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All Journal journal of internal medicine Indonesian Journal of Cancer The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Ami Ashariati
Medical Hematology Oncology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Biomolecular and Health Science Journal

 1 
The Role of JAK2 in Myeloproliferative Diseases Diagnosis Yudith Annisa Ayu Rezkitha; S. Ugroseno Yudho Bintoro; Ami Ashariati
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.416 KB) | DOI: 10.20473/bhsj.v1i2.9831

Abstract

Janus Kinase 2 (JAK2) plays an important role in mediating transduction signal of hematopoiesis, including in the pathogenesis of Myeloproliferative diseases (MPD). Various studies have been carried out to identify the position of aleles in tyrosine encoding mutations. Although the effect of JAK2 mutations is still not fully understood, the discovery of these mutations might be able to differentiate the types of polycythaemia vera, essential thrombocytemia, and primary myelofibrosis with malignant abnormalities. WHO has revised the MPD diagnosis criteria following this finding. This review will discuss the role of JAK2.
A 40-year-old Woman with Hypercalcemia Crisis Caused by Bone Metastasis in Stage IV Breast Cancer Wiharjo Hadisuwarno; Merlyna Savitri; Ami Ashariati; S. Ugroseno Yudho Bintoro; M. Noor Diansyah; Putu Niken Ayu Amrita; Pradana Zaky Romadhon
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.29633

Abstract

Breast cancer is still global burden especially for woman with 2.3 million cases every year dan 15% mortality among cancer diseases. In developing countries, most of the cases are diagnosed at terminal stage when metastasis already found. Bone metastasis is the highest among other metastasis sites such as: lung, liver and brain. Bone metastasis will cause hypercalcemia and bone pain as complications.  Both will gradually decrease patient’s quality of life. Comprehensive and holistic management for these complications will reduce deterioration and hopefully increase patient’s quality of life even they were at terminal stage. We describe a 40-year-old woman who got hypercalcemia crisis. Hypercalcemia usually manifest as a consequence of other diseases. Epidemiologically, majority come from metastasis, but can be other diseases, such as multiple myeloma. Interestingly, during medical investigation through her medical history, and physical examination, and laboratory examinations, we conclude that her hypercalcemia crisis was caused by bone metastasis from breast cancer.
Diathesis Hemorrhagic, Coagulation and Fibrinolytic System Rizky Amalia Putri; Muhammad Noor Diansyah; Ami Ashariati Ashariati; Siprianus Ugroseno Yudho Bintoro; Putu Niken Ayu Amrita; Merlyna Savitri Savitri; Pradana Zaky Romadhon
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.35280

Abstract

Bleeding is one of the most common complaints when coming to the hospital which can be mild to life-threatening. The balance of the impaired hemostasis system allows for abnormal bleeding such as hemorrhagic diathesis. Balance between blood clotting and bleeding is always maintained in the body under normal physiology. The coagulation system stops existing bleeding with vasoconstricts of blood vessels and the formation of early platelet plugs, this blockage is strengthened by the presence of a cascade of coagulations to form stable and sturdy blockages. Once bleeding has stopped, the fibrinolytic pathway is initiated to dissolve the blood clot to restore normal blood flow. balance the coagulants, fibrinolytic and inhibitor systems, creating a perfect physiological balance. Hemostatic imbalance is a global problem that can lead to thrombosis or hemorrhage.
Co-Authors Abdurachman Abdurachman Adi Mulyono Andi Yasmin Wijaya Andy Purnomo ARIO DJATMIKO, ARIO Bintoro, Siprianus Ugroseno Yudho Boediwarsono - Choirina Windradi Fedik Abdul Rantam I'tishom, Reny ISKANDAR ALI, ISKANDAR Krisnina Nurul Widiyastuti KUSUMASTUTI, ETTY HARY Lukman Hakim Made Putra Sedana Merlyna S Merlyna Savitri Merlyna Savitri Merlyna Savitri Merlyna Savitri Savitri Muhammad Noor Diansyah Muhammad Noor Muhammad Nur Imroatul Mursyidah Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Rizky Amalia Putri Romadhon, Pradana Zaky S.Pd. M Kes I Ketut Sudiana . Soebandiri - Steven Sheng Looi Sugianto - Ugroseno - Ugroseno Yudho Bintoro Ugroseno Yudho Bintoro Wiharjo Hadisuwarno Winona May Hendrata Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu