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All Journal Jurnal Medik Veteriner Care : Jurnal Ilmiah Ilmu Kesehatan
Putri, Anandia Nafisah
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Biochemistry, Genetics & Molecular Biology Health Professions Nursing Public Health Veterinary

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Efficacy of Transdermal Delivery Nano Ethosomal Gel from Ashitaba Leaves on In-vivo Burn Wound Healing in Albino Rats Al-Anshori, Akhmad Afifudin; Putri, Anandia Nafisah; Ismi, Alif Noviana; Suhud, Mohamad Kharis; Plumeriastuti, Hani; Maslachah, Lilik
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.145-154

Abstract

This study aimed to evaluate the in-vivo burn wound healing process in albino rats treated using transdermal delivery nano ethosomal gel from ashitaba leaves. Ethosomal vesicles were formulated using soy lecithin, cholesterol, ethanol, water, and ashitaba leaf nanoparticles using the cold method. A total of 25 male rats were randomly divided into 5 groups, i.e., (C-) treated without nanoparticle extract, (C+) treated using 1% Silver Sulfadiazine®, treatment group treated nano ethosomal gel from ashitaba leaves with the respective doses were (T1) 1%, (T2) 2,5%, and (T3) 5%. Therapy was initiated on day 1 or after being induced by a burn wound for 14 days, twice a day. On the 15th day, a termination was carried out to take skin tissue from burn scars, then histopathology preparations were made with routine staining. Microscopic observations with an optical microscope on collagen, polymorphonuclear cell infiltration, angiogenesis, and re-epithelialization. The T3 group that was treated using 5% nano ethosomal gel showed the best burn wound healing, this may be caused by compounds in ashitaba leaf nanoparticles which have antioxidant, anti-inflammatory, and antibacterial effects, thus the use of transdermal delivery therapy of 5% ashitaba leaf nano ethosomal gel was effective for wound treatment burn on rat skin.
PROFIL PENDERITA DIABETES MELITUS DENGAN HIPOGLIKEMIA DI INSTALASI RAWAT INAP PENYAKIT DALAM RSUD DR. SOETOMO PERIODE 2017 Putri, Anandia Nafisah; Novida, Hermina; Wardhani, Puspa
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 1 (2021): EDITION MARCH 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i1.1384

Abstract

Diabetes mellitus can cause hypoglycemia that caused by various factors. This study aimed to determine the profile of general characteristics and metabolic parameters of diabetics with hypoglycemia at the Internal Medicine Inpatient Installation of Dr. Soetomo Hospital on 2017 period. This study was a cross-sectional descriptive study using medical record data of type 1 and type 2 diabetic patients. The total number of hypoglycemic patients in type 2 diabetes was 79 patients. Most patients were in the 50-70 years age group (72.1%), female (60.8%), diabetes duration >5 years (40.5%), and consumsing sulfonylurea (27.8%). Most patients had eGFR value of
Co-Authors Al-Anshori, Akhmad Afifudin Hani Plumeriastuti Hermina Novida, Hermina Ismi, Alif Noviana Lilik Maslachah Suhud, Mohamad Kharis Wardhani, Puspa