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All Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Respiratory Science Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Journal of International Surgery and Clinical Medicine
Novita Andayani, Novita
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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 1 
Role of Insulin Like Growth Factor (IGF) in Lung Cancer with Underlying Diabetes Melitus Andayani, Novita; Mauliza
Journal of Medical Science Vol 4 No 2 (2023): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v4i2.116

Abstract

Lung cancer is one of the diseases which the highest incidence and mortality in the world. Lung cancer consists of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) with various subtypes. Diabetes mellitus is one of the comorbidities that is often found in lung cancer patients, which is around 6% - 18% in lung cancer patients. Diabetes is a comorbidity factor that has a serious effect in increasing cancer cell progressivity through the activity of insulin growth factor (IGF) which consists of receptors (IGF-R) and binding proteins (IGFP). The role of IGF produces oncogenic mutations at the DNA level with the process of lung cancer immunity stimulates mitogenesis initiated by insulin and initiates neoplasm cells. IGF receptor mechanism has antineoplastic properties, to fulfill glycemia control that will reduce lung cancer progressivity and prevent clinical worsening so that it can help reduce lung cancer mortality with oral hypoglycemia drugs along with lung cancer therapy modalities such as cytotoxic agents, radiotherapy, immunotherapy, and surgery. The role of IGF is to amplify insulin levels in glucose, lipid, and protein metabolism. IGF can induce cell differentiation and initiation of neoplasm. Diabetes mellitus as a comorbidity can poor clinical outcomes and promote progression through IGF receptor activation in the tumorigenesis process.
Distribution and antibacterial susceptibility pattern of isolated bacteria from endotracheal aspirates among ventilator-assisted pneumonia patients in Indonesia Andayani, Novita; Mahdani, Wilda; Nisyra, Mailani; Agustin, Heidy
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.149

Abstract

An accurate and timely identification of causative microorganisms as well as determination of their antibiotic susceptibility patterns will help in the selection of proper antibiotics and prevention of their misuse in pneumonia patients. The aim of this study was to determine the distribution and antibiotic susceptibility pattern of bacteria isolated from endotracheal aspirates of ventilator-assisted pneumonia patients in Indonesia. A retrospective cross-sectional study was conducted at Dr. Zainoel Abidin Hospital, a provincial reference hospital in Banda Aceh, Indonesia, from January to December 2021. Ventilator-assisted pneumonia patients aged ≥17 years treated in the hospital were considered eligible. Antibiotic susceptibility was valuated using Kirby-Bauer disc-diffusion followed with VITEK 2 Compact. We included 57 patients of which 73.7% males and 26.3% aged 56–65 years (represent the majority group of the patients). Each patient reported at least one comorbidity and the average duration of receiving mechanical ventilation was 8.68 days, and more than half (59.7%) of the patients had a poor clinical outcome (died). A total 57 bacteria isolates (consisting nine species) were recovered; 68.5% Gram-negative and 31.5% Gram-positive bacteria. Among 57 patients, Acinetobacter baumannii was the most frequent isolated Gram-negative bacteria (19.3%), followed by Klebsiella pneumoniae (17.5%), Pseudomonas aeruginosa (15.8%), and Achromobacter denitrificans (12.3%). A. baumannii exhibited <70% sensitivity to aminoglycoside and carbapenem antibiotics and 100% resistance to third-generation cephalosporins. The most abundant Gram-positive bacteria was Staphylococcus aureus (17.5%), followed by S. haemolyticus (10.5%) and S. epidermidis (3.5%). All S. aureus were sensitive to linezolid, tigecycline, vancomycin, and macrolide antibiotics (azithromycin, clarithromycin, clindamycin, and erythromycin), whereas 50% were sensitive to some beta-lactams. However, 50% of S. aureus were methicillin resistant S. aureus (MRSA). Given the magnitude of multi-drug resistance, an empiric antimicrobial therapy in particular to specific settings and implementation of antibiotic stewardship programs are crucial.
The Relationship between Particulate Matter and Length of Exposure to Respiratory Complaints and Lung Function Disorder among Brick Craftsmen in Aceh Besar Dianova, Sri; Febriansyah, TM.; Yanti, Budi; Andayani, Novita; Yusuf, Nurrahmah; Kurniawan, Ferry Dwi; Salawati, Liza
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.161

