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All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Ophthalmologica Indonesiana
Widyawati, Syska
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Health Professions Medicine & Pharmacology Public Health

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Effects of different preparation protocols of blood serum eyedrops on corneal healing after alkali burn: Clinical evaluation and α-SMA expression Susiyanti, Made; Widyawati, Syska; Susanto, Eka; Louisa, Melva; Kania, Theresia
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art9

Abstract

Background: In cases of alkali burn, blood serum eyedrops may supply protein and growth factors. A standard preparation protocol is necessary for consistency in epitheliotropic capacity. Objective: We aim to evaluate how post-alkali-burn administration of blood serum eyedrops from different preparation protocols results in different outcomes on rabbits. Methods: This randomized experimental study used three treatments: placebo, non-diluted serum, and 25% concentration serum. We analyzed the corneal haziness, neovascularization degree, histopathological examination of neovascularization scores, and alpha-smooth muscle actin (α-SMA) expression. Results: Twelve rabbits (24 eyes) were split evenly into three treatment groups. On day 14, the group receiving the 25% concentration serum had the least corneal haziness (p = 0.005). No adverse effect was observed on the treated eyes. Histopathologically, no significant difference in neovascularization scores and α-SMA expression was observed. Conclusions: Treatment using the 25% concentration serum resulted in less corneal haziness, smaller defect size, and greater healing rate. There was also no significant difference in histopathological outcomes among the three treatment groups.
Co-Authors Agung Nugroho Aljufri, Nabila Amanda, Lia Andayani, Gitalisa Anissa, Gisela Haza Annisa Windyani Arief Wildan, Arief Dearaini Fermitaliansyah, Muhammad Keyvan Kania, Theresia Laksmita, Yulinda Arty Made Susiyanti Mahyuddin, Mutmainah Martha, Faraby Maulidinia, Ayang Rashelda Melva Louisa Nursakina, Yosilia Oktariani, Virna Dwi Pangestika, Rishka Pangestika, Riskha Petra, Dany Pintary, Marsha Rayfa Presialia, Athira Rancakbudi, Aydan J. Rhendy, Rio Sadikin, Irma Suwandi Safira, Nadya Siregar, Astrid Mariam Khairani Susanto, Eka Susantono, Diannisa Susantono, Diannisa Paramitha Syahruzad, Rosa Waznan, Fadhli Witjaksono, Anissa Nindhyatriayu Zarwan, Jessica