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All Journal Jurnal Ilmiah Desain & Konstruksi Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Proceedings of the International Conference on Nursing and Health Sciences Calvaria Medical Journal Prosiding Seminar Nasional COSMIC Kedokteran
Wulandari, Retno Dwi
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Transportation

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Effect of Unripe Berlin Banana Flour on Lipid Profile of Dyslipidemia Rats Agustin, Firda; Febriyatna, Ayu; Damayati, Ratih Putri; Hermawan, Hendra; Faiziah, Nurul; Santoso, Razi Dwi; Wulandari, Retno Dwi
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.289 KB) | DOI: 10.15395/mkb.v51n2.1630

Abstract

Dyslipidemia is one of the risk factors of coronary heart disease and stroke. Unripe Berlin banana flour contains chemical compounds and nutrients that may affect lipid profile. This study aimed to determine the potential effects of unripe berlin banana flour on lipid profile, especially in dyslipidemia. This experiment was conducted from July to December 2018 at the Food Analysis Laboratory of State Polytechnic of Jember and the Biomedical Laboratory of the Faculty of Dentistry, University of Jember using male wistar white rats weighed 150–200g. The rats were then divided into a negative control group consisting of  normal rats (K-), a positive control group consisting of dyslipidemia rats (K+), and a treatment group consisting of dyslipidemia rats that received 0.144 g unripe berlin banana flour (UBF). Dyslipidemia condition was achieved by administering high-fat diet (HFD) for 9 weeks. Unripe banana flour was fed to the treatment group starting from the 10th weeks for  4 weeks. The measurement of pre-intervention lipid profile was performed at 9th week while the post-intervention lipid profile was measured at 13th week. Data collected were analyzed using ANOVA. Results o showed that the Berlin unripe flour (UBF) could reduce total cholesterol and LDL levels. In addition, a decrease in HDL levels in treatment group  with Berlin unripe banana flour (UBF) and in the negative control group (K-). The same decrease in HDL level was also seen in the dyslipidemia group (K+). Hence, it is concluded that Berlin banana flour has the potential to improve lipid profile in dyslipidemia rats. Pengaruh Pemberian Tepung Pisang Berlin Unripe terhadap Perbaikan Profil Lipid Tikus Dislipidemia  Dislipidemia merupakan faktor risiko penyakit jantung koroner dan strok. Tepung pisang berlin unripe mengandung senyawa aktif dan zat gizi yang berpengaruh terhadap profil lipid. Penelitian ini bertujuan mengetahui potensi tepung pisang berlin unripe terhadap profil lipid pada tikus jantan galur wistar model displidemia. Penelitian dilaksanakan pada bulan Juli sampai dengan Desember 2018 di Laboratorium Analisis Pangan, Politeknik Negeri Jember dan Laboratorium Biomedik, Fakultas Kedokteran Gigi, Universitas Jember. Penelitian menggunakan tikus jantan galur Wistar dengan bobot badan 150–200 gr. Kelompok perlakuan terdiri atas kelompok tikus normal (K-), tikus dislipidemia (K+), tikus dislipidemia + tepung pisang Berlin unripe dosis 0,144 gram (UBF). Perlakuan dislipidemia dilakukan dengan cara pemberian  high fat diet (HFD) selama 9 minggu. Selanjutnya, pemberian UBF diberikan dalam bentuk pakan selama 4 minggu. Pengukuran profil lipid pre-intervensi (minggu ke-9) dan post-intervensi (minggu ke-13). Data dianalisis dengan uji ANOVA. Hasil penelitian menunjukkan bahwa kelompok perlakuan tepung pisang Berlin unripe (UBF) dapat menurunkan kadar kolesterol total dan LDL. Selain itu, terjadi penurunan kadar HDL pada kelompok perlakuan tepung pisang Berlin unripe (UBF) dan kelompok negatif (K-). Pada kelompok K+ juga terjadi penurunan kadar HDL. Simpulan penelitian, tepung pisang Berlin memiliki potensi terhadap perbaikan profil lipid pada tikus dislipidemia.
ANALISIS JARINGAN PIPA DISTRIBUSI AIR BERSIH PERUMAHAN GOLDEN VIENNA 1 DAN 2 KOTA TANGERANG SELATAN Wulandari, Retno Dwi; Santosa, Budi
Jurnal Ilmiah Desain & Konstruksi Vol 20, No 1 (2021)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/dk.2021.v20i1.3410

