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All Journal Jurnal Medik Veteriner Care : Jurnal Ilmiah Ilmu Kesehatan Folia Medica Indonesiana
Putri, Anandia Nafisah
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Efficacy of Transdermal Delivery Nano Ethosomal Gel from Ashitaba Leaves on In-vivo Burn Wound Healing in Albino Rats Al-Anshori, Akhmad Afifudin; Putri, Anandia Nafisah; Ismi, Alif Noviana; Suhud, Mohamad Kharis; Plumeriastuti, Hani; Maslachah, Lilik
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.145-154

Abstract

This study aimed to evaluate the in-vivo burn wound healing process in albino rats treated using transdermal delivery nano ethosomal gel from ashitaba leaves. Ethosomal vesicles were formulated using soy lecithin, cholesterol, ethanol, water, and ashitaba leaf nanoparticles using the cold method. A total of 25 male rats were randomly divided into 5 groups, i.e., (C-) treated without nanoparticle extract, (C+) treated using 1% Silver Sulfadiazine®, treatment group treated nano ethosomal gel from ashitaba leaves with the respective doses were (T1) 1%, (T2) 2,5%, and (T3) 5%. Therapy was initiated on day 1 or after being induced by a burn wound for 14 days, twice a day. On the 15th day, a termination was carried out to take skin tissue from burn scars, then histopathology preparations were made with routine staining. Microscopic observations with an optical microscope on collagen, polymorphonuclear cell infiltration, angiogenesis, and re-epithelialization. The T3 group that was treated using 5% nano ethosomal gel showed the best burn wound healing, this may be caused by compounds in ashitaba leaf nanoparticles which have antioxidant, anti-inflammatory, and antibacterial effects, thus the use of transdermal delivery therapy of 5% ashitaba leaf nano ethosomal gel was effective for wound treatment burn on rat skin.
PROFIL PENDERITA DIABETES MELITUS DENGAN HIPOGLIKEMIA DI INSTALASI RAWAT INAP PENYAKIT DALAM RSUD DR. SOETOMO PERIODE 2017 Putri, Anandia Nafisah; Novida, Hermina; Wardhani, Puspa
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 9, No 1 (2021): EDITION MARCH 2021
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v9i1.1384

Abstract

Diabetes mellitus can cause hypoglycemia that caused by various factors. This study aimed to determine the profile of general characteristics and metabolic parameters of diabetics with hypoglycemia at the Internal Medicine Inpatient Installation of Dr. Soetomo Hospital on 2017 period. This study was a cross-sectional descriptive study using medical record data of type 1 and type 2 diabetic patients. The total number of hypoglycemic patients in type 2 diabetes was 79 patients. Most patients were in the 50-70 years age group (72.1%), female (60.8%), diabetes duration >5 years (40.5%), and consumsing sulfonylurea (27.8%). Most patients had eGFR value of
The Effect of Orlistat Administration in Change of Glycemic Control and Weight Loss of Obesity or Overweight Patients with Type 2 Diabetes Mellitus Johan, Abu Rizal Dwikatmono; Dewanti, Linda; Putri, Anandia Nafisah; Pantoro, Benny Iswanto; Albab, Chabib Fachry; Hutauruk, Maria Marind Desrianti; Novitasari, Triana
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

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Hightlight: • The effect of orlistat on glycemic control and weight loss in overweight or obese type 2 diabetes mellitus patients was determined • HbA1c and FPG level in overweight and obese type 2 diabetes mellitus patient can improved by orlistat as an adjuvant therapy. Abstract: Risk of Type 2 diabetes mellitus (T2DM) increases steadily with increasing overweight and obesity, and these two-health problems are emerging epidemics worldwide. Orlistat, a lipase inhibitor for weight loss drug, is often used in T2DM medication as adjuvant therapy, but effectiveness of the drug for improving glycemic control on T2DM patients is unclear. This study was to determine the effect of orlistat on glycemic control and weight loss in overweight or obese patients with T2DM. Term "Orlistat” AND "(obesity OR overweight)” AND "(HbA1c OR A1C)” AND "diabetes” were systematically searched in Pubmed and Science Direct web databases up to March 2021. Only randomized controlled study (RCT) methods studies were included in this study. Collected final samples were presented in a table with narrative review. There were 9 RCT studies with a total 2,175 subjects that met inclusion criteria. Of the sample, 360 mg/day orlistat as an adjuvant therapy, was administered to overweight or obese T2DM patients together with hypocaloric intake (8 studies) or without hypocaloric intake (1 study) intervention. They were examined for 12-52 weeks. From 2 short-term (12 weeks) studies, one study revealed that orlistat improved HbA1c and fasting plasma glucose (FPG) level significantly, while one study showed no significant effect compared to placebo. Seven other studies (long term observation) had found that orlistat significantly improved HbA1c and FPG level. All studies found that orlistat significantly reduced body weight. As an adjuvant therapy, Orlistat improved HbA1c and FPG level in overweight and obese T2DM patients.
Co-Authors Al-Anshori, Akhmad Afifudin Albab, Chabib Fachry Hani Plumeriastuti Hermina Novida, Hermina Hutauruk, Maria Marind Desrianti Ismi, Alif Noviana Johan, Abu Rizal Dwikatmono Lilik Maslachah Linda Dewanti Pantoro, Benny Iswanto Suhud, Mohamad Kharis Triana Novitasari, Triana Wardhani, Puspa