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PENGARUH EKSTRAK ETANOL KULIT SALAK (Salacca zalacca) TERHADAP KADAR MDA SERUM (Studi Eksperimental terhadap Tikus Jantan Galur Wistar yang Diinduksi Hati Ayam) Pertiwi, Danis; Guscella, Dede; Riza, Mohamad
Jurnal Ilmiah Penelitian Mahasiswa Vol 3, No 1 (2024): Maret 2024
Publisher : Jurnal Ilmiah Sultan Agung

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Abstract

Stress oksidatif menjadi dasar perkembangan komplikasi hiperurisemia. Kulit salak (Salacca zalacca) memiliki efek antioksidan sehingga dapat meredam stress oksidatif yang ditandai penurunan Malondialdehida (MDA). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol kulit salak (Salacca zalacca) terhadap kadar MDA serum tikus jantan galur Wistar yang diinduksi hati ayam.Penelitian eksperimental dengan rancangan post test only control group design menggunakan 25 ekor tikus. Tikus dibagi kedalam 5 kelompok dengan 5 ekor tikus pada masing-masing kelompok. K1: kelompok yang tidak diinduksi hiperurisemia serta mendapatkan pakan standar dan aquades sampai akhir penelitian, K2: kelompok hiperurisemia yang tidak diberi intervensi, K3: kelompok hiperurisemia yang diberi allopurinol dosis 1,8 mg/200gBB , P1 dan P2: kelompok hiperurisemia dan diberi ekstrak etanol kulit salak dengan 210 mg/kgBB dan 420mg/kgBB. Induksi hiperurisemia menggunakan jus hati ayam 8 gram/ekor selama 10 hari dan dilanjut pemberian perlakuan selama 7 hari. Sampel darah tikus diambil pada akhir penelitian untuk mendapat data kadar MDA serum per kelompok. Rerata kadar MDA serum yaitu K1 0.91 ± 0.12 nmol/mL, K2 10.91 ± 0.36 nmol/mL (tertinggi), K3 4.10 ± 0.24 nmol/mL(menurun), P1 4.47 ± 0.19 nmol/mL (menurun), P2 3.34 ± 0.28 nmol/mL(menurun). Data yang diperoleh dianalisis menggunakan one way Anova dan dilanjutkan uji post hoc LSD, menunjukan ada perbedaan signifikan antara semua kelompok baik kelompok kontrol maupun kelompok perlakuan (p < 0,05). Dari hasil tersebut dapat disimpulkan bahwa ekstrak etanol kulit salak berpengaruh terhadap kadar MDA serum tikus yang diinduksi jus hati ayam. Kata kunci: antioksidan, hati ayam, MDA, kulit salak, stress oksidatif
THE EFFECTIVENESS OF THE BPJS HEALTH PROGRAM IN ADDRESSING HEALTH PROBLEMS IN INDONESIA Riza, Mohamad
Proceeding International Seminar of Islamic Studies INSIS 6 (February 2024)
Publisher : Proceeding International Seminar of Islamic Studies

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Abstract

Social Security Administering Body (BPJS) Law Number 24 of 2011 concerning Social Security Administering Body (BPJS) established two Social Security administering bodies, namely BPJS Health and BPJS Employment. The Social Security Administering Agency (BPJS) for health is the result of the transformation of access, Jamkesda or Jamkesmas. BPJS health is divided into three categories of membership, namely BPJS Mandiri or Individual, BPJS for Wage Recipient Workers (PPU), and BPJS Contribution Assistance Participants (PBI). The BPJS health program in Indonesia as a whole can now be said to be running, with the existence of rules or a legal system that regulates this, making it legal, fair and beneficial for the Indonesian people. BPJS health in Indonesia can be said to be effective in maintaining the health of the Indonesian people, who basically have rights that the State must fulfill regarding health.
Pengaruh Kombinasi Ekstrak Belimbing Wuluh (Averrhoa Bilimbi L.) dan Ekstrak Kunyit (Curcuma Longa L.) terhadap Kadar Low Density Lipoprotein: Effect of Combination of Averrhoa Bilimbi Extract and Curcuma Longa Extract on Low Density Lipoprotein Levels in Rats Fed a High Fat Diet Fatikhasari, Amalia Nurazima; Yuniarifa, Conita; Utami, Kamilia Dwi; Riza, Mohamad; Soetoko, Anita Soraya
Amerta Nutrition Vol. 8 No. 3 (2024): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3.2024.363-367

