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All Journal BERKALA SAINSTEK Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Majalah Kedokteran Andalas Cermin Dunia Kedokteran Indonesian Journal of Cancer Jurnal Info Kesehatan
Lestari, Desriani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Diagnosis dan Tatalaksana Enterokolitis Nekrotikans Luthfi Taufik, Muhammad; Lestari, Desriani
Cermin Dunia Kedokteran Vol 48, No 4 (2021): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.828 KB) | DOI: 10.55175/cdk.v48i4.1366

Abstract

Enterokolitis nekrotikans (EKN) ialah peradangan berat saluran pencernaan yang terjadi pada 5-7% neonatus prematur. EKN merupakan penyebab utama morbiditas dan mortalitas di NICU. Patofisiologi multifaktorial dan belum sepenuhnya diketahui. Deteksi dini sulit karena manifestasi klinis sulit dibedakan dan masih tergantung pada radiologi abdomen yang kurang sensitif. Patofisiologi dan pendekatan diagnosis menjadi topik penelitian prioritas di bidang neonatologi saat ini. Strategi pencegahan dan tatalaksana komprehensif diharapkan dapat ditemukan agar memperbaiki luaran penyakit.Necrotizing enterocolitis (NEC) is a serious inflammatory disease of intestine which affects 5-7% preterm neonates. NEC is the leading cause of morbidity and mortality in NICU despite rapid advance in preterm neonatal care. Pathophysiology of NEC is multifactorial and not fully understood. Early detection is challenging because of indistinguishable clinical manifestation and still relies on less sensitive abdominal radiography. Nowadays, pathophysiology and diagnostic approach are priority topics for research in neonatology. Comprehensive prevention and treatment strategies expectedly can improve outcome of disease.
Proximate and Essential Macrominerals Analysis of Tembakul (Mudskipper) Fish Flour as a Food Source for Stunting Prevention Lestari, Desriani; Hartanti, Lucky; Sofiana, Mega Sari Juane; Yuliono, Agus; Kurniadi, Bambang
BERKALA SAINSTEK Vol 10 No 1 (2022)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v10i1.31030

Abstract

The main cause of stunting is due to inadequate food intake according to the needs for growth and development of children, or insufficient nutrition of pregnant women. The low nutritional intake of pregnant and lactating mothers as well as children under five years old who are still growing and developing is generally caused by the wrong diet. One of the efforts to prevent stunting from an early age is to search for several sources of animal source food containing protein, fat and macro essential minerals according to nutritional standards. The purpose of this study was to determine the proximate content including protein and fat nutrition, water content and ash content, as well as mineral content including calcium, iron and phosphorus, from Tembakul (mudskipper) fish flour as the main needs in the growth of children, during pregnancy and lactation. Protein analysis was carried out using the Kjeldahl method, and fat analysis by extraction using a non-polar solvent, while the determination of essential macro minerals calcium and iron was carried out using an Atomic Absorption Spectrophotometer, and phosphorus analysis using ultraviolet spectrophotometry. The proximate content of Tembakul (mudskipper) fish flour from the Mempawah mangrove ecosystem is fat content (1.80%), protein content (50.67%), water content (24.58%), and ash content (20.20%). Mudskipper fish flour contains 3 essential minerals, namely Calcium (2.15%), Phosphorus (2.50%) and Iron (270.26 ppm).
PERBEDAAN KARAKTERISTIK PASIEN KANKER KOLOREKTAL BERDASARKAN LOKASI TUMOR DI RSUD DR. SOEDARSO PONTIANAK TAHUN 2017-2020 Yasri, Rafif Ibtsa; Trianto, Heru Fajar; Lestari, Desriani
JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama Vol 13, No 1 (2025): JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jkm.v13i1.2597

Abstract

Kanker kolorektal merupakan salah satu jenis kanker yang paling sering terjadi dan menduduki peringkat ketiga sebagai kanker dengan jumlah kasus tertinggi di dunia. Kanker kolorektal dapat disebabkan oleh beberapa faktor risiko, baik faktor genetik maupun lingkungan. Secara klinis, kanker kolorektal tumbuh dan berasal dari lokasi yang berbeda-beda. Perbedaan lokasi ini dapat berpengaruh pada manifestasi klinis dan metastasis tumor yang berbeda. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan usia, jenis kelamin, riwayat merokok, status pekerjaan dan Indeks Massa Tubuh (IMT) pasien kanker kolorektal berdasarkan lokasi tumor di RSUD Dr. Soedarso Pontianak periode tahun 2017-2020. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Sampel penelitian ini adalah pasien kanker kolorektal di RSUD Dr. Soedarso Pontianak periode tahun 2017-2020 serta memenuhi kriteria inklusi dan eksklusi dengan teknik total sampling. Analisis statistik dilakukan dengan menggunakan Uji Chi-Square dan Uji Alternatif Fisher’s Exact Terdapat perbedaan yang bermakna dari riwayat merokok (p<0,05) dan IMT (p<0,05) berdasarkan lokasi tumor kanker kolorektal. Tidak terdapat perbedaan yang bermakna dari usia (p>0,05), jenis kelamin (p>0,05) dan status pekerjaan (p>0,05) berdasarkan lokasi tumor kanker kolorektal. Terdapat perbedaan yang bermakna dari riwayat merokok dan IMT berdasarkan lokasi kanker kolorektal
Hubungan antara tumor-infiltrating lymphocytes dengan parameter klinikopatologi pada kanker kolorektal Trianto, Heru Fajar; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Hartono, Henky; Ftrianingrum, Iit; Lestari, Desriani
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p949-958.2023

Abstract

Latar Belakang: Kanker kolorektal termasuk dalam keganasan terbanyak di dunia. Berbagai faktor turut mempengaruhi prognosis dari kanker salah satunya sistem imun. Sistem imun di sekitar tumor memiliki pengaruh terhadap progesivitas sel kanker. Salah satu sistem imun yang dapat diamati adalah Tumor-infiltrating lymphocytes (TIL). Tujuan: Penelitian ini bertujuan untuk membuktikan adanya hubungan antara TIL dengan berbagai parameter klinikopatologi pada kanker kolorektal. Metode : Penelitian ini menggunakan desain potong lintang. Subjek penelitian berupa 38 sampel blok parafin dan slide hematoksilin-eosin (HE) serta data klinikopatologi yang berasal dari sediaan operasi kanker kolorektal pada Laboratorium Patologi Anatomi RSUD Dr. Soedarso periode Januari – Desember 2020. Penilaian jumlah TIL dibagi menjadi tiga kelompok yaitu ringan (0-10%), sedang (11-59%), dan berat (60-100%). Hasil: Hasil penelitian menunjukkan bahwa jumlah TIL terbanyak adalah TIL berat yaitu sebanyak 16 kasus (42,1%). Hasil uji korelasi Spearman menunjukkan hubungan antara jumlah TIL dengan derajat diferensiasi, stadium Dukes dan stadium p TNM dengan nilai p<0,005. Tidak terdapat hubungan antara jumlah TIL dengan ukuran tumor, status metastasis kelenjar getah bening, status metastasis jauh, dan lokasi tumor. Kesimpulan: Terdapat hubungan antara jumlah TIL dengan derajat keganasan, stadium Dukes dan stadium pTNM yang merupakan faktor-faktor prognosis pada kanker kolorektal.
Relationship between Growth and Development with Nutritional Status Profile of Children Aged 0-5 Years Candramila, Wolly; Pasaribu, Erna Cristina; Mardiyyaningsih, Asriah Nurdini; Lestari, Desriani
JURNAL INFO KESEHATAN Vol 23 No 3 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss3.1734