Abstract

Jaringan pipa distribusi air eksisting di perumahan Golden Vienna 1 dan 2 dikatakan belum optimal dikarenakan faktor tekanan dan kecepatan air di dalam pipa yang rendah pada waktu tertentu. Serta kebutuhan debit air yang lebih besar dibandingkan suplai yang tersedia. Penelitian ini bertujuan mengetahui kebutuhan air bersih harian pelanggan serta menganalisis jaringan pipa distribusi air bersih di perumahan Golden Vienna 1 dan 2, Kota Tangerang Selatan. Analisis jaringan pipa distribusi ini menggunakan perangkat lunak EPANET 2.0. Hasil simulasi EPANET 2.0 kemudian dibandingkan dengan hasil analisis manual menggunakan perhitungan hidraulika (Hazen-William). Dari hasil penelitian, diketahui kebutuhan debit harian yang harus dipenuhi  sebesar 209.547 liter/hari dan total fluktuasi debit sebesar 210.359 liter/hari. Sebanyak 15 pipa yang nilai headloss nya tidak memenuhi standar sebesar 10m/km . Sebanyak 2 pipa tekanan airnya tidak sesuai kriteria sebesar 1-5  atm, serta sebanyak 28 pipa yang nilai kecepatan aliran airnya tidak sesuai kriteria sebesar 0,3-3 m/s. Rekomendasi perbaikan dari segi manajerial pada jaringan perpipaan distribusi air bersih perumahan Golden Vienna 1 dan 2, yakni melakukan perubahan diameter pipa eksisting sehingga tekanan dan kecepatan pada jaringan pipa dapat optimal . Terdapat perbedaan nilai tekanan air yang cukup signifikan antara hasil simulasi model EPANET dengan hasil analisis manual menggunakan hidraulika (Hazen-Williams) dikarenakan penambahan beberapa item pada EPANET 2.0 yang tidak ada pada jaringan eksisting. Hal ini dilakukan untuk memenuhi kondisi untuk running.
Hubungan Stres Dengan Kejadian Akne Vulgaris Pada Remaja (Studi Literatur) topang, edward; Soekanto, Ayly; Sugeng, Maria Widijanti; Wulandari, Retno Dwi
Calvaria Medical Journal Vol 2 No 1 (2024): Edisi Juni 2024 (available online Juli 2024)
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i1.30

Abstract

Background: Acne vulgaris appears because it is triggered by one of the factors being psychological stress or existing acne vulgaris which will get worse. This research aims to determine the relationship between stress and the incidence of acne vulgaris in adolescents. Methods: The research method used is literature study, which is analyzed based on the results of previous research that have been published in scientific journals and other research sources. Result: From this literature study, all 10 journals reviewed (100%) showed a significant relationship which proved to be a correlation between stress levels and the emergence of acne vulgaris in teenagers. Plus, there are other factors that have been found to trigger acne vulgaris. The correlation from this research is related to the level of stress and the emergence of acne vulgaris. Thus, the higher a person experiences a level of stress, the more likely it is that acne vulgaris will appear. Conclusion: Conclusions obtained from research in all journals that provide studies on the relationship between stress levels are proven to be related to the emergence of acne vulgaris that appears in adolescents, and these variables are significantly related.
Application of Classical Music Therapy to Reduce Signs and Symptoms of Auditory Hallucinations Wulandari, Retno Dwi; Widagdo, Agus; Purwaningsih, Iswanti
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 2 (2024): July-December 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i2.4769

