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All Journal Eduvest - Journal of Universal Studies Jurnal Farmasi Klinik - Best Practice (JFKlin)
Wardani, Tita Kusuma
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Aerospace Engineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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POLA PENGGUNAAN ANTIBIOTIK RESERVE DI UNIT INTENSIF DAN NON INTENSIF RAWAT INAP RSUP FATMAWATI Subhan, Ahmad; Oktamauri, Ariesa; Haifa, Alifia; Wardani, Tita Kusuma
Jurnal Farmasi Klinik Best Practice Vol 3 No 1 (2024): Jurnal Farmasi Klinis Best Practice Volume 3 No. 1 Juni 2024
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v3i1.43

Abstract

The widespread prescription and utilization of antibiotics in hospitals globally, including Indonesia, pose a significant risk of inappropriate antibiotic usage, leading to antibiotic resistance. In response to this crisis, the World Health Organization (WHO) has devised the AWaRe (Access, Watch, Reserve) classification system. The use of reserve category antibiotics has been restricted. However, the available evidence is insufficient to draw definitive conclusions regarding the impact of these limitations and their correlation with patient clinical outcomes. This study aims to evaluate the usage patterns of reserve category antibiotics and their associated clinical outcomes in both intensive and non-intensive inpatient care at RSUP Fatmawati during the April - May 2024 period. Utilizing a prospective cohort design, the research subjects consisted of a total sampling of all inpatients who received reserve antibiotics. Statistical analysis was performed using SPSS 25. The largest proportion of reserve antibiotic use was observed in the ICU, accounting for 27.6%. The reserve antibiotics employed included Meropenem (83.71%), Aztreonam (2.33%), Cefepime (2.33%), Vankomisin (9.30%), and Ceftazidime (2.33%). These antibiotics were predominantly utilized for the diagnosis of sepsis & septic shock, constituting 72.10% of cases. The percentage of patients who received the correct antibiotic was 9.3%, with 75.0% experiencing improvement and 25.0% experiencing deterioration. Conversely, among patients receiving incorrect antibiotics, 48.7% experienced worsening. The inappropriate administration of antibiotics elevated the risk of patient deterioration (OR = 2.8; p = 0.359), with the most common inadequacies occurring in the duration and dosage of antibiotics.
Pattern of Prophylactic Antibiotic Prescribing in Surgical Patients at the University of Indonesia Hospital Wardani, Tita Kusuma; Andrajati, Retnosari; Putra, M. Arza; Dwiputra, Anggara Gilang
Eduvest - Journal of Universal Studies Vol. 5 No. 5 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i5.51105

Abstract

Surgical procedures involve interventions that may compromise tissue integrity, necessitating prophylactic antibiotics to prevent surgical site infections (SSIs). Proper timing, selection, and administration of antibiotics are crucial to achieving optimal therapeutic outcomes. This study aimed to evaluate the prescribing patterns of prophylactic antibiotics in patients undergoing surgical procedures at the University of Indonesia Hospital and assess adherence to established guidelines. A retrospective observational study analyzed medical records of patients who underwent surgery. Data collected included the type of antibiotics prescribed, timing of administration, dosage, duration, and adherence to national and international guidelines. Descriptive statistics were used to summarize the findings. The study analyzed 213 surgical patients at the University of Indonesia Hospital in September 2024. Prophylactic antibiotics were prescribed in 90.61% of cases, predominantly Cefazolin (86.48%), with doses of 2 g (76.12%) and 1 g (10.36%). Most patients (97.93%) received antibiotics 30–60 minutes pre-incision. All antibiotics were administered intravenously with research results, 4.29% were affected by IDO. These findings highlight overall adherence to prophylactic antibiotic guidelines, with minor deviations in timing and dosage observed in a few cases. Optimal prescribing practices were achieved in most surgical patients to reduce the risk of SSI.
Co-Authors Ahmad Subhan Ariesa Oktamauri Dwiputra, Anggara Gilang Haifa, Alifia Putra, M. Arza Retnosari Andrajati