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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) JOPS (Journal Of Pharmacy and Science) Jambura Journal of Health Sciences and Research Journal of Pharmaceutical and Health Research Mejuajua Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Indonesian Journal of Science and Pharmacy
Saputri, Muharni
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Perbandingan Kadar Fenolik Total Air Rebusan dan Ekstrak Etanol Daun dan Batang Sawi Langit (Cyanthillium cinereum (L.) H.Rob) Saputri, Muharni; Yulia, Rahma; Febriani, Yessi; Ginting, Ernawaty; Amara, Saniatul; Zulkhaira, Zulkhaira; Utami, Intan Putri
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4578

Abstract

Sky mustard is one of the herbaceous plants used by the community to treat diseases such as inflammation, malaria and fever. This herbaceous plant is believed to have secondary metabolites such as phenolics which have many functions. The aim of this research was to determine the total content of phenolic compounds in leaves and stems of sky mustard greens (Cyanthillium cinereum (L.) H.Rob). This research is experimental in nature, including collecting plant material, identifying plants, cold extraction using the maceration method using ethanol and boiled water as a solvent, phytochemical screening, and determining the total phenolic content of boiled water and equivalent ethanol extract of leaves and stems (Gallic Acid Equivalent (GAE)) or gallic acid by colorimetric method using reagents Folin-ciocalteu a wavelength of 760 nm using UV-Visible spectrophotometry. The result of phytochemical screening of sky mustard leaves and stems contain alkaloids, steroids, saponins, flavonoids, tannin, glycosides and phenols. The result showed that phenol levels were greater in the leaves than in the stem the ethanol solvents attracted more phenolic compounds than boiling, and the phenol by boiling was higher at 5 minutes at 0,649 mg/g GAE. For phenolic compounds using ethanol solvent, there was a yield of 748,33 mg/g extract.
Activity Antibacterial Assay of Coffee Mistletoe Leaves (Loranthus Ferrugineus Roxb) Ethanol Extract is Against Bacteria Staphylococcus aureus and Escherichia coli Ningrum, Siti Rahmi; Dachi, Kanne; Saputri, Muharni
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coffee mistletoe (Loranthus ferrugineus Roxb) is a plant that has been researched globally and contains metabolite compounds such as flavonoids, tannins, saponins, and alkaloids, which have been extensively researched to have natural antimicrobial and antioxidant effects. For centuries, mistletoe has been widely used in traditional medicine as an anti-cancer agent for diarrhea and other infectious diseases. The study's goals are to find out what kind of metabolite compounds are in the ethanol extract of mistletoe coffee leaves and how well that extract kills Staphylococcus aureus and Escherichia coli bacteria. This research method is experimental, which includes collecting plant material, identifying plants, processing samples of coffee mistletoe into an ethanol extract of coffee mistletoe with a 96% ethanol solvent, and then testing phytochemical screening against coffee mistletoe simplisa. Antibacterial activity of an ethanol extract of coffee mistletoe against Staphylococcus aureus and Escherichia coli bacteria using the well diffusion test method. The ethanol extract of coffee mistletoe provides phytochemical screening results, including phenyl, terpenoids, and alkaloids. From the test results, it can be seen that the ethanol extract of coffee mistletoe can kill bacteria with the inhibitory power value of the extract on Staphylococcus aureus and Escherichia coli bacteria, with a minimum inhibitory power of 7.5 mm at a concentration of 3.125 mg/ml against Staphylococcus aureus and 8.9 mm at a concentration of 3.125 mg/ml against Escherichia coli bacteria. Judging from the inhibitory zone value, it is in the weak category for the lowest concentration in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria.
Uji Efektivitas Ekstrak Etanol Daun Ketapang (Terminalia cattapa L.) Terhadap Bakteri Patogen Saputri, Muharni; Mierza, Vriezka; Zebua, Nilsya Febrika; Panjaitan, M Ridho Pangestu
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6139

