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All Journal Jurnal Kedokteran Brawijaya Medika Kartika : Jurnal Kedokteran dan Kesehatan Journal of Community Development Calvaria Medical Journal
Setijowati, Eva Diah
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Pengetahuan dan Pendapat Mahasiswa Poltekkes Surabaya Tentang Kelainan Genetik dan Skrining Pra-Nikah Wulandari, Retno Dwi; Setijowati, Eva Diah
Journal of Community Development Vol. 4 No. 3 (2024): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v4i3.165

Abstract

To ensure couples planning to get married understand the genetic risks related with their future offspring, they need to acquire information about genetic disorders and pre-marital genetic counselling that can be followed by genetic screening. Genetic disorders can be inherited from normal parents who are carriers of abnormal genes, such as thalassemia and Haemophilia. Genetic disorder also encompass chromosomal abnormalities, either the number or structure chromosome. Unlike numerical chromosomal abnormalities in offspring, which have an increased risk associated with the mother’s age during pregnancy, structural abnormalities in parents can be passed to their offspring. This community service activity targets seventh-semester students at Poltekkes Kemenkes Surabaya, who are at an age ready for marriage. The implementation of this activity begins with a pre-test to assess the student ‘s knowledge before the education presentation, followed by presentation with interactive discussion and ended with post-test to determine whether the education was comprehensible to them. Poltekkes Kemenkes Surabaya students showed a better understanding of genetic disorder indicated with an average score increase of 8.2 points (9.2%) based on post test result . All students agree on the importance of pre-marital screening, with the majority willing to undergo premarital screening and still proceed with the marriage if their partner is a carrier of thalassemia.
EFEKTIVITAS MADU Apis cerana SEBAGAI ANTIBIOFILM TERHADAP Candida albicans Ananta, Zahrah Aswa; masfufatun, masfufatun; Setijowati, Eva Diah; Utami, Sri Lestari
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 3 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Madu dikonsumsi karena dinilai memiliki nutrisi yang tinggi serta efek yang bermanfaat bagi kesehatan. Madu mempunyai sifat sebagai antioksidan, antiinflamasi, antimikroba, bakteriostastik, serta efek penyembuhan luka yang baik. Madu memiliki kandungan asam fenolik, tanin, sapanoid, dan terpenoid yang menyebabkan madu berpotensi sebagai antibiofilm. Penelitian ini bertujuan untuk mengetahui efektivitas madu Apis cerana sebagai antibiofilm dan nilai Konsentrasi Hambatan Minimum Biofilm (KHBM) madu dalam menghambat pertumbuhan biofilm Candida albicans. Madu A. cerana yang digunakan berasal dari kecamatan Pemangkat, kabupaten Sambas, Kalimantan Barat. Penelitian ini menggunakan jenis penelitian true experimental menggunakan pendekatan Post-Test Only Control Group Design dengan metode microplate untuk mengetahui efek antibiofilm madu A. cerana terhadap pertumbuhan C. albicans. Madu A. cerana dibuat menjadi konsentrasi 50%; 25%; 12,5%; 6,25%; 3,125%; dan 1,525%. Hasil penenelitian menunjukkan konsentrasi madu A. cerana 50%, 25%, 12,5%, 6,25%, 3,125%, dan 1,525% memiliki kemampuan sebagai antibiofilm dengan persentase penghambatan 80,449%, 79,156%, 78,136%, 75,642%, 73,073%, dan 62,953%. Hambatan pertumbuhan biofilm terbesar terjadi pada kelompok madu dengan konsentrasi 50%. Berdasarkan analisis probit, nilai KHBM50 konsentrasi madu A. cerana sebesar 1,686%. Oleh karena itu, berdasarkan penelitian tersebut dapat disimpulkan bahwa madu A. cerana memiliki kemampuan untuk menghambat pertumbuhan biofilm C. albicans sehingga berpotensi sebagai antibiofilm dalam terapi infeksi yang terkait biofilm. Kata kunci : antibiofilm, Candida albicans, madu Apis ceranaDOI : 10.35990/mk.v7n3.p219-230
Analisis Kromosom Pada Pasangan dengan Keguguran Berulang (Studi Kasus) Antara, Rizel; Wulandari, Retno Dwi; Narottama, Harya; Setijowati, Eva Diah
Calvaria Medical Journal Vol 2 No 2 (2024): Edisi Desember 2024
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i2.75

Abstract

  Background: Miscarriage is the termination of pregnancy before the fetus can live outside the womb. Miscarriage consists of spontaneous miscarriage and induced miscarriage. In Indonesia, the miscarriage rate reaches around 2 million with 10-15% having spontaneous miscarriages. Miscarriages that occur 2 or more times are defined as recurrent pregnancy loss. The incidence of recurrent pregnancy loss is increasing and is estimated to be experienced by around 1-5% of women in productive age. Recurrent pregnancy loss is multifactorial, including uterine anatomical abnormalities, autoimmune factors, endocrine and metabolic disorders, thrombosis, and genetic disorders. Genetic abnormalities include chromosomal abnormalities or mutations in genes. This study aims to determine the chromosomal profile in couples with recurrent miscarriage. Method: This study was a descriptive observational study. Chromosome analysis was performed on a couple with a history of three spontaneous miscarriages. Result: Karyotyping result of the couple were 46,XY and 46,XX. Conclusion: Chromosome analysis in couple with recurrent pregnancy loss in this case study showed no numerical or structural aberration.
Identification of ACE2 and TMPRSS2 Gene Polymorphisms in Covid-19 Survivors with Hypertension and Diabetes Mellitus using the rhAmp PCR Method Setijowati, Eva Diah; Suprapti, Herni; Waskito, Budi Arief; Wulandari, Retno Dwi
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.1

Abstract

The Covid-19 pandemic has caused significant global mortality and morbidity. Covid -19 infection is caused by the SARS-CoV-2 virus, which requires a receptor on the host cell to enter, primarily Angiotensin-Converting Enzyme 2, encoded by the ACE2 gene, and Transmembrane Serine Protease 2, encoded by the TMPRSS2 gene. Several factors can influence Covid-19 mortality and morbidity, including gender, comorbidities such as diabetes mellitus (DM), obesity, cardiovascular diseases, and genetic factors. ACE2 and TMPRSS2 polymorphisms are believed to worsen the condition of Covid-19 patients. This study aimed to identify polymorphisms in the ACE2 (rs2285666 G>C) and TMPRSS2 (rs2070788 A>G) in  Covid-19 survivors with hypertension and diabetes mellitus. The total sample was 30 hypertension and diabetes mellitus   patients treated at Islamic Hospital Surabaya. A total of 3 ml of blood was drawn from the median cubital vein and placed into an EDTA vacutainer. DNA extraction was performed using the High Pure PCR Template Preparation Kit (Roche). Identification of ACE2 and TMPRSS2 polymorphisms was performed using the rhAmp SNP genotyping method with the LightCycler® system (Roche 480II). Genotyping results for ACE2 showed that 55.2% of patients had the GG (wild-type) with a G allele frequency of 68.9%. Genotyping for the TMPRSS2 showed that 60% of patients had the GG (mutant-type) with a G allele frequency of 78.3%. During Covid-19 infection, neither GG genotype (ACE2) and the GG genotype (TMPRSS2) exhibited severe symptoms.
Co-Authors Ananta, Zahrah Aswa Antara, Rizel Budi Arief Waskito, Budi Arief Herni Suprapti, Herni Masfufatun Masfufatun Narottama, Harya Utami, Sri Lestari Wulandari, Retno Dwi