Abstract

Stunting remains a major concern in Indonesia, particularly in Jungkat Village, where early detection is crucial for mitigating its impact on child growth and development. While the Pre-Screening Development Questionnaire (KPSP) is commonly used to assess child development, its relationship with nutritional status remains unclear. This study is aimed to determine the nutritional status, KPSP category, and the relationship between these variables in children aged 0-5 years in Jungkat Village. A cross-sectional quantitative study was conducted from June to August 2023 in Jungkat Village, Mempawah Regency. Ethical approval was obtained from the Health Research Ethics Committee, Faculty of Medicine, Tanjungpura University. A total of 400 children aged 0 to 5 years and 11 months were selected using participatory sampling. Height, weight, and KPSP scores were measured following standardized guidelines, and nutritional status was categorized based on height-for-age, weight-for-age, and BMI-for-age indices. Ordinal logistic regression was performed using R to analyze the relationship between nutritional status and KPSP scores. The prevalence of stunting was 36.3% (10.5% severely stunted, 25.8% stunted), while 5.2% had very low weight and 19.2% were underweight. BMI analysis showed 80% had values within the normal range, while 2.2% were overweight, 0.2% obese, and 2.4% severely wasted. In terms of child development, 77.75% exhibited normal development, 19.75% required reassessment, and 2.5% showed developmental deviations. However, no significant correlation was found between nutritional status and KPSP scores (p > 0.05). These findings suggest that factors beyond nutritional status, such as environmental conditions and parenting practices, may have a greater influence on child development. Thus, national nutritional standards should be adapted to local ecological and genetic characteristics to improve the effectiveness of nutritional and health interventions. Further research integrating socio-environmental factors is recommended to gain a more comprehensive understanding of child development determinants.
Differentiation of Microvessel Density Based on The Breast Cancer Patient Characteristics Including Age, Stage, Tumor Size, and Lymph Node Metastasis Salsabila, Tasya; Pratiwi, Sari Eka; Trianto, Heru Fajar; Ilmiawan, Muhammad In'am; Lestari, Desriani; Fitrianingrum, Iit; Hartono, Henky
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1041

Abstract

Background: Breast cancer is the most common malignant tumor in the world and Indonesia. One well-known prognostic marker is microvessel density (MVD), the numerical value of angiogenesis. In recent years, it has been recognized that tumor growth depends on angiogenesis. Therefore, this study aimed to determine the differentiation of MVD based on the breast cancer patients' characteristics including age, stage, tumor size, and lymph node metastasis in the Anatomical Pathology Laboratory of Soedarso Hospital. Methods: This research was an observational study with a cross-sectional approach. The study was conducted by observing the slides of Hematoxylin-Eosin (HE) in breast cancer patients. Samples were taken using the total sampling technique. The samples were observed by two observers. 51 tissue preparations met the inclusions and exclusions criteria. MVD cut-off points are taken by calculating the median. Research analysis was using the Kruskal-Wallis test in SPSS version 24. Results: All samples of this study were women and had invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-53 years, has stage III, lymph node metastasis (N2). The patients have a low MVD rate but have a large tumor size (T4). Kruskal Wallis test showed that there was a differentiation of MVD based on age (p = 0.029). While, there was no differentiation of MVD based on stage (p=0.974), tumor size (0.069), and lymph node metastasis (0.571). Conclusions: There was a differentiation of MVD based on the age of breast cancer patients in the Anatomical Pathology Laboratory at Soedarso Hospital.
Co-Authors Asriah Nurdini M. Bambang Kurniadi, Bambang Ftrianingrum, Iit Hartono, Henky Ilmiawan, Muhammad In'am Lucky Hartanti, Lucky Luthfi Taufik, Muhammad Mega Sari Juane Sofiana Pasaribu, Erna Cristina Pratiwi, Sari Eka Salsabila, Tasya Trianto, Heru Fajar WOLLY CANDRAMILA Yasri, Rafif Ibtsa Yuliono, Agus