Abstract

Antiba Antibacterials work by preventing and managing the growth of pathogenic bacteria. The goal of controlling bacterial growth is to stop the spread of infection. Basically, people use synthetic drugs in antibacterial prevention but often there is a lot of resistance in the human body that can cause adverse effects. The active ingredients in ketapang leaves have the potential to act as natural antibiotics and antibacterials to combat antibiotic resistance. To determine the antibacterial effectiveness of these chemical compounds against bacteria Pseudomonas aeruginosa, Demacoccus nishinomiyaensi, Stapylococcus epidermidis and Micrococcus luteus, a study was conducted with the aim of knowing the content of chemical compounds contained in ketapang leaves based on maceration results. This study uses an experimental descriptive method with Ketapang leaf test material (Terminalia cattapa L.) This research stage includes making simplisia, maceration extraction using ethanol solvent, antibacterial activity test agar well diffusion method and analysis of chemical compound components by phytochemical screening.The results of drying fresh ketapang leaves produce as much as 1.6 kg of simplisia, and when 300 grams of ketapang leaf simplisia is macerated using ethanol pro analysis, 1.5 kg of simplisia is obtained. The ethanol extract from the maceration of ketapang leaves has antibacterial activity as shown by the inhibition of Pseudomonas aeruginosa bacteria by 18.38 mm, Dermacoccus nishinomiyaensis bacteria by 23.05 mm, Staphylococcus epidermidis bacteria by 18.71 mm, and Micrococcus luteus bacteria by 20.71 mm. After screening the ethanol extract of ketapang leaves, triterpenoid components, anthraquinone glycosides, saponins, and tannins were found. Flavonoid compounds were also found.
The Effect of Adding Ethanol Extract of Pomegranate Peel (Punica Granatum L.) on the Sun Protection Factor (SPF) Value of Sunscreen Cream Combination of Avobenzone and Octyl Methoxycinnamate Julianty, Siti Muliani; Ginting, Ernawaty; Sudewi, Sudewi; Rizki, Fanny; Nadia, Syarifah; Saputri, Muharni
Indonesian Journal of Science and Pharmacy Vol. 2 No. 1 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i1.57

Abstract

The compounds contained in pomegranate skin are phenolic acids, flavonoids, and tannins, including anthocyanidin, gallic acid, ellagic acid, ellagitannin, gallotanin, catechin, quercetin, which have antioxidant properties. The benefits of pomegranate peels are that they treat health problems and maintain beautiful skin. This research aimed to see the effect of adding pomegranate peel (Punica granatum L.) ethanol extract on the Sun Protection Factor (SPF) value of a combination of avobenzone and octyl methoxycinnamate sunscreen cream. This research was carried out using experimental methods. The formulation of sunscreen cream preparations uses pomegranate peel ethanol extract in various concentrations. The cream was evaluated to determine its Sun Protection Factor (SPF) value, organoleptic test, homogeneity, pH, emulsion type, and irritation test. The organoleptic test results showed that the cream produced in the blank had no odor and was white, while the cream with the addition of pomegranate peel ethanol extract had a distinctive smell and was brown. The emulsion type test shows the oil in the water type.  The addition of pomegranate peel ethanol extract to each formula increased the sun protection factor (SPF) value of sunscreen preparations. The average SPF value of each formula was FI 12.5956, FII 13.9673, FIII 16 .8205, FIV 17.9187, and FV 18.8437.
Phytochemical Screening and Anti-hyperglycemic Effect Test of Ethanol Extract of Waru Leaf (Hibiscus tiliaceus) on Glucose-loaded Mice Sofia, Vivi; Firdaus, Tya Novita; Saputri, Muharni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.345-355

