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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Journal of Pharmaceutical and Health Research Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Natural
Fujiko, Muflihah
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Religion Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Antibacterial, antioxidant and total flavonoid of Adenostemma lavenia (L.) ZEBUA, NILSYA FEBRIKA; FUJIKO, MUFLIHAH; DACHI, KANNE; NERDY, NERDY; SEPTAMA, ABDI WIRA
Jurnal Natural Volume 24 Number 2, June 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i2.36396

Abstract

Adenostemma lavenia (L.) is one of the medicinal plants on Nias Island that is used to treat many symptoms including cough, fever and diarrhea. Empirical data of this plant suggests that these medicinal benefits can be attributed to its antibacterial and antioxidant properties, as well as the total flavonoids contained within it, but research on this is still limited. Adenostemma lavenia (L.) was extracted with ethanol, while the antibacterial properties were measured using the disc method. Antioxidant testing was conducted with the DPPH (1,1-diphenyl-2-2picrihydrazyl) inhibition method. Total flavonoids were assessed using a modified AlCl3 method with a quercetin standard. Antibacterial test results of Staphylococcus aureus, Klebsiela pneumoniae, Propionibacterium acnes, Escherichia coli, Salmonella typhi, Bacillus cereus and Shigella sonnei with mean inhibition were 8.76 0.44, 8.13 0.72, 8.77 0.45, 6.47 0.54, 7.77 0.60, 7.33 0.44, 12.06 0.60 respectively. IC50 was 59.844 3.36 ppm. Total flavonoids were 13.566 0.021 mcg/g. The results of the antibacterial test of the ethanolic extract of Adenostemma lavenia (L.) were classified as moderate. The antioxidant activity and total flavonoids were in the high category, which can be attributed to the capture of free radicals to overcome disease.
ANTIDIABETES TEST OF ETANOL EXTRACT OF ARA SUNGSANG LEAVES (Asystasia gangetica L.) ON ALOKSAN INDUCED WHITE MICE Saputri, Muharni; Fujiko, Muflihah; Dasopang, Eva Sartika; Arianti, Nova; Naswa, Shinta
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 2 (2025): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i2.13382

Abstract

Type 2 diabetes mellitus is caused by progressive impairment of insulin secretion leading to insulin resistance. Long-term use of antidiabetic drugs has gastrointestinal side effects as well as an increased risk of hypoglycemia. Therefore, a safer herbal treatment was developed. The purpose of the study was to determine the antidiabetic activity of ethanol extract of ara sungsang leaves on the reduction of glucose levels. The research is experimental, with the stages of making and standardizing simplisia, phytochemical screening, extraction, testing antidiabetic activity in vivo with 25 male mice. Blood glucose levels were determined at the beginning of fasting, after alloxan induction dose of 150 mg/kgbw, day 3, 6, 9, 12, 15. Blood glucose levels were analyzed statistically using the oneway ANOVA method. The results of the examination of simplisia standardization showed that the standardization of simplisia met the requirements. Phytochemical screening results showed that ara sungsang contains alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The antidiabetic activity test in mice showed that the ethanol extract of ara sungsang at a dose of 225 mg/kgbw had a greater effect on reducing blood glucose levels than doses of 75 and 150 mg/kgbw.
Uji Aktivitas Analgesik Dari Ekstrak Daun Ara Sungsang (Asystasia gangetica L.) Terhadap Mencit Jantan dengan Metode Hot Plate Fujiko, Muflihah; Saputri, Muharni; Sofia, Vivi; Mauliza, Indah
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6881

Abstract

Pain is a body response that indicates a disorder. The use of conventional drugs to treat pain is quite worrying because of its long-term effects. This causes people to use drugs derived from nature. Breech fig leaves contain flavonoids and alkaloids that are able to reduce pain. This study aims to see the potential of breech fig leaves as an analgesic induced to male mice using the hot plate method. This research began with plant identification, material collection, simplicia and extract, phytochemical screening, and testing on mice. This study was carried out in vivo using male mice. Twenty birds were divided into five groups, namely the negative control group (CMC-Na 0.5%), the positive control group (Ibuprofen 200 mg/kg BB), the breech fig leaf extract group (dosage 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB). Then the analgesic activity test was carried out by looking at the responsse of mice who were given pain using the hot plate method with a temperature of 55ºC. Then the percent of analgesic power and percent of the effectiveness of the analgesic were calculated. The results of the study showed that flavonoid compounds, alkaloids, tannins, steroids, and saponins were contained in breech fig leaves (Asystasia gangetica L.). dose 200 mg/kg BB has the highest percent analgesic power and effectiveness percentage, which is 99.12% (p<0,05) and 99.67% (p<0,05). From dose 50 mg/kg BB, the analgesic effect can be seen, and the best analgesic effect is at a dose of 200 mg/kg BB. This shows that breech fig leaf extract has analgesic activity in male mice by hot plate method.
Edukasi Pemanfaatan Tanaman Alami Dalam Pembuatan Sediaan Balsem Kelurahan Empus Langkat Julianty, Siti Muliani; Siahaan, Desy Natalia; Fujiko, Muflihah; Sofia, Vivi
ABDIMASKU : Jurnal Pengabdian Masyarakat UTND Vol 4 No 1 (2025): Edisi Januari 2025 - Juni 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/jpmtnd.v4i1.1575

Abstract

Masyarakat Indonesia tidak asing lagi dengan sediaan balsam dikarenakan balsam memiliki aromatherapy serta memiliki rasa yang hangat saat digunakan. Balsem merupakan sediaan yang penggunaannya dioleskan ke kulit dengan tangan sehingga dapat mengotori dan memberikan rasa panas yang sulit hilang. Pengabdian kepada masyarakat ini bertujuan untuk mewujudkan membagi pengetahuan kepada warga dalam edukasi pemanfaatan tanaman bahan alami dalam pembuatan sediaan balsam. Kegiatan ini dilakukan di Kelurahan Empus, Kab. Langkat, Sumatera Utara. Kegiatan yang dilakukan berupa pemeriksaan kesehatan, pemaparan edukasi dan tanya jawab. Adapun pemeriksaan kesehatan berupa pengecekan tekanan darah dan gula darah, pemaparan materi yang disampaikan terkait edukasi pemanfaatan tanaman bahan alami dalam pembuatan sediaan balsam kepada masyarakat. Hasil kegiatan ini untuk menambah pengetahuan masyarakat dalam memanfaatkan bahan alam sebagai sediaan balsam. Berdasarkan hasil tanya jawab semua peserta yang hadir menyatakan kegiatan ini memberikan manfaat positif serta tertarik dan ingin untuk mencoba memulai memanfaatkan bahan alami yang ada. secara mandiri. Kata kunci : Balsam, Edukasi, Masyarakat, Pengabdian LSEM
Co-Authors Abdi Wira Septama Arianti, Nova Dachi, Kanne Eva Sartika Dasopang Julianty, Siti Muliani Mauliza, Indah Naswa, Shinta Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Saputri, Muharni Siahaan, Desy Natalia Vivi Sofia