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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Ilmu Perpustakaan Jambura Accounting Review Window of Public Health Journal Molekul: Jurnal Ilmiah Kimia Jurnal Standardisasi Jurnal Ekonomi, Manajemen, Akuntansi
Ririn Anggraeni
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Engineering Health Professions Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Public Health Social Sciences Other

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Journal : Molekul: Jurnal Ilmiah Kimia

 1 
Immunostimulant Compounds Identification in Indonesian Underutilized Zingiberaceae Spices Rosalina, Dian; Yuliana, Nancy Dewi; Anggraeni, Ririn; Prangdimurti, Endang
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.7589

Abstract

Spices are known for its health beneficial effect beside its function as flavouring and condiment. This study aimed to screen immunostimulant activities of 12 underutilized species of Zingiberaceae grown in Indonesia. The compound associated with immunostimulant activity in the most active sample was identified by linking the chromatogram profile of hexane, chloroform, ethyl acetate, methanol, and water fractions of the selected spices to its activity using orthogonal projection to the least square (OPLS) analysis, followed by LC-MS characterization. The result showed that Alpinia malaccensis and Zingiber ottensii had the highest lymphocyte cell proliferation index (SI) at concentrations of 400 ppm. A. malaccensis was chosen for the next step. The results of OPLS analysis showed that the retention time interval which strongly correlated with the immunostimulant activity was 27.0 – 28.5 minutes, which were abundant in methanol fraction. The mass spectra analysis of methanol fraction using UHPLC-HRMS showed that the respective retention time was attributed to flavokawain B. This compound was reported to increase rat splenocyte proliferation in vivo.
Identification of Antibacterial Compounds in Black Garlic against Salmonella typhimurium using HPLC-Fingerprinting and Chemometrics Abiyyuddin, M. Farras; Rahayu, Winiati P; Yuliana, Nancy Dewi; Setiawan, Abdul Aziz; Anggraeni, Ririn; Marwanta, Edy; Marasabessy, Ahmad
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.11378

Abstract

ABSTRACT. Black garlic is an aged product derived from fresh garlic and exhibits potential antibacterial properties. This study aims to identify the antibacterial compounds in black garlic against Salmonella typhimurium using HPLC fingerprinting and chemometrics. The antibacterial activity of the n-hexane fraction, methanol fraction, and water fraction were analyzed using the well diffusion method. Only the water fraction exhibited an inhibitory zone against S. typhimurium of 11.96 ± 1.86 mm. The chemical profile of each fraction, analyzed by HPLC-MWD, was correlated with antibacterial activity data using Orthogonal Projection to Latent Structure. A retention interval of 2.50 – 2.99 and 2.00 – 2.49 minutes of the water fraction at a wavelength of 214 nm demonstrated a correlation with antibacterial activity. The peaks identified in HPLC-MWD at a retention interval of 2.50 – 2.99 and 2.00 – 2.49 minutes exhibited a similar pattern to the peaks appearing at a retention time of 1.12 and 1.06 minutes on the UHPLC-Q-Orbitrap-HRMS chromatogram. The resultant peak in the UHPLC-Q-Orbitrap-HRMS analysis of the water fraction indicated that it was attributed to S-allyl cysteine and S-allyl mercaptocysteine. Keywords: black garlic, metabolomics, S-allyl cysteine, S-allyl mercapto cysteine
Co-Authors Abiyyuddin, M. Farras Ahmad Marasabessy, Ahmad Amelya Rosalina Siringoringo Dicky Perwira Ompusunggu Edy Marwanta, Edy Endang Prangdimurti Enjenli Sihotang Farihah Muhsanah Hanifah Nuryani Lioe Irene Syukur Niat Wati Harefa Mecca Arfa, Mecca Muhammad Raubeti Attauladan Nancy Dewi Yuliana Rosalina, Dian Setiawan, Abdul Aziz Siti Alma Arisanti Syarwani Canon Tika Setianingrum Tuli, Hartati Vircie Sutandi Winiati P Rahayu Yulina Lailatul Maslukhah