Abstract

Background: The treatment of diabetes mellitus relies on synthetic drugs with various side effects. Therefore, it is necessary to explore alternative treatments with herbal therapies, such as Hibiscus tiliaceus leaves. Objectives: The aim of this study was to determine the anti-hyperglycemic effect of an ethanol extract from Hibiscus tiliaceus leaves in glucose-loaded mice. Methods: The initial stage of dried leaf characterization was to ensure the identity, quality, purity, and safety to be used, and then extracted using the maceration method with 70% ethanol solvent. The next step was phytochemical screening to identify secondary metabolite content. The anti-hyperglycemic effect was evaluated using the oral glucose tolerance test (OGTT) on 25 male mice divided into five treatment groups. The negative control group was given Na CMC 0.5% w/v Na CMC, and the positive control group was administered glibenclamide. The ethanol extract of Hibiscus tiliaceus leaves was administered at doses of 200, 400, and 800 mg/kg. Approximately 200 µL of blood was collected and analyzed for glucose levels. The data were statistically analyzed using one-way analysis of variance (ANOVA) with SPSS ver. 25 program. Results: Hibiscus tiliaceus leaves contain alkaloids, flavonoids, saponins, and tannins. The highest decrease in blood glucose levels was observed in the ethanol extract group at a dose of 400 mg/kg BW, with a decrease of 78.52%, followed by a dose of 200 mg/kg BW of 76.63%, a dose group of 800 mg/kg BW of 73.48%, and a positive control group (glibenclamide) of 34.68%, which was significantly different from the negative control group (Na CMC 0.5%) (p < 0.05). Conclusion: The ethanol extract of H. tiliaceus has anti-hyperglycemic effects.
ANTIDIABETES TEST OF ETANOL EXTRACT OF ARA SUNGSANG LEAVES (Asystasia gangetica L.) ON ALOKSAN INDUCED WHITE MICE Saputri, Muharni; Fujiko, Muflihah; Dasopang, Eva Sartika; Arianti, Nova; Naswa, Shinta
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 2 (2025): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i2.13382

Abstract

Type 2 diabetes mellitus is caused by progressive impairment of insulin secretion leading to insulin resistance. Long-term use of antidiabetic drugs has gastrointestinal side effects as well as an increased risk of hypoglycemia. Therefore, a safer herbal treatment was developed. The purpose of the study was to determine the antidiabetic activity of ethanol extract of ara sungsang leaves on the reduction of glucose levels. The research is experimental, with the stages of making and standardizing simplisia, phytochemical screening, extraction, testing antidiabetic activity in vivo with 25 male mice. Blood glucose levels were determined at the beginning of fasting, after alloxan induction dose of 150 mg/kgbw, day 3, 6, 9, 12, 15. Blood glucose levels were analyzed statistically using the oneway ANOVA method. The results of the examination of simplisia standardization showed that the standardization of simplisia met the requirements. Phytochemical screening results showed that ara sungsang contains alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The antidiabetic activity test in mice showed that the ethanol extract of ara sungsang at a dose of 225 mg/kgbw had a greater effect on reducing blood glucose levels than doses of 75 and 150 mg/kgbw.
Uji Aktivitas Analgesik Dari Ekstrak Daun Ara Sungsang (Asystasia gangetica L.) Terhadap Mencit Jantan dengan Metode Hot Plate Fujiko, Muflihah; Saputri, Muharni; Sofia, Vivi; Mauliza, Indah
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6881