Abstract

Background: Brick craftsmen are heavily exposed to particulate matter (PM) from brick burning, possibly contributing to respiratory complaints. The research aims to evaluate the association between PM levels, duration of exposure, respiratory complaints, and lung function disorders among brick craftsmen in Aceh Besar. Method: The research method is observational analytic with a cross-sectional design. It was conducted in September 2023 on 68 respondents to assess lung function using spirometry and PM levels using the Air Quality Monitor. Results: The data analysis revealed restrictive types of lung function disorders (47.1%), 75% of participants had worked for more than three years with working hours ≥8 hours/day (100%), the most frequent respiratory complaint was coughing (23.5%) and shortness of breath (13.2%), and the dominant type of work was brick molding (67.6%) rather than burning (32.4%). The PM2.5 index in the brick manufacturing area is classified as very dangerous (100%), while the PM10 index is identified as very unsafe (55.6%) and very dangerous (44.4%). The correlation analysis revealed a significant connection between PM2.5 as well as PM10 and lung function impairments (values of P=0.002 and 0.012, respectively). There was a significant correlation between work periods and lung function impairments (P=0.037). Multivariate analysis showed that a working term of 1-3 years was strongly linked with lung function disorder (FEV1) among brick craftsmen in Aceh Besar (P=0.026). Conclusion: This study showed that PM exposure was significantly associated with impaired lung function but not with respiratory complaints. Furthermore, a long working period is significantly associated with respiratory symptoms, especially for workers with 1-3 years, and is associated with impaired lung function in brick artisans in Aceh Besar.
Syndrome of Inappropriate Antidiuretic Hormone (Siadh) in Lung Cancer Andayani, Novita; Husna, Cut Asmaul
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.9 No.2 November 2023
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v9i2.10719

Abstract

Lung cancer is one of the deadliest cancers in both men and women. Lung cancer is generally divided into 2, categories: small-cell lung carcinoma and non-small-cell lung carcinoma. Small cell lung carcinoma (SCLC) represents approximately 15% of all lung cancers. Paraneoplastic syndromes occur in 10% of lung cancer cases and constitute a group of disorders associated with the secretion of functional polypeptides or hormones from tumor cells. The syndrome of inappropriate antidiuretic hormone is a paraneoplastic syndrome that is closely related to SCLC and is associated with worse survival. The key to understanding SIADH is that the hyponatremia that occurs in this syndrome is not caused by Na+ deficiency but rather by excess fluid. The syndrome of inappropriate antidiuretic hormone that occurs is a secondary event caused by the release of antidiuretic hormone due to tumor lysis or because the tumor releases ectopic ADH. Hyponatremia in SCLC is a negative prognostic factor in hospitalized patients and patients with advanced disease
Histopathological profile and radiological features of lung cancer with and without a history of pulmonary tuberculosis at dr. Zainoel Abidin Hospital, Banda Aceh Mardhatillah; Kurniawan, Ferry Dwi; Maulina, Novi; Arliny, Yunita; Sakdiah; Andayani, Novita
Journal of International Surgery and Clinical Medicine Vol. 4 No. 2 (2024): (Available online: 1 December 2024)
Publisher : Surgical Residency Program Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jiscm.v4i2.64

Abstract

Introduction: Lung cancer is one of the types of malignancies that is the leading cause of cancer deaths worldwide. In Indonesia, the incidence of lung cancer is quite high, with pulmonary TB as a risk factor that can increase the risk of lung cancer in the future. This study aims to describe the histopathological profile and radiological picture of lung cancer patients in patients with and without a history of pulmonary TB at dr. Zainoel Abidin Hospital Banda Aceh. Methods: This study uses retrospective methods and univariate analysis. The subjects of this study are lung cancer patients at dr. Zainoel Abidin Hospital from January 2022 to December 2023. Result: The results of this study showed that of the 184 patients, 6.5% of them had lung cancer with a history of pulmonary TB, while the other 93.5% had lung cancer without a history of pulmonary TB. Of the two groups of lung cancer, the majority of patients were aged 51-60 years (32.6%), male (83.7%), still working (81%), from Aceh (99.5%), and Muslim (99.5%). Most lung cancer patients were diagnosed at stage IV (86.4%), with Squamous Cell Carcinoma being the most common type of histopathology (57.1%). In lung cancer patients with a history of pulmonary TB, post-TB lesions are often found, such as fibrosis (83.3%), calcification (50%), cavitation (33.3%), pleural thickening (16.7%), and atelectasis (8.3%). Conclusion: Efforts to prevent lung cancer, especially in patients with a history of pulmonary TB, need to be continued so that the risk of developing lung cancer can be reduced.
The Correlation of Neutrophil-Lymphocyte Ratio (NLR) and the Response Evaluation Criteria in Solid Tumors (RECIST) in Non-small Cell Lung Cancer (NSCLC) Patient Andayani, Novita; Arliny, Yunita
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1178

Abstract

Background: The biological marker Neutrophil-Lymphocyte Ratio (NLR) is still being studied for its effectiveness as a predictor of prognosis and treatment response to cancer. This study aims to assess the effectiveness of the NLR as a prognostic biomarker in Non-small Cell Lung Cancer (NSCLC) patients. Methods: This observational study with a cross-sectional design intends to determine the effect of NLR on the response to the treatment of the patients as measured by Response Evaluation Criteria in Solid Tumors (RECIST). The samples collected were advanced-stage NSCLC patients who underwent chemotherapy from January 2021 to December 2022 to assess the prognosis and its relationship with NLR. The area Under the Curve Receiver Operating Characteristic (AUC ROC) curve was used to see the sensitivity, specificity, and cut-off point. Results: Sixty-seven samples met the criteria of the samples’ study. The best NLR cut-off point was 4.335 with a sensitivity of 86.7% and a specificity of 55.5%. The AUC value was 0.701 with a significance of 0.019. NLR values above the cut-off point were more frequently found in patients with progressive disease (29 samples; 43.3%). Conclusions: This study showed that there was a relationship between NLR and RECIST in NSCLC patients. NLR was quite effective as a prognostic biomarker of NSCLC patients who underwent chemotherapy.
The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia Syahruddin, Elisna; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Wulandari, Laksmi; Setijadi, Ana Rima; Ermayanti, Sabrina; Pratiwi, Suryanti Dwi; Infianto, Andreas; Andayani, Novita; Munir, Sri Melati; Pratama, Avissena Dutha; Kusumawardani, Ida Ayu Jasminarti Dwi; Haryati, Haryati; Duyen, Natalie; Hanif, Muhammad Alfin; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.22-30

