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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of Clinical Microbiology and Infectious Diseases
Noorhamdani
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Comparison of synergistic effects of multiple combinations of anti-pseudomonas antibiotics against Pseudomonas aeruginosa pan drug resistance in in vitro test with AZDAST Method Putri, Citra Destya Rahma; Etty Fitria Ruliatna; Retnoningsih, Dewi; Rahayu, Siwipeni Irmawanti; Noorhamdani
Journal of Clinical Microbiology and Infectious Diseases Vol. 4 No. 1 (2024): Available online: June 2024
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v4i1.48

Abstract

Background: Antimicrobial resistance is a global threat to public health. Pseudomonas aeruginosa Pan Drug-Resistant requires the latest antimicrobials. This limitation of therapy requires a breakthrough in the treatment of this infection. Combining antimicrobials with a synergistic effect is thought to increase the cure rate in clinical use. This study aimed to determine the synergistic effect of several combinations of anti-pseudomonas antibiotics against Pan Drug-Resistant Pseudomonas aeruginosa in an in vitro test using the AZDAST method. Method: An Antibiotic combination test was carried out using the AZDAST method to assess in vitro synergistic activity. The antibiotic single disk used was Amikacin 30 µg, Ceftazidime 30 µg, Meropenem 10 µg, Ciprofloxacin 5 µg; double disk antibiotic is Amikacin 30 µg, Ceftazidime 30 µg, Meropenem 10 µg, Ciprofloxacin 5 µg and combination antibiotic disks Amikacin 30 µg-Ceftazidime 30 µg, Amikacin 30 µg-Meropenem 10 µg, Amikacin 30 µg-Ciprofloxacin 5 µg in which two antibiotic paper disks are combined stacked together, with a 24 mm gap between the other antibiotic combinations. Result: The results showed that combining the four antibiotics had a synergistic effect. The zone of inhibition resulting from testing the combination of several antibiotics against Pan Drug Resistant Pseudomonas aeruginosa showed no statistical significance (p > 0.05) compared to all antibiotics and comparisons in the combination group of antibiotics only. Conclusion: The combination of anti-pseudomonas antibiotics synergizes with Pan Drug-Resistant Pseudomonas aeruginosa in the AZDAST method in vitro test.
Effect of Bengkoang (Pachyrhizus erosus) Extract on Estrogen Receptor-?, Progesterone Receptor Expression, and Follicle-Stimulating Hormone Levels Suryanti; Putri Ardela, Mayasari; Frenty Hadiningsih, Eka; Winarsih, Sri; Noorhamdani; Nurseta, Tatit; Norahmawati, Eviana
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2180

Abstract

Abstract Objective: Progesterone functions by inhibiting the release of Gonadotropin-Releasing Hormone (GnRH), which decreases Follicle-Stimulating Hormone (FSH) levels and converts them into hypoestrogens. This condition affects the expression of steroid, estrogen, and progesterone receptors, contributing to endometrial proliferation and secretion during the menstrual cycle. Methods: This study aims to demonstrate that Bengkoang extract administration increases the expression of Estrogen Receptor (ER), Progesterone Receptor (PR), and Follicle-Stimulating Hormone (FSH) in Wistar model rats. This study divided 25 female Wistar rats into five groups: one control group without progesterone and Bengkoang extract and four treatment groups injected with progesterone. After exposure, Bengkoang extract was administered to three treatment groups at doses of 70 mg/200 g BW/day (treatment 1), 140 mg/200 g BW/day (treatment 2), and 280 mg/200 g BW/day (treatment 3). Results: The results showed an increase in the expression of Estrogen Receptor- ? (Er?), Progesterone Receptor (PR), and Follicle-Stimulating Hormone (FSH) levels in treatment 1, treatment 2, and treatment 3 groups compared to the KP with p <0.05 Conclusion: The study investigating the effect of Bengkoang (Pachyrhizus erosus) extract on estrogen receptor-? (ER?), progesterone receptor (PR) expression, and follicle-stimulating hormone (FSH) levels has demonstrated significant findings. Keywords: Estrogen, Estrogen receptor-?, Follicle-stimulating hormone, Pachyrhizus erosus, Progesterone, Progesterone receptor
Co-Authors Etty Fitria Ruliatna Eviana Norahmawati Frenty Hadiningsih, Eka Putri Ardela, Mayasari Putri, Citra Destya Rahma Rahayu, Siwipeni Irmawanti Retnoningsih, Dewi Sri Winarsih SURYANTI Tatit Nurseta