Abstract

Pain is a body response that indicates a disorder. The use of conventional drugs to treat pain is quite worrying because of its long-term effects. This causes people to use drugs derived from nature. Breech fig leaves contain flavonoids and alkaloids that are able to reduce pain. This study aims to see the potential of breech fig leaves as an analgesic induced to male mice using the hot plate method. This research began with plant identification, material collection, simplicia and extract, phytochemical screening, and testing on mice. This study was carried out in vivo using male mice. Twenty birds were divided into five groups, namely the negative control group (CMC-Na 0.5%), the positive control group (Ibuprofen 200 mg/kg BB), the breech fig leaf extract group (dosage 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB). Then the analgesic activity test was carried out by looking at the responsse of mice who were given pain using the hot plate method with a temperature of 55ºC. Then the percent of analgesic power and percent of the effectiveness of the analgesic were calculated. The results of the study showed that flavonoid compounds, alkaloids, tannins, steroids, and saponins were contained in breech fig leaves (Asystasia gangetica L.). dose 200 mg/kg BB has the highest percent analgesic power and effectiveness percentage, which is 99.12% (p<0,05) and 99.67% (p<0,05). From dose 50 mg/kg BB, the analgesic effect can be seen, and the best analgesic effect is at a dose of 200 mg/kg BB. This shows that breech fig leaf extract has analgesic activity in male mice by hot plate method.
Sosialisasi Cara Penyimpanan Obat yang Baik dan Benar pada Masyarakat Sekitar Lapangan Merdeka-Binjai, Sumatera Utara Puput, Muharni Saputri; Saputri, Muharni; Sitepu, Karolina; Usman, Ari
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 2 No. 2 (2022): Desember 2022
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v2i2.67

Abstract

Obat merupakan bahan tunggal atau campuran yang dapat digunakan oleh semua mahluk hidup untuk bagian luar, untuk mencegah, meringankan, maupun menyembuhkan penyakit. Penyimpanan adalah kegiatan menyimpan dan memelihara dengan cara menempatkan obat pada tempat yang dinilai aman dari gangguan fisik yang dapat merusak mutu obat. Secara umum masyarakat masih belum memahami penyimpanan obat yang baik dan benar. Tujuan dari kegiatan pengabdian masyarakat ini untuk meningkatkan pengetahuan tentang pentingnya menyimpanan obat yang baik dan benar, serta meningkatkan peran penting Apoteker bagi masyarakat. Metode pengabdian masyarakat yang dilakukan berbentuk empiris atau pendekatan melalui sosialisasi penyimpanan obat yang baik dan benar. Pengabdian masyarakat dilaksanakan di Lapangan Merdeka Binjai pada hari sabtu tanggal 3 Desember 2022. Sosialisasi dilakukan oleh 5 mahasiswa Fakultas farmasi, Universitas Tjut Nyak Dhien dengan didampingi 3 dosen dari Universitas Tjut Nyak Dhien dan 1 orang dosen dari Universitas Harapan Medan. Hasil yang didapatkan pada kegiatan sosialisasi penyimpanan obat yang baik dan benar meningkatkan pemahaman yang baik dari beberapa masyarakat sekitar lapangan merdeka binjai mengenai pentingnya menyimpan obat sesuai dengan aturan, serta memahami peran dari apoteker sebagai tempat untuk konsultasi terkait masalah obat. Kesimpulan yang dapat ditarik dari kegiatan yang dilakukan dapat memberikan pemahaman pada beberapa masyarakat khususnya masyarakat Binjai dalam penyimpanan obat yang tepat. Sosialisasi yang dilakukan juga memberi informasi terkait peran Apoteker sebagai tempat untuk konsultasi terkait masalah penyimpanan obat.
Pelatihan Sistem Sertifikasi International Sustainability and Carbon Certification (ISCC) di Industri Oleokimia Pengolahan Bahan Baku Berbasis Kelapa Sawit Tambunan, Pravil Mistryanto; Juniar, Anna; Rajali, Mariany; Saputri, Muharni; Kembaren, Fanny
ABDIMASKU : Jurnal Pengabdian Masyarakat UTND Vol 4 No 2 (2025): Edisi Juli 2025 - Desember 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/jpmtnd.v4i2.1783