Abstract

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI. Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression. Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001). Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.
Analysis of Monocyte to Lymphocyte Ratio and Clinical Symptoms of Clinically Confirmed Pulmonary Tuberculosis New Case Patients Before Treatment and After Intensive Phase Handoko, Basti; Arliny, Yunita; Priyanto, Herry; Andayani, Novita; Yanifitri, Dewi Behtri
Jurnal Respirologi Indonesia Vol 45 No 1 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i1.533

Abstract

Background: Treatment evaluation of clinically confirmed pulmonary tuberculosis (TB) is limited to clinical symptoms and chest X-rays that tend to be subjective and no better than bacteriological examination. Monocytes and lymphocytes mediate the immunopathology of TB infection as a form of host defense that affects the systemic concentration of the body’s defense cells. The study assesses the monocyte-to-lymphocyte ratio (MLR) to evaluate TB treatment. Methods: Longitudinal prospective paired t-test with characteristics of clinically confirmed pulmonary TB new cases then compared to monocytes, lymphocytes, and monocyte-lymphocyte ratio (MLR) before administration of anti-tuberculosis drugs (ATD) and the end of the intensive phase. Results: In thirty clinically confirmed pulmonary TB patients before and after the anti-tuberculosis drug (ATD) there was no difference in monocytes pre 8.3 - post 8.5 (P=0.82), there was a difference in lymphocytes pre 17.8 - post 25.6 (P<0.05) that affected the MLR ratio value pre 0.57 - post 0.39 (P<0.05). Conclusion: This study identifies there is a significant difference in MLR before treatment and after the intensive phase of clinically confirmed pulmonary TB.
Type 2 diabetes mellitus as an independent risk factor of pulmonary tuberculosis: A hospital based cross-sectional study Yanti, Budi; Firdausa, Sarah; Irsyah, Abid Dhiyauddin Alfani; Andayani, Novita; Salwani, Desi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art9

Abstract

Background: The growing frequency of infectious and non-communicable illnesses on a global scale is primarily associated with the changing patterns observed in epidemiology. Diabetes mellitus (DM) significantly leads to the development of tuberculosis (TB) and less effective treatment outcomes if not identified early. Objective: This study aims to investigate type 2 DM as a risk factor for TB infection.Methods: Participants in this cross-sectional research study comprised DM patients who reported cough complaints at the TB treatment center and the internal medicine department of Zainoel Abidin Hospital. Random blood glucose and glycated hemoglobin (HbA1c) levels were measured in all respondents. The Chi-Square test assesses the association between DM and Pulmonary TB.Results: There are 48 DM patients with new pulmonary TB, an averageage of 53 years (SD 9.1). Most of them have symptoms of cough for more than 2 weeks (85.4%), loss of body weight (77.1%), chest pain (58.3%), and loss of appetite (72.9%). The high HbA1c levels were associated with TB, as detected by Xpert MTB/RIF assay and typical radiographic signs (p<0.05). DM patients with increased HbA1c were found to have a two times chance of showing results from a chest x-ray typical of TB and probability of TB infection (PR: 2.850, 95% CI (1.152-7.053); 2.745, 95% CI (0.969-7.780)) respectively.Conclusion: DM patients had two times the risk of lung damage based on chest X-rays and having TB. DM may seriously compromise the efficacy of TB control programs and impede a nation's progress toward TB elimination.
Co-Authors Agustin, Heidy Ana Rima Setijadi Ananda, Fannie Rizki Cut Asmaul Husna, Cut Asmaul Desi Salwani, Desi Dianova, Sri Duyen, Natalie Elisna Syahruddin Ermayanti, Sabrina Febriansyah, TM. FIRDAUSA, SARAH Handoko, Basti Hanif, Muhammad Alfin Haryati Haryati Ida Ayu Jasminarti Dwi Kusumawardani Infianto, Andreas Irsyah, Abid Dhiyauddin Alfani Kurniawan, Ferry Dwi Laksmi Wulandari Lim, Darren Wan-Teck Liza Salawati, Liza Mahdani, Wilda Mardhatillah Maulina, Novi Mauliza Nisyra, Mailani Noni Novisari Soeroso Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Priyanto, Herry Sakdiah Sri Melati Munir Yanifitri, Dewi Behtri Yanti, Budi Yunita Arliny Yusuf, Nurrahmah