Abstract

Hallucinations are a type of mental disorder where a person is unable to differentiate between real life and fake life. There are around 24 million schizophrenia patients in the world, while in DIY the incidence of mental disorders reaches 14,514 people. One effective non-pharmacological treatment for treating hallucinations is classical music therapy. Objective to understand the application of classical music therapy to reduce signs and symptoms of auditory hallucinations in schizophrenia patients. In this case study, 1 respondent was taken using the case study method with inclusion criteria, the instruments used were the classical music therapy SOP, the AHRS (Auditory Hallucination Rating Scale) assessment sheet and the assessment sheet for signs and symptoms of hallucinations. The application of Classical Music Therapy was carried out on 1 respondent, namely Mr.S. Before therapy, the patient's AHRS score was 18 and 9 on the score for observing signs and symptoms of hallucinations. After 5 days of therapy, the AHRS score was 8 and a score of 4 for observing signs and symptoms of hallucinations. Classical music therapy is effective in reducing the level of hallucinations and reducing signs and symptoms of auditory hallucinations in schizophrenia patients.
Analisis Kromosom Pada Pasangan dengan Keguguran Berulang (Studi Kasus) Antara, Rizel; Wulandari, Retno Dwi; Narottama, Harya; Setijowati, Eva Diah
Calvaria Medical Journal Vol 2 No 2 (2024): Edisi Desember 2024
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i2.75

Abstract

  Background: Miscarriage is the termination of pregnancy before the fetus can live outside the womb. Miscarriage consists of spontaneous miscarriage and induced miscarriage. In Indonesia, the miscarriage rate reaches around 2 million with 10-15% having spontaneous miscarriages. Miscarriages that occur 2 or more times are defined as recurrent pregnancy loss. The incidence of recurrent pregnancy loss is increasing and is estimated to be experienced by around 1-5% of women in productive age. Recurrent pregnancy loss is multifactorial, including uterine anatomical abnormalities, autoimmune factors, endocrine and metabolic disorders, thrombosis, and genetic disorders. Genetic abnormalities include chromosomal abnormalities or mutations in genes. This study aims to determine the chromosomal profile in couples with recurrent miscarriage. Method: This study was a descriptive observational study. Chromosome analysis was performed on a couple with a history of three spontaneous miscarriages. Result: Karyotyping result of the couple were 46,XY and 46,XX. Conclusion: Chromosome analysis in couple with recurrent pregnancy loss in this case study showed no numerical or structural aberration.
HUBUNGAN ANTARA TINGKAT PENGETAHUAN IBU TENTANG ASI EKSKLUSIF DENGAN REALISASI PEMBERIAN ASI EKSKLUSIF PADA BAYI IBU MASING-MASING DI PUSKESMAS DUKUH KUPANG SURABAYA Dwijayanti, Septya; Erny, Erny; Wulandari, Retno Dwi
Calvaria Medical Journal Vol 3 No 1 (2025): Edisi Juni 2025
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v3i1.108

Abstract

Latar Belakang: Air Susu Ibu (ASI) eksklusif selama 6 bulan pertama kehidupan bayi merupakan kunci utama untuk kesehatan dan pertumbuhan bayi yang optimal. Dalam Upaya pemberian ASI eksklusif seorang ibu disamping harus memiliki pengetahuan mengenai ASI juga harus memiliki motivasi yang kuat. Fakta di Masyarakat banyak ibu yang memiliki pengetahuan yang baik tentang ASI tetapi beberapa tidak memberikan ASI dengan berbagai alasan.  Berdasarkan hal tersebut dilakukan penelitian untuk menilai seberapa kuat pengetahuan ibu dalam membentuk motivasi ibu untuk memberi ASI eksklusif. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat pengetahuan ibu tentang ASI eksklusif dengan realisasi pemberian ASI eksklusif pada bayi mereka di Puskesmas Dukuh Kupang Surabaya.  Metode: Penelitian dekriptif analitik cross sectional dengan simple random sampling. Data penelitian menggunakan data dari kuesioner sejumlah 110 populasi ibu yang memiliki bayi usia 0-6 bulan. Hasil: Penelitian menunjukkan bahwa tingkat pengetahuan ibu tentang ASI eksklusif berhubungan erat dengan realisasi pemberian ASI eksklusif. Kesimpulan: Terdapat hubungan yang positif dan signifikan antara tingkat pengetahuan ibu tentang ASI eksklusif dengan realisasi pemberian ASI eksklusif pada bayi ibu. Artinya, semakin tinggi tingkat pengetahuan ibu tentang ASI eksklusif, semakin tinggi pula kemungkinan ibu untuk memberikan ASI eksklusif kepada bayinya.
Identification of ACE2 and TMPRSS2 Gene Polymorphisms in Covid-19 Survivors with Hypertension and Diabetes Mellitus using the rhAmp PCR Method Setijowati, Eva Diah; Suprapti, Herni; Waskito, Budi Arief; Wulandari, Retno Dwi
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.1