Abstract

This community service activity aims to provide training on the International Sustainability and Carbon Certification (ISCC) system to employees of a palm oil-based oleochemical industry company that processes residues and waste from palm oil derivative products. The training utilized a blended learning approach with pre-test and post-test evaluation using 20 multiple-choice questions, involving 30 participants. The results showed a significant improvement in participants' understanding, with average pre-test scores of 62.3 (SD=15.8) increasing to 87.7 (SD=9.4) on post-test, indicating an improvement of 25.4 points (40.7%, p<0.001). Twenty-one participants (70%) achieved excellent category (90-100) on post-test compared to only 6 participants (20%) on pre-test. Participant satisfaction reached 4.6/5.0 with 83.3% expressing high satisfaction. Follow-up after 1 month showed that 80% of participants had applied their knowledge in the workplace and 66.7% of companies began ISCC certification preparation. This activity successfully increased the human resource capacity of the oleochemical industry in understanding and implementing ISCC standards, supporting the competitiveness of Indonesian products in the global market that prioritizes sustainability aspects.
Optimalisasi Pekarangan Rumah Sebagai Kebun Toga Untuk Kesehatan Keluarga pada Desa Bukit Lawang Saputri, Muharni; Dasopang, Eva Sartika; Nerdy; Margata, Linda; Ramzayani, Astuti; Kamila, Tazkia; Dhafi, Muhammad
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2025): Agustus 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v5i1.250

Abstract

Pemanfaatan tanaman obat keluarga (TOGA) sebagai upaya menjaga kesehatan mandiri di tingkat rumah tangga masih belum optimal di sebagian masyarakat pedesaan. Minimnya pengetahuan masyarakat terhadap pengobatan tradisional menjadi alasan kurangnya minat terhadap tanaman yang berkhasiat sebagai obat. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan minat warga Desa Bukit Lawang dalam mengelola pekarangan rumah sebagai kebun TOGA yang fungsional dan berkelanjutan. Metode yang digunakan meliputi perkenalan, pretest, pemaparan materi, diskusi terkait pemanfaatan tanaman obat secara sederhana, dan di tutup dengan posttest. Hasil kegiatan menunjukkan adanya peningkatan pemahaman warga tentang jenis-jenis tanaman TOGA dan manfaatnya bagi kesehatan keluarga. Hasil kuisioner menunjukkan adanya kenaikan persentase pada pemahaman tentang TOGA dari 39% menjadi 94% dan pengetahuan terhadap manfaat TOGA juga mengalami kenaikan dari 31% menjadi 92%. Selain itu, warga mulai termotivasi untuk menjadikan TOGA sebagai bagian dari gaya hidup sehat dan ketahanan kesehatan keluarga berbasis kearifan lokal. Hal ini terlihat dari antusiasme warga mulai menanam TOGA dipekarangan rumahnya 1 hari setelah kegiatan berlangsung. Kegiatan ini menunjukkan bahwa sosialisasi terhadap TOGA harus bisa dilakukan secara rutin di daerah-daerah khususnya yang masih minim jaringan informasi dan kegiatan ini diharapkan menjadi langkah awal dalam menciptakan lingkungan sehat dan mandiri dalam pengelolaan kesehatan keluarga melalui tanaman obat tradisional.
Co-Authors Amara, Saniatul Anna Juniar Ari Usman, Ari Arianti, Nova Br Sitepu, Ulva Wirdana Dachi, Kanne Dhafi, Muhammad Eva Sartika Dasopang Fanny Rizki Sembiring Febriani, Yessi Firdaus, Tya Novita Fujiko, Muflihah Ginting, Ernawaty Hasanah, Fenny Irnabila, Salsa Julianty, Siti Muliani Kamila, Tazkia Karima, Nurul Linda Margata Mauliza, Indah Mierza, Vriezka Nabila Syahputri, Nabila Nadia, Syarifah Nasuha, Nabila Naswa, Shinta Nerdy Nilsya Febrika Zebua, Nilsya Febrika Ningrum, Siti Rahmi Panjaitan, M Ridho Pangestu Puput, Muharni Saputri Rajali, Mariany Ramzayani, Astuti Siahaan, Desy Natalia Sinaga, Manuella Sitepu, Karolina Sudewi Sudewi Syahputri, Devi Yanti Tambunan, Ika Julianti Tambunan, Pravil Mistryanto Ulayya, Nadaa Utami, Intan Putri Vivi Sofia Yulia, Rahma Zulkhaira, Zulkhaira