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All Journal Universa Medicina Jurnal Respirologi Indonesia Respiratory Science Narra J Journal of International Surgery and Clinical Medicine
Yunita Arliny
Faculty of Medicine, University of Indonesia, Persahabatan Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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High glycosylated hemoglobin level as a risk factor of latent tuberculosis infection in patients with uncomplicated type 2 diabetes mellitus Arliny, Yunita; Yanifitri, Dewi Behtri; Mursalin, Diennisa
Universa Medicina Vol. 41 No. 1 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.47-55

Abstract

Background Diabetes mellitus (DM) is known to increase the risk of infection including tuberculosis (TB). Some studies also showed that 2-15% of latent TB infection (LTBI) will progress to active TB. This study aimed to obtain the prevalence of LTBI and to determine the risk factors of LTBI in patients with type 2 diabetes mellitus (T2DM). Methods This was a cross-sectional study on 242 adult T2DM patients. For LTBI screening we performed the interferon gamma release assay (IGRA) (Quantiferon TB Gold Plus test) and for confirmation of active TB (pulmonary TB) we performed GeneXpert MTB/Rif sputum examination and chest X-ray. Glycosylated hemoglobin (HbA1c) levels, smoking history and BCG scar were collected. Multivariate logistic regression was used to analyze the data. Results Positive IGRA results were found in 99 of 242 uncomplicated T2DM patients while LTBI was found in 82 patients (33.8%). There were significant differences between T2DM patients with latent TB and T2DM patients without infection in HbA1c and specific IFN-ã levels (TB1 minus nil and TB2 minus nil), i.e. 8.5% and 7.6%, 2.5 IU/mL and 0.06 IU/mL, and 2.6 IU/mL and 0.08 IU/mL, respectively. Multivariate analysis showed that the risk factors for LTBI in T2DM patients were smoking history, HbA1c >7%, and no BCG scar. Conclusions Because LTBI is prevalent in T2DM, it is important to screen for it in T2DM patients due to the risk of developing severe active TB. Absence of a BCG scar and high HbA1c levels are strong predictors of LTBI in T2DM patients.
Coexistence of pulmonary tuberculosis and small cell lung carcinoma: A significant problem in tuberculosis-endemic country? Arliny, Yunita; Yanifitri, Dewi B.; Purqan, Muhammad; Fachri, Muhammad
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.135

Abstract

Pulmonary tuberculosis and lung cancer are public health problems, causing significant morbidity and mortality worldwide. The coexistence of the two diseases has rarely been reported while their causative association has been noticed leading to diagnosis delayed and prognosis worsening. In this case report, we present the case of a patient with coexistence of pulmonary tuberculosis and small cell lung carcinoma. A 54-year-old male was presented with the complained of lower left chest pain for six months, which was getting worse four days before admission to the hospital. The patient also complained of cough and decreased appetite and weight loss. Initial chest X-ray revealed an infiltrate and cavity in the upper right lung and inhomogeneous consolidation in the left paracardial. After the patient was diagnosed with pulmonary tuberculosis and was given anti-tuberculosis drugs for two months, the cavity and consolidation decreased with no clinically significant improvement. We performed a bronchoscopy with suspicion of lung cancer and a forceps biopsy in which small cell carcinoma was confirmed. The patient received two cycles of chemotherapy and anti-tuberculosis was continued for four months. During the observation in the fourth month, there was a reduction in the tumor size. This case highlights that similarity of clinical symptoms between pulmonary tuberculosis and lung cancer often lead to misdiagnosis of both. Therefore, in the absence of complete clinical and radiological improvement in pulmonary tuberculosis patients, the coexistence of lung cancer should be considered. This also highlights that early diagnosis is critical for the favorable outcome.
Analysis of Clinical Manifestation at Admission and Comorbidity on Clinical Outcome of COVID-19 Patients in RSUDZA Banda Aceh Isma, Heliyana; Arliny, Yunita; Yanifitri, Dewi Behtri; Budiyanti, Budiyanti; Zulfikar, Teuku
Jurnal Respirologi Indonesia Vol 42, No 4 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i4.288

Abstract

Background: Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV- 2 virus and has become a pandemic until now. Clinical outcomes in patients vary depending on many factors, such as demographics, vital signs, laboratory results, and comorbidities.Methods: This study aims to analyze clinical outcomes in COVID-19 patients associated with the patient's general information (age, sex), demographic factors, admission vital signs, degree of symptoms at admission, blood laboratory results at admission, and comorbidities. This study is an analytic observational study with a cross-sectional design. All variables were examined based on medical records at the time of admission to the hospital. A multivariate analysis was conducted to determine what factors most influence clinical outcomes in treated COVID-19 patients.Results: There were 183 COVID-19 patients included in this study with moderate to critical degrees. Factors that influence the clinical outcome of COVID-19 patients are the presence of comorbidities, old age, high blood pressure and heart rate, anemia, leukocytosis, and increased blood sugar and creatinine at admission. Multivariate analysis showed that clinical symptoms of severe COVID-19 were a factor that influenced poor clinical outcomes in COVID-19 patients, with OR=5.6 (95% CI=2.223-13.90).Conclusion: Age, comorbidity, blood pressure, heart rate, hemoglobin, random blood glucose, and creatinine at admission influence the clinical outcome of admitted COVID-19 patients.
The Relationship Between Tuberculosis Knowledge and The Attitudes and Behaviors Of Dayah Students Rahman, Muhammad; Kurniawan, Ferry Dwi; Habibie, Yopie Afriandi; Arliny, Yunita; Maulina, Novi
Journal of International Surgery and Clinical Medicine Vol. 4 No. 2 (2024): (Available online: 1 December 2024)
Publisher : Surgical Residency Program Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jiscm.v4i2.60