Abstract

The Covid-19 pandemic has caused significant global mortality and morbidity. Covid -19 infection is caused by the SARS-CoV-2 virus, which requires a receptor on the host cell to enter, primarily Angiotensin-Converting Enzyme 2, encoded by the ACE2 gene, and Transmembrane Serine Protease 2, encoded by the TMPRSS2 gene. Several factors can influence Covid-19 mortality and morbidity, including gender, comorbidities such as diabetes mellitus (DM), obesity, cardiovascular diseases, and genetic factors. ACE2 and TMPRSS2 polymorphisms are believed to worsen the condition of Covid-19 patients. This study aimed to identify polymorphisms in the ACE2 (rs2285666 G>C) and TMPRSS2 (rs2070788 A>G) in  Covid-19 survivors with hypertension and diabetes mellitus. The total sample was 30 hypertension and diabetes mellitus   patients treated at Islamic Hospital Surabaya. A total of 3 ml of blood was drawn from the median cubital vein and placed into an EDTA vacutainer. DNA extraction was performed using the High Pure PCR Template Preparation Kit (Roche). Identification of ACE2 and TMPRSS2 polymorphisms was performed using the rhAmp SNP genotyping method with the LightCycler® system (Roche 480II). Genotyping results for ACE2 showed that 55.2% of patients had the GG (wild-type) with a G allele frequency of 68.9%. Genotyping for the TMPRSS2 showed that 60% of patients had the GG (mutant-type) with a G allele frequency of 78.3%. During Covid-19 infection, neither GG genotype (ACE2) and the GG genotype (TMPRSS2) exhibited severe symptoms.
STUNTING DAN UPAYA PENCEGAHAN STUNTING: GAMBARAN TINGKAT PENGETAHUAN DAN SIKAP MAHASISWA UNIVERSITAS WIJAYA KUSUMA SURABAYA Tuarita, Ros Diana; Wulandari, Retno Dwi; Narottama, Harya; Erny
Prosiding Seminar Nasional COSMIC Kedokteran Vol 4 (2026): Edisi 2026
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: Stunting masih menjadi salah satu masalah kesehatan masyarakat utama di Indonesia, yang sebagian besar disebabkan oleh rendahnya kesadaran dan kurangnya pengetahuan mengenai upaya pencegahan dini, khususnya pada masa remaja. Sebagai bagian dari generasi muda, mahasiswa memiliki potensi yang besar untuk berperan sebagai agen perubahan dalam menurunkan prevalensi stunting di masa mendatang. Tujuan: Penelitian ini bertujuan untuk menggambarkan tingkat pengetahuan dan sikap mahasiswa Universitas Wijaya Kusuma Surabaya terhadap stunting dan upaya pencegahannya. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang (cross-sectional). Responden adalah mahasiswa tahun ajaran 2023/2024 dari beberapa fakultas yang dipilih melalui teknik fixed-quota dan convenience sampling. Analisis data dilakukan secara univariat untuk menggambarkan distribusi dari setiap variabel penelitian. Hasil: Sebagian besar responden menunjukkan tingkat pengetahuan dan sikap yang tergolong sedang hingga baik terhadap pencegahan stunting. Kesimpulan: Mahasiswa Universitas Wijaya Kusuma Surabaya memiliki tingkat pengetahuan yang cukup hingga baik serta sikap positif terhadap pencegahan stunting. Temuan ini menunjukkan bahwa mahasiswa berpotensi menjadi kelompok yang berperan aktif dalam upaya pencegahan stunting melalui pendidikan kesehatan, promosi perilaku hidup sehat, serta dukungan terhadap program perbaikan gizi nasional.
Chromosome Aberration on Growth and Developmental Disorder Setijowati, Eva Diah; Suprapti, Herni; Sugeng, Maria Widijanti; Wulandari, Retno Dwi
Jurnal Kedokteran Brawijaya Vol. 32 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.02.5

Abstract

Growth and development in humans begin at conception, which shows progress and interdependence. Normal children show the characteristic of growth and development. In children with growth and development disorder, chromosomal abnormality may be found. This study aimed to determine chromosomal abnormality in patients with growth and development disorder. The samples were taken from karyotype results of patients in the Medical Genetics Laboratory, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, from 2010-2020. The inclusion criteria were infants to adolescents aged 24 years and unmarried who experienced impaired growth and development, including sexual development. Chromosomal abnormalities were obtained from cytogenetic analysis using the G-banding method. From 75 samples with growth and development disorders, there were abnormalities in the number of autosomal chromosomes and sex chromosomes found in patients with Down syndrome, Turner syndrome, Klinefelter syndrome, and Edwards syndrome. Chromosomal structural abnormalities found were deletion, translocation, inversion, duplication, marker chromosome, and heteromorphism. This study showed the importance of karyotyping in children and adolescents with growth and developmental disorders.
Identification of ACE2 and TMPRSS2 Gene Polymorphisms in Covid-19 Survivors with Hypertension and Diabetes Mellitus using the rhAmp PCR Method Setijowati, Eva Diah; Suprapti, Herni; Waskito, Budi Arief; Wulandari, Retno Dwi
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.1

Abstract

The Covid-19 pandemic has caused significant global mortality and morbidity. Covid -19 infection is caused by the SARS-CoV-2 virus, which requires a receptor on the host cell to enter, primarily Angiotensin-Converting Enzyme 2, encoded by the ACE2 gene, and Transmembrane Serine Protease 2, encoded by the TMPRSS2 gene. Several factors can influence Covid-19 mortality and morbidity, including gender, comorbidities such as diabetes mellitus (DM), obesity, cardiovascular diseases, and genetic factors. ACE2 and TMPRSS2 polymorphisms are believed to worsen the condition of Covid-19 patients. This study aimed to identify polymorphisms in the ACE2 (rs2285666 G>C) and TMPRSS2 (rs2070788 A>G) in  Covid-19 survivors with hypertension and diabetes mellitus. The total sample was 30 hypertension and diabetes mellitus   patients treated at Islamic Hospital Surabaya. A total of 3 ml of blood was drawn from the median cubital vein and placed into an EDTA vacutainer. DNA extraction was performed using the High Pure PCR Template Preparation Kit (Roche). Identification of ACE2 and TMPRSS2 polymorphisms was performed using the rhAmp SNP genotyping method with the LightCycler® system (Roche 480II). Genotyping results for ACE2 showed that 55.2% of patients had the GG (wild-type) with a G allele frequency of 68.9%. Genotyping for the TMPRSS2 showed that 60% of patients had the GG (mutant-type) with a G allele frequency of 78.3%. During Covid-19 infection, neither GG genotype (ACE2) and the GG genotype (TMPRSS2) exhibited severe symptoms.
Co-Authors Antara, Rizel Ayly Soekanto Ayu Febriyatna, Ayu Budi Arief Waskito, Budi Arief Budi Santosa Budi Santosa Dwijayanti, Septya ERNY Erny Erny, Erny Firda Agustin, Firda Hermawan, Hendra Herni Suprapti, Herni Maria Widijanti Sugeng Narottama, Harya Nurul Faiziah Ratih Putri Damayati Santoso, Razi Dwi Setijowati, Eva Diah topang, edward Tuarita, Ros Diana Widagdo, Agus