV project emphasizes the importance of early intensification of lipid-lowering therapy to reduce the risk of recurrent cardiovascular events and improve patient outcomes. This literature review the current state of dyslipidemia management in Indonesia and discussing the potential role of ACS Europath strategies in improving patient outcomes.
Management of Acute Coronary Syndrome Indonesia: Insight from One ACS Multicenter Registry Juzar, Dafsah Arifa; Muzakkir, Akhtar Fajar; Ilhami, Yose Ramda; Taufiq, Nahar; Astiawati, Tri; R A, I Made Junior; Pramudyo, Miftah; Priyana, Andria; Hakim, Afdhalun; Anjarwani, Setyasih; Endang, Jusup; Widyantoro, Bambang
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2005

Abstract

In “Management of Acute Coronary Syndrome in Indonesia: Insight from One ACS Multicenter Registry” (Indonesian Journal of Cardiology, 43(2), 45-55. https://doi.org/10.30701/ijc.1406), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1406. The error occurs only in the PDF; the DOI listed in the article metadata is already correct. The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.1406
Serial Case of Acute Pulmonary Embolism: Different Therapies based on Different Patient Profiles Ahmad, Ilzy Jum; Mappangara, Idar; Muzakkir, Akhtar Fajar
Jambura Medical and Health Science Journal Vol 4, No 2 (2025): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v4i2.33747

Abstract

Pulmonary embolism (PE) is the third leading cause of cardiovascular death. The high mortality rate prompted an analysis of these three-case series to evaluate various treatment options. Case I, a 66-year-old woman with acute shortness of breath and a history of EVLA because of chronic venous insufficiency in the left leg. She had comorbid of hypertension. She was diagnosed with massive PE with unstable hemodynamics. Catheter-directed thrombolysis (CDT) using Alteplase showed significant improvement within 24 hours. Case II, a 45-year-old woman with dyspnea de effort for one month and a 5-year history of hypertension. MSCT angiography showed a significant PE with partial stenosis, pulmonary hypertension, and a bidirectional atrial septal defect. Combination therapy with heparin, sildenafil, and furosemide had been provided but the patient had sudden cardiac death. Case III, a 36-year-old woman with dyspnea on effort after the delivery. Initial echocardiography showed right atrial and left ventricular thrombi. On the second day of treatment, clinical deterioration occurred due to thrombus migration to the pulmonary artery, confirming the diagnosis of acute PE. CDT therapy was performed. A 24-hour evaluation revealed persistent occlusion of pulmonary artery, leading to percutaneous transluminal angioplasty, which successfully restored blood flow. This case series report emphasizes the importance of risk-based therapy, including CDT for high-risk PE, anticoagulation for intermediate- to low-risk PE, and hemodynamic support in cases of shock. Keywords: Clinical deterioration, heparin, pulmonary embolism, thrombolytic therapy, tissue plasminogen activator
Co-Authors Abdul Hakim Alkatiri Ahmad, Ilzy Jum Ali Aspar Mappahya Andi Alfian Zainuddin Andria Priyana Anjarwani, Setyasih Antonius, Richard Astiawati, Tri Bambang Widyantoro Dewi Utari Djafar, Dewi Utari Endang, Jusup Fathlina, F. Ghaznawie, Aussie Fitriani Habib, Faisal Hakim, Afdhalun Hendry Purnasidha Bagaswoto Idar Mappangara, Idar Ilhami, Yose Ramda Indra Prasetya Juzar, Dafsah Arifa Nahar Taufiq, Nahar Pramudyo, Miftah Prihantono, Prihantono R A, I Made Junior Siska Suridanda Danny Sungkar, Safir Wirawan, Hendy