Abstract

Introduction: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis and is one of the leading causes of death worldwide. Indonesia ranks second in global TB case counts, with a high transmission rate, particularly in high-risk environments such as Islamic boarding schools. This study aims to evaluate the knowledge, attitudes, and behaviors related to TB among students at Dayah Madrasah Aliyah Swasta Babun Najah in Banda Aceh. Additionally, it will analyze the relationship between their knowledge, attitudes, and behaviors in the context of TB prevention. Methods: This study employed an observational analytic method with a cross-sectional design and utilized cluster sampling. Primary data were gathered through questionnaires. The research was conducted at Dayah Madrasah Aliyah Swasta Babun Najah, located in the Ulee Kareng District of Banda Aceh, on August 29, 2024. Bivariate analysis was performed using the non-parametric Spearman's rank correlation coefficient test. Results: A total of 90 students participated in the study. The findings revealed that 67.8% of respondents had good knowledge, 78.9% demonstrated positive attitudes, and 47.8% exhibited good behaviors regarding tuberculosis (TB) prevention. Spearman Rank analysis indicated a moderately strong positive correlation between knowledge and attitudes (r = 0.527) and between knowledge and behaviors (r = 0.535), with a p-value of less than 0.025. Conclusion: Enhancing knowledge among students is crucial for fostering better attitudes and behaviors related to TB prevention, particularly in high-risk environments.
Cutaneous Adverse Drug Reaction due to Anti-TB Drug Allergy in TB-HIV Patient: A Case Report Yanifitri , Dewi Behtri; Arliny, Yunita; Hayati, Rahmi
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.164

Abstract

Background: In people living with HIV/AIDS (PLHIV), tuberculosis (TB) is the leading cause of death, with a 20 times higher risk of developing active TB compared to people without HIV. PLHIV are also at higher risk of experiencing cutaneous adverse drug reactions (CADR) caused by anti-TB drugs. The delayed therapy of TB caused by CADR might make TB management more difficult. Case: A 23-year-old male with clinically confirmed pulmonary TB on intensive phase anti-TB therapy experienced erythroderma due to allergies to anti-TB drugs and stage III HIV. In the drug challenge, it was found that the patient showed an allergic reaction in the form of a reddish rash that spread widely on the anterior and posterior thorax and abdomen after consuming rifampicin and pyrazinamide. Discussion: The patient's treatment was then added with cetirizine and methylprednisolone. The anti-TB drugs will be given for 9 months, with the intensive phase of 2 months, and the continuation phase of 7 months. Conclusion: There is a very high risk of CADR in TB patients with HIV infection. Monitoring the side effects of anti-TB regularly and identifying immediately which anti-TB drug causes the allergy is significant as the key to managing CADR in TB-HIV patients. Anti-TB drug provocation tests for each drug and a gradual dose increase are carried out if the clinical CADR has disappeared or improved.
Histopathological profile and radiological features of lung cancer with and without a history of pulmonary tuberculosis at dr. Zainoel Abidin Hospital, Banda Aceh Mardhatillah; Kurniawan, Ferry Dwi; Maulina, Novi; Arliny, Yunita; Sakdiah; Andayani, Novita
Journal of International Surgery and Clinical Medicine Vol. 4 No. 2 (2024): (Available online: 1 December 2024)
Publisher : Surgical Residency Program Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jiscm.v4i2.64

Abstract

Introduction: Lung cancer is one of the types of malignancies that is the leading cause of cancer deaths worldwide. In Indonesia, the incidence of lung cancer is quite high, with pulmonary TB as a risk factor that can increase the risk of lung cancer in the future. This study aims to describe the histopathological profile and radiological picture of lung cancer patients in patients with and without a history of pulmonary TB at dr. Zainoel Abidin Hospital Banda Aceh. Methods: This study uses retrospective methods and univariate analysis. The subjects of this study are lung cancer patients at dr. Zainoel Abidin Hospital from January 2022 to December 2023. Result: The results of this study showed that of the 184 patients, 6.5% of them had lung cancer with a history of pulmonary TB, while the other 93.5% had lung cancer without a history of pulmonary TB. Of the two groups of lung cancer, the majority of patients were aged 51-60 years (32.6%), male (83.7%), still working (81%), from Aceh (99.5%), and Muslim (99.5%). Most lung cancer patients were diagnosed at stage IV (86.4%), with Squamous Cell Carcinoma being the most common type of histopathology (57.1%). In lung cancer patients with a history of pulmonary TB, post-TB lesions are often found, such as fibrosis (83.3%), calcification (50%), cavitation (33.3%), pleural thickening (16.7%), and atelectasis (8.3%). Conclusion: Efforts to prevent lung cancer, especially in patients with a history of pulmonary TB, need to be continued so that the risk of developing lung cancer can be reduced.
Co-Authors Budiyanti Budiyanti Habibie, Yopie Afriandi Hayati, Rahmi Isma, Heliyana Kurniawan, Ferry Dwi Mardhatillah Maulina, Novi Muhammad Fachri Mursalin, Diennisa Novita Andayani, Novita Purqan, Muhammad Rahman, Muhammad Sakdiah Teuku Zulfikar Yanifitri , Dewi Behtri Yanifitri, Dewi B. Yanifitri, Dewi Behtri