Abstract

Background: Hypercholesterolemia is a state of total blood cholesterol levels transported by LDL exceeding normal limits. As a result, it can clog blood vessels, and this condition is a risk factor for CHD. Alternative medicine includes flavonoids in Averrhoa bilimbi (belimbing wuluh) known to reduce cholesterol and LDL levels, and curcumin in turmeric known to reduce fat absorption and increase fat excretion. Objectives: The aim of this study was to analyze the combined effect of bilimbi fruit and turmeric extracts on LDL levels. Methods: This experimental research used post-test only with a control group design involving male Wistar rats divided into 6 (six) random groups. Group KN (standard feed, aquadest for 28 days), K- (high-fat feed for 14 days, followed by standard feed and aquadest), K+ (high-fat feed for 14 days, followed by standard feed, aquadest, and simvastatin 0.18mg/200 g BW/day), P1 (high-fat feed for 14 days, followed by standard feed, aquadest and extracts of bilimbi fruit and turmeric extract at a dose of 240: 270 mg/200 g BW/day), P2 (high-fat diet for 14 days, followed by standard feed, distilled water and bilimbi fruit and turmeric extract at a dose of 360: 175 mg/200 g BW/day), P3 (high-fat diet for 14 days, followed by standard feed, distilled water and extracts of bilimbi fruit and turmeric at a dose of 120: 405 mg/200 g BW/day). The determination of LDL levels was done through a direct method using a spectrophotometer with a wavelength of 550 nm. Results: The mean LDL levels were KN (53.60 ± 10.69) mg/dL, K- (193.40 ± 16.86) mg/dL, K+ (100.20 ± 42.48) mg/dL, P1 (118.00 ± 64.71) mg/dL, P2 (104.00 ± 45.28) mg/dL, P3 (78.00 ± 4.69) mg/dL. The data received was analyzed using the Kruskal-Wallis test. Then, the results obtained differences in LDL levels between various groups (p<0.001). Subsequently, it was continued with the Mann-Whitney test on KN compared to K-, K+, P1, P2, P3 indicating p=0.009. As a result, it was found a significant difference in LDL levels between KN and K-, K+, P1, P2, and P3. Conclusions: This research concludes that providing a mixture of bilimbi fruit extract and turmeric extract can reduce LDL levels.
Pengaruh Kombinasi Probiotik, Ubi Jalar Ungu, dan Zinc terhadap Tebal Epitel Usus Mencit Jantan BALB/c Kolitis Ulseratif terinduksi Asam Asetat: Effect of Combination of Probiotics, Ipomoea Batatas, and Zinc on Thickness of Instestinal Epithelium in Mice Model of Acetic Acid-Induced Colitis Tsuraya, Ghefira; Yuniarifa, Conita; Hussaana, Atina; Riza, Mohamad; Masfiyah, Masfiyah
Amerta Nutrition Vol. 9 No. 2 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i2.2025.350-354

Abstract

Background: The use of probiotics to treat colitis is unsatisfactory, leading to a need for the combination with purple sweet potatoes (Ipomoea Batatas) and zinc. Objectives: This study aims to determine the effect of the combination of probiotics, purple sweet potatoes, and zinc on epithelial thickness.Methods: This was a post-test-only randomized controlled group experimental study using 30 mice divided into six groups, including KN, K-, K+, P1, P2, and P3. All groups except KN were induced with 4% acetic acid on day 1, then each received treatment for five days. KN, K+, P1, and P2 groups were given distilled water, sulfasalazine 1.3 mg/20 g BW, probiotics 0.078 mg/20 gBW + purple sweet potatoes 0.00169 g/20 gBW, and probiotics 0.078 mg/20 gBW + zinc 0.052 mg/20 gBW, respectively. Meanwhile, P3 received a combination of probiotics 0.078 mg/20 gBW + purple sweet potatoes 0.00169 g/20 gBW + zinc 0.0052 mg/20 gBW. Histological preparations were stained with Hematoxylin-Eosin and examined under 400× magnification across 10 fields of view. Results: The average epithelial thicknesses were KN (75.48±5.09), K− (28.02±5.60), K+ (69.1±13.82), P1 (47.05±9.41), P2 (48.6±9.73), and P3 (71.57±14.31). One-way analysis of variance (ANOVA) showed a significant difference among the groups with a p-value <0.001. Post Hoc LSD test identified significant differences (p-value<0.05) among all group pairs except between K+ and P3 (p-value=0.134) as well as P1 and P2 (p-value=0.349), but P3 had the highest average thickness value (71.57±14.31).Conclusions: The combination of probiotics, purple sweet potatoes, and zinc had an effect on intestinal epithelial thickness in male BALB/c mice with ulcerative colitis.
EMPOWERING FOREST BATHING TOUR GUIDES FOR YOGURT PRODUCTION IN LEREP UNGARAN BARAT VILLAGE, SEMARANG REGENCY Susilorini, Susilorini; Yuniarifa, Conita; Hussaana, Atina; Riza, Mohamad
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 8 No. 1 (2024): MARET
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v8i1.2257

Abstract

Wellness tourism is a tourist activity that not only aims for entertainment and pleasure, but also health. Lerep Village is one of the tourist villages that has a lot of potential to be developed into one of the wellness tourism objects. One of the highlights is the culinary sold in the traditional Sunday Pon market based on local wisdom. Currently there is no development of yogurt-based products in this traditional market, even though there is a lot of potential from livestock and agricultural products that can be developed as yogurt products. Yogurt is one type of food rich in bacteria which is expected to be one way to maintain public health, especially digestive health. Tourism cadres in this village have long been fostered by the Faculty of Medicine of Sultan Agung Islamic University, especially in the development of forest bathing tourism. This service activity aims to provide basic education and training to 20 forest bathing tourism cadres in traditional yogurt making. The training was held for 1 day with counseling methods and one-day training. Before and after the training, the participants were given pretest and post test, and the results of a significant increase in knowledge were obtained from the participants. After this training, it is hoped that the tourism cadres can produce yogurt so that it can become one of the healthy snack choices in Lerep